-
公开(公告)号：US20120011113A1
公开(公告)日：2012-01-12
申请号：US12834592
申请日：2010-07-12
申请人： Ira Cohen , Gilad Barash , Eli Mordechai , Carl Staelin
发明人： Ira Cohen , Gilad Barash , Eli Mordechai , Carl Staelin
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30011
摘要： A method of determining reliability of electronic documents associated with an event occurring in connection with a computing device may comprise, with a processor, composing a number of search queries based on text included in an event message, searching for a number of electronic documents via a network, said searching performed based on the composed search queries, and ranking the electronic documents identified by said searching based upon an indication of reliability in addressing the event associated with the event message, in which, ranking the electronic documents comprises applying a content source ranking criteria.
摘要翻译： 确定与计算设备相关联的事件相关联的电子文档的可靠性的方法可以包括与处理器基于事件消息中包含的文本来组合搜索查询的数量，经由以下操作搜索多个电子文档： 网络，基于所组合的搜索查询执行所述搜索，并且基于在解决与事件消息相关联的事件的可靠性的指示来对由所述搜索所识别的电子文档进行排名，其中，对电子文档进行排名包括应用内容源排名 标准
-
32.发明申请Novel single nucleotide polymorphisms and community-associated methicillin-resistant staphylococcus aureus 有权新型单核苷酸多态性和社区相关耐甲氧西林金黄色葡萄球菌公开(公告)号：US20120009572A1
公开(公告)日：2012-01-12
申请号：US13068331
申请日：2011-05-09
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： The present invention is based on the discovery of novel polymorphisms (SNPs) in the penicillin binding protein (pbp3) gene in Staphylococcus aureus. The presence of G88A and/or G2047A SNPs provides an accurate, reliable biomarker for the presence of Methicillin Resistant Staphylococcus aureus (MRSA), specifically the community-associated MRSA (CA-MRSA). The present invention provides reagents used for detecting the SNPs as well as methods of identifying and using these variants to screen subjects for presence of CA-MRSA. The methods involve isolating a biological sample from a mammal (preferably a human) and testing for the presence of a SNP in the pbp3 gene which is associated with CA-MRSA.
摘要翻译： 本发明基于在金黄色葡萄球菌中青霉素结合蛋白（pbp3）基因中新型多态性（SNP）的发现。 G88A和/或G2047A SNP的存在为耐甲氧西林金黄色葡萄球菌（MRSA），特别是社区相关MRSA（CA-MRSA）的存在提供了准确，可靠的生物标志物。 本发明提供用于检测SNP的试剂以及鉴定和使用这些变体筛选受试者存在CA-MRSA的方法。 所述方法包括从哺乳动物（优选人）分离生物样品并测试与CA-MRSA相关的pbp3基因中SNP的存在。
-
公开(公告)号：US08026056B2
公开(公告)日：2011-09-27
申请号：US12156029
申请日：2008-05-29
申请人： Melanie Feola , Martin Adelson , Eli Mordechai , Lisa Novak
发明人： Melanie Feola , Martin Adelson , Eli Mordechai , Lisa Novak
摘要： Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of Borrelia afzelii, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Borrelia afzelii. Real-time PCR and detection using florescence resonance energy transfer is disclosed.
摘要翻译： 公开了用于确定样品是否含有人类的莱姆病的致病因子的螺旋体（Borrelia afzelii）的方法中的寡核苷酸。 这些寡核苷酸具有衍生自编码b24基因的基因的编码区段的核苷酸序列，用于使用来自生物样品的核酸作为模板的聚合酶链反应的正向和反向引物， 以及用于检测任何所得扩增子的探针。 扩增子的检测表明样品含有Borrelia afzelii。 公开了使用荧光共振能量转移的实时PCR和检测。
-
公开(公告)号：US07745595B2
公开(公告)日：2010-06-29
申请号：US11502694
申请日：2006-08-10
申请人： Jason Trama , Martin E. Adelson , Eli Mordechai
发明人： Jason Trama , Martin E. Adelson , Eli Mordechai
CPC分类号： C12Q1/689
摘要： Disclosed are oligonucleotides useful in methods for determining whether a sample contains Atopobium vaginae or has an increased likelihood of containing Atopobium vaginae, an organism which is seen in conjunction with bacterial vaginosis or is a causative agent of bacterial vaginosis. These oligonucleotides, which have nucleotide sequences derived from a segment of the genome of Atopobium vaginae, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as a template, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Atopobium vaginae or has an increased likelihood of containing Atopobium vaginae.
