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    Cytological analysis by raman spectroscopic imaging
    32.
    发明申请
    Cytological analysis by raman spectroscopic imaging 有权
    通过拉曼光谱成像进行细胞学分析

    公开(公告)号：US20050277816A1

    公开(公告)日：2005-12-15

    申请号：US11000591

    申请日：2004-11-30

    申请人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    发明人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/4519 ,  G01N21/65

    摘要： Raman molecular imaging is used to differentiate between normal and diseased cells or tissue. For instance benign and malignant lesions of bladder and other tissues can be distinguished, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the disease state of cells or tissue can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view.

    摘要翻译： 拉曼分子成像用于区分正常和病变细胞或组织。 例如，可以区分膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾脏，乳腺和结肠，以及非上皮组织，如骨髓和脑。 可以将与细胞或组织的疾病状态相关的拉曼散射数据与视觉图像数据组合，以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。

    Nozzle
    33.
    发明申请
    Nozzle 有权
    喷嘴

    公开(公告)号：US20050252218A1

    公开(公告)日：2005-11-17

    申请号：US10843908

    申请日：2004-05-11

    申请人： Alexander Chen ,  Jeffrey Cohen

    发明人： Alexander Chen ,  Jeffrey Cohen

    IPC分类号： F23C5/32 ,  F23R3/12 ,  F23R3/28 ,  F23R3/32 ,  F23R3/34

    CPC分类号： F23R3/286 ,  F23C5/32 ,  F23R3/34

    摘要： A fuel injector has a number of groups of nozzles. The groups are generally concentric with an injector axis. Each nozzle defines a gas flowpath having an outlet for discharging a fuel/air mixture jet. There are means for introducing the fuel to the air. One or more groups of the nozzles are oriented to direct the associated jets skew to the injector axis.

    摘要翻译： 燃料喷射器具有多组喷嘴。 这些组通常与喷射器轴线同心。 每个喷嘴限定了具有用于排出燃料/空气混合物射流的出口的气体流路。 有将燃料引入空气的方法。 一组或多组喷嘴被定向以将相关联的射流引导到喷射器轴线。

    Continuous, solvent-free process for making copolymers of maleic anhydride and C1−4 alkyl vinyl ether
    34.
    发明授权
    Continuous, solvent-free process for making copolymers of maleic anhydride and C1−4 alkyl vinyl ether 有权
    连续，无溶剂的马来酸酐和C 1-4烷基乙烯基醚共聚物的方法

    公开(公告)号：US06451944B2

    公开(公告)日：2002-09-17

    申请号：US09861044

    申请日：2001-05-18

    申请人： Russell Biss ,  Jeffrey Cohen ,  John Zamora ,  Krystyna Plochocka ,  Jeffrey A. Lynn

    发明人： Russell Biss ,  Jeffrey Cohen ,  John Zamora ,  Krystyna Plochocka ,  Jeffrey A. Lynn

    IPC分类号： C08F3402

    CPC分类号： C08F222/06 ,  C08F2/02 ,  C08F216/18 ,  Y02P20/582

    摘要： A continuous, solvent-free process for obtaining solvent-free, fine white powders of high molecular weight alternating copolymers of maleic anhydride and a C1-C4 alkyl vinyl ether, without odor or taste, having the molecular structure (A—B)n, where A is maleic anhydride, B is an alkyl vinyl ether and n is an integer indicative of the molecular weight of the copolymer, which comprises feeding alkyl vinyl ether as reactant and solvent in excess over the desired 1:1 mole ratio of A:B in the copolymer, molten maleic anhydride and a free radical initiator, continuously at predetermined feeding rates into a reactor heated at a reaction temperature of about 50° to 100° C., charging the reactor and withdrawing reaction product, residual alkyl vinyl ether and initiator from the reactor at the same rate as the feed rate of reactants into the reactor simultaneously thereby maintaining a constant volume in the reactor, stripping residual alkyl vinyl ether from the reaction product, drying the copolymer obtained of any remaining traces of alkyl vinyl ether, and recycling recovered alkyl vinyl ether back into reactor as reactant and solvent.

