公开(公告)号：US09399075B2

公开(公告)日：2016-07-26

申请号：US13872539

申请日：2013-04-29

Applicant: General Electric Company

Inventor： Matthew David Butts ,  Robert Edgar Colborn ,  Peter John Bonitatibus, Jr. ,  Andrew Soliz Torres ,  Brian Christopher Bales ,  Michael Ernest Marino ,  Bruce Allan Hay ,  Amit Mohan Kulkarni

IPC: A61K49/04 ,  C01G35/00 ,  A61K49/00 ,  A61K49/18 ,  B82Y5/00 ,  B82Y30/00

CPC classification number: A61K49/101 ,  A61K49/0002 ,  A61K49/04 ,  A61K49/0428 ,  A61K49/0485 ,  A61K49/1818 ,  A61K49/1848 ,  B82Y5/00 ,  B82Y30/00 ,  C01G35/00 ,  Y10S977/773 ,  Y10S977/779 ,  Y10S977/927 ,  Y10S977/928 ,  Y10T428/2982

Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。

公开(公告)号：US20160144059A1

公开(公告)日：2016-05-26

申请号：US14550689

申请日：2014-11-21

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Matthew David Butts ,  Jason William Castle ,  Andrew Soliz Torres ,  Jeannette Christine Roberts ,  Binil Itty Ipe Kandapallil

IPC: A61K49/22

CPC classification number: A61K49/223 ,  A61K9/0009 ,  A61K9/5052

Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.

Abstract translation: 本公开内容涉及白蛋白微泡的组合物，其结合了相对于游离的天然HSA显示白蛋白微泡的结合偏好的一个或多个部分。 还讨论了白蛋白微泡组合物的生产和白蛋白微泡组合物在超声介导的递送治疗剂或诊断剂中的用途。

公开(公告)号：US20150203836A1

公开(公告)日：2015-07-23

申请号：US14158106

申请日：2014-01-17

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Antonio Caiafa ,  Vasile Bogdan Neculaes ,  Allen Lawrence Garner ,  Andrew Soliz Torres

IPC: C12N13/00 ,  A61B5/15 ,  H03K3/53

CPC classification number: C12N13/00 ,  A61B5/150755 ,  C12M35/02 ,  G01N33/49 ,  H03K3/53

Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.

Abstract translation: 根据本公开，描述了通过电容耦合将样本暴露于一个或多个电脉冲。 在某些实施方案中，样品可以是使用脉冲电场处理或修饰的生物样品。 在某些实施例中，电脉冲可以使用电容耦合传送到负载。 在其他实施例中，电脉冲可以是双极性脉冲。

公开(公告)号：US20140363412A1

公开(公告)日：2014-12-11

申请号：US13912050

申请日：2013-06-06

Applicant: General Electric Company

Inventor： Vasile Bogdan Neculaes ,  Antonio Caiafa ,  Brian Duh-Lan Lee ,  Nicole Evelyn LaPlante ,  Andrew Soliz Torres ,  Allen Lawrence Garner

IPC: C12N13/00 ,  A61K35/14

CPC classification number: A61K35/19 ,  A61K41/00 ,  A61N1/00 ,  C12N5/0644 ,  C12N13/00

Abstract: Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.

Abstract translation: 本公开的实施方案涉及使用电脉冲的血小板活化和/或聚集。 在一个实施方案中，将含血小板的样品暴露于电脉冲。 电脉冲中的至少一个具有大于1微秒的持续时间和低于50kV / cm的场强。 在另一个实施例中，电脉冲可以被设计为具有特定的场强和持续时间。