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公开(公告)号：US5354659A
公开(公告)日：1994-10-11
申请号：US964586
申请日：1992-10-21
申请人： Robert Rothlein , Steven D. Marlin
发明人： Robert Rothlein , Steven D. Marlin
IPC分类号： A61K39/395 , G01N33/53 , G01N33/564 , G01N33/569 , G01N33/577 , G01N33/68 , C12Q1/00
CPC分类号： G01N33/56972 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/245
摘要： A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation.
摘要翻译： 一种通过测量患者的一种或多种体液的样品中循环细胞间粘附分子（cICAM-1）的量，然后比较患者体内的cICAM-1的量来检测患者中炎症的存在的方法 样品到体液或体液测定的正常值。 可以使用抗ICAM-1抗体测量cICAM-1的量。 高于正常量的cICAM-1表示存在炎症。
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公开(公告)号：US5162371A
公开(公告)日：1992-11-10
申请号：US683917
申请日：1991-04-11
申请人： Robert Rothlein , Ronald Faanes , Genus Possanza
发明人： Robert Rothlein , Ronald Faanes , Genus Possanza
IPC分类号： A61K31/04 , A61K31/135
CPC分类号： A61K31/135 , A61K31/04
摘要： A method for treating inflammation in a patient which comprises administering to the patient a therapeutically effective amount of a compound of the formula: ##STR1## wherein A and R.sub.1 -R.sub.6 are defined herein.
摘要翻译： 一种治疗患者炎症的方法，其包括向患者施用治疗有效量的下式化合物：其中A和R 1 -R 6在本文中定义。
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公开(公告)号：US08344120B2
公开(公告)日：2013-01-01
申请号：US13158748
申请日：2011-06-13
IPC分类号： C07H21/04
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/30 , C12N15/62
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点的RAGE多肽结构域和直接连接到免疫球蛋白CH2结构域的N末端的域间连接。 还公开了RAGE融合蛋白制剂以及使用RAGE融合蛋白和RAGE融合蛋白制剂作为RAGE介导的病理学的治疗剂。
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公开(公告)号：US20110244516A1
公开(公告)日：2011-10-06
申请号：US13029622
申请日：2011-02-17
CPC分类号： C07K14/705 , A61K38/00
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
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公开(公告)号：US07981424B2
公开(公告)日：2011-07-19
申请号：US11789637
申请日：2007-04-25
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/30 , C12N15/62
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点的RAGE多肽结构域和直接连接到免疫球蛋白CH2结构域的N末端的域间连接。 还公开了RAGE融合蛋白制剂以及使用RAGE融合蛋白和RAGE融合蛋白制剂作为RAGE介导的病理学的治疗剂。
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公开(公告)号：US07981423B2
公开(公告)日：2011-07-19
申请号：US11629437
申请日：2005-08-03
CPC分类号： C07K14/705 , A61K38/00
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
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公开(公告)号：US07544699B2
公开(公告)日：2009-06-09
申请号：US10913168
申请日：2004-08-06
申请人： Adnan M. M. Mjalli , Robert C. Andrews , Xiao-Chuan Guo , Daniel Peter Christen , Devi Reddy Gohimmukkula , Guoxiang Huang , Robert Rothlein , Sameer Tyagi , Tripura Yaramasu , Christopher Behme
发明人： Adnan M. M. Mjalli , Robert C. Andrews , Xiao-Chuan Guo , Daniel Peter Christen , Devi Reddy Gohimmukkula , Guoxiang Huang , Robert Rothlein , Sameer Tyagi , Tripura Yaramasu , Christopher Behme
IPC分类号： C07D217/00 , A61K31/47
CPC分类号： C07D295/155 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07C2601/08
摘要： This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway.
摘要翻译： 本发明提供芳基和杂芳基化合物，其制备方法，包含该化合物的药物组合物及其在治疗人或动物病症中的用途。 本发明的化合物可以是拮抗剂或因子IX和/或因子XI的部分拮抗剂，因此可用于抑制凝血的内在途径。 所述化合物可用于各种应用，包括部分由内在凝血途径引起的疾病的管理，治疗和/或控制。
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38.发明申请Rage Antagonists As Agents To Reverse Amyloidosis And Diseases Associated Therewith 审中-公开愤怒的拮抗剂作为反应与之相关的淀粉样变性和疾病的药物公开(公告)号：US20090035302A1
公开(公告)日：2009-02-05
申请号：US12238087
申请日：2008-09-25
IPC分类号： A61K39/395 , A61K31/4164 , A61K31/4184 , A61K31/16 , A61K38/00
CPC分类号： A61K31/4164 , A61K31/4184 , A61K31/425
摘要： Disclosed are RAGE antagonist compounds that have the ability to reverse pre-existing amyloidosis. Treatment with the RAGE antagonist compounds described herein may be used to reduce plaque size and improve cognition for subjects in the later stages of Alzheimer's disease. Additionally, the RAGE antagonists described herein may be used to reduce the onset of plaque formation and thereby prevent loss of cognition and other symptoms associated with Alzheimer's Disease and other diseases of amyloid deposition.
摘要翻译： 公开了具有逆转预先存在的淀粉样变性的能力的RAGE拮抗剂化合物。 本文所述的RAGE拮抗剂化合物的治疗可用于减少斑块大小并改善阿尔茨海默病后期受试者的认知。 此外，本文所述的RAGE拮抗剂可用于减少斑块形成的发作，从而防止与阿尔茨海默病和其他淀粉样蛋白沉积疾病相关的认知和其它症状的丧失。
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公开(公告)号：US20080199467A1
公开(公告)日：2008-08-21
申请号：US12069499
申请日：2008-02-11
CPC分类号： C12N15/62 , C07K2319/30
摘要： Disclosed are immunoglobulin fusion proteins and methods of making such proteins. In certain embodiments, the fusion protein may include a non-immunoglobulin polypeptide linked to an immunoglobulin polypeptide. In certain embodiments, the non-immunoglobulin polypeptide may comprise a region that replaces an immunoglobulin Fc hinge region, but that allows for correct assembly of the immunoglobulin chains.
摘要翻译： 公开了免疫球蛋白融合蛋白和制备这些蛋白质的方法。 在某些实施方案中，融合蛋白可包括与免疫球蛋白多肽连接的非免疫球蛋白多肽。 在某些实施方案中，非免疫球蛋白多肽可以包含替代免疫球蛋白Fc铰链区但允许免疫球蛋白链的正确装配的区域。
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公开(公告)号：US5831036A
公开(公告)日：1998-11-03
申请号：US140554
申请日：1993-10-25
IPC分类号： C07K16/28 , C07K14/705 , A61K38/17
CPC分类号： C07K16/2845 , C07K16/2821 , C07K2317/34 , C07K2317/73
摘要： The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
摘要翻译： 本发明涉及细胞间粘附分子（ICAM-1），其涉及淋巴细胞识别和迁移到炎症部位以及在炎症期间附着于细胞底物的过程。 本发明涉及这样的分子，筛选用于鉴定能够结合这些分子的分子和抗体的测定。 本发明还包括用于粘附分子和能够结合它们的抗体的用途。
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