摘要翻译： 公开了用于确定样品是否含有阴道弧菌的方法中的寡核苷酸或具有增加的可能性，其含有与细菌性阴道炎联合观察的生物体或阴道细菌性阴道炎的致病因子的阴道角膜的可能性增加。 这些寡核苷酸具有源自阴道角膜的基因组的片段的核苷酸序列，可用作使用来自生物样品的核酸作为模板的聚合酶链反应的正向和反向引物，以及用于检测任何所得扩增子的探针。 扩增子的检测表明样品含有阴道角膜，或具有增加阴道角化的可能性。
-
公开(公告)号：US20080213749A1
公开(公告)日：2008-09-04
申请号：US11713408
申请日：2007-03-02
申请人： Melanie Feola , Larisa Gofman , Eli Mordechai , Martin E. Adelson
发明人： Melanie Feola , Larisa Gofman , Eli Mordechai , Martin E. Adelson
CPC分类号： C12Q1/701
摘要： Disclosed are oligonucleotides useful in methods for determining whether a sample contains a human metapneumovirus or has an increased likelihood of containing a human metapneumovirus, a virus which is a causative agent of respiratory tract disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fusion protein of a human metapneumovirus, are useful as forward and reverse primers for a polymerase chain reaction using reverse transcripts of RNA from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains a human metapneumovirus or has an increased likelihood of containing a human metapneumovirus.
摘要翻译： 公开了用于确定样品是否含有人类偏肺病毒或具有增加的可能性的可能性的寡核苷酸，所述可能性包含人类偏肺病毒，人类偏肺病毒是人类呼吸道疾病的致病因子的病毒。 具有源自编码人类偏肺病毒融合蛋白的基因的编码区的核苷酸序列的这些寡核苷酸可用作使用来自生物样品的RNA的逆转录作为模板的聚合酶链反应的正向引物和反向引物，以及 用于检测任何所得扩增子的探针。 扩增子的检测表明样品含有人类偏肺病毒，或具有增加含有人间质肺病毒的可能性。
-
36.发明申请Integrated method for collection and maintenance of detectability of a plurality of microbiological agents in a single clinical sample and for handling a plurality of samples for reporting a sum of diagnostic results for each sample 有权用于收集和维护单个临床样品中多个微生物试剂的可检测性并用于处理多个样品以报告每个样品的诊断结果总和的综合方法公开(公告)号：US20070042355A1
公开(公告)日：2007-02-22
申请号：US11343822
申请日：2006-01-31
申请人： Martin Adelson , Eli Mordechai
发明人： Martin Adelson , Eli Mordechai
CPC分类号： G06F19/366 , C12Q1/04 , C12Q1/045 , C12Q1/689 , C12Q1/6893 , C12Q1/6895 , C12Q1/705 , G01N33/569 , G06F19/00 , G16H10/20 , G16H10/40
摘要： A method and kit related thereto are described for the collection and maintenance of detectability of a plurality of species of microbiological agents in a single clinical sample as well as an integral method for handling a plurality of the samples and managing information associated therewith for reporting a sum of diagnostic results for each sample.
摘要翻译： 描述了与其相关的方法和试剂盒，用于收集和维护单个临床样品中多种微生物剂的可检测性，以及用于处理多个样品并管理与之相关的信息以报告总和的整体方法 的每个样品的诊断结果。
-
37.发明授权Detection of chronic fatigue syndrome by increased apoptosis and cell cycle arrest of peripheral blood mononuclear cells 失效通过增加外周血单核细胞凋亡和细胞周期阻滞来检测慢性疲劳综合征
公开(公告)号：US5853996A
公开(公告)日：1998-12-29
申请号：US843951
申请日：1997-04-17
申请人： Eli Mordechai , Aristo Vojdani
发明人： Eli Mordechai , Aristo Vojdani
CPC分类号： G01N33/573 , C12Q1/48 , G01N1/30 , G01N33/5091
摘要： A method for diagnosing chronic fatigue syndrome in an individual. Peripheral blood monocytes are isolated and p68 kinase activity, mRNA levels, protein levels, apoptosis and cell cycle analysis are measured. Significantly increased levels of any of these compared to healthy control individuals indicates the presence of chronic fatigue syndrome.
