公开(公告)号：US5649971A

公开(公告)日：1997-07-22

申请号：US568044

申请日：1995-12-06

申请人： Eric S. Fain ,  Benjamin D. Pless

发明人： Eric S. Fain ,  Benjamin D. Pless

IPC分类号： A61N1/38 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61N1/385 ,  A61N1/3943

摘要： A method and apparatus for inducing fibrillation in a patient's heart by delivering a direct current stimulus to the heart from a DC-to-DC converter. The hardware of a conventional implantable cardioverter/defibrillator (ICD) is utilized with a modification to the control algorithms. Particularly, when it is desired to induce fibrillation in a patient's heart, typically during ICD implant defibrillation threshold (DFT) testing, a command is delivered from an external instrument to the ICD to deliver the fibrillation shock. The DC-to-DC converter which is normally used to charge the ICD high voltage capacitors is activated and immediately thereafter or following a short period to allow the high voltage capacitors to charge, the high voltage output switches of the output stage are closed. This delivers the output current from the DC-to-DC converter to the defibrillation electrodes and through the patient's heart. This stimulus is continued for a predetermined time of between about 30 milliseconds to 5 seconds. At that point the output switches are opened and the converter is shut off. This DC stimulus delivered directly to the patient's heart induces fibrillation.

摘要翻译： 一种用于通过从DC-DC转换器向心脏递送直流刺激来诱导患者心脏颤动的方法和装置。 传统的植入式心律转复除颤器（ICD）的硬件被用于控制算法的修改。 特别地，当期望在患者心脏中诱发纤维颤动时，通常在ICD植入物除颤阈值（DFT）测试期间，将命令从外部仪器传送至ICD以递送原纤维颤动。 通常用于对ICD高电压电容器充电的DC-DC转换器被激活并且紧接其后或在短时间之后，以允许高压电容器充电，输出级的高电压输出开关闭合。 这将输出电流从DC-DC转换器提供给除颤电极并通过患者的心脏。 该刺激持续约30毫秒至5秒的预定时间。 此时，输出开关打开，转换器关闭。 直接传递给患者心脏的直流刺激会导致纤维颤动。

公开(公告)号：US5620477A

公开(公告)日：1997-04-15

申请号：US455824

申请日：1995-05-31

申请人： Benjamin D. Pless ,  Steven M. Mitchell ,  M. Elizabeth Bush

发明人： Benjamin D. Pless ,  Steven M. Mitchell ,  M. Elizabeth Bush

IPC分类号： A61N1/375

CPC分类号： A61N1/3752

摘要： A pulse generator having a housing for enclosing and containing pulse generator defibrillation circuitry, particularly adapted to allow for ease of manufacture and use, is disclosed. At least one surface of the housing is electrically conductive and connected to the pulse generator circuitry for delivering defibrillating energy to the heart. The defibrillator is provided with a case activating lead connector cavity having two connector blocks. By plugging in a lead with a pin long enough to contact the only first connector block, the lead becomes active. Using a plug with a longer pin to contact both blocks activates the can. To use neither a lead in the case activating port, nor an active can, a plug with a short or nonconductive pin may be used to plug the cavity without activating the can. By using this system, various electrode configurations can be used as required to provide the optimum system for a given patient. The pulse generator housing is preferably implanted in the left pectoral region proximate the heart with the conductive surface facing the heart. Other implantable electrodes are discharged against the pulse generator housing electrode.

