公开(公告)号：US10653391B2

公开(公告)日：2020-05-19

申请号：US14683235

申请日：2015-04-10

Applicant: Muffin Incorporated

Inventor： Neal E. Fearnot ,  Peter S. McKinnis ,  Sarah Robbins ,  Yun Zhou

IPC: A61B8/12 ,  A61B8/00 ,  G01S15/89 ,  G01S7/52 ,  G10K11/35 ,  G10K11/00 ,  A61B90/00

Abstract: Among other things, there is disclosed structure and methods for registering images obtained through internal (e.g. intravascular) ultrasound devices. Embodiments of a device with a rotating ultrasound beam is provided, with a wall of the device being anisotropic in ultrasound passage. As examples, a cable opaque to ultrasound is attached along the wall of the device, so that the ultrasound beam at the location of the cable is blocked, reflected or scattered. As another example, a thin film of metallic material is placed on or in the wall to allow a portion of the beam to be blocked or attenuated. The imaging system recognizes the changes to the signals made by the anisotropic wall, and registers successive images according to those changes.

公开(公告)号：US10328290B2

公开(公告)日：2019-06-25

申请号：US13956407

申请日：2013-08-01

Applicant: Muffin Incorporated

Inventor： Yun Zhou ,  Peter S. McKinnis ,  Sarah Robbins ,  Neal E. Fearnot

IPC: A61B17/22 ,  A61N7/00 ,  A61N7/02 ,  A61M25/10 ,  A61M37/00 ,  A61B18/00

Abstract: Systems and methods for treating a blood clot positioned within a blood vessel are disclosed. In one embodiment, a balloon member is positioned on a distal end region of a catheter and an ultrasound emitting element is positioned within the balloon member and arranged for actively emitting ultrasound. In some exemplary embodiments, the disclosure provides a multi-wall balloon member and a multi-lumen catheter with at least one and/or all cavities of the balloon member arranged for heat transfer with the ultrasound emitting element. The disclosure also provides catheter arrangements with an ultrasound emitting element arranged to heat tissue adjacent to the balloon member. Additionally, in some embodiments, at least one and/or all walls of the balloon member have apertures arranged to release a therapeutic agent such as a thrombolytic drug.

公开(公告)号：US20190167122A1

公开(公告)日：2019-06-06

申请号：US15829186

申请日：2017-12-01

Applicant: Cook Medical Technologies LLC ,  Muffin Incorporated d/b/a Cook Advanced Technologies

Inventor： F. Joseph Obermiller ,  William J. Havel

IPC: A61B5/0215 ,  A61M25/10 ,  A61B5/00

Abstract: A system for monitoring the flow of blood within an endoluminal passage is provided comprising a medical device and a sensor. The medical device is implantable within the endoluminal passage and includes a shaft and an expandable segment coupled to the shaft. The expandable segment is movable between a first state and a second state. Movement of the expandable segment is responsive to a change in the fluid pressure external to the expandable segment. The sensor is positioned on the medical device and is adapted to collect information associated with the state of the expandable segment.

公开(公告)号：US10098739B2

公开(公告)日：2018-10-16

申请号：US14821067

申请日：2015-08-07

Applicant: Muffin Incorporated

Inventor： Peter S. McKinnis ,  Neal E. Fearnot

IPC: A61F2/24 ,  A61F2/01

Abstract: Among other things, there are disclosed embodiments of a valve implant that in particular examples are implantable within a blood vessel, which include a first set of elongate members, a second set of elongate members, and a hood affixed to the first set of elongate members. The first set of elongate members is resiliently deformable, and their distal ends are flared radially outward. The distal ends of the second set of elongate members are distal to the ends of the first set of elongate members. The hood is affixed to the first set of elongate members, and seals against the interior wall of the blood vessel in an expanded configuration. When blood flows from the proximal to the distal side of the valve implant, it presses on the hood, compressing the first set of elongate members, breaking the seal.

公开(公告)号：US10071187B2

公开(公告)日：2018-09-11

申请号：US14835005

申请日：2015-08-25

Applicant: Muffin Incorporated ,  Cook Biotech Incorporated

Inventor： Michael C. Hiles ,  Chad E. Johnson ,  Neal E. Fearnot ,  Thomas Payne ,  Ronald Jankowski

IPC: A61L27/50 ,  C12M1/00 ,  A61L27/24 ,  A61L27/36 ,  A61L27/38 ,  C12M3/00 ,  C12M1/12 ,  C12N5/00

CPC classification number: A61L27/50 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/3633 ,  A61L27/3808 ,  A61L27/3826 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/26 ,  A61L2430/28 ,  A61L2430/30 ,  A61L2430/32 ,  A61L2430/34 ,  C12M21/08 ,  C12M23/06 ,  C12M23/34 ,  C12M25/14 ,  C12N5/0062 ,  C12N2533/54

Abstract: Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.

公开(公告)号：US09855401B2

公开(公告)日：2018-01-02

申请号：US15159025

申请日：2016-05-19

Applicant: Muffin Incorporated

Inventor： Frank J. Fischer, Jr.

IPC: A61M31/00 ,  A61M5/32 ,  A61M25/00 ,  A61M5/158

CPC classification number: A61M25/007 ,  A61M5/158 ,  A61M5/3286 ,  A61M5/329 ,  A61M5/3291 ,  A61M5/3295 ,  A61M5/3298 ,  A61M2202/0064 ,  A61M2202/097

Abstract: Arrangements and methods for delivering bioactive agents and/or cells into an extended volume of tissue are disclosed. In one embodiment, a cell-delivering needle arrangement has a tube positioned within a tube and fixedly attached to a wall thereof. In one exemplary method, a cell-delivering needle is advanced into tissue, a suspension of cells is passed through a first lumen and out of side ports, and a suspension of cells is passed through a second lumen and out of a distal opening. Other embodiments are disclosed.

