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公开(公告)号：US4846182A
公开(公告)日：1989-07-11
申请号：US551055
申请日：1983-11-14
CPC分类号： G01N33/84 , A61B5/4266 , G01N33/526 , Y10T436/193333
摘要： Preparation of an absorbent quantitative test device in the form of a flat patch. When placed on the skin of a subject, the device collects a fixed volume of sweat. It is particularly intended to be used in screen testing for cystic fibrosis by measuring the chloride level in sweat and providing a visual indication when the level is in excess of a predetermined concentration. A fill tab indicator undergoes a color change when the fixed volume of sweat has been collected signifying completion of the test. The device includes two concentric circular reaction areas of chemically treated absorbent paper or the like. The sweat sample is introduced into the device at the center of the first or inner circular reaction area which contains a chemical composition capable of reacting with all chloride in the sweat sample below a predetermined concentration value to screen out that amount of chloride. A second or outer ring-shaped reaction area contains a chemical composition which indicates a color change for any chloride reaching it in excess of the predetermined concentration value. The color change in the outer ring-shaped portion thereby provides a quantitative indication of the pressure of a concentration of chloride in the subject's sweat in excess of the predetermined concentration level.
摘要翻译： 制备平面贴片形式的吸收剂定量测试装置。 当放置在受试者的皮肤上时，该装置收集固定体积的汗液。 特别旨在通过测量汗液中的氯化物含量并在水平超过预定浓度时提供视觉指示来用于囊性纤维化的屏幕测试。 当收集的固定体积的汗水表示测试完成时，填充标签指示器会发生颜色变化。 该装置包括化学处理的吸收纸等的两个同心圆形反应区域。 汗液样品在第一或内部圆形反应区域的中心被引入到装置中，该区域包含能够使低于预定浓度值的汗液样品中的所有氯化物反应的化学组成，以筛除该量的氯化物。 第二个或外部环形反应区域包含化学组成，其指示任何达到超过预定浓度值的氯化物的颜色变化。 外环形部分中的颜色变化从而提供了超过预定浓度水平的受试者汗水中氯浓度的压力的定量指示。
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32.发明授权公开(公告)号：US10907001B2
公开(公告)日：2021-02-02
申请号：US15760830
申请日：2016-09-19
发明人： Arthur J. Coury , Marvin J. Slepian
IPC分类号： C08G75/02 , C08G75/20 , C08F228/02 , C08G85/00 , C08G81/00 , C08G75/23 , C08G75/0286 , C08L81/00 , C08G75/00 , A61L27/16 , A61L29/04 , A61L31/04 , C08F236/04 , C08F299/02 , C08K5/41 , C08G75/04 , C08G75/045 , A61L27/54 , A61L29/16 , A61L31/16
摘要： Polymers having mechanical properties approaching or exceeding commercial elastomers and engineering thermoplastics, but improved biostability, are described herein. In one embodiment, the polymers have a hard segment containing one or more disulfoxide or disulfone moieties and a soft segment connected to the hard segment to form an elastomeric polymer. The polymer is resistant to oxidation and/or hydrolytic degradation, particularly in vivo, which allows for the use of these materials in implants/devices which are implanted for an extended period of time. The ratio or percentage by weight of soft segment to hard segment can be varied based on the physical and mechanical properties of the desired device.
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33.发明授权Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties 有权具有非污垢表面的制品及其制备方法，而不改变体积物理性能公开(公告)号：US08574660B2
公开(公告)日：2013-11-05
申请号：US13156904
申请日：2011-06-09
申请人： Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： A61L33/00
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
摘要翻译： 本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。 聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。 这些方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理特性，然后在经处理的基材表面上形成接枝聚合物层。
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公开(公告)号：US5282823A
公开(公告)日：1994-02-01
申请号：US853682
申请日：1992-03-19
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译： 一种用于植入体腔内的径向可扩张的支架，其具有开放的近端和远端的大致圆柱体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱形主体沿着身体的纵向轴线弯曲，由此支架可 符合弯曲体腔和在支架的金属元件之间延伸的聚合物膜。 支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。 支架对于修复血管成形术过程中引起的血管损伤特别有用。
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35.发明授权Biomedical apparatus having fatty acid dimer derived skin compatible adhesive composition thereon 失效具有脂肪酸二聚体衍生的皮肤相容的粘合剂组合物的生物医学装置
公开(公告)号：US5176956A
公开(公告)日：1993-01-05
申请号：US737791
申请日：1991-07-01
CPC分类号： A61L24/001 , A61L15/58 , A61L24/046 , C08G18/3206 , C08G18/3221 , C08G18/6674 , C08G18/75 , C08G2170/40 , Y10T428/2852 , Y10T428/2896 , Y10T428/2933
摘要： An improved biomedical appliance having disposed on a skin-contacting, operant portion thereof, a film or layer of a skin compatible, tacky, pressure sensitive polymeric adhesive, the reaction product consisting of at least one fatty acid dimer based or derived component and a suitable co-reactant. Electrodes, surgical tapes, TENS devices and iontophoresis devices employing the adhesive are disclosed.