摘要翻译： 公开了一种脉冲发生器，其具有用于封闭和容纳脉冲发生器除颤电路的壳体，特别适于容易制造和使用。 壳体的至少一个表面是导电的并且连接到脉冲发生器电路，用于将去纤维化能量递送到心脏。 除颤器设置有具有两个连接器块的壳体启动引线连接器腔。 通过插入一根引脚，引脚长度足以接触唯一的第一个连接器块，引线将变为活动状态。 使用较长针脚的插头接触两个块可激活罐头。 为了在启动端口的情况下既不使用引线，也不使用活动端子，可以使用具有短导体或非导通插头的插头来插入腔体而不激活罐体。 通过使用该系统，可以根据需要使用各种电极配置来为给定的患者提供最佳的系统。 脉冲发生器壳体优选地植入靠近心脏的左胸部区域，导电表面面向心脏。 其他可植入电极被排出脉冲发生器壳体电极。

公开(公告)号：US5476500A

公开(公告)日：1995-12-19

申请号：US170133

申请日：1993-12-20

申请人： Eric S. Fain ,  Drew A. Hoffman ,  Benjamin D. Pless

发明人： Eric S. Fain ,  Drew A. Hoffman ,  Benjamin D. Pless

IPC分类号： A61N1/04 ,  A61N1/05

CPC分类号： A61N1/0573 ,  A61N1/0563

摘要： A lead system for use with an implantable cardioverter/defibrillator is disclosed. The lead system includes a fixation hook positioned approximately half-way between the distal tip of the lead and the tricuspid valve. The distal tip of the lead is positioned at the apex of the right ventricle and may or may not be secured there by a second fixation means such as a screw tip or tines. The fixation hook allows the defibrillation electrode to be accurately positioned by the patient's surgeon and maintained in contact with the septum wall of the patient's heart. By providing such intimate contact between the defibrillation electrode and the septum wall, defibrillation thresholds are reduced.

摘要翻译： 公开了一种与植入式心律转复除颤器一起使用的引导系统。 引导系统包括定位在引线的远端和三尖瓣之间大致中途的固定钩。 引线的远端位于右心室的顶点处，并且可以通过第二固定装置（例如螺钉尖端或尖齿）固定或不固定。 固定钩允许除颤电极被患者的外科医生精确地定位并保持与患者心脏的隔膜壁接触。 通过在除颤电极和隔膜壁之间提供这种紧密接触，降低了除颤阈值。

公开(公告)号：US5226260A

公开(公告)日：1993-07-13

申请号：US819106

申请日：1992-01-09

申请人： Craig Mar ,  Benjamin D. Pless

发明人： Craig Mar ,  Benjamin D. Pless

IPC分类号： A61N1/05 ,  B24C1/00 ,  B24C3/32

CPC分类号： B24C1/003 ,  A61N1/05 ,  B24C3/322

摘要： A method of manufacturing a medical electronic lead portion having an elastomeric mass and typically having a conductive metal member embedded in the elastomeric mass. The method includes the step of eroding elastomer of the mass from around the conductive metal member to form a predetermined shape by exposing the lead portion to a jet of gas containing entrained, particulate abrasive. Preferably, the particulate abrasive is softer than the conductive metal member to avoid scratching thereof. For example, soluble particulate abrasive such as sodium bicarbonate can be used.

摘要翻译： 一种制造具有弹性质量并且通常具有嵌入在弹性体中的导电金属构件的医疗电子引线部分的方法。 该方法包括通过将引线部分暴露于含有夹带的颗粒磨料的气体射流，来侵蚀质量的弹性体从导电金属构件周围形成预定形状的步骤。 优选地，颗粒磨料比导电金属构件更软，以避免其刮擦。 例如，可以使用可溶性颗粒磨料如碳酸氢钠。

公开(公告)号：US4880005A

公开(公告)日：1989-11-14

申请号：US198614

申请日：1988-05-23

申请人： Benjamin D. Pless ,  Michael B. Sweeney

发明人： Benjamin D. Pless ,  Michael B. Sweeney

IPC分类号： A61N1/362

CPC分类号： A61N1/3621

摘要： A heart pacemaker detects pace-terminable tachycardia conditions in the atrium of the heart in accordance with selected high rate, rate stability, sudden onset and sustained high rate criteria. When a pace-terminable tachycardia is detected, programmed treatment modalities are applied to attempt to terminate the tachycardia. The tachycardia is treated by applying timed bursts of electrical pulses in formats defined by programmed primary and secondary treatment modalities. The primary and secondary treatments may be applied in an order which is dependent upon the prior successful treatment of similar tachycardias. The pacemaker may also utilize remembered treatment values which were successfully applied to treat similar tachycardias. The pacemaker may be programmed to restart the primary and secondary modes of treatment in the event that the modes initially failed to terminate a tachycardia. The pacemaker may also be programmed to limit the rate of burst pulses to avoid overstimulating the heart.

