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公开(公告)号:US07553827B2
公开(公告)日:2009-06-30
申请号:US10640412
申请日:2003-08-13
申请人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
发明人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
IPC分类号: A61K31/65
CPC分类号: A61K31/65 , A61K38/20 , A61K45/06 , A61K2300/00
摘要: The present invention relates to injecting a cycline compound into a diseased intervertebral disc.
摘要翻译: 本发明涉及将环状化合物注射到患病的椎间盘中。
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32.Transdiscal administration of anti-TNFalpha antibodies and growth differentiation factors 有权
标题翻译: 抗TNFalpha抗体和生长分化因子的经半径给药公开(公告)号:US20090155364A1
公开(公告)日:2009-06-18
申请号:US12290998
申请日:2008-11-05
申请人: Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K9/10 , A61K39/395
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号:US20090068270A1
公开(公告)日:2009-03-12
申请号:US12291016
申请日:2008-10-31
CPC分类号: A61K35/19 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/1841 , A61K2300/00
摘要: The present invention relates to administering autologous uncultured cells into a diseased intervertebral disc.
摘要翻译: 本发明涉及将自体未培养的细胞施用于患病的椎间盘。
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34.Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权
标题翻译: 跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号:US07344716B2
公开(公告)日:2008-03-18
申请号:US10456948
申请日:2003-06-06
IPC分类号: A61K45/00 , A61K39/395
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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35.Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权
标题翻译: 跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号:US08728523B2
公开(公告)日:2014-05-20
申请号:US12291378
申请日:2008-11-07
申请人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K45/00 , A61K39/395
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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36.Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权
标题翻译: 将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号:US08361467B2
公开(公告)日:2013-01-29
申请号:US10630227
申请日:2003-07-30
申请人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
发明人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
IPC分类号: A61K39/395 , A61K39/00 , A61K38/18
CPC分类号: A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要: The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译: 本发明涉及向患病关节中透射施用高特异性拮抗剂,所述高特异性拮抗剂选自:i)促炎白细胞介素的抑制剂; ii)TNF-α合成抑制剂; iii)膜结合TNF-α的抑制剂; iv)TNF-α的天然受体的抑制剂; v)NO合酶抑制剂,vi)PLA2酶抑制剂; vii)抗增殖剂; viii)抗氧化剂; ix)选自EPO模拟肽,EPO模拟物,IGF-I,IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂,和x)MMP的抑制剂; 和xi)p38激酶的抑制剂。
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公开(公告)号:US07744555B2
公开(公告)日:2010-06-29
申请号:US10774105
申请日:2004-02-06
申请人: Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Tim Beardsley
发明人: Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Tim Beardsley
CPC分类号: A61F2/30767 , A61B17/866 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/38 , A61F2/4455 , A61F2002/30663 , A61F2002/30668 , A61F2002/30929 , A61F2002/30981 , A61F2002/3611 , A61F2002/3625 , A61F2002/443 , A61F2250/0001 , A61F2310/00023 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61L27/06 , A61L27/427 , A61L27/56 , A61L31/022 , A61L31/124 , A61L31/146 , A61M5/158 , A61N5/0601 , A61N5/0624 , A61N2005/0651 , A61N2005/0661 , B01J35/004
摘要: An implant comprises a photocatalytic layer on at least one surface. In some embodiments, the photocatalytic layer is a semiconductor oxide that is doped. According to some embodiments, the implant comprises a wave guide. According to some embodiments the implant comprises a light port. According to some embodiments, the implant comprises a reflective material on a surface of the waveguide. According to some embodiments the implant comprises a composite material comprising a first material that has a transmissivity when exposed to a predetermined wavelength of light and a second material that has photocatalytic activity when exposed to the predetermined wavelength of light. According to some embodiments the implant comprises a light source adapted to irradiate the photocatalytic surface.
摘要翻译: 植入物包括在至少一个表面上的光催化层。 在一些实施方案中,光催化层是掺杂的半导体氧化物。 根据一些实施例,植入物包括波导。 根据一些实施例,植入物包括光端口。 根据一些实施例,植入物在波导的表面上包括反射材料。 根据一些实施例,植入物包括复合材料,其包括当暴露于预定波长的光时具有透射率的第一材料和当暴露于预定波长的光时具有光催化活性的第二材料。 根据一些实施例,植入物包括适于照射光催化表面的光源。
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公开(公告)号:US07399742B2
公开(公告)日:2008-07-15
申请号:US11018438
申请日:2004-12-21
IPC分类号: A61K38/19
CPC分类号: A61L27/54 , A61K38/1841 , A61K38/2066 , A61K38/2264 , A61K38/39 , A61K38/57 , A61L2300/252 , A61L2430/38 , A61K2300/00
摘要: This invention is directed to administering an effective amount of adiponectin into an osteolytic region for treating osteolysis.
摘要翻译: 本发明涉及将有效量的脂连蛋白施用于溶骨性溶解区域用于治疗骨质溶解。
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公开(公告)号:US20060134164A1
公开(公告)日:2006-06-22
申请号:US11015926
申请日:2004-12-17
申请人: Thomas DiMauro , Mohamed Attawia , Chantal Holy , Hugo Pedrozo
发明人: Thomas DiMauro , Mohamed Attawia , Chantal Holy , Hugo Pedrozo
CPC分类号: A61L27/54 , A61L27/446 , A61L27/52 , A61L2300/252
摘要: Active immunization and a formulation for treating or preventing osteolysis caused by Wear Particles, comprising: a) a Th2 -inducing adjuvant, and b) Wear Particles.
摘要翻译: 主动免疫和用于治疗或预防由磨损颗粒引起的骨质溶解的制剂,其包含:a)Th2诱导佐剂,和b)磨损颗粒。
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公开(公告)号:US20060224185A1
公开(公告)日:2006-10-05
申请号:US11096085
申请日:2005-03-31
申请人: Thomas DiMauro , Mohamed Attawia , Sean Lilienfeld
发明人: Thomas DiMauro , Mohamed Attawia , Sean Lilienfeld
IPC分类号: A61N1/39
CPC分类号: A61N5/02 , A61N1/403 , A61N7/00 , A61N2005/1087
摘要: Heating the hypothalamus, preferably by ultrasound, to cause the release of αMSH in the brain.
摘要翻译: 加热下丘脑,优选通过超声波,以引起脑中αMSH的释放。
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