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    SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER
    34.
    发明申请
    SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER 审中-公开

    公开(公告)号：US20190070796A1

    公开(公告)日：2019-03-07

    申请号：US16179800

    申请日：2018-11-02

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J.A. Chen ,  Randy Davis

    IPC: B29C67/20 ,  G01N33/487 ,  C12Q1/6869 ,  B82Y5/00 ,  B82Y40/00 ,  B82Y10/00

    Abstract: Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

    SENSOR CIRCUIT FOR CONTROLLING, DETECTING, AND MEASURING A MOLECULAR COMPLEX
    35.
    发明申请
    SENSOR CIRCUIT FOR CONTROLLING, DETECTING, AND MEASURING A MOLECULAR COMPLEX 审中-公开

    公开(公告)号：US20190064107A1

    公开(公告)日：2019-02-28

    申请号：US16172488

    申请日：2018-10-26

    Applicant: Genia Technologies, Inc.

    Inventor： Kevin Deierling ,  Roger J.A. Chen ,  David J. Fullagar

    IPC: G01N27/447 ,  G01N33/487 ,  C12Q1/6874 ,  C12Q1/6869

    Abstract: A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.

    TEMPERATURE REGULATION OF MEASUREMENT ARRAYS
    38.
    发明申请
    TEMPERATURE REGULATION OF MEASUREMENT ARRAYS 有权
    测量阵列的温度调节

    公开(公告)号：US20170043314A1

    公开(公告)日：2017-02-16

    申请号：US15183560

    申请日：2016-06-15

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J.A. Chen

    IPC: B01J19/00 ,  G05D23/20

    CPC classification number: B01J19/0046 ,  B01J2219/00495 ,  B01J2219/00698 ,  G05D23/1919 ,  G05D23/2034 ,  G05D23/2037

    Abstract: A system for regulating a temperature of a measurement array is disclosed. The system includes a measurement array including a plurality of sensors, wherein the plurality of sensors are integrated onto an integrated circuit die. The system includes a thermal sensor integrated onto the integrated circuit die, wherein the thermal sensor senses a temperature associated with the plurality of sensors. The system further includes a heat pump coupled to the integrated circuit die, wherein the heat pump is controlled by a feedback control circuit including the thermal sensor.

    Abstract translation: 公开了一种用于调节测量阵列的温度的系统。 该系统包括包括多个传感器的测量阵列，其中多个传感器集成在集成电路管芯上。 该系统包括集成在集成电路管芯上的热传感器，其中热传感器感测与多个传感器相关联的温度。 该系统还包括耦合到集成电路管芯的热泵，其中热泵由包括热传感器的反馈控制电路控制。

    ADJUSTABLE BILAYER CAPACITANCE STRUCTURE FOR BIOMEDICAL DEVICES
    40.
    发明申请
    ADJUSTABLE BILAYER CAPACITANCE STRUCTURE FOR BIOMEDICAL DEVICES 审中-公开
    用于生物医学设备的可调节双层电容结构

    公开(公告)号：US20160216233A1

    公开(公告)日：2016-07-28

    申请号：US14606632

    申请日：2015-01-27

    Applicant: Genia Technologies, Inc.

    Inventor： Jennifer Hovis ,  Hui Tian ,  Roger J.A. Chen

    IPC: G01N27/447 ,  G01N33/487

    CPC classification number: G01N33/48721

    Abstract: A nanopore sequencing device is disclosed. The nanopore sequencing device includes a working electrode. It further includes a dielectric layer, wherein a portion of the dielectric layer is disposed horizontally adjacent to the working electrode and a portion of the dielectric layer is disposed above and covering a portion of the working electrode, and wherein the dielectric layer forms a well having an opening above an uncovered portion of the working electrode. A base surface area of the working electrode is greater than a base surface area of the opening above the uncovered portion of the working electrode.

    Abstract translation: 公开了一种纳米孔测序装置。 纳米孔测序装置包括工作电极。 还包括电介质层，其中电介质层的一部分水平地邻近工作电极设置，并且介电层的一部分设置在工作电极的一部分上方并覆盖其中，并且其中介电层形成具有 在工作电极的未覆盖部分上方的开口。 工作电极的基面面积大于工作电极的未覆盖部分上方开口的基面面积。

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