公开(公告)号：US20120329037A1

公开(公告)日：2012-12-27

申请号：US13165464

申请日：2011-06-21

Applicant: ZHAO ZHANG ,  CHIH-CHEN LIN ,  SHIMING LIN

Inventor： ZHAO ZHANG ,  CHIH-CHEN LIN ,  SHIMING LIN

IPC: C12Q1/70 ,  G01N33/53 ,  C12M1/34 ,  G01N27/00 ,  G01N30/00

CPC classification number: G01N33/5438 ,  G01N27/3276

Abstract: Embodiments of the present disclosure set forth a biosensor for detecting a target. One example sensor includes a first electrode. The first electrode includes a first electron conducting molecule and a first probe. The first probe includes a second electron conducting molecule. The first probe is configured to bind to the target of interest in solution. The first and second electron conducting molecules are different.

Abstract translation: 本公开的实施例提出了用于检测目标的生物传感器。 一个示例性传感器包括第一电极。 第一电极包括第一电子传导分子和第一探针。 第一探针包括第二电子传导分子。 第一个探针被配置为绑定到解决方案中的感兴趣的目标。 第一和第二电子传导分子是不同的。

公开(公告)号：US08124994B2

公开(公告)日：2012-02-28

申请号：US12440019

申请日：2007-09-04

Applicant: Shu Yuan ,  Shiming Lin

Inventor： Shu Yuan ,  Shiming Lin

IPC: H01L33/00 ,  H01L21/00

CPC classification number: H01L33/38 ,  H01L24/97 ,  H01L33/20 ,  H01L2924/12041 ,  H01L2924/3011 ,  H01L2933/0016

Abstract: A light emitting device is disclosed that has a plurality of epitaxial layers including an active layer, at least one of a reflective layer and an ohmic contact on a first side of the epitaxial layers; and a layer of a conductive metal on a second side of the epitaxial layers and having a light emitting surface. A terminal is on the light emitting surface, the terminal comprising an array for diffusing electrical current and minimizing its effect on light output. The array may have a bonding pad, an outer portion, and a joining portion connecting the bonding pad and the outer portion; the outer portion and the joining portion being for current dissipation.

Abstract translation: 公开了一种发光器件，其具有多个外延层，包括有源层，在外延层的第一侧上的反射层和欧姆接触中的至少一个; 以及位于所述外延层的第二侧上并具有发光表面的导电金属层。 端子在发光表面上，该端子包括用于扩散电流并最小化其对光输出的影响的阵列。 阵列可以具有接合焊盘，外部部分和连接接合焊盘和外部部分的接合部分; 外部部分和接合部分用于电流消散。

公开(公告)号：US20100167501A1

公开(公告)日：2010-07-01

申请号：US12667418

申请日：2008-07-03

Applicant: Xuejun Kang ,  Shu Yuan ,  Jenny Lam ,  Shiming Lin

Inventor： Xuejun Kang ,  Shu Yuan ,  Jenny Lam ,  Shiming Lin

IPC: H01L21/78

CPC classification number: H01L29/2003 ,  H01L21/6835 ,  H01L33/0079 ,  H01L33/0095 ,  H01L33/32 ,  H01L33/38 ,  H01L33/40 ,  H01L33/44 ,  H01L33/46 ,  H01L2221/6835 ,  H01L2933/0016

Abstract: A method of fabricating semiconductor devices is disclosed. The method comprises providing a substrate with a plurality of epitaxial layers mounted on the substrate and separating the substrate from the plurality of epitaxial layers while the plurality of epitaxial layers is intact. This preserves the electrical, optical, and mechanical properties of the plurality of epitaxial layers.

Abstract translation: 公开了制造半导体器件的方法。 所述方法包括：提供具有安装在所述衬底上的多个外延层的衬底，并且所述衬底与所述多个外延层分离，同时所述多个外延层是完整的。 这保持了多个外延层的电学，光学和机械特性。

公开(公告)号：US07271914B2

公开(公告)日：2007-09-18

申请号：US11049085

申请日：2005-02-02

Applicant: Chii-Wann Lin ,  Chih Kung Lee ,  Zhi-Hsiang Sung ,  Shiming Lin

Inventor： Chii-Wann Lin ,  Chih Kung Lee ,  Zhi-Hsiang Sung ,  Shiming Lin

IPC: G01N21/55

CPC classification number: G01N21/553

Abstract: A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.

Abstract translation: 描述了利用表面等离子体共振（SPR）的横向传播波的生物分子传感器系统。 该系统包括：基板; 介电层，其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置，每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。 此外，传感器系统还包括光源，光检测器（其前端连接到光谱仪和连接到差分放大器的后端）以及形成在凹槽内的盖的通道，用于获取反射光的反射光 棱镜装置。 由于传感器系统是通过利用SPR技术在横向传播中构建的，因此整个接触面被检测（并行检测），与传统的单区域SPR检测方法相区分。 传感器系统不仅适用于横向距离为几厘米的远红外遥感，而且适用于微型尺寸和高通量的生物医学传感应用。

公开(公告)号：US07148057B2

公开(公告)日：2006-12-12

申请号：US10216911

申请日：2002-08-13

Applicant: Yo-Hsin Su ,  Hsi-Lien Lu ,  Hsun-Min Lung ,  Chung-Ho Tung ,  Ta-Chang Liu ,  Chih-Kung Lee ,  Su-Ming Hsu ,  Shiming Lin ,  Long-Sun Huang ,  Chii-Wann Lin

