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公开(公告)号：US08574853B2
公开(公告)日：2013-11-05
申请号：US13310463
申请日：2011-12-02
IPC分类号： G01N33/53
CPC分类号： C07K16/1278 , A61K51/1009 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56911 , G01N33/573 , G01N2333/32 , G01N2333/954 , G01N2469/10
摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
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公开(公告)号：US08501182B2
公开(公告)日：2013-08-06
申请号：US13130044
申请日：2009-11-19
IPC分类号： A61K39/40
CPC分类号： C07K16/1278 , A61K39/07 , A61K39/3955 , A61K39/40 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/92 , G01N33/56911 , G01N2333/32
摘要： The present disclosure relates to monoclonal antibodies that bind poly-γ-D-glutamic acid (γDPGA), which is present on the surface of Bacillus anthracis. The disclosure also provides chimeric forms of the monoclonal antibodies, humanized forms of the monoclonal antibodies, and fragments thereof, as well as nucleic acids encoding the antibodies and fragments thereof. Pharmaceutical compositions including such antibodies are also disclosed herein. The disclosure further provides prophylactic, therapeutic, and diagnostic methods of using the disclosed antibodies.
摘要翻译： 本公开涉及结合存在于炭疽芽孢杆菌表面上的多聚-γ-D-谷氨酸（gammaDPGA）的单克隆抗体。 本公开还提供了单克隆抗体的嵌合形式，单克隆抗体的人源化形式及其片段，以及编码抗体及其片段的核酸。 包括这种抗体的药物组合物也在本文中公开。 本公开进一步提供使用所公开的抗体的预防，治疗和诊断方法。
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33.发明申请MONOCLONAL ANTIBODIES THAT REACT WITH THE CAPSULE OF BACILLUS ANTHRACIS 有权与BACILLUS ANTHRACIS胶囊反应的单克隆抗体公开(公告)号：US20110223163A1
公开(公告)日：2011-09-15
申请号：US13130044
申请日：2009-11-19
IPC分类号： A61K39/395 , C07K16/00 , C07K16/12 , C07H21/00 , C12N15/63 , C12N5/10 , C12N5/16 , G01N33/554 , A61P31/04
CPC分类号： C07K16/1278 , A61K39/07 , A61K39/3955 , A61K39/40 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/92 , G01N33/56911 , G01N2333/32
摘要： The present disclosure relates to monoclonal antibodies that bind poly-γ-D-glutamic acid (γDPGA), which is present on the surface of Bacillus anthracis. The disclosure also provides chimeric forms of the monoclonal antibodies, humanized forms of the monoclonal antibodies, and fragments thereof, as well as nucleic acids encoding the antibodies and fragments thereof. Pharmaceutical compositions including such antibodies are also disclosed herein. The disclosure further provides prophylactic, therapeutic, and diagnostic methods of using the disclosed antibodies.
摘要翻译： 本公开涉及结合存在于炭疽芽孢杆菌表面上的聚-γ-D-谷氨酸（γDPGA）的单克隆抗体。 本公开还提供了单克隆抗体的嵌合形式，单克隆抗体的人源化形式及其片段，以及编码抗体及其片段的核酸。 包括这种抗体的药物组合物也在本文中公开。 本公开进一步提供使用所公开的抗体的预防，治疗和诊断方法。
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公开(公告)号：US20110097270A1
公开(公告)日：2011-04-28
申请号：US11795255
申请日：2006-01-13
IPC分类号： A61K49/00 , C07K16/08 , C07H21/00 , C12N15/63 , C12N5/10 , A61K39/395 , C12Q1/70 , A61P31/20 , A61P37/04
CPC分类号： C07K16/082 , A61K2039/505 , C07K2317/21 , C07K2317/55
摘要： The present invention relates to the isolation and characterization of a novel neutralizing chimpanzee monoclonal antibody to hepatitis B virus. The invention provides such antibodies, fragments of such antibodies retaining hepatitis B virus-binding ability, fully human or humanized antibodies retaining hepatitis B virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及一种用于乙型肝炎病毒的新型中和黑猩猩单克隆抗体的分离和表征。 本发明提供了这样的抗体，保留乙型肝炎病毒结合能力的这种抗体的片段，保留乙型肝炎病毒结合能力的完全人或人源化抗体，以及包含这种抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US20110008256A1
公开(公告)日：2011-01-13
申请号：US12607035
申请日：2009-10-27
申请人： Ching-Juh Lai , Robert H. Purcell
发明人： Ching-Juh Lai , Robert H. Purcell
