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    Methods and devices for forming treatment agent carriers
    32.
    发明授权
    Methods and devices for forming treatment agent carriers 有权
    用于形成治疗剂载体的方法和装置

    公开(公告)号：US08784894B2

    公开(公告)日：2014-07-22

    申请号：US11485934

    申请日：2006-07-12

    Applicant: Shubhayu Basu ,  Eugene T. Michal

    Inventor： Shubhayu Basu ,  Eugene T. Michal

    IPC: A61K38/18 ,  A61K9/14

    CPC classification number: A61K9/4833 ,  A61K9/145 ,  A61K9/5031 ,  A61K38/30

    Abstract: A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.

    Abstract translation: 描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。 从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。 颗粒可以沉积在包含液相的收集组件中。 另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将颗粒与可生物侵蚀的材料混合 描述了形成凝胶的能力。 具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

    NEEDLE CATHETER WITH AN ANGLED DISTAL TIP LUMEN
    37.
    发明申请
    NEEDLE CATHETER WITH AN ANGLED DISTAL TIP LUMEN 有权
    带有远距离提示灯的针式导管

    公开(公告)号：US20100004627A1

    公开(公告)日：2010-01-07

    申请号：US12167791

    申请日：2008-07-03

    Applicant: Florian N. Ludwig ,  Shubhayu Basu

    Inventor： Florian N. Ludwig ,  Shubhayu Basu

    IPC: A61M25/00 ,  A61M5/32

    CPC classification number: A61M25/0068 ,  A61M25/0074 ,  A61M25/0084 ,  A61M2025/0081 ,  A61M2025/009

    Abstract: A needle catheter configured for injecting an agent into a wall of a patient's body cavity, which directs a needle from the distal tip of the catheter into the wall of the body cavity at an angle relative to the axis of the shaft. The resulting angled injection pathway improves the retention of the agent in the body cavity wall, while keeping a distal section of the catheter substantially perpendicular to the body cavity wall for optimal push against the tissue at the injection site.

    Abstract translation: 一种针导管，其构造成用于将药剂注射到患者体腔的壁中，其将针从导管的远侧末端引导到相对于轴的轴线成一定角度的体腔的壁中。 所产生的角度注射通道改善了药剂在体腔壁中的保留性，同时保持导管的远端部分基本上垂直于体腔壁，以最佳地推动注射部位处的组织。

    ELECTROSPRAYING METHOD FOR FABRICATION OF PARTICLES AND COATINGS AND TREATMENT METHODS THEREOF
    39.
    发明申请
    ELECTROSPRAYING METHOD FOR FABRICATION OF PARTICLES AND COATINGS AND TREATMENT METHODS THEREOF 审中-公开
    用于制备颗粒和涂层的电喷涂方法及其处理方法

    公开(公告)号：US20090035381A1

    公开(公告)日：2009-02-05

    申请号：US11832257

    申请日：2007-08-01

    Applicant: John J. Stankus ,  Shubhayu Basu

    Inventor： John J. Stankus ,  Shubhayu Basu

    IPC: A61K47/30 ,  A61K38/18 ,  A61K9/14 ,  B29B13/08 ,  B29B9/00

    CPC classification number: A61K9/0024 ,  A61K9/5031 ,  A61K9/5073 ,  A61K9/5089 ,  B05B5/001 ,  B05B5/025

    Abstract: Electrospray systems and modified electrospray systems for the fabrication of core-shell particles for controlled-release and/or sustained-release treatment and delivery are herein disclosed. The electrospray system may include between one and a plurality of co-axially situated tubes. Each tube may be electrically connected to a power supply wherein a voltage may be applied thereto. Core-shell particles may be collected on a collection target, which may be a wet or dry collector, and electrically connected to the power supply. Core-shell particles and methods of manufacture are also disclosed. The precursors of the core-shell particles may be polymer- or biomacromolecule-based solutions and may include at least one treatment agent incorporated therein. The number of “core” particle(s) within the “shell” may vary and may provide different treatment agent release profiles depending on the material and/or chemical characteristics of the polymer and/or biomacromolecule used. Methods of treating a condition are also disclosed. A treatment may include delivery of a plurality of core-shell particles which include a treatment agent to a treatment site. Delivery may be performed by a surgical procedure or by a non-invasive procedure such as catheter delivery.

    Abstract translation: 本文公开了用于制备用于控制释放和/或持续释放处理和递送的核 - 壳颗粒的电喷雾系统和改进的电喷雾系统。 电喷雾系统可以包括在一个和多个同轴位于的管之间。 每个管可以电连接到电源，其中可以施加电压。 核 - 壳颗粒可以收集在收集目标上，其可以是湿的或干的收集器，并且电连接到电源。 还公开了核 - 壳颗粒和制造方法。 核 - 壳颗粒的前体可以是基于聚合物或生物大分子的溶液，并且可以包括并入其中的至少一种处理剂。 “壳”内的“芯”颗粒的数量可以变化，并且可以根据所使用的聚合物和/或生物大分子的材料和/或化学特性提供不同的处理剂释放曲线。 还公开了治疗病症的方法。 治疗可以包括将包括治疗剂的多个核 - 壳颗粒递送到治疗部位。 可以通过外科手术或非侵入性手术（例如导管递送）进行输送。

    Methods and devices for forming treatment agent carriers
    40.
    发明申请
    Methods and devices for forming treatment agent carriers 有权
    用于形成治疗剂载体的方法和装置

    公开(公告)号：US20080014276A1

    公开(公告)日：2008-01-17

    申请号：US11485934

    申请日：2006-07-12

    Applicant: Shubhayu Basu ,  Eugene T. Michal

    Inventor： Shubhayu Basu ,  Eugene T. Michal

    IPC: A61K38/18 ,  A61K9/14

    CPC classification number: A61K9/4833 ,  A61K9/145 ,  A61K9/5031 ,  A61K38/30

    Abstract: A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.

    Abstract translation: 描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。 从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。 颗粒可以沉积在包含液相的收集组件中。 另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将其与生物可蚀塑料混合 描述了形成凝胶的能力。 具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

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