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    Sampling device and sampling method
    33.
    发明授权
    Sampling device and sampling method 失效
    取样装置及采样方法

    公开(公告)号：US08770049B2

    公开(公告)日：2014-07-08

    申请号：US13000728

    申请日：2009-06-22

    申请人： Eduard Gerard Marie Pelssers ,  Jeroen Hans Nieuwenhuis

    发明人： Eduard Gerard Marie Pelssers ,  Jeroen Hans Nieuwenhuis

    IPC分类号： G01N1/02 ,  A61B10/00 ,  B01L3/00 ,  G01N1/10

    CPC分类号： B01L3/502715 ,  A61B10/0045 ,  B01L3/5029 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0481 ,  G01N2001/028

    摘要： A device, system and method for sampling sample material for an analyte including a receiving swab, wherein at least a portion of the receiving swab is compressible; a sensor for sensing the analyte; and a casing, wherein the casing at least partially encloses the receiving swab and the sensor and allows for a transfer of sample material received by the receiving swab to the sensor along a transfer path inside of the casing. The compressible portion of the receiving swab is located inside the casing, wherein by compressing the compressible portion, the transfer path is closable towards the outside of the device.

    摘要翻译： 一种用于对包括接收拭子的分析物的样品材料进行采样的装置，系统和方法，其中所述接收拭子的至少一部分是可压缩的; 用于感测分析物的传感器; 以及壳体，其中所述壳体至少部分地包围所述接收拭子和所述传感器，并允许沿着所述壳体内部的传送路径将由所述接收棉签接收的样品材料传送到所述传感器。 接收拭子的可压缩部分位于壳体内部，其中通过压缩可压缩部分，传送路径可朝向装置的外部封闭。

    SENSOR DEVICE FOR MAGNETICALLY ACTUATED PARTICLES
    34.
    发明申请
    SENSOR DEVICE FOR MAGNETICALLY ACTUATED PARTICLES 有权
    用于磁力驱动颗粒的传感器装置

    公开(公告)号：US20140057366A1

    公开(公告)日：2014-02-27

    申请号：US13988833

    申请日：2011-11-28

    申请人： Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko ,  Toon Hendrik Evers ,  Jeroen Hans Nieuwenhuis ,  Joannes Baptist Adrianus dionisius Van Zon

    发明人： Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko ,  Toon Hendrik Evers ,  Jeroen Hans Nieuwenhuis ,  Joannes Baptist Adrianus dionisius Van Zon

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54373 ,  G01N21/274 ,  G01N21/552 ,  G01N27/72 ,  G01N27/745 ,  G01N27/825 ,  G01N33/54326 ,  G01N35/0098

    摘要： The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR). The evaluation results can be used to validate and/or correct the measurements obtained in the target region (TR).

    摘要翻译： 本发明涉及一种传感器装置（100）和用于在具有接触表面（11））的样品室（2）中检测磁性颗粒（1）的方法。 传感器装置（100）包括用于检测目标区域（TR）中和/或接触表面上的至少一个参考区域中的磁性颗粒（1）的传感器单元（120,130）。 此外，它包括用于产生磁场的磁场发生器（140），该磁场将磁性颗粒引导到接触表面。 在这些组件的帮助下，确定与磁性颗粒（1）和/或它们的运动相关的“辅助参数”，但是与磁性颗粒和接触表面之间的目标区域中发生的结合过程无关。 辅助参数可以例如与在磁场和目标区域（TR）的影响下由磁性颗粒（1）达到的位置之间的失配程度相关。 评估结果可用于验证和/或校正在目标区域（TR）中获得的测量结果。

    MAGNETIC SENSOR DEVICE
    38.
    发明申请
    MAGNETIC SENSOR DEVICE 审中-公开
    磁传感器装置

    公开(公告)号：US20100194386A1

    公开(公告)日：2010-08-05

    申请号：US12669211

    申请日：2008-07-14

    申请人： Menno Willem Jose Prins ,  Wendy Uyen Dittmer ,  Jeroen Hans Nieuwenhuis

    发明人： Menno Willem Jose Prins ,  Wendy Uyen Dittmer ,  Jeroen Hans Nieuwenhuis

    IPC分类号： G01R33/12

    CPC分类号： G01N33/54333 ,  G01N27/745

    摘要： The present invention provides a sensor device (20) and a method for determining the presence and/or amount of target moieties (22) in a sample fluid (27), the target moieties (22) being labeled with magnetic or magnetizable objects (23). The sensor device (20) comprises a magnetic field generating means adapted for applying a retention field for retaining the labeled target moieties (22, 23) to the sensor surface (24) during fluid manipulations. Through this the binding between the labeled target moieties (22, 23) and the sensor surface (24) and/or the magnetic particles (23) and the target moieties (22) is substantially not disturbed during these fluid manipulations. This leads to a reliable and accurate sensor device (20).

    摘要翻译： 本发明提供一种传感器装置（20）和用于确定样品流体（27）中目标部分（22）的存在和/或数量的方法，目标部分（22）用磁性或可磁化物体（23）标记 ）。 传感器装置（20）包括磁场产生装置，其适于在流体操纵期间施加用于将标记的目标部分（22,23）保持到传感器表面（24）的保持场。 通过这一点，标记的目标部分（22,23）和传感器表面（24）和/或磁性颗粒（23）和目标部分（22）之间的结合在这些流体操纵过程中基本上不受干扰。 这导致可靠且准确的传感器装置（20）。

    MEANS FOR THE SEPARATION OF MAGNETIC PARTICLES
    39.
    发明申请
    MEANS FOR THE SEPARATION OF MAGNETIC PARTICLES 审中-公开
    手段分离磁性颗粒

    公开(公告)号：US20100108578A1

    公开(公告)日：2010-05-06

    申请号：US12525833

    申请日：2008-01-31

    申请人： Wendy Uyen Dittmer ,  Jeroen Hans Nieuwenhuis ,  Peggy De Kievit ,  Kim Van Ommering

    发明人： Wendy Uyen Dittmer ