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公开(公告)号：US20240150520A1
公开(公告)日：2024-05-09
申请号：US18546039
申请日：2022-02-10
发明人： Geoffrey W. Coates , Yiye Lu , Tara Y. Meyer
摘要： Methods for regioselective ring-opening polymerization of unsymmetrical cyclic diester monomers, polymers, which may be made by the methods, and uses of same. Monomers may include cyclic hydroxy-acid dimers, such as, for example, 3-methyl glycolide and the like. Polymerization initiators may include chiral metal alkoxide initiators, such as, for example, (SalBinam)Al-01Pr initiators and the like. Polymers may include polyesters, such as, for example, poly(lactic-co-glycolic acid) (PLGA) and the like, with 90% or greater regioselectivity for alternating ester units (e.g., glycolic unit-lactic unit (G—L) linkages). Polymers may be utilized for substained or targeted drug delivery vehicles, scaffolding for tissue engineering, bioabsorbable sutures, or the like.
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32.发明公开公开(公告)号：US20240141285A1
公开(公告)日：2024-05-02
申请号：US18495903
申请日：2023-10-27
CPC分类号： C12N1/20 , C12N5/0018 , C12R2001/445
摘要： An airway model for culturing microbes such as bacteria Pseudomonas aeruginosa, is provided, comprising culturing the microbes in synthetic sputum media on an air-liquid interface culture of airway epithelial cells. The bacteria may be Pseudomonas aeruginosa, and the epithelial cells may be from a cystic fibrosis (CF) patient and/or comprise a mutation in CFTR found in CF patients.
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公开(公告)号：US20240118289A1
公开(公告)日：2024-04-11
申请号：US18321405
申请日：2023-05-22
发明人： Kai Singbartl , John A. Kellum
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/495 , G01N2333/70578 , G01N2400/40 , G01N2800/347 , G01N2800/50
摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor β1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury.
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公开(公告)号：US20240102836A1
公开(公告)日：2024-03-28
申请号：US18474469
申请日：2023-09-26
发明人： HENG BAN , GREGORY E.J. KINZLER
IPC分类号： G01F1/46
CPC分类号： G01F1/46
摘要： A linear variable differential pitot tube includes a primary solenoid, a first secondary solenoid, a second secondary solenoid, wherein the primary solenoid is positioned in between the first secondary solenoid and the second secondary solenoid, wherein the first secondary solenoid and the first secondary solenoid have identical geometries, and a high permeability magnetic core, the high permeability magnetic core being structured to move relative to the primary solenoid, the first secondary solenoid, and the second secondary solenoid. Also, a system and method for measuring the localized velocity of a flow of a fluid using the linear variable differential pitot tube.
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公开(公告)号：US11938248B2
公开(公告)日：2024-03-26
申请号：US17001177
申请日：2020-08-24
IPC分类号： A61L27/56 , A61F2/06 , A61F2/07 , A61L27/18 , A61L27/36 , A61L27/38 , A61L27/50 , A61L27/54 , A61L33/06 , B33Y10/00 , B33Y70/00 , B33Y80/00 , D01D5/00 , D01F6/62 , D01F6/74
CPC分类号： A61L27/507 , A61F2/06 , A61F2/07 , A61L27/18 , A61L27/3679 , A61L27/3808 , A61L27/3886 , A61L27/50 , A61L27/54 , A61L33/068 , B33Y10/00 , B33Y70/00 , B33Y80/00 , D01D5/0007 , D01F6/62 , D01F6/74 , A61F2210/0004 , A61F2210/0076 , A61F2230/0026 , A61F2240/001 , A61F2240/004 , A61F2240/005 , A61F2250/0067 , A61L27/3804 , A61L2300/42 , A61L2300/606 , D10B2509/06
摘要： Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (AM), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed. The method includes electrospinning a first layer of fibrous material; printing a micropatterned sacrificial template; transferring the micropatterned sacrificial template onto the electrospun fibers; electrospinning a second layer of fibrous biomaterial onto the micropatterned sacrificial template thereby encapsulating the template and generating a construct with two layers; and removing the sacrificial template, producing a fibrous construct with channels or microstructures formed therein. Also disclosed are fibrous constructs and scaffolds produced by the provided methods.
