摘要:
A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.
摘要:
A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要:
A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要:
In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 5 milliliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.
摘要:
A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module comprises a housing, an infusion fluid passageway, a sample fluid passageway, and a fluid component separator. The infusion fluid passageway has a first port and a second port spaced from the first port, and a lumen extending from the first port to the second port. The sample fluid passageway is connected to the infusion fluid passageway. The fluid component separator is connected to the sample fluid passageway.
摘要:
A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. A transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation is provided. Phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. A method for adjusting an analyte measurement is provided. The method provides a hydration correction process for calibration and correction whereby analyte concentrations within the material sample may be determined. The hydration correction process is particularly suitable for determining blood analyte concentrations within human tissue.
摘要:
A processing circuit is disclosed for computing a fast Fourier transform (FFT). In one embodiment, the processing circuit includes a memory device, a multiplier, a detector, a state machine, and a circuit for performing the 2's compliment of a coefficient. The memory storage device stores data values and coefficient (or twiddle) values. The detector integrates a data pointer with the state machine. The detector is designed to identify the symmetry lines (by memory address). The state machine, when notified by the detector that a line of symmetry has been encountered, appropriately adjusts either the coefficients, the imaginary sign, or the real sign for input to a multiplier.
摘要:
A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.
摘要:
A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.
摘要:
The present invention is generally directed to a processing circuit for computing a fast Fourier transform (FFT). The present invention reflects the recognition that excessive reads to and writes from memory consume excessive amounts of power. Accordingly, the circuit of the present is specifically designed to minimize the number of reads and writes to memory. In addition, the circuit is designed so that processing parallelism may be achieved in order to reduce the total number of clock cycles required to compute a FFT. In accordance with one aspect of the invention, the processing circuit includes a data memory for storing data values, and a separate coefficient memory for storing coefficient (or twiddle) values. The circuit further includes a multiplier configured to multiply values received from the coefficient memory and another value retrieved from some other location. The circuit further includes a first adder configured to add a value output from the multiplier with a value retrieved from another location. The circuit further includes a second adder configured to add a value retrieved from the data memory with a value retrieved from another location. Finally, the circuit includes write-back data path disposed between the second adder and the data memory. The write-back data path is configured to write data output from the second adder to the data memory, to a location where a data value was previously retrieved.