摘要翻译： 一种诊断个体慢性疲劳综合征的方法。 分离外周血单核细胞，测定p68激酶活性，mRNA水平，蛋白水平，细胞凋亡和细胞周期分析。 与健康对照个体相比，任何这些相比显着增加，表明存在慢性疲劳综合征。
-
38.发明申请公开(公告)号：US20170260570A1
公开(公告)日：2017-09-14
申请号：US15067700
申请日：2016-03-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to an antibiotic resistance profile for Neisseria gonorrhoeae by assessing the presence of mutations (e.g., SNP) in antibiotic resistant genes that confer bacterial resistance against antibiotics such as penicillin, tetracycline, fluoroquinolones, cephalosporin, macrolides and spectinomycin. There is provided a method and a kit for generating an antibiotic resistance profile for Neisseria gonorrhoeae by utilizing a multiplex PCR to amplify segments of antibiotic-resistant genes, allele-specific primer extension to detect gene mutation, and detection of such gene mutations with gel electrophoresis, capillary electrophoresis, or DNA microarray. The present method provides useful information to physicians relating the antibiotic susceptibility of Neisseria gonorrhoeae against different classes of antibiotics. Relying on this personalized diagnostic tool, physicians can better inform about antibiotic susceptibility and thereby open up medical intervention avenues for treating Neisseria gonorrhoeae with antibiotics. There is provided a therapeutic application of the antibiotic resistance profile that has advantages of: (i) providing a more effective regime for gonorrhea treatment; and (ii) halting the evolutionary pressures towards antibiotic resistance in the Neisseria gonorrhoeae therapy.
-
39.发明授权公开(公告)号：US09267179B2
公开(公告)日：2016-02-23
申请号：US13935599
申请日：2013-07-05
申请人： Jason Trama , Martin E. Adelson , Eli Mordechai
发明人： Jason Trama , Martin E. Adelson , Eli Mordechai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12Q1/689
摘要： Methods and compositions useful in the detection and identification of species of Candida are disclosed. The compositions are combinations of oligonucleotides, where the forward primers of the primer pairs have identical sequences, while each reverse primer of the primer pairs has a unique sequence relative to all of the other reverse primers; or the reverse primers of the primer pairs have identical sequences, while each forward primer of the primer pairs has a unique sequence relative to all of the other forward primers. The oligonucleotides also include probes capable of detecting these amplicons, and sequencing primers for determining, in primer extension reactions, the nucleotide sequences contained within the amplicons. The detection of an amplicon indicated that the sample contains at least one isolate of Candida ablicans, Candida glabrata, Candida parapsilosis, or Candida tropicalis, and the nucleotide sequence data is used to determine which of these four Candida species is present.
摘要翻译： 公开了用于检测和鉴定假丝酵母菌种的方法和组合物。 组合物是寡核苷酸的组合，其中引物对的正向引物具有相同的序列，而引物对的每个反向引物相对于所有其它反向引物具有唯一的序列; 或引物对的反向引物具有相同的序列，而引物对的每个正向引物相对于所有其它正向引物具有唯一的序列。 寡核苷酸还包括能够检测这些扩增子的探针和测序引物，用于在引物延伸反应中测定扩增子中包含的核苷酸序列。 扩增子的检测表明样品含有至少一种假丝酵母，光滑念珠菌，热带假丝酵母或热带假丝酵母的分离物，核苷酸序列数据用于确定这四种假丝酵母属中存在哪一种。
-
公开(公告)号：US09002830B2
公开(公告)日：2015-04-07
申请号：US12834592
申请日：2010-07-12
申请人： Ira Cohen , Gilad Barash , Eli Mordechai , Carl Staelin
发明人： Ira Cohen , Gilad Barash , Eli Mordechai , Carl Staelin
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30011
摘要： A method of determining reliability of electronic documents associated with an event occurring in connection with a computing device may comprise, with a processor, composing a number of search queries based on text included in an event message, searching for a number of electronic documents via a network, said searching performed based on the composed search queries, and ranking the electronic documents identified by said searching based upon an indication of reliability in addressing the event associated with the event message, in which, ranking the electronic documents comprises applying a content source ranking criteria.
摘要翻译： 确定与计算设备相关联的事件相关联的电子文档的可靠性的方法可以包括与处理器基于事件消息中包含的文本来组合搜索查询的数量，经由以下操作搜索多个电子文档： 网络，基于所组合的搜索查询执行所述搜索，并且基于在解决与事件消息相关联的事件的可靠性的指示来对由所述搜索所识别的电子文档进行排名，其中，对电子文档进行排名包括应用内容源排名 标准
-
-
-
-
-
-
-
-
-
搜索结果
92 条记录 (耗时 0.033 秒)