CPC分类号： C07K16/10 , A61K2039/505 , C07K14/005 , C07K16/1081 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C12N2770/24122 , Y02A50/386
摘要： The present invention relates to monoclonal antibodies that bind or neutralize dengue type 1, 2, 3, and/or 4 virus. The invention provides such antibodies, fragments of such antibodies retaining dengue virus-binding ability, fully human or humanized antibodies retaining dengue virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和1型，2,3型和/或4型登革热病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体的片段保留登革热病毒结合能力，完全人或人源化抗体保留登革热病毒结合能力，以及包括这种抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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36.发明申请MONOCLONAL ANTIBODIES AGAINST DENGUE AND OTHER VIRUSES WITH DELETION IN FC REGION 失效针对东盟地区的登革热和其他病毒的单克隆抗体公开(公告)号：US20100247549A1
公开(公告)日：2010-09-30
申请号：US12594756
申请日：2008-04-03
CPC分类号： C07K16/1081 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/71 , C07K2317/76 , Y02A50/386
摘要： The present invention relates to a variant of a parent polypeptide comprising an Fc region, which variant binds an Fc gamma receptor (FcγR) with lower affinity than the parent polypeptide and comprises a deletion of at least one amino acid in about position 100 to about position 150 in the Fc region and related nucleic acids, vectors, host cells and methods of producing the variant and methods for preventing or treating a disorder in a mammal.
摘要翻译： 本发明涉及包含Fc区的亲本多肽的变体，所述变体以比亲本多肽更低的亲和力结合Fcγ受体（FcγR），并且包含约100位至约位置的至少一个氨基酸的缺失 Fc区和相关核酸，载体，宿主细胞和产生变体的方法以及用于预防或治疗哺乳动物疾病的方法。
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37.发明申请Monoclonal Antibodies That Neutralize Anthrax Protective Antigen (PA) Toxin 有权中和炭疽保护性抗原（PA）毒素的单克隆抗体公开(公告)号：US20100074892A1
公开(公告)日：2010-03-25
申请号：US11793735
申请日：2005-12-21
CPC分类号： C07K16/1278 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (PA) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax PA toxin-binding ability, fully human or humanized antibodies retaining anthrax PA toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和炭疽保护性抗原（PA）毒素的单克隆抗体。 本发明提供了这样的抗体，这种抗体的片段，其保留了炭疽PA毒素结合能力，完全人或人源化抗体保留了炭疽杆菌PA毒素结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US20090155250A1
公开(公告)日：2009-06-18
申请号：US12142594
申请日：2008-06-19
IPC分类号： A61K39/395 , C07K16/08 , C12N15/39 , C12N15/85 , C12Q1/70 , A61P31/20 , C12N5/10 , C12N5/16 , C12N7/01
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US07282205B2
公开(公告)日：2007-10-16
申请号：US10494676
申请日：2002-11-07
IPC分类号： A61K39/395 , C07K16/00 , C12N15/00 , C12P21/06 , G01N33/53
CPC分类号： C07K16/1009 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： Chimpanzee monoclonal antibodies and antigen binding fragments including a γ1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding fragments in the detection of hepatitis A virus, the inhibition of infection of a subject with hepatitis A virus, and in screening for agents that affect HAV.
摘要翻译： 本文公开了黑猩猩单克隆抗体和包含结合甲型肝炎病毒（HAV）抗原的γ1链CDR3区域的抗原结合片段。 抗体中和HAV。 还公开了在检测甲型肝炎病毒中使用这些抗体和抗原结合片段的方法，用甲型肝炎病毒抑制受试者的感染，以及筛选影响HAV的药剂。
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公开(公告)号：US06423318B1
公开(公告)日：2002-07-23
申请号：US09653499
申请日：2000-08-31
IPC分类号： C12N700
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , C12N7/00 , C12N2770/32421 , C12N2770/32422 , C12N2770/32432 , C12N2770/32434 , Y02A50/464
摘要： A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
摘要翻译： 适用于MRC-5细胞生长的活A型甲型肝炎病毒，其中HAV优选特征在于对于没有灭活的人和动物的有效疫苗施用的合适的衰减特征在于，适于使HAV适应MRC-5生长的方法，疫苗组合物和疫苗接种方法 人类对HAV感染。
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