公开(公告)号：US20180370950A1

公开(公告)日：2018-12-27

申请号：US16016718

申请日：2018-06-25

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Steven J. Henry ,  John O. Link ,  Charles William Rowe ,  Roland D. Saito ,  Scott D. Schroeder ,  Dimitrios Stefanidis ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61K45/06 ,  A61K31/537 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/4439 ,  C07C317/08 ,  C07D231/54 ,  C07F5/02

Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US10071985B2

公开(公告)日：2018-09-11

申请号：US15680041

申请日：2017-08-17

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Steven J. Henry ,  John O. Link ,  Charles William Rowe ,  Roland D. Saito ,  Scott D. Schroeder ,  Dimitrios Stefanidis ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61K31/4439 ,  A61K31/537 ,  A61K31/675 ,  A61K31/7076 ,  A61K45/06 ,  C07C317/08 ,  C07D231/54 ,  C07F5/02

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/537 ,  A61K31/675 ,  A61K31/7076 ,  A61K45/06 ,  C07C317/08 ,  C07D231/54 ,  C07F5/025

Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US09617310B2

公开(公告)日：2017-04-11

申请号：US14214477

申请日：2014-03-14

Applicant: Gilead Sciences, Inc.

Inventor： Kyla L. Bjornson ,  Kapil K. Karki ,  John O. Link ,  Hyung-jung Pyun ,  Adam J. Schrier ,  Kirk L. Stevens ,  James G. Taylor ,  Randall W. Vivian ,  Jeff Zablocki ,  Sheila Zipfel

IPC: C07D498/22 ,  A61K31/437 ,  A61K31/519 ,  A61K31/4985 ,  A61P31/14 ,  C07K7/64 ,  C07D487/00 ,  C07D487/02 ,  C07D203/02

CPC classification number: C07K7/64 ,  A61K31/437 ,  A61K31/519 ,  C07D203/02 ,  C07D487/00 ,  C07D487/02 ,  C07D498/22

Abstract: Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.

公开(公告)号：US20170008873A1

公开(公告)日：2017-01-12

申请号：US15199779

申请日：2016-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D409/14 ,  C07F7/08 ,  C07D453/02 ,  C07D401/14 ,  C07D405/14

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07F7/0814

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract translation: 本公开一般涉及Cot（癌症大阪甲状腺）的调节剂及其使用和制造方法。

公开(公告)号：US20160108030A1

公开(公告)日：2016-04-21

申请号：US14771779

申请日：2014-02-28

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chien-Hung Chou ,  Michael Graupe ,  Yunfeng Eric Hu ,  Scott E. Lazerwith ,  John O. Link ,  Qi Liu ,  Yafan Lu ,  Roland D. Saito ,  Scott D. Schroeder ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  A61K45/06 ,  C07D401/14 ,  A61K31/517 ,  A61K31/4439 ,  C07D417/14 ,  A61K31/506 ,  A61K31/4709 ,  C07D413/14 ,  A61K31/496 ,  A61K31/5377 ,  C07D491/052 ,  A61K31/444 ,  C07D401/12

CPC classification number: C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract translation: 公开了式（I）化合物或其盐。 还公开了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于治疗包括HIV病毒引起的感染的逆转录病毒科病毒感染的治疗方法。

公开(公告)号：US09296782B2

公开(公告)日：2016-03-29

申请号：US13934090

申请日：2013-07-02

Applicant: Gilead Sciences, Inc.

Inventor： Kyla Bjornson ,  Eda Canales ,  Jeromy J. Cottell ,  Kapil Kumar Karki ,  Ashley Anne Katana ,  Darryl Kato ,  Tetsuya Kobayashi ,  John O. Link ,  Ruben Martinez ,  Barton W. Phillips ,  Hyung-Jung Pyun ,  Michael Sangi ,  Adam James Schrier ,  Dustin Siegel ,  James G. Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Randall W. Vivian ,  Zheng-Yu Yang ,  Jeff Zablocki ,  Sheila Zipfel

IPC: A61K6/00 ,  C07K1/00 ,  C07K5/08 ,  C07D498/16 ,  A61K31/4985 ,  C07D498/22 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06 ,  C07K5/087 ,  C07K5/083 ,  A61K38/21 ,  A61K38/06 ,  A61K38/00

CPC classification number: A61K31/498 ,  A61K31/10 ,  A61K31/401 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K38/00 ,  A61K38/06 ,  A61K38/21 ,  A61K45/06 ,  C07D241/36 ,  C07D403/14 ,  C07D498/16 ,  C07D498/22 ,  C07K5/08 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0827 ,  A61K2300/00

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract translation: 公开的式I化合物及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。

公开(公告)号：US08809266B2

公开(公告)日：2014-08-19

申请号：US13794389

申请日：2013-03-11

Applicant: Gilead Sciences, Inc.

Inventor： Aesop Cho ,  Michael O'Neil Hanrahan Clarke ,  Choung U. Kim ,  John O. Link ,  Hyung-jung Pyun ,  Xiaoning C. Sheng ,  Qiaoyin Wu

IPC: A61K38/00

CPC classification number: C07D417/14 ,  C07D207/16 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D487/04 ,  C07K5/0804 ,  C07K5/0808 ,  C07K5/0819 ,  C07K5/0821

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130274439A1

公开(公告)日：2013-10-17

申请号：US13794389

申请日：2013-03-11

Applicant: Gilead Sciences, Inc.

Inventor： Aesop Cho ,  Michael O'Neil Hanrahan Clarke ,  Choung U. Kim ,  John O. Link ,  Hyung-jung Pyun ,  Xiaoning C. Sheng ,  Qiaoyin Wu

IPC: C07K5/097 ,  C07K5/093

CPC classification number: C07D417/14 ,  C07D207/16 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D487/04 ,  C07K5/0804 ,  C07K5/0808 ,  C07K5/0819 ,  C07K5/0821

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US12084455B2

公开(公告)日：2024-09-10

申请号：US17224557

申请日：2021-04-07

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Elbert Chin ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang

IPC: C07D405/14 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  A61K45/06 ,  A61P31/18 ,  C07C243/28 ,  C07C275/16 ,  C07D401/12 ,  C07D403/12 ,  C07D471/08 ,  C07D487/08 ,  C07D487/10 ,  C07D491/04

CPC classification number: C07D487/08 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  A61K45/06 ,  A61P31/18 ,  C07C243/28 ,  C07C275/16 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D471/08 ,  C07D487/10 ,  C07D491/04

Abstract: The invention provides a compound of Formula I:






or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US12037340B2

公开(公告)日：2024-07-16

申请号：US17748853

申请日：2022-05-19

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  John O. Link ,  James G. Taylor ,  Zheng-Yu Yang

IPC: C07D491/052 ,  A61P31/14

CPC classification number: C07D491/052 ,  A61P31/14

Abstract: Provided herein are compounds of Formula (I):

the formula(I):






wherein the various substituents are defined herein.