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31.
公开(公告)号:US20180326484A1
公开(公告)日:2018-11-15
申请号:US15591941
申请日:2017-05-10
Applicant: General Electric Company
CPC classification number: B22F3/1021 , B22F2998/10 , B33Y10/00 , B33Y50/02 , B33Y70/00 , B33Y80/00
Abstract: A green body multi-sectional binder jet printed part includes a plurality of binder jet printed strategic sections. Each of the plurality of strategic sections comprises a powdered material adhered together with at least one binder and define a portion of an internal feature of the green body multi-sectional part. The plurality of binder jet printed strategic sections are adhered together by a modified binder disposed at interfaces between the plurality of binder jet printed strategic sections of the green body multi-sectional part.
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公开(公告)号:US09915592B2
公开(公告)日:2018-03-13
申请号:US14772305
申请日:2014-03-05
Applicant: General Electric Company
Inventor: Anup Sood , Kevin Bernard Kenny , Arunkumar Natarajan , Lakshmi Sireesha Kaanumalle , Elizabeth Mary McDonough
CPC classification number: G01N1/30 , G01N33/5005 , G01N33/582
Abstract: Methods comprising probing multiple targets in an H&E stained biological sample are provided. The methods include the steps of providing a hematoxylin and eosin stained biological sample containing multiple targets, optionally detecting H&E staining of the sample, removing the hematoxylin and eosin signals, and detecting additional features or targets in the biological sample. The detecting step may include performing the steps of binding at least one probe to one or more targets to the sample, detecting a signal from the probe and contacting the sample with a bleaching agent. The process of binding, detecting and bleaching may be iteratively repeated.
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33.
公开(公告)号:US20160238592A1
公开(公告)日:2016-08-18
申请号:US14621715
申请日:2015-02-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor: Arunkumar Natarajan , Anup Sood , Lakshmi Sireesha Kaanumalle , Christina Lowes
IPC: G01N33/536 , G01N1/30 , G01N33/58
CPC classification number: G01N33/536 , G01N1/30 , G01N21/6428 , G01N33/582 , G01N2001/302
Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with a cationic or zwitterionic borate compound and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.
Abstract translation: 提供了包括使用光活化化学漂白来检测生物样品中的多个靶的方法。 所述方法包括以下步骤:提供含有多个靶标的生物样品,将至少一个探针结合到样品中存在的一个或多个靶,并观察来自探针的信号。 该方法还包括使包含结合的探针的样品与阳离子或两性离子的硼酸盐化合物接触并照射样品的步骤,从而引发通过光活化的化学漂白基本上灭活探针的光反应。 该方法还包括将至少一个探针结合到样品中存在的一个或多个靶,并观察来自探针的信号的步骤。 结合,观察和漂白的过程可以迭代地重复。
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公开(公告)号:US12103227B2
公开(公告)日:2024-10-01
申请号:US17743674
申请日:2022-05-13
Applicant: General Electric Company
Inventor: Daniel Jason Erno , Arunkumar Natarajan , Ken Ivcar Salas Nobrega , Ananda Barua
IPC: B22F10/68 , B22F3/24 , B22F10/14 , B22F10/28 , B22F10/40 , B28B1/00 , B28B11/22 , B29C64/153 , B29C64/35 , B29C64/393 , B33Y10/00 , B33Y40/00 , B33Y40/20 , B33Y50/02 , B33Y80/00
CPC classification number: B29C64/153 , B22F3/24 , B22F10/14 , B22F10/28 , B22F10/40 , B22F10/68 , B28B1/001 , B28B11/22 , B29C64/35 , B29C64/393 , B33Y10/00 , B33Y40/00 , B33Y40/20 , B33Y50/02 , B33Y80/00 , B22F2003/247 , B22F2202/01 , Y10T428/12014 , Y10T428/12063 , Y10T428/12076 , B22F2999/00 , B22F10/28 , B22F5/10 , B22F5/003 , B22F2998/10 , B22F5/10 , B22F10/68 , B22F2999/00 , B22F3/24 , B22F10/68 , B22F2202/01
Abstract: An article of manufacture includes a part structure formed via a first additive manufacturing process and a floating structure within the part structure which is mechanically decoupled from the part structure. The floating structure is formed concurrently with the part structure via the first additive manufacturing process.
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公开(公告)号:US11919233B2
公开(公告)日:2024-03-05
申请号:US17889852
申请日:2022-08-17
Applicant: General Electric Company
Inventor: Mary Kathryn Thompson , Arunkumar Natarajan , Kwok Pong Chan , Vadim Bromberg , Xi Yang , Ananda Barua , William C. Alberts
IPC: B29C64/165 , B29C64/209 , B29C64/336 , B29K105/00 , B33Y10/00
CPC classification number: B29C64/165 , B29C64/209 , B29C64/336 , B33Y10/00 , B29K2105/0002 , B29K2105/0073 , B29K2995/0082
Abstract: Various embodiments provide a method of additively manufacturing a part including depositing a layer of a powder on a working surface, depositing a binder solution on the layer of the powder at first locations, and depositing a sintering aid solution on the layer of the powder at second locations. The sintering aid solution comprises a sintering aid in a solvent. In various embodiments, the sintering aid enables an increased brown strength as compared to parts containing unbound powder. The method enables binders that provide high green strength to be used at the edges of the part, while also balancing a shortened debind time with an increased brown strength. Embodiments in which binder solution is deposited according to a predetermined pattern at second locations are also described.