Inventor： Yo-Hsin Su ,  Hsi-Lien Lu ,  Hsun-Min Lung ,  Chung-Ho Tung ,  Ta-Chang Liu ,  Chih-Kung Lee ,  Su-Ming Hsu ,  Shiming Lin ,  Long-Sun Huang ,  Chii-Wann Lin

IPC: C12M1/34

CPC classification number: B01L9/527 ,  B01F11/0266 ,  B01F13/0059 ,  B01L2200/027 ,  B01L2300/0819 ,  G01N1/312 ,  G01N35/1074 ,  G01N2035/00158 ,  G01N2035/1039

Abstract: A microarray biochip workstation allowing positioning of chips, immobilization of molecules, mixing of sample solution, molecular interactions and washing and processing qualitative and quantitative analyses consists of a positioning device for holding a biochip, a mixing device for acting on the sample solution applied on the biochip, a pumping device for removing the sample solution from the biochip surface that does not react, and a reading device for detecting reaction results of the biochip. The workstation thus constructed provides an integrated and effective work interface.

Abstract translation: 一种微阵列生物芯片工作站，用于定位芯片，分子固定，样品溶液混合，分子相互作用以及洗涤和加工定性和定量分析，包括用于保持生物芯片的定位装置，用于作用在样品溶液上的混合装置 生物芯片，用于从未反应的生物芯片表面去除样品溶液的泵送装置，以及用于检测生物芯片的反应结果的读取装置。 这样构造的工作站提供了一个集成且有效的工作界面。

公开(公告)号：US06844935B2

公开(公告)日：2005-01-18

申请号：US10761116

申请日：2004-01-20

Applicant: Chih-Kung Lee ,  Shuen-Chen Shiue ,  Shu-Sheng Lee ,  Jiun-Yan Wu ,  Chii-Wann Lin ,  Shiming Lin

Inventor： Chih-Kung Lee ,  Shuen-Chen Shiue ,  Shu-Sheng Lee ,  Jiun-Yan Wu ,  Chii-Wann Lin ,  Shiming Lin

IPC: G01B11/00 ,  G01B9/02

CPC classification number: G01B11/00

Abstract: A multi-function opto-electronic detection apparatus for detecting molecular characteristics of a test sample. The appratuses comprises functional mode subsystems including a detecting light source subsystem for generating sampling beams for illuminating the test sample; a manipulation optics subsystem for aligning the sampling beam onto the test sample; a target signal processing subsystem for analyzing target beams emerging from the test sample resulting from the illuminating of the sampling beam; and a sample fixation subsystem for holding the test sample. The detecting light source subsystem, manipulation optics subsystem and target signal processing subsystem are assembled into one of several possible optical sampling setups for the detection characteristics of the test sample. The functional mode setups include at least ellispometer, confocal image scanner, photon tunneling scanning microscope and interferometer.

Abstract translation: 一种用于检测试样的分子特性的多功能光电检测装置。 该装置包括功能模式子系统，包括用于产生用于照亮测试样本的采样光束的检测光源子系统; 用于将采样光束对准到测试样品的操纵光学子系统; 目标信号处理子系统，用于分析从采样光束的照明产生的从测试样本出射的目标光束; 以及用于保持测试样本的样本固定子系统。 检测光源子系统，操作光学子系统和目标信号处理子系统被组合成用于测试样本的检测特性的几种可能的光学采样设置之一。 功能模式设置至少包括椭圆计，共焦图像扫描仪，光子隧道扫描显微镜和干涉仪。

公开(公告)号：US06828807B2

公开(公告)日：2004-12-07

申请号：US10334910

申请日：2003-01-02

Applicant: Yo-Hsin Su ,  Hsi-Lien Lu ,  Ta-Chang Liu ,  Hsun-Min Lung ,  Long-Sun Huang ,  Shiming Lin ,  Der-Xing Liou ,  Chien-Hsun Chen ,  Chih-Kung Lee

Inventor： Yo-Hsin Su ,  Hsi-Lien Lu ,  Ta-Chang Liu ,  Hsun-Min Lung ,  Long-Sun Huang ,  Shiming Lin ,  Der-Xing Liou ,  Chien-Hsun Chen ,  Chih-Kung Lee

IPC: G01R2708

CPC classification number: C12M23/12 ,  C12M35/02 ,  C12M41/46

Abstract: A biological cell test method and apparatus employs a conventional perforated cell carrier which has a plurality of holes. Each hole has two metal electrodes. A cell is disposed in the hole to contact the two electrodes. The electrodes are connected to electric current or voltage. The electric current or field flows from one electrode through the cell to another electrode. Through the inherent impedance, inductance or capacitance of the cell, the presence or property reactions of the cell may be detected.

Abstract translation: 生物细胞试验方法和装置采用具有多个孔的常规穿孔细胞载体。 每个孔都有两个金属电极。 一个电池设置在孔中以接触两个电极。 电极连接电流或电压。 电流或场从一个电极通过电池流到另一个电极。 通过电阻的固有阻抗，电感或电容，可以检测电池的存在或性质反应。