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57 条记录 (耗时 0.045 秒)

    Process for fabricating thin film transistors
    31.
    发明申请
    Process for fabricating thin film transistors 有权
    制造薄膜晶体管的工艺

    公开(公告)号：US20050067656A1

    公开(公告)日：2005-03-31

    申请号：US10919657

    申请日：2004-08-17

    申请人： Kevin Denis ,  Yu Chen ,  Paul Drzaic ,  Joseph Jacobson ,  Peter Kazlas

    发明人： Kevin Denis ,  Yu Chen ,  Paul Drzaic ,  Joseph Jacobson ,  Peter Kazlas

    IPC分类号： H01L21/336 ,  H01L29/786 ,  H01L21/00 ,  H01L21/84 ,  H01L27/01 ,  H01L27/12 ,  H01L31/0392

    CPC分类号： H01L29/66765 ,  H01L29/78603

    摘要： Transistors are formed by depositing at least one layer of semiconductor material on a substrate comprising a polyphenylene polyimide. The substrate permits the use of processing temperatures in excess of 300° C. during the processes used to form the transistors, thus allowing the formation of high quality silicon semiconductor layers. The substrate also has a low coefficient of thermal expansion, which closely matches that of silicon, thus reducing any tendency for a silicon layer to crack or delaminate.

    摘要翻译： 晶体管通过在包含聚亚苯基聚酰亚胺的衬底上沉积至少一层半导体材料形成。 在用于形成晶体管的工艺期间，衬底允许使用超过300℃的处理温度，从而允许形成高质量的硅半导体层。 该基板也具有低的热膨胀系数，其与硅的热膨胀系数非常接近，从而减少硅层破裂或分层的任何趋势。

    Methods and apparatus for ultrathin catalyst layer for photoelectrode
    33.
    发明授权
    Methods and apparatus for ultrathin catalyst layer for photoelectrode 有权

    公开(公告)号：US09920438B2

    公开(公告)日：2018-03-20

    申请号：US13544940

    申请日：2012-07-09

    申请人： Kimin Jun ,  Joseph Jacobson

    发明人： Kimin Jun ,  Joseph Jacobson

    IPC分类号： C25B1/00 ,  C25B11/02 ,  C25B11/06 ,  C25B11/04 ,  H01G9/20

    CPC分类号： C25B1/003 ,  C25B11/02 ,  C25B11/0452 ,  H01G9/2031 ,  H01G9/2036 ,  Y02E10/542 ,  Y02P20/135

    摘要： In exemplary implementations of this invention, a photoelectrode includes a semiconductor for photocarrier generation, and a catalyst layer for altering the reaction rate in an adjacent electrolyte. The catalyst layer covers part of the semiconductor. The thickness of the catalyst layer is less than 60% of its minority carrier diffusion distance. If the photoelectrode is a photoanode, it has an OEP that is more than the potential of the valance band edge but less than the potential of the Fermi level of the semiconductor. If it is a photocathode, it has an RHE potential that is less than the potential of the conduction band edge but more than the potential of the Fermi level of the semiconductor. The absolute value of difference (OEP minus potential of valence band edge, or RHE potential minus potential of conduction band edge) is greater than zero and less than or equal to 0.2V.

    Assembly of high fidelity polynucleotides
    35.
    发明授权
    Assembly of high fidelity polynucleotides 有权
    装配高保真多核苷酸

    公开(公告)号：US09217144B2

    公开(公告)日：2015-12-22

    申请号：US13520383

    申请日：2011-01-06

    申请人： Joseph Jacobson ,  Larry Li-Yang Chu

    发明人： Joseph Jacobson ,  Larry Li-Yang Chu

    IPC分类号： C12Q1/68 ,  C12N15/10

    CPC分类号： B01J19/0046 ,  B01J2219/00608 ,  B01J2219/00722 ,  C12N15/1031 ,  C12Q1/6811 ,  C12Q1/6837 ,  C12Q2565/525 ,  C12Q2525/301

    摘要： Methods and apparatus relate to the synthesis of high fidelity polynucleotides and to the reduction of sequence errors generated during synthesis of nucleic acids on a solid support. Specifically, design of support-bound template oligonucleotides is disclosed. Assembly methods include cycles of annealing, stringent wash and extension of polynucleotides comprising a sequence region complementary to immobilized template oligonucleotides. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.

