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    Angled bushing mount for stabilizer bar
    35.
    发明申请
    Angled bushing mount for stabilizer bar 审中-公开
    用于稳定杆的倾斜衬套安装

    公开(公告)号：US20060103101A1

    公开(公告)日：2006-05-18

    申请号：US10992590

    申请日：2004-11-18

    Applicant: Timothy Sowinski ,  Mark Kleckner ,  Joseph Fader ,  Stephen Yue ,  Luiz Lopes ,  William Elders ,  Maurice Bechard ,  Leo Medeiros ,  Pete Kiousis

    Inventor： Timothy Sowinski ,  Mark Kleckner ,  Joseph Fader ,  Stephen Yue ,  Luiz Lopes ,  William Elders ,  Maurice Bechard ,  Leo Medeiros ,  Pete Kiousis

    IPC: B60G21/055

    CPC classification number: B60G21/0551 ,  B60G2202/135 ,  B60G2204/1222 ,  B60G2204/41

    Abstract: A stabilizer bar includes having bends forming angled portions. The angled portions are supported by bushings that are secured by straps to a vehicle frame. The stabilizer bar rotates about a axis. The bushings supporting the stabilizer bar have an axes that are transverse to the pivotal axis of the stabilizer bar and to one another. The bushings have flared or thickened portions at their outer ends to provide additional bushing material since the misaligned pivotal axis permits the stabilizer bar to deflect the bushing as it rotates. The straps may be cupped so that they laterally locate the bushings as the stabilizer bar rotate about its pivotal axis.

    Abstract translation: 稳定杆包括具有形成成角度部分的弯曲部。 倾斜部分由通过带子固定到车架的衬套支撑。 稳定杆围绕轴旋转。 支撑稳定杆的衬套具有横向于稳定杆的枢转轴线并彼此相对的轴线。 衬套在其外端具有扩口或加厚部分以提供额外的衬套材料，因为不对准的枢轴允许稳定杆在其旋转时使套管偏转。 带子可以被杯形，使得当稳定杆围绕其枢转轴线旋转时，它们横向地定位衬套。

    Detection of immobilized nucleic acid
    37.
    发明申请
    Detection of immobilized nucleic acid 有权
    检测固定化核酸

    公开(公告)号：US20050239096A1

    公开(公告)日：2005-10-27

    申请号：US10956868

    申请日：2004-09-30

    Applicant: Matthew Beaudet ,  W. Cox ,  Stephen Yue

    Inventor： Matthew Beaudet ,  W. Cox ,  Stephen Yue

    IPC: C07D413/02 ,  C07D417/02 ,  C07D417/06 ,  C09B23/02 ,  C12Q1/68 ,  C07D43/02

    CPC classification number: G01N21/64 ,  C07D417/06 ,  C09B23/02 ,  C09B23/04 ,  C12Q1/6816 ,  C12Q1/6825 ,  G01N1/30 ,  G01N2001/302 ,  Y10T436/143333 ,  C12Q2563/173 ,  C12Q2565/125

    Abstract: The present invention provides methods for determining the presence of immobilized nucleic acid employing unsymmetrical cyanine dyes that are derivatives of thiazole orange, a staining solution and select fluorogenic compounds that are characterized as being essentially non-genotoxic. The methods comprise immobilizing nucleic acid, single or double stranded DNA, RNA or a combination thereof, on a solid or semi solid support, contacting the immobilized nucleic acid with an unsymmetrical cyanine dye compound and then illuminating the immobilized nucleic acid with an appropriate wavelength whereby the presence of the nucleic acid is determined. The cyanine dye compounds are typically present in an aqueous staining solution comprising the dye compound and a tris acetate or tris borate buffer wherein the solution facilitates the contact of the dye compound and the immobilized nucleic acid. Typically the solid or semi-solid support is selected from the group consisting of a polymeric gel, a membrane, an array, a glass bead, a glass slide, and a polymeric microparticle. Preferably, the polymeric gel is agarose or polyacrylamide. The methods employing the non-genotoxic compounds represent an improvement over commonly used methods employing ethidium bromide wherein the present methods retain the advantages of ethidium bromide, ease of use and low cost, but without the disadvantageous, known mutagen requiring special handling and waste procedures.

    Abstract translation: 本发明提供了使用作为噻唑橙衍生物的不对称花青染料确定固定化核酸的存在的方法，染色溶液和选择性荧光化合物，其特征在于基本上是非遗传毒性的。 所述方法包括在固体或半固体支持物上固定核酸，单链或双链DNA，RNA或其组合，使固定的核酸与不对称的花青染料化合物接触，然后用合适的波长照射固定的核酸，由此 确定核酸的存在。 花青染料化合物通常存在于包含染料化合物和三乙酸盐或三硼酸盐缓冲液的水性染色溶液中，其中溶液促进染料化合物和固定化核酸的接触。 通常，固体或半固体支持物选自聚合物凝胶，膜，阵列，玻璃珠，载玻片和聚合物微粒。 优选地，聚合物凝胶是琼脂糖或聚丙烯酰胺。 使用非遗传毒性化合物的方法代表了使用溴化乙锭的常用方法的改进，其中本发明的方法保留了溴化乙锭的优点，易于使用和低成本，但没有不利的已知的需要特殊处理和废物方法的诱变剂。

    Cyanine compounds and their application as quenching compounds
    38.
    发明申请
    Cyanine compounds and their application as quenching compounds 有权
    花青化合物及其作为淬灭化合物的应用

    公开(公告)号：US20050191643A1

    公开(公告)日：2005-09-01

    申请号：US10916822

    申请日：2004-08-11

    Applicant: Rosaria Haugland ,  Ching-Ying Cheung ,  Stephen Yue

    Inventor： Rosaria Haugland ,  Ching-Ying Cheung ,  Stephen Yue

    IPC: C07D209/12 ,  C07D209/24 ,  C07D401/04 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C12Q1/68

    CPC classification number: C12Q1/6876 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24 ,  C07D401/04 ,  C09B23/12

    Abstract: The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quinolinium, unsubstituted quinolinium, substituted benzazolium, unsubstituted benzazolium, substituted indolinium, or substituted indolinium. The invention further provides luminescent donor molecule-quencher pairs and luminescent donor molecule-quencher-luminescent acceptor molecule conjugates wherein the quencher is a cyanine compound of the present invention. The energy transfer pairs are used to detect an analyte of interest in a sample.

    Abstract translation: 本发明提供了具有以下通式的方法和非荧光碳花青猝灭剂：其中A部分是取代的吡啶鎓，未取代的吡啶鎓，取代的喹啉鎓，未取代的喹啉鎓，取代的苯并唑鎓，未取代的苯并咪唑鎓，取代的吲哚鎓或取代的吲哚啉鎓。 本发明还提供了发光供体分子猝灭剂对和发光供体分子 - 猝灭剂 - 发光受体分子缀合物，其中猝灭剂是本发明的花青化合物。 能量转移对用于检测样品中感兴趣的分析物。

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