公开(公告)号：US20130178829A1

公开(公告)日：2013-07-11

申请号：US13781936

申请日：2013-03-01

申请人： Ali R. Rezai ,  Anthony V. Caparso ,  Benjamin D. Pless

发明人： Ali R. Rezai ,  Anthony V. Caparso ,  Benjamin D. Pless

IPC分类号： A61M5/00 ,  A61N1/05

CPC分类号： A61N1/3611 ,  A61B5/0205 ,  A61B5/04001 ,  A61B5/1473 ,  A61B5/4029 ,  A61B5/4058 ,  A61B5/4836 ,  A61B5/6877 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/50 ,  A61N1/0551 ,  A61N1/36021 ,  A61N1/36071

摘要： The present invention is directed to a method of treating a respiratory or pulmonary condition in a patient by transvascular neuromodulation of an adrenal gland or neural structures that innervate the adrenal gland or components thereof. Methods also include implanting a controller in the patient to control delivery of a therapy signal to the patient's adrenal gland. The therapy signal can be an electrical and/or chemical signal.

摘要翻译： 本发明涉及一种通过肾上腺或神经结构的血管神经调节来治疗患者的呼吸或肺部疾病的方法，所述神经结构支配肾上腺或其组分。 方法还包括将控制器植入患者体内以控制对患者的肾上腺的治疗信号的传递。 治疗信号可以是电和/或化学信号。

公开(公告)号：US20110118661A1

公开(公告)日：2011-05-19

申请号：US13011917

申请日：2011-01-23

申请人： Benjamin D. Pless ,  Michael Sasha John

发明人： Benjamin D. Pless ,  Michael Sasha John

IPC分类号： A61N1/36 ,  A61M37/00

CPC分类号： A61N1/36071 ,  A61F7/007 ,  A61F2007/0075 ,  A61M5/1723 ,  A61M2005/1726 ,  A61N1/36135 ,  A61N2/006 ,  A61N5/0622

摘要： An implantable neurostimulator system for treating pain includes scheduled and responsive therapy capabilities including responsive stimulation applied to the brain and peripheral sections of the nervous system. Methods for treating chronic nociceptive, neuropathic, and psychogenic pain employ an inventive system to advantageously reduce multiple symptoms and components of pain and to address underlying causes of pain.

公开(公告)号：US07894890B2

公开(公告)日：2011-02-22

申请号：US11704451

申请日：2007-02-09

申请人： Felice Sun ,  Benjamin D. Pless ,  Barbara Gibb

发明人： Felice Sun ,  Benjamin D. Pless ,  Barbara Gibb

IPC分类号： A61B5/048

CPC分类号： A61B5/4812 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/02438 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0452 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/11 ,  A61B5/1118 ,  A61B5/14551 ,  A61B5/4815 ,  A61B5/686 ,  A61N1/36082 ,  A61N1/36135 ,  G06F19/00

摘要： Described here are implantable devices and methods for monitoring physiological information relating to sleep. The implantable devices are generally designed to include at least one sensor for sensing physiological information, a processor for processing the physiological information using low computational power to detect a sleep stage, and a battery. The detected sleep stage information may then be used to indicate sleep quality, identify or monitor a medical condition, or guide treatment thereof.