摘要翻译： 一种改进的生物医学器具，其设置在其皮肤接触的操作部分上，皮肤相容的，粘性的，压敏聚合物粘合剂的膜或层，所述反应产物由至少一种基于脂肪酸二聚体或衍生的成分组成， 共反应物。 公开了使用粘合剂的电极，手术带，TENS装置和离子电渗疗法装置。
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36.发明授权Radio frequency glow discharge surface treatment of silicone tubing used as covering for electrical leads to improve slip properties thereof 失效用于电导线覆盖的硅胶管的无线电频率放电表面处理，以提高其滑动性能
公开(公告)号：US5133422A
公开(公告)日：1992-07-28
申请号：US754326
申请日：1991-09-04
申请人： Arthur J. Coury , Patrick T. Cahalan , Edward D. Di Domenico, Jr. , Kenneth W. Keeney , John M. Swoyer
发明人： Arthur J. Coury , Patrick T. Cahalan , Edward D. Di Domenico, Jr. , Kenneth W. Keeney , John M. Swoyer
CPC分类号： B29C59/103 , B29C59/12 , B29C59/142 , A61N1/056 , B29K2083/00 , B29L2031/7534
摘要： Improved electrical leads provided by the surface treatment of silicone rubber tubing covering on implantable pulse generator, or IPG leads and the like by exposure of the silicone rubber to radio frequency glow discharge in a polymer forming or non-polymer forming gas at reduced pressure whereby improved slip properties are provided and binding between two or more of the leads in contact with each other is minimized.
摘要翻译： 通过在降低聚合物形成或非聚合物形成气体中的硅橡胶暴露于射频辉光放电，通过在植入式脉冲发生器上覆盖硅橡胶管的表面处理或IPG引线等而提供的改进的电引线，由此改善 提供滑动性能并且彼此接触的两个或更多个引线之间的结合被最小化。
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公开(公告)号：US4873308A
公开(公告)日：1989-10-10
申请号：US251418
申请日：1988-09-30
IPC分类号： A61L27/00 , C08G18/10 , C08G18/32 , C08G18/38 , C08G18/65 , C08G18/66 , C08G18/73 , C08G18/75
CPC分类号： C08G18/3206 , C08G18/3212 , C08G18/3831 , C08G18/75
摘要： Highly stable, segmented, aliphatic polyurethanes prepared by particular processes are disclosed. The segmented polyurethanes of this invention are substantially free of ester and ether linkages and are found to be particularly hydrolytically and oxidatively stable. The polyurethanes of this invention are prepared by a particular two stage process involving the formation of a prepolymer and subsequent reaction with simultaneously or sequentially added diisocyanate and diol monomers.
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公开(公告)号：US4768523A
公开(公告)日：1988-09-06
申请号：US941994
申请日：1986-12-15
IPC分类号： A61N1/05 , C08J3/00 , C09J141/00
CPC分类号： C08J3/00 , A61N1/05 , C09J141/00 , C08J2333/26
摘要： An improved hydrogel adhesive, particularly adapted for adhesion and contact to tissue. It is especially useful in attaching electrical leads to tissue, for example in attaching pacemaker leads to the heart, interiorly or exteriorly.
摘要翻译： 改进的水凝胶粘合剂，特别适于粘附和接触组织。 将电引线附接到组织中是特别有用的，例如将心脏起搏器引线附接到内部或外部。
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公开(公告)号：US4444193A
公开(公告)日：1984-04-24
申请号：US338274
申请日：1982-01-11
CPC分类号： G01N33/84 , A61B5/4266 , G01N33/526 , Y10T436/193333
摘要： An absorbent quantitative test device in the form of a flat patch. When placed on the skin of a subject; the device collects a fixed volume of sweat. It is particularly intended to be used in screen testing for cystic fibrosis by measuring the chloride level in sweat and providing a visual indication when the level is in excess of a predetermined concentration. A fill tab indicator undergoes a color change when the fixed volume of sweat has been collected signifying completion of the test. The device includes two concentric circular reaction areas of chemically treated absorbent paper or the like. The sweat sample is introduced into the device at the center of the first or inner circular reaction area which contains a chemical composition capable of reacting with all chloride in the sweat sample below a predetermined concentration value to screen out that amount of chloride. A second or outer ring-shaped reaction area contains a chemical composition which indicates a color change for any chloride reaching it in excess of the predetermined concentration value. The color change in the outer ring-shaped portion thereby provides a quantitative indication of the presence of a concentration of chloride in the subject' s sweat in excess of the predetermined concentration level.
摘要翻译： 呈贴片形式的吸收性定量测试装置。 当放置在受试者的皮肤上时; 该装置收集固定体积的汗水。 特别旨在通过测量汗液中的氯化物含量并在水平超过预定浓度时提供视觉指示来用于囊性纤维化的屏幕测试。 当收集的固定体积的汗水表示测试完成时，填充标签指示器会发生颜色变化。 该装置包括化学处理的吸收纸等的两个同心圆形反应区域。 汗液样品在第一或内部圆形反应区域的中心被引入到装置中，该区域包含能够使低于预定浓度值的汗液样品中的所有氯化物反应的化学组成，以筛除该量的氯化物。 第二个或外部环形反应区域包含化学组成，其指示任何达到超过预定浓度值的氯化物的颜色变化。 外环形部分中的颜色变化由此提供了在受试者的汗中超过预定浓度水平的氯化物浓度的定量指示。
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公开(公告)号：US4391278A
公开(公告)日：1983-07-05
申请号：US121387
申请日：1980-02-14
IPC分类号： A61B5/0408 , C09J133/26 , A61B5/04
CPC分类号： A61B5/04087 , C09J133/26
摘要： An improved medical electrode particularly adaptable to tape-like configurations for use in sensing and stimulation applications in which the electrode is applied to the skin. An essential electrode component comprises a mixture of a polymerized form of 2-acrylamido-2-methylpropanesulfonic acid or one of its salts with water and/or an alcohol. The mixture possesses electrically conductive properties, flexible properties and adhesive properties particularly lending itself to skin contact and adhesion.
摘要翻译： 一种改进的医用电极，特别适用于用于将电极施加到皮肤的感测和刺激应用中的带状构造。 必需电极组分包括聚合形式的2-丙烯酰胺基-2-甲基丙磺酸或其盐与水和/或醇的混合物。 该混合物具有导电性能，柔软的性能和粘合性能，特别适用于皮肤接触和粘附。
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