公开(公告)号：US20090267703A1

公开(公告)日：2009-10-29

申请号：US12108009

申请日：2008-04-23

申请人： Andrzej May ,  Siavash Yazdanfar

发明人： Andrzej May ,  Siavash Yazdanfar

IPC分类号： H03H7/38

CPC分类号： H03H7/40

摘要： A system including a driving source that supplies an alternating current (AC) electrical signal is provided. At least one electro-optical device is coupled as an electrical load of the driving source. The system further includes an apparatus configured to provide a dynamically adaptable electrical impedance matching between the driving source and the electro-optical load over a frequency range.

摘要翻译： 提供一种包括提供交流（AC）电信号的驱动源的系统。 至少一个电光装置作为驱动源的电负载耦合。 该系统还包括被配置为在频率范围内提供驱动源和电光负载之间的动态适应性电阻抗匹配的装置。

公开(公告)号：US20090236541A1

公开(公告)日：2009-09-24

申请号：US12054214

申请日：2008-03-24

申请人： Stephen Johnson Lomnes ,  Michael Cooper ,  Anup Sood ,  Siavash Yazdanfar ,  Kathleen Bove

发明人： Stephen Johnson Lomnes ,  Michael Cooper ,  Anup Sood ,  Siavash Yazdanfar ,  Kathleen Bove

IPC分类号： G01T1/00

CPC分类号： A61B1/05 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084

摘要： The invention relates to imaging methods and systems. The systems may comprise a white light source configured to generate light in a first wavelength range, an excitation source configured to generate light at one or more wavelengths for exciting a fluorescent substance, a first detector configured to acquire reflectance image data that represents white light reflected from a subject, and a second detector configured to acquire fluorescence image data that represents fluorescence emissions from the subject. At least one of the one or more wavelengths generated by the excitation light source is within the first wavelength range of the white light source. The fluorescent substance may be, for example, a fluorescent dye that is injected into a patient before or during a surgery. The system may also include an image processing engine and a display. The image processing engine may receive the reflectance image data and the fluorescence image data and generate a merged image in which the fluorescence image data is superimposed on the reflectance image data. The display may be used by a surgeon, for example, to more effectively visualize the surgical site during surgery.

摘要翻译： 本发明涉及成像方法和系统。 所述系统可以包括被配置为产生第一波长范围的光的白光源，被配置为产生用于激发荧光物质的一个或多个波长的光的激发源，被配置为获取表示反射的白光的反射率图像数据的第一检测器 以及第二检测器，被配置为获取表示来自所述受试者的荧光发射的荧光图像数据。 由激发光源产生的一个或多个波长中的至少一个在白光源的第一波长范围内。 荧光物质可以是例如在手术之前或手术期间注射到患者体内的荧光染料。 该系统还可以包括图像处理引擎和显示器。 图像处理引擎可以接收反射图像数据和荧光图像数据，并生成其中荧光图像数据叠加在反射率图像数据上的合并图像。 外科医生可以使用显示器，例如在手术期间更有效地使外科手术部位可视化。

公开(公告)号：US20080266652A1

公开(公告)日：2008-10-30

申请号：US11741839

申请日：2007-04-30

申请人： Siavash Yazdanfar ,  Robert John Filkins

发明人： Siavash Yazdanfar ,  Robert John Filkins

IPC分类号： G02B21/18 ,  G02B21/36

CPC分类号： G02B21/245 ,  G02B21/365

摘要： A digital optical microscope includes a primary image sensor that generates a primary image of a sample at a primary frame rate, an auxiliary image sensor that generates an auxiliary image of the sample at an auxiliary frame rate that is faster than the primary frame rate, and a controller that adjusts a focal distance between an objective lens and the sample along an optical axis in response to the auxiliary image, thereby autofocusing the primary image on the sample. The primary image sensor generates the primary image in response to the autofocusing.

摘要翻译： 数字光学显微镜包括以主要帧速率产生样本的主图像的主图像传感器，以比主帧速率快的辅助帧速率生成样本的辅助图像的辅助图像传感器，以及 控制器，其响应于辅助图像，沿着光轴调整物镜和样本之间的焦距，从而将原始图像自动聚焦在样本上。 主图像传感器响应于自动对焦而产生主图像。

公开(公告)号：US20050036150A1

公开(公告)日：2005-02-17

申请号：US10765010

申请日：2004-01-26

申请人： Joseph Izatt ,  Divakar Rao ,  Changhuei Yang ,  Michael Choma ,  Siavash Yazdanfar ,  Andrew Rollins ,  Brian Applegate

发明人： Joseph Izatt ,  Divakar Rao ,  Changhuei Yang ,  Michael Choma ,  Siavash Yazdanfar ,  Andrew Rollins ,  Brian Applegate

IPC分类号： G01B9/02

CPC分类号： G01B9/02004 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/02014 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/70

摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.

摘要翻译： 关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。 可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。 采集的图像用于分析样品的分子造影剂浓度分布。

公开(公告)号：US09273950B2

公开(公告)日：2016-03-01

申请号：US13335211

申请日：2011-12-22

申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

IPC分类号： A61B3/14 ,  G01B9/02 ,  A61B3/10 ,  A61B3/12

CPC分类号： G01B9/02044 ,  A61B3/102 ,  A61B3/12 ,  G01B9/02048 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02091

摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.

摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从样品臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动测距过程以使参考臂与样本臂匹配的逻辑的控制器。

公开(公告)号：US08878923B2

公开(公告)日：2014-11-04

申请号：US12422363

申请日：2009-04-13

申请人： David LaVan Henderson ,  Kevin Bernard Kenny ,  Siavash Yazdanfar

发明人： David LaVan Henderson ,  Kevin Bernard Kenny ,  Siavash Yazdanfar

IPC分类号： H04N5/225

CPC分类号： G02B21/244 ,  G02B21/002 ,  G02B21/245 ,  G02B21/365

摘要： In an imaging device having an objective and a stage for holding a sample to be imaged, a method for autofocusing is presented. The method includes determining a measured focus value corresponding to at least a first of a plurality of logical image segments. Further, the method includes imaging the first logical image segment using the measured focus value. The method also includes determining a predicted focus value for a second of the plurality of logical image segments using the measured focus value and a stored focus variation parameter. In addition, the method includes imaging the second logical image segment using the predicted focus value.

摘要翻译： 在具有用于保持要成像的样品的目标和阶段的成像装置中，提出了一种用于自动聚焦的方法。 该方法包括确定对应于多个逻辑图像片段中的至少第一个的测量焦点值。 此外，该方法包括使用测量的聚焦值对第一逻辑图像片段进行成像。 该方法还包括使用测量的聚焦值和存储的聚焦变化参数来确定多个逻辑图像片段中的第二个的预测聚焦值。 此外，该方法包括使用预测的聚焦值来成像第二逻辑图像片段。

公开(公告)号：US08842287B2

公开(公告)日：2014-09-23

申请号：US13335175

申请日：2011-12-22

申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  G01B9/02044 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02068

摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.

摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从采样臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以在检测器处获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动聚焦处理以确定样本臂中的透镜的最佳位置以便使样本聚焦的逻辑的控制器。

公开(公告)号：US08778682B2

公开(公告)日：2014-07-15

申请号：US13221161

申请日：2011-08-30

申请人： Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Siavash Yazdanfar ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

发明人： Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Siavash Yazdanfar ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

IPC分类号： C12N15/87 ,  C12N13/00

CPC分类号： C12N13/00 ,  A61K48/0083 ,  C12N15/87

摘要： A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 104 W/cm2.

摘要翻译： 一种递送外源性分子的方法，包括：提供多个具有细胞膜的细胞; 向细胞中加入多种外源性分子; 将细胞暴露于散焦的红外（IR）光以使细胞的细胞膜透化; 并且通过透过细胞膜将外源性分子递送至细胞，其中所述光学焦点处的IR光的强度至少大于或等于104W / cm 2。

公开(公告)号：US20130261415A1

公开(公告)日：2013-10-03

申请号：US13435966

申请日：2012-03-30

申请人： Jeffrey Michael Ashe ,  Aharon Yakimov ,  Siavash Yazdanfar ,  Milos Todorovic

发明人： Jeffrey Michael Ashe ,  Aharon Yakimov ,  Siavash Yazdanfar ,  Milos Todorovic

IPC分类号： A61B5/0205 ,  A61B5/02 ,  A61B5/0295 ,  A61B5/026 ,  A61B5/024 ,  A61B5/029 ,  A61B5/1455 ,  A61B5/08

CPC分类号： A61B5/14552 ,  A61B5/02427 ,  A61B5/029 ,  A61B5/08

摘要： Embodiments of devices, methods, and non-transitory computer readable media for monitoring a subject are presented. The monitoring device includes at least one sensor configured to monitor one or more physiological parameters of a subject and a processing unit operatively coupled to the sensor. The sensor comprises a plurality of radiation sources and detectors disposed on a flexible substrate in a designated physical arrangement. The processing unit is configured to dynamically configure an operational geometry of the sensor by controlling the intensity of one or more of the radiation sources and the gain of one or more of the detectors so as to satisfy at least one quality metric associated with one or more physiological parameters of the subject.

摘要翻译： 呈现用于监测对象的设备，方法和非暂时性计算机可读介质的实施例。 监测装置包括至少一个被配置成监测被摄体的一个或多个生理参数的传感器和可操作地耦合到传感器的处理单元。 传感器包括以指定的物理布置设置在柔性基板上的多个辐射源和检测器。 处理单元被配置为通过控制一个或多个辐射源的强度和一个或多个检测器的增益来动态地配置传感器的操作几何，以满足与一个或多个检测器相关联的至少一个质量度量 受试者的生理参数。

公开(公告)号：US08179432B2

公开(公告)日：2012-05-15

申请号：US11843754

申请日：2007-08-23

申请人： Siavash Yazdanfar ,  Robert John Filkins ,  Elizabeth Lockenberg Dixon ,  Walter Vincent Dixon, legal representative ,  Krenar Tasimi ,  Kevin Bernard Kenny

发明人： Siavash Yazdanfar ,  Robert John Filkins ,  Elizabeth Lockenberg Dixon ,  Krenar Tasimi ,  Kevin Bernard Kenny

IPC分类号： H04N5/225 ,  H04N5/232

CPC分类号： G02B21/244 ,  G02B21/365

摘要： A method of autofocusing includes capturing first, second and third images of a sample, at respective first, second and third sample distances and respective first, second and third lateral positions determined with respect to an objective; determining a quantitative characteristic for the first, second and third images; determining a primary sample distance based upon at least the quantitative characteristics for the first, second, and third images; and capturing a primary image of the sample at the primary sample distance and at a primary lateral position that is offset from the first, second and third lateral positions.

摘要翻译： 自动对焦的方法包括：以相对于目标确定的各自的第一，第二和第三采样距离以及相应的第一，第二和第三横向位置捕获样本的第一，第二和第三图像; 确定第一，第二和第三图像的定量特性; 至少基于第一，第二和第三图像的定量特性来确定主样本距离; 以及在所述主要采样距离处和在偏离所述第一，第二和第三横向位置的主横向位置处捕获所述样本的主要图像。