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公开(公告)号：US20240058283A1
公开(公告)日：2024-02-22
申请号：US18336712
申请日：2023-06-16
申请人： West Virginia University Board of Governors on Behalf of West Virginia University , Temple University-Of the Commonwealth System of Higher Education , University of Pittsburgh-Of the Commonwealth System of Higher Education , The United States Government as represented by the Department of Veterans Affairs
IPC分类号： A61K31/167
CPC分类号： A61K31/167
摘要： A method of restoring the balance of osteoclast to osteoblast activity in a patient having rheumatoid arthritis comprising administering to a patient a therapeutically effective amount of the compound N-(3,4-dichlorophenyl)-N-methylpropanamide is provided. A method for treating arthritis-induced bone erosion in a patient comprising administering to a patient a therapeutically effective amount of the compound N-(3,4-dichlorophenyl)-N-methylpropanamide is provided. The compound N-(3,4-dichlorophenyl)-N-methylpropanamide is administered in a pharmaceutically acceptable composition to said patient. A mode of action of N-(3,4-dichlorophenyl)-N-methyl propanamide comprising targeting transient receptor potential channels is provided.
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37.发明授权公开(公告)号：US11898055B2
公开(公告)日：2024-02-13
申请号：US17495543
申请日：2021-10-06
发明人： Prashant N. Kumta , Sangeetha Kunjukunju , Nicole J. Ostrowski , Abhijit Roy , Boeun Lee , Madhumati Ramanathan
IPC分类号： C09D177/04 , A61F2/02 , A61L27/04 , A61L27/34 , A61L27/54 , A61L27/58 , B05D7/00 , C09D105/04 , C09D167/04
CPC分类号： C09D177/04 , A61F2/02 , A61L27/04 , A61L27/34 , A61L27/54 , A61L27/58 , B05D7/58 , C09D105/04 , C09D167/04 , A61F2210/0076 , A61F2310/00976 , A61L2300/608 , A61L2420/08
摘要： The invention relates to polyelectrolyte multilayer coatings and, methods for their preparation and application to substrates to enhance the bioactivity and corrosion protection of the substrates' surface. The invention is particularly suitable for coating substrates employed for medical applications, such as but not limited to medical implant devices for drug and/or biologics delivery in a patient. The substrate has a positive or negative charge. The polyelectrolyte multilayer coatings include at least a first polymer layer and a second polymer layer. The first polymer and second polymer have opposite charges. Each of the polymer layers is individually applied using a layer-by-layer such that an alternating charge multilayer coating is formed.
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公开(公告)号：US20240042211A1
公开(公告)日：2024-02-08
申请号：US18490822
申请日：2023-10-20
发明人： Changfeng Tai
CPC分类号： A61N1/36164 , A61N1/36062 , A61N1/0551 , A61N1/36071 , A61N1/36153 , A61N1/36157
摘要： Provided herein is a method of blocking a nerve or neuron by applying an electrical stimulation to the nerve or neuron, wherein the electrical stimulation is of an intensity below the excitation threshold of the nerve or neuron for a length of time sufficient to produce a block of nerve conduction or neuron excitation.
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公开(公告)号：US20240041847A1
公开(公告)日：2024-02-08
申请号：US18461023
申请日：2023-09-05
申请人： CASE WESTERN RESERVE UNIVERSITY , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
IPC分类号： A61K31/4402 , A61P29/00 , A61K31/365 , A61K31/381
CPC分类号： A61K31/4402 , A61P29/00 , A61K31/365 , A61K31/381
摘要： A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I).
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公开(公告)号：US11883180B2
公开(公告)日：2024-01-30
申请号：US17070530
申请日：2020-10-14
IPC分类号： A61B5/36 , A61B5/366 , A61B5/00 , A61B5/02 , A61B5/30 , A61B5/316 , A61B5/363 , A61B5/364 , A61B5/282
CPC分类号： A61B5/366 , A61B5/02007 , A61B5/303 , A61B5/316 , A61B5/363 , A61B5/364 , A61B5/6823 , A61B5/282
摘要： Disclosed herein are methods, systems, and devices for identifying increased likelihood of non-ST elevation myocardial infarction (NSTEMI) in a patient based on ECG data. The methods can include determining based on the ECG data that the patient lacks ST elevation (STE) and that the patient exhibits a ventricular repolarization dispersion (VRD) score that exceeds a predetermined threshold value. The VRD score can be based in part on a T wave complexity ratio that serves as a temporal marker of VRD for the patient. Other markers of spatial and time qualities of repolarization can also be included in the VRD score. An elevated VRD score in the absence of STE can indicate a likelihood of NSTEMI in the patient and a potential major adverse cardiac event.
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