    摘要翻译： 一种连续，无溶剂的方法，用于获得具有分子结构（AB）n的不含气味或味道的马来酸酐和C1-C4烷基乙烯基醚的高分子量交替共聚物的无溶剂的细白色粉末，其中A 是马来酸酐，B是烷基乙烯基醚，n是表示共聚物的分子量的整数，其包括将烷基乙烯基醚作为反应物和过量的丙烯进料到所需的1:1摩尔比的A:B中 共聚物，熔融马来酸酐和自由基引发剂，以预定的进料速率连续加入到在约50℃至100℃的反应温度下加热的反应器中，将反应器和残留的烷基乙烯基醚和引发剂从 反应器以与反应物进入反应器的进料速率相同的速率同时由此在反应器中保持恒定体积，从反应产物中汽提残余的烷基乙烯基醚，干燥该共聚物 获得任何剩余痕量的烷基乙烯基醚的聚合物，并将回收的烷基乙烯基醚回收到反应器中作为反应物和溶剂。

    High-level data link control packet assembler/disassembler
    36.
    发明授权
    High-level data link control packet assembler/disassembler 失效
    高级数据链路控制包汇编/反汇编

    公开(公告)号：US4951278A

    公开(公告)日：1990-08-21

    申请号：US238581

    申请日：1988-08-31

    申请人： Jeffrey Biber ,  Jeffrey Cohen ,  John Holmbald ,  Zon-Hong Hsieh ,  Douglas Kay ,  Roy Spitzer

    发明人： Jeffrey Biber ,  Jeffrey Cohen ,  John Holmbald ,  Zon-Hong Hsieh ,  Douglas Kay ,  Roy Spitzer

    IPC分类号： H04L29/06

    CPC分类号： H04L29/06

    摘要： A data communications system has a layered communication architecture including network services protocols including a link layer and higher level protocols, and has IBM or IBM-compatible synchronous data link control (SDLC) devices including a host computer and a plurality of end user devices desiring to communicate across an X.25 packet-switching network (PSN) of the communications system. A packet assembler/disassembler (PAD) support X.25 communication across the PSN between the SDLC-utilizing host computer and the SDLC-utilizing end user device. In one embodiment, separate high level data link control (HDLC) PADs are provided at each end of the PSN operationally associated with the host computer and the plurality of end user devices, respectively. The PADS generate and respond to at least three formats of SDLC commands and responses, and, in association with their respective SDLC devices, perform at least four functions including a call setup phase, a data transfer phase, a call clearing phase, and handling of abnormal conditions. PAD means comprises qualified logical link control (QLLC) PAD means located at an end of said packet switching network for either operational association with said host computer or operational association with said plurality of end user devices. In another embodiment, a single qualified logical link control (QLLC) PAD performs functions similar to those of the HDLC PAD embodiment, except that rather than having a PAD at both ends (host end and terminal end) of a connection, a PAD is provided at only one end of the connection.

    摘要翻译： 数据通信系统具有包括包括链路层和更高级别协议的网络服务协议的分层通信体系结构，并且具有IBM或IBM兼容的同步数据链路控制（SDLC）设备，包括主计算机和多个最终用户设备 通信通信系统的X.25分组交换网络（PSN）。 分组汇编器/分解器（PAD）支持在SDLC利用主机与使用SDLC的最终用户设备之间的PSN上的X.25通信。 在一个实施例中，分别在与主计算机和多个终端用户设备相关联的PSN的每一端分别提供单独的高级数据链路控制（HDLC）PAD。 PADS产生并响应至少三种格式的SDLC命令和响应，并且与其各自的SDLC设备相关联地执行至少四个功能，包括呼叫建立阶段，数据传送阶段，呼叫清除阶段以及处理 异常情况。 PAD装置包括位于所述分组交换网络的末端的合格逻辑链路控制（QLLC）PAD装置，用于与所述主机计算机的操作关联或与所述多个终端用户设备的操作关联。 在另一个实施例中，单个限定逻辑链路控制（QLLC）PAD执行与HDLC PAD实施例类似的功能，除了不是在连接的两端（主机端和终端）处具有PAD，而是提供PAD 在连接的一端。

