专利检索 ap:("10X GENOMICS, INC.") AND inv:"Andrew D. Price" 第 4 页

31.

发明授权
Methods and systems for processing polynucleotides 有权

公开(公告)号：US12110549B2

公开(公告)日：2024-10-08

申请号：US17822117

申请日：2022-08-24

申请人： 10x Genomics, Inc.

发明人： Phillip Belgrader , Zachary Bent , Rajiv Bharadwaj , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Michael Ybarra Lucero , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Tobias Daniel Wheeler , Indira Wu , Solongo Batjargal Ziraldo , Stephane Claude Boutet , Sarah Taylor , Niranjan Srinivas

IPC分类号： C12Q1/68 , C12Q1/6806 , C12Q1/683 , C12Q1/6874

CPC分类号： C12Q1/6874 , C12Q1/6806 , C12Q1/683 , C12Q2525/191 , C12Q2537/143 , C12Q2563/179

摘要： The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.

32.

发明授权
Methods and systems for multiplexing of droplet based assays 有权

公开(公告)号：US11845983B1

公开(公告)日：2023-12-19

申请号：US16737770

申请日：2020-01-08

申请人： 10X GENOMICS, INC.

发明人： Zahra Kamila Belhocine , Andrew D. Price

IPC分类号： C12Q1/68 , C12Q1/6869 , C12Q1/02

CPC分类号： C12Q1/6869 , C12Q1/02

摘要： Compositions, methods, and systems are provided for sample preparation techniques and sequencing of macromolecular constituents derived from a cell (i.e., a cell bead) in a multiplexed reaction. Using the compositions, systems, and methods disclosed herein, the association of the macromolecular constituents with the biological particle from which they are derived and the association of the cell bead with the cell bead sample from which they are derived is maintained.

33.

发明授权
Methods and systems for cell and bead processing 有权

公开(公告)号：US11703427B2

公开(公告)日：2023-07-18

申请号：US16434605

申请日：2019-06-07

申请人： 10X GENOMICS, INC.

发明人： Christopher Hindson , Andrew D. Price , Michael Schnall-Levin

IPC分类号： G01N1/28 , G01N1/40 , C12N5/00

CPC分类号： G01N1/28 , C12N5/0006 , G01N1/4077 , C12N2537/10

摘要： The present disclosure provides methods and systems for cell and bead processing or analysis. A method for processing a cell or bead may include subjecting a bead to conditions sufficient to change a first characteristic or set of characteristics (e.g., cell or bead size). Such a method may further include subjecting the cell or bead to conditions sufficient to change a second characteristic or set of characteristics. In some cases, crosslinks may be formed within the cell or bead.

34.

发明申请
METHODS AND SYSTEMS FOR CHARACTERIZING ANALYTES FROM INDIVIDUAL CELLS OR CELL POPULATIONS 有权

公开(公告)号：US20220276229A1

公开(公告)日：2022-09-01

申请号：US17680209

申请日：2022-02-24

申请人： 10X GENOMICS, INC.

发明人： Tarjei Sigurd Mikkelsen , Eswar Prasad Ramachandran Iyer , Andrew Kohlway , Luigi Jhon Alvarado Martinez , Katherine Pfeiffer , Andrew D. Price

IPC分类号： G01N33/532 , C07K14/74 , C12N15/85 , G01N33/543 , G01N33/548 , C12N15/10 , C12Q1/6804 , C12Q1/6806 , G01N33/50 , G01N33/53 , G01N33/58 , C12Q1/6818 , C12Q1/6827 , C12Q1/6881 , C12N15/11 , G01N33/569

摘要： The present disclosure provides methods of processing or analyzing a sample. A method for processing a sample may comprise hybridizing a probe molecule to a target region of a nucleic acid molecule (e.g., a ribonucleic acid (RNA) molecule), barcoding the probe-nucleic acid molecule complex, and performing extension, denaturation, and amplification processes. A method for processing a sample may comprise hybridizing first and second probes to adjacent or non-adjacent target regions of a nucleic acid molecule (e.g., an RNA molecule), linking the first and second probes to provide a probe-linked nucleic acid molecule, and barcoding the probe-linked nucleic acid molecule. One or more processes of the methods described herein may be performed within a partition, such as a droplet or well. One or more processes of the methods described herein may be performed on a cell, such as a permeabilized cell.

35.

发明申请
METHODS AND SYSTEMS FOR CELL AND BEAD PROCESSING 审中-公开

公开(公告)号：US20200033237A1

公开(公告)日：2020-01-30

申请号：US16434605

申请日：2019-06-07

申请人： 10X GENOMICS, INC.

发明人： Christopher Hindson , Andrew D. Price , Michael Schnall-Levin

IPC分类号： G01N1/28 , C12N5/00 , G01N1/40

摘要： The present disclosure provides methods and systems for cell and bead processing or analysis. A method for processing a cell or bead may comprise subjecting a bead to conditions sufficient to change a first characteristic or set of characteristics (e.g., cell or bead size). Such a method may further comprise subjecting the cell or bead to conditions sufficient to change a second characteristic or set of characteristics. In some cases, crosslinks may be formed within the cell or bead.

36.

发明申请
METHODS AND SYSTEMS FOR ANALYSIS OF MAJOR HISTOCOMPATABILITY COMPLEX 审中-公开

公开(公告)号：US20190367966A1

公开(公告)日：2019-12-05

申请号：US16375102

申请日：2019-04-04

申请人： 10X Genomics, Inc.

发明人： Kamila Belhocine , Jason Bell , Zachary Bent , Rajiv Bharadwaj , Christopher Hindson , Mohammad Rahimi Lenji , Bill Kengli Lin , Anthony Makarewicz , Geoffrey McDermott , Elliott Meer , Francesca Meschi , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Michael Schnall-Levin , Sarah Taylor , Jessica Michele Terry , Tobias Daniel Wheeler , Yifeng Yin , Xinying Zheng , Solongo Batjargal Ziraldo , Eswar Prasad Ramachandran Iyer , Luigi Jhon Alvarado Martinez

IPC分类号： C12Q1/6806 , G01N33/53 , G01N33/58 , C12Q1/6804 , G01N33/50 , C12N15/10

摘要： The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells. Such polynucleotide processing may be useful for a variety of applications, including characterization of major histocompatibility complex (MHC) molecules. The compositions, methods, systems, and devices disclosed herein generally describe peptides and barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing MHC molecules from one or more cells.

37.

发明授权
Methods and systems for processing polynucleotides 有权

公开(公告)号：US10480029B2

公开(公告)日：2019-11-19

申请号：US15933299

申请日：2018-03-22

申请人： 10X GENOMICS, INC.

发明人： Zachary Bent , Josephine Harada , Christopher Hindson , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Solongo Batjargal Ziraldo

IPC分类号： C12Q1/68 , C12Q1/6874 , C12Q1/683 , C12Q1/6806

摘要： The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.

38.

发明申请
METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES 审中-公开

公开(公告)号：US20190338353A1

公开(公告)日：2019-11-07

申请号：US16426762

申请日：2019-05-30

申请人： 10X GENOMICS, INC.

发明人： Phillip Belgrader , Zachary Bent , Rajiv Bharadwaj , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Michael Ybarra Lucero , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Tobias Daniel Wheeler , Indira Wu , Solongo Batjargal Ziraldo

IPC分类号： C12Q1/6874 , C12N15/10 , C12Q1/683 , C12Q1/6806 , C12Q1/6804

摘要： The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.