摘要翻译： 这里描述的是用于监测与睡眠相关的生理信息的可植入装置和方法。 可植入装置通常设计成包括用于感测生理信息的至少一个传感器，用于使用低计算能力处理生理信息以检测睡眠阶段的处理器以及电池。 然后可以使用检测到的睡眠阶段信息来指示睡眠质量，识别或监测医疗状况或指导治疗。

公开(公告)号：US20100073680A1

公开(公告)日：2010-03-25

申请号：US12626577

申请日：2009-11-25

申请人： Benjamin D. Pless

发明人： Benjamin D. Pless

IPC分类号： G01B9/02

CPC分类号： G06K9/2036 ,  G06K9/00577

摘要： Disclosed are a method and system for performing device identification and a medical device susceptible to identification using interference patterns for performing device identification. A source signal may be directed from an energy source towards the surface of a device for reflection therefrom. An interference pattern may be detected from the surface of the device, such as by a sensor. A determination as to whether a match exists between the representation of the interference pattern and a stored representation of an interference pattern may be performed. If a match exists, the device may be identified based on the stored representation of the interference pattern. Otherwise, a representation of the interference pattern may be stored and a unique identifier may be assigned to the stored representation of the interference pattern.

摘要翻译： 公开了用于执行设备识别的方法和系统以及易于使用用于执行设备识别的干扰图案的识别的医疗设备。 源信号可以从能量源朝向装置的表面引导以从其反射。 可以从设备的表面（例如通过传感器）检测干涉图案。 可以执行关于在干涉图案的表示和存储的干涉图案的表示之间是否存在匹配的确定。 如果存在匹配，则可以基于存储的干涉图案的表示来识别该设备。 否则，可以存储干扰图案的表示，并且可以将唯一标识符分配给所存储的干涉图案的表示。

公开(公告)号：US20080319511A1

公开(公告)日：2008-12-25

申请号：US11767432

申请日：2007-06-22

申请人： Benjamin D. Pless

发明人： Benjamin D. Pless

IPC分类号： A61N1/36 ,  A61B5/04

CPC分类号： A61N1/37247 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/0476 ,  A61B5/11 ,  A61B5/4094 ,  A61B2562/0219 ,  A61N1/36071

摘要： An implantable neurostimulator for treating disorders such as epilepsy, pain, movement disorders and depression includes a detection subsystem capable of detecting a physiological condition and a therapy subsystem capable of providing a course of therapy in response to the condition. The therapy subsystem includes an auto-adjust module for automatically adjusting one or more parameters of the therapy so that the therapy subsystem can provide an adjusted parameter to the patient and solicit the patient's feedback concerning the adjustment without requiring the presence of, or immediate involvement with, a clinician or physician. The patient feedback can be analyzed by computer, clinician or a combination of both to determine an optimal range of parameters for subsequent courses of therapy. In this manner, information useful in tuning the neurostimulator therapy parameters to optimize them for individual patient can be acquired automatically outside of the traditional clinical setting, saving time and minimizing patient fatigue that otherwise would be experience in marathon, in-clinic tuning sessions. The auto-adjust module also can be configured to prompt the patient to provide feedback even when parameters are not being adjusted, so as to acquire information for a baseline or about any placebo effect when the patient is otherwise expecting changes to the therapy to be made.

摘要翻译： 用于治疗诸如癫痫，疼痛，运动障碍和抑郁症的疾病的可植入神经刺激器包括能够检测生理状况的检测子系统和能够响应于该病症提供治疗过程的治疗子系统。 治疗子系统包括用于自动调整治疗的一个或多个参数的自动调整模块，使得治疗子系统可以向患者提供经调整的参数，并征求患者关于调整的反馈，而不需要存在或立即参与 ，临床医生或医师。 患者反馈可以由计算机，临床医师或两者的组合进行分析，以确定后续治疗疗程的最佳参数范围。 以这种方式，可以在传统临床环境之外自动获取调整神经刺激器治疗参数以优化个体患者的信息的有用信息，节省时间并最大限度地减少患者疲劳，否则将在马拉松，临床内调整课程中体验。 自动调整模块还可以被配置为即使在参数未被调整的情况下也提示患者提供反馈，以便当患者以其他方式期望改变治疗时获得基线信息或约为任何安慰剂效应 。