    System and Method for Diagnosing a Biological Sample
    37.
    发明申请
    System and Method for Diagnosing a Biological Sample 审中-公开
    用于诊断生物样品的系统和方法

    公开(公告)号：US20120310538A1

    公开(公告)日：2012-12-06

    申请号：US13450579

    申请日：2012-04-19

    申请人： Shona Stewart ,  Arny Drauch ,  Jeffrey Cohen ,  John Maier

    发明人： Shona Stewart ,  Arny Drauch ,  Jeffrey Cohen ,  John Maier

    IPC分类号： G01J3/46 ,  G06F19/00 ,  G01J5/02

    CPC分类号： G06K9/00127

    摘要： The present disclosure provides for a system and method for analyzing biological samples to thereby provide a diagnosis. A system may comprise an illumination source, a filter and a detector configured to generate at least one of: a visible data set representative of a biological sample, a SWIR data set representative of a biological sample, and combinations thereof. A method may comprise illuminating a biological sample to generate a plurality of photons, filtering a said plurality of interacted photons, detecting

    摘要翻译： 本公开提供了用于分析生物样品从而提供诊断的系统和方法。 系统可以包括照明源，滤光器和检测器，其被配置为产生代表生物样品的可见数据集，表示生物样品的SWIR数据集及其组合中的至少一个。 一种方法可以包括照射生物样品以产生多个光子，过滤所述多个相互作用的光子，检测

    RADIO FREQUENCY ABLATION DEVICE FOR THE DESTRUCTION OF TISSUE MASSES
    38.
    发明申请
    RADIO FREQUENCY ABLATION DEVICE FOR THE DESTRUCTION OF TISSUE MASSES 有权
    用于破坏组织质量的无线电频率消除装置

    公开(公告)号：US20120165813A1

    公开(公告)日：2012-06-28

    申请号：US13323722

    申请日：2011-12-12

    申请人： Bruce Lee ,  Gordon E. Epstein ,  Adam Hagmann ,  Jeffrey Cohen

    发明人： Bruce Lee ,  Gordon E. Epstein ,  Adam Hagmann ,  Jeffrey Cohen

    IPC分类号： A61B18/14

    CPC分类号： A61B18/1477 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475

    摘要： The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen within the cannula and a cannula axis. A plurality of conductors contained within the lumen, each of the conductors has a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled at the respective proximal end of the stylet to the distal end of a respective conductor, the stylets comprise a deflectable material, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula.

    摘要翻译： 本发明的消融元件包括具有近端和远端的细长插管。 套管限定插管内的内腔和插管轴线。 包含在内腔内的多个导体，每个导体具有靠近插管的近端的近端，以及靠近套管远端的远端。 多个消融模具各自具有近端和远端，并且每个消融模具各自在相应的导管的相应近端处连接到相应导体的远端，所述模式包括可偏转材料，所述导体与它们各自的形式 安装用于轴向移动。 定位在套管远端附近的套针针点。

    Cytological Analysis by Raman Spectroscopic Imaging
    40.
    发明申请
    Cytological Analysis by Raman Spectroscopic Imaging 有权
    通过拉曼光谱成像进行细胞学分析

    公开(公告)号：US20100262378A1

    公开(公告)日：2010-10-14

    申请号：US12755463

    申请日：2010-06-23

    申请人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    发明人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    IPC分类号： G06F19/00 ,  G01J3/44 ,  G06K9/62

    CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/4519 ,  G01N21/65

    摘要： A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample.

    摘要翻译： 一种产生样品图像的方法，其用于提供样品中细胞的疾病状态。 用单色光照射包含电池的样品。 评估拉曼散射光。 产生拉曼散射光的数字明场图像，并与细胞发射的拉曼散射光组合，由此拉曼散射光提供样品中细胞的疾病状态。 该方法还可以用于确定细胞的代谢活性，细胞的炎性状态和/或样品中细胞的感染状态。