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公开(公告)号：US20240342195A1
公开(公告)日：2024-10-17
申请号：US18294924
申请日：2022-08-03
Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM
Inventor： Yoshie KAMETANI , Yoshiyuki MANABE
IPC: A61K31/57 , A61K9/127 , A61K39/395
CPC classification number: A61K31/57 , A61K9/127 , A61K39/3955
Abstract: The present invention provides a novel activity regulator capable of regulating T cell and/or B cell activity. The activity regulator is a T cell and/or B cell activity regulator comprising progesterone or a derivative thereof as an active ingredient.
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公开(公告)号：US11892456B2
公开(公告)日：2024-02-06
申请号：US16764595
申请日：2018-11-16
Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM , RIKEN
Inventor： Ryoji Nagai , Naoyuki Taniguchi
CPC classification number: G01N33/66 , G01N33/6812 , G01N2800/042 , G01N2800/56
Abstract: A marker for examining a diabetic complication comprising a compound represented by the following Formula (1), or a salt thereof. A method of examining a diabetic complication with an amount of the marker as an indicator including: (A) a step of measuring the amount of the marker in a sample collected from a test subject; and (B) a step of determining presence or absence, or a risk of development of the diabetic complication based on a result of measurement of the amount of the marker comprising Formula (1), or a salt thereof:
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公开(公告)号：US20230340541A1
公开(公告)日：2023-10-26
申请号：US18068061
申请日：2022-12-19
Inventor： Channabasavaiah B. Gurumurthy , Hiromi Miura , Masato Ohtsuka
CPC classification number: C12N15/907 , A01K67/0275 , A01K67/0276 , A01K67/0278 , C12N9/22 , C12N9/96 , C12N15/102 , C12N15/11 , C12N15/8509 , A01K2217/058 , A01K2217/203 , A01K2227/105 , C12N2310/20 , C12N2510/00
Abstract: Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.
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公开(公告)号：US20230118035A1
公开(公告)日：2023-04-20
申请号：US17911112
申请日：2021-03-12
Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM , CellSeed Inc.
Inventor： Masato Sato , Takumi Takahashi , Yuka Kawaguchi , Chikako Sato , Satoshi Tsunoda , Chiharu Tohyama , Dandan Song , Michihide Miyazawa
Abstract: The present invention provides a cell culture having a cartilage-like tissue forming property, including a cell population in which the expression intensity of at least one cell surface marker selected from the group consisting of CD166, CD165, CD99, GD2, STRO-1, CD108, CD164, CD6, CD106, and CD107b is not higher than the threshold for each cell surface marker, and/or, the expression intensity of at least one cell surface marker selected from the group consisting of CD26, CD73, CD105, CD44, CD120a, CD201, EGFR, CD146, CD140a, and CD90 is not lower than the threshold for each cell surface marker.
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公开(公告)号：US11549126B2
公开(公告)日：2023-01-10
申请号：US15828979
申请日：2017-12-01
Inventor： Channabasavaiah B. Gurumurthy , Hiromi Miura , Masato Ohtsuka
Abstract: Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.
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Patent Agency Ranking
公开(公告)号：US20220370380A1
公开(公告)日：2022-11-24
申请号：US17772032
申请日：2020-10-29
Applicant: AstaReal Co., Ltd. , Tokai University Educational System
Inventor： Nobuko Hongo , Rika Hirashima , Kumi Tominaga , Yasuhiro Nishizaki
IPC: A61K31/122 , A61K9/00 , A61P7/06
Abstract: [Problem] To provide a composition or the like that suppresses the physical destruction of red blood cells (hemolysis) due to exercises and behaviors associated with impact such as striking, for example, as when continually hitting the soles of the feet on the ground by continued running, by using astaxanthin which has a long history of use as a food, and to provide a composition or the like for making the number of red blood cells destroyed (hemolysis number) to lower than the number of red blood cells newly created by hematopoiesis (hematopoiesis number), to suppress and/or improve exercise-induced hemolytic anemia caused by the physical destruction of red blood cells (hemolysis).
[Solution] Astaxanthin is used as an active ingredient.-
37.发明申请公开(公告)号：US20220064592A1
公开(公告)日：2022-03-03
申请号：US17465425
申请日：2021-09-02
Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM , CellSeed Inc.
Inventor： Masato SATO , Shiho WASAI , Yuka KAWAGUCHI
Abstract: Cell microsheets are formed from a culture of cells. The cell microsheets has a size that can pass through an injection needle with a certain thickness. The cell microsheets can be produced on a surface of a cell cultureware. A stimulus-responsive polymer is immobilized on the surface having small divisions of the cell cultureware. The cell microsheets are suitable for minimally invasive treatment.
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公开(公告)号：US20220056418A1
公开(公告)日：2022-02-24
申请号：US17598057
申请日：2020-03-25
Inventor： Daisuke SAKAI , Yoshihiko NAKAMURA , Erika MATSUSHITA
IPC: C12N5/0775
Abstract: Preparing a cell population rich in cells having a given phenotype depending on their use (e.g., type II collagen-positive nucleus pulposus cells) from a cell population containing Tie2-positive stem/progenitor cells (e.g., nucleus pulposus stem/progenitor cells). The present invention provides culture methods wherein a cell population containing Tie2-positive stem/progenitor cells is cultured (1) while present in a non-digested tissue, (2) in a culture medium containing at least one kind of Tie2 expression enhancer other than growth factors, (3) using cultureware with a culture surface having undergone cell attachment-increasing treatment, or (4) while suppressing formation of spheroid colonies in a culture medium containing an extracellular matrix-degrading agent.
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公开(公告)号：US20200263198A1
公开(公告)日：2020-08-20
申请号：US16799398
申请日：2020-02-24
Inventor： Channabasavaiah Gurumurthy , Masato Ohtsuka , Masahiro Sato
IPC: C12N15/85 , C12N9/22 , C12N15/113 , C12N5/071
Abstract: Disclosed are methods and compositions for in situ germline genome engineering. The disclosed methods and compositions may be utilized for germline genome engineering in a subject having a reproductive organ containing a fertilized zygote, via: (i) isolating or obtaining the reproductive organ from the subject after a time period following insemination of the subject; (ii) introducing a reagent composition into the reproductive organ, the reagent composition comprising a nuclease system and/or an exogeneous polynucleotide; and (iii) electroporating the reproductive organ.
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公开(公告)号：US20200225167A1
公开(公告)日：2020-07-16
申请号：US16627011
申请日：2017-06-29
Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM , KANOMAX JAPAN INC.
Inventor： Akihiko Azetsu , Ikkei Kitajima , Kazaki Kuratsuji , Masayuki Ochiai
Abstract: A measurement method for visualizing the flow of a fluid that includes: a preparation process where a photochromic compound, whose amount of absorption of light changes upon irradiation with transformation-inducing light, is dissolved in the fluid; a transformation-inducing irradiation process where the fluid is irradiated with transformation-inducing light that causes photochromism; and a post-transformation imaging process where an image of the fluid is taken after irradiation by the transformation-inducing light. During the post-transformation imaging process, a first image is generated by taking an image of the fluid by using first light in the first wavelength range in which the amount of absorption of light changes upon irradiation with transformation-inducing light.
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