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    In Vitro Methodology for Predicting in Vivo Absorption Time of Bioabsorbable Polymeric Implants and Devices
    32.
    发明申请
    In Vitro Methodology for Predicting in Vivo Absorption Time of Bioabsorbable Polymeric Implants and Devices 审中-公开
    用于预测生物可吸收聚合物植入物和器件的体内吸收时间的体外方法

    公开(公告)号：US20130330827A1

    公开(公告)日：2013-12-12

    申请号：US13682275

    申请日：2012-11-20

    Applicant: Ethicon, Inc.

    Inventor： Dennis D. Jamiolkowski ,  Benjamin D. Fitz ,  Dachuan Yang

    IPC: G01N33/44

    CPC classification number: G01N33/442 ,  A61F2210/0004 ,  A61L27/58

    Abstract: A novel in vitro methodology for predicting the in vivo behavior, such as absorption time or mechanical strength retention, of biodegradable polymeric implants and medical devices. The present invention provides a novel in vitro methodology, hydrolysis profiling, for studying the degradation of absorbable polymers. Accuracy and reproducibility have been established for selected test conditions. Data from this in vitro method are correlated to in vivo absorption data, allowing for the prediction of accurate in vivo behaviors, such as absorption times.

    Abstract translation: 用于预测可生物降解的聚合物植入物和医疗装置的体内行为（例如吸收时间或机械强度保留）的新型体外方法。 本发明提供了一种用于研究可吸收聚合物降解的新的体外方法学，水解分析。 已经为选定的试验条件建立了准确性和重复性。 来自该体外方法的数据与体内吸收数据相关，允许预测准确的体内行为，例如吸收时间。

    Polylactone Polymers Prepared from Monol and Diol Polymerization Initiators Processing Two or More Carboxylic Acid Groups
    37.
    发明申请
    Polylactone Polymers Prepared from Monol and Diol Polymerization Initiators Processing Two or More Carboxylic Acid Groups 审中-公开
    由单醇和二醇聚合引发剂制备的聚内酯聚合物加工两种或更多种羧酸基团

    公开(公告)号：US20140275467A1

    公开(公告)日：2014-09-18

    申请号：US14195220

    申请日：2014-03-03

    Applicant: Ethicon, Inc.

    Inventor： Dennis D. Jamiolkowski ,  Modesto Erneta ,  Terry E. Lawler ,  Rao S. Bezwada

    IPC: A61L17/10 ,  A61L31/06

    CPC classification number: A61L17/105 ,  A61B17/06166 ,  A61B17/064 ,  A61B17/122 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61L17/12 ,  A61L31/06 ,  A61L31/148 ,  C08G63/08 ,  C08G63/823 ,  C08L67/04

    Abstract: The present invention is directed to a novel polymerization process for making novel absorbable, linear polylactone polymers prepared using novel polymerization initiators to achieve rates of mechanical property loss or of absorption of articles made from the polymers that are at least about 1.2 times faster than the rates of mechanical property loss of polymers made by similar processes utilizing conventional initiators. The novel polymerization initiators include monols or diols possessing at least one primary alcohol group and two or more carboxylic acid groups. The invention also is directed to absorbable polylactone polymers prepared by processes of the present invention and to medical devices made from such polymers.

    Abstract translation: 本发明涉及一种新颖的聚合方法，用于制备新的可吸收的线性聚内酯聚合物，其使用新的聚合引发剂制备，以获得由聚合物制成的制品的机械性能损失或吸收速率，其速率比速率高至少约1.2倍 的通过使用常规引发剂的类似方法制备的聚合物的机械性能损失。 新型聚合引发剂包括具有至少一个伯醇基团和两个或更多个羧酸基团的单醇或二醇。 本发明还涉及通过本发明的方法制备的可吸收的聚内酯聚合物和由这样的聚合物制成的医疗装置。

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