    摘要翻译： 方法和装置涉及高保真多核苷酸的合成和降低在固体支持物上核酸合成过程中产生的序列错误。 具体地，公开了载体结合的模板寡核苷酸的设计。 组装方法包括退火循环，严格洗涤和延伸包含与固定化模板寡核苷酸互补的序列区的多核苷酸。 由此产生的无错误的合成核酸可用于各种应用，包括合成生物燃料和增值药物产品。

    Compositions and Methods for High Fidelity Assembly of Nucleic Acids
    37.
    发明申请
    Compositions and Methods for High Fidelity Assembly of Nucleic Acids 审中-公开
    核酸高保真组装的组成和方法

    公开(公告)号：US20150203839A1

    公开(公告)日：2015-07-23

    申请号：US14241242

    申请日：2012-08-23

    申请人： Joseph Jacobson ,  Daniel Schindler ,  Scott S. Lawton

    发明人： Joseph Jacobson ,  Daniel Schindler ,  Scott S. Lawton

    IPC分类号： C12N15/10

    CPC分类号： C12N15/1031 ,  C12N15/10 ,  C12N15/1027 ,  C12N15/1089 ,  C12N15/1093 ,  C12N15/66 ,  C12P19/34 ,  C12Q2521/301 ,  C12Q2521/501

    摘要： Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end double-stranded nucleic acid fragments having a restriction enzyme recognition sequence at both ends thereof; (2) producing via enzymatic digestion a plurality of cohesive-end double-stranded nucleic acid fragments each having two different and non-complementary overhangs; (3) ligating the plurality of cohesive-end double-stranded nucleic acid fragments with a ligase; and (4) forming a linear arrangement of the plurality of cohesive-end double-stranded nucleic acid fragments, wherein the unique arrangement comprises the target nucleic acid. In certain embodiments, the plurality of blunt-end double-stranded nucleic acid fragments can be provided by: releasing a plurality of oligonucleotides synthesized on a solid support; and synthesizing complementary strands of the plurality of oligonucleotides using a polymerase based reaction.

    摘要翻译： 本发明的方面涉及用于设计和产生靶核酸的方法，组合物和算法。 该方法可以包括：（1）提供多个在其两端具有限制酶识别序列的平末端双链核酸片段; （2）通过酶消化产生多个具有两个不同和非互补突出端的粘性末端双链核酸片段; （3）用连接酶连接多个内聚端双链核酸片段; 和（4）形成多个内聚端双链核酸片段的线性排列，其中独特的排列包含靶核酸。 在某些实施方案中，多个平末端双链核酸片段可以通过以下方式提供：释放在固体支持物上合成的多种寡核苷酸; 并使用基于聚合酶的反应合成多个寡核苷酸的互补链。

    Methods and Apparatus for Ultrathin Catalyst Layer for Photoelectrode
    39.
    发明申请
    Methods and Apparatus for Ultrathin Catalyst Layer for Photoelectrode 有权
    用于光电极的超薄催化剂层的方法和装置