公开(公告)号：US20160263282A1

公开(公告)日：2016-09-15

申请号：US15058329

申请日：2016-03-02

Applicant: Muffin Incorporated

Inventor： Shelly L. Wallace ,  Amanda F. Taylor ,  Steven Charlebois ,  Christine M. Steinhart ,  Neal E. Fearnot

IPC: A61L27/36 ,  A61L27/12 ,  A61L27/54

CPC classification number: A61L27/3633 ,  A61L27/12 ,  A61L27/54 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2430/02

Abstract: Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.

Abstract translation: 成骨组合物包括脱细胞的细胞外基质组织和骨形态发生蛋白，优选BMP-2。 所述组合物有利地使用BMP，其可以以相对低的剂量使用并且可以结合残留在脱细胞的细胞外基质组织中的天然组分（例如天然硫酸化糖胺聚糖如肝素和/或硫酸乙酰肝素）。 还描述了制备和使用这些组合物的方法。 组合物和相关方法可用于治疗患病或受损的骨组织。

公开(公告)号：US20160058664A1

公开(公告)日：2016-03-03

申请号：US14835757

申请日：2015-08-26

Applicant: Muffin Incorporated

Inventor： William J. Havel ,  Neal E. Fearnot ,  Peter S. McKinnis ,  Richard B. Sisken ,  Charles Leland Baxter

IPC: A61J1/14 ,  B65B51/26 ,  B65D75/42

CPC classification number: A61J1/1406 ,  A61J1/10 ,  A61J1/1468 ,  A61J1/2093 ,  B29C65/02 ,  B29C65/04 ,  B29C65/08 ,  B29C65/10 ,  B29C65/14 ,  B29C65/16 ,  B29C65/48 ,  B29C65/4895 ,  B29C66/1122 ,  B29C66/344 ,  B29C66/3452 ,  B29C66/43121 ,  B29C66/71 ,  B29C66/7212 ,  B29C66/73921 ,  B29C66/8266 ,  B29C66/8322 ,  B29L2031/7148 ,  B31B70/00 ,  B65B51/26 ,  B65D75/42 ,  B65D75/44 ,  B65D75/5883 ,  B29K2023/083 ,  B29K2307/04 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2027/06 ,  B29K2075/00

Abstract: Described in one aspect is a multi-cell or multi-chambered container for sealing various materials such as therapeutic or diagnostic agents, animal or human tissue, tissue samples, specimens, blood, genetic material, or any other material. The container includes seals formed by folding the wall of the elongate body transverse to the interior of the elongate body and maintaining the folded wall portions adjacent one another or joining them together. In another aspect, the container disclosed may be made according to a method involving creating multiple seals at various locations along the elongate body thus creating sealed voids or cells between the seals within the elongate body.

Abstract translation: 一方面描述了用于密封诸如治疗或诊断剂，动物或人体组织，组织样品，标本，血液，遗传物质或任何其它材料的各种材料的多细胞或多室容器。 容器包括通过将细长体的壁横向于细长体的内部折叠并且将折叠的壁部分彼此相邻或将它们连接在一起而形成的密封件。 在另一方面，所公开的容器可以根据包括在细长体的各个位置处产生多个密封件的方法制造，从而在细长体内的密封件之间形成密封的空隙或细胞。

公开(公告)号：US20160000405A1

公开(公告)日：2016-01-07

申请号：US14854163

申请日：2015-09-15

Applicant: Muffin Incorporated

Inventor： William J. Havel ,  Sarah Robbins ,  Peter S. McKinnis ,  Yun Zhou ,  Neal E. Fearnot

IPC: A61B8/00 ,  A61B8/12

Abstract: There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.

Abstract translation: 公开了用于对身体部分，特别是血管的内部进行成像的装置和方法的实施例。 在特定实施例中，导管具有尖端腔室，其中安装有枢转机构的超声换能器，用于转动换能器的马达和用于枢转换能器的器具。 这种工具的实例是线性电动机，轴或细丝，并且当工具不枢转换能器时，枢转机构可被偏置以返回到基座位置。 在其他实施例中，使用类似的机构可以使来自换能器的反射超声信号的镜子旋转和/或枢转。

公开(公告)号：US20140276083A1

公开(公告)日：2014-09-18

申请号：US14211780

申请日：2014-03-14

Applicant: Muffin Incorporated

Inventor： Peter S. McKinnis ,  Yun Zhou ,  Sarah Robbins ,  Neal E. Fearnot

IPC: A61B8/00

CPC classification number: A61B8/4281 ,  A61B1/00064 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/4272 ,  A61B8/445 ,  A61B8/4461 ,  A61N7/022 ,  A61N2007/0043 ,  A61N2007/0082

Abstract: There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.

Abstract translation: 公开了用于对身体部分，特别是血管的内部进行成像的装置和方法的实施例。 在特定实施例中，导管具有尖端腔室，其中安装有枢转机构的超声换能器，用于转动换能器的马达和用于枢转换能器的器具。 这种工具的实例是线性电动机，轴或细丝，并且当工具不枢转换能器时，枢转机构可被偏置以返回到基座位置。 在其他实施例中，使用类似的机构可以使来自换能器的反射超声信号的镜子旋转和/或枢转。