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公开(公告)号:US20230250272A1
公开(公告)日:2023-08-10
申请号:US18130089
申请日:2023-04-03
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , William C. Alberts , Vadim Bromberg
CPC classification number: C08L39/06 , B22F10/14 , B29C64/165 , B33Y10/00 , B33Y70/00 , B33Y80/00 , B29K2029/04
Abstract: In various embodiments, a water-based binder solution for use in additive manufacturing, includes a thermoplastic binder. The thermoplastic binder includes a first polymer strand having a weight average molecular weight (Mw) of from greater than or equal to 5,000 g/mol to less than or equal to 15,000 g/mol, a second polymer strand having a weight average molecular weight of from greater than or equal to 10,000 g/mol to less than or equal to 50,000 g/mol, and a third polymer strand having a weight average molecular weight of from greater than or equal to 1,000 g/mol to less than or equal to 5,000 g/mol. The binder solution further comprises from greater than or equal to 0.1 wt% to less than or equal to 5 wt% of a non-aqueous solvent having a boiling point of greater than 100° C.
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公开(公告)号:US11667078B2
公开(公告)日:2023-06-06
申请号:US17326710
申请日:2021-05-21
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , Kwok Pong Chan , William C. Alberts , Vadim Bromberg
IPC: B29C64/165 , B33Y10/00 , B33Y80/00 , B33Y70/10 , B29C64/264 , B29C64/40
CPC classification number: B29C64/165 , B29C64/264 , B29C64/40 , B33Y10/00 , B33Y70/10 , B33Y80/00
Abstract: A method of manufacturing comprises depositing a layer of a powder on a working surface and selectively depositing a water-based binder solution comprising from 0.1 wt % to 5 wt % of a non-aqueous solvent having a boiling point of greater than 100° C. and less than or equal to 175° C. at 1 atm and a thermoplastic binder comprises a first polymer strand including a first functional group and a second polymer strand including a second functional group into the layer of powder in a pattern representative of a structure of a part. The method further comprises non-covalently coupling the first and second polymer strands together via interaction between the first and second functional groups to form a green body part.
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公开(公告)号:US11643542B2
公开(公告)日:2023-05-09
申请号:US17326698
申请日:2021-05-21
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , William C. Alberts , Vadim Bromberg
CPC classification number: C08L39/06 , B22F10/14 , B29C64/165 , B33Y10/00 , B33Y70/00 , B33Y80/00 , B29K2029/04 , B29K2039/06 , C08L2205/03
Abstract: In various embodiments, a water-based binder solution for use in additive manufacturing, includes a thermoplastic binder. The thermoplastic binder includes a first polymer strand having a weight average molecular weight (Mw) of from greater than or equal to 5,000 g/mol to less than or equal to 15,000 g/mol, a second polymer strand having a weight average molecular weight of from greater than or equal to 10,000 g/mol to less than or equal to 50,000 g/mol, and a third polymer strand having a weight average molecular weight of from greater than or equal to 1,000 g/mol to less than or equal to 5,000 g/mol. The binder solution further comprises from greater than or equal to 0.1 wt % to less than or equal to 5 wt % of a non-aqueous solvent having a boiling point of greater than 100° C.
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39.
公开(公告)号:US20220145102A1
公开(公告)日:2022-05-12
申请号:US17500420
申请日:2021-10-13
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , Sivaruban Shivanathan , Samantha Jo Rowe , Carlos H. Bonilla
IPC: C09D7/61 , C09D135/04 , C09D139/06 , C09D7/40 , B33Y40/20 , B22F10/60
Abstract: A dip-coat binder solution comprises a metal dip-coat powder and a dip-coat binder. The dip-coat binder solution has a viscosity greater than or equal to 1 cP and less than or equal to 40 cP. The metal dip-coat powder may comprise a stainless steel alloy, a nickel alloy, a copper alloy, a copper-nickel alloy, a cobalt-chrome alloy, a titanium alloy, an aluminum alloy, a tungsten alloy, or a combination thereof. A method of forming a part includes providing a green body part comprising a plurality of layers of print powder, dipping the green body part in a dip-coat binder solution to form a dip-coated green body part, and heating the dip-coated green body part. After dipping, the dip-coated green body part has a surface roughness Ra less than or equal to 10 μm.
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公开(公告)号:US20210371619A1
公开(公告)日:2021-12-02
申请号:US17326692
申请日:2021-05-21
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , Kwok Pong Chan , William C. Alberts , Vadim Bromberg
Abstract: A binder solution comprises greater than or equal to 0.5 wt % and less than or equal to 20 wt % of nanoparticles, a thermoplastic binder, and a solvent. The nanoparticles may comprise metallic nanoparticles comprising nickel, silver, chromium, aluminum, cobalt, iron, or combinations thereof. The nanoparticles may comprise ceramic nanoparticles, the comprising alumina, aluminum nitride, zirconia, titania, silica, silicon nitride, silicon carbide, boron nitride, or combinations thereof. A method of manufacturing a part includes depositing a layer of particulate material on a working surface, applying a binder solution into the layer of particulate material in a pattern, repeating the steps of depositing and selectively applying to form a plurality of layers of particulate material with the applied binder solution, and curing the applied binder solution in the plurality of layers of particulate material with the applied binder solution to evaporate the solvent and thereby form a green body part.
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