    公开(公告)号：US20130008495A1

    公开(公告)日：2013-01-10

    申请号：US13544940

    申请日：2012-07-09

    申请人： Kimin Jun ,  Joseph Jacobson

    发明人： Kimin Jun ,  Joseph Jacobson

    IPC分类号： H01L31/0264 ,  H01L31/0376 ,  H01L31/0352 ,  H01L31/02 ,  H01G9/20

    CPC分类号： C25B1/003 ,  C25B11/02 ,  C25B11/0452 ,  H01G9/2031 ,  H01G9/2036 ,  Y02E10/542 ,  Y02P20/135

    摘要： In exemplary implementations of this invention, a photoelectrode includes a semiconductor for photocarrier generation, and a catalyst layer for altering the reaction rate in an adjacent electrolyte. The catalyst layer covers part of the semiconductor. The thickness of the catalyst layer is less than 60% of its minority carrier diffusion distance. If the photoelectrode is a photoanode, it has an OEP that is more than the potential of the valance band edge but less than the potential of the Fermi level of the semiconductor. If it is a photocathode, it has an RHE potential that is less than the potential of the conduction band edge but more than the potential of the Fermi level of the semiconductor. The absolute value of difference (OEP minus potential of valence band edge, or RHE potential minus potential of conduction band edge) is greater than zero and less than or equal to 0.2V.

    摘要翻译： 在本发明的示例性实施方案中，光电极包括用于光载体产生的半导体和用于改变相邻电解质中的反应速率的催化剂层。 催化剂层覆盖半导体的一部分。 催化剂层的厚度小于其少数载流子扩散距离的60％。 如果光电极是光电阳极，则其具有超过有效带边缘的电位但小于半导体的费米能级的电位的OEP。 如果它是一个光电阴极，它的RHE电位小于导带边缘的电位，但大于半导体费米能级的电位。 差值的绝对值（OEP减去价带边缘的电位，或RHE电位减去导带边缘的电位）大于零且小于或等于0.2V。

    Methods and Microfluidic Devices for the Manipulation of Droplets in High Fidelity Polynucleotide Assembly
    40.
    发明申请
    Methods and Microfluidic Devices for the Manipulation of Droplets in High Fidelity Polynucleotide Assembly 审中-公开
    用于在高保真多核苷酸装配中操纵水滴的方法和微流体装置

    公开(公告)号：US20120220497A1

    公开(公告)日：2012-08-30

    申请号：US13505646

    申请日：2010-11-03

    申请人： Joseph Jacobson ,  Larry Li-Yang Chu ,  Senthil Ramu

    发明人： Joseph Jacobson ,  Larry Li-Yang Chu ,  Senthil Ramu

    IPC分类号： C40B50/14 ,  C07H1/00 ,  C40B40/06

    CPC分类号： B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00495 ,  B01J2219/00608 ,  B01J2219/00621 ,  B01J2219/00644 ,  B01J2219/0065 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01L3/0262 ,  B01L3/0268 ,  B01L3/502792 ,  B01L3/5088 ,  B01L7/52 ,  B01L2300/10 ,  B01L2300/1861 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0439 ,  B01L2400/0454 ,  B82Y30/00 ,  C12Q2565/629

    摘要： Methods and devices are provided for manipulating droplets on a support using surface tension properties, moving the droplets along a predetermined path and merging two droplets together enabling a number of chemical reactions. Disclosed are methods for controlling the droplets volumes. Disclosed are methods and devices for synthesizing at least one oligonucleotide having a predefined sequence. Disclosed are methods and devices for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides having a predefined sequence. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products.

    摘要翻译： 提供的方法和装置用于使用表面张力特性来操纵支撑体上的液滴，沿着预定路径移动液滴并将两个液滴合并在一起，从而实现多个化学反应。 公开了用于控制液滴体积的方法。 公开了用于合成具有预定序列的至少一种寡核苷酸的方法和装置。 公开了用于从具有预定序列的多种不同寡核苷酸合成和/或组装至少一种具有预定序列的多核苷酸产物的方法和装置。 在示例性实施方案中，所述方法涉及固定在固体支持物上的不同寡核苷酸的合成和/或扩增，在溶液中释放合成/扩增的寡核苷酸以形成液滴，识别和去除含错误的寡核苷酸，移动或组合两个液滴以允许杂交 和/或两个不同寡核苷酸之间的连接，以及杂交和/或连接之后的进一步的链延伸反应以分级地产生所需长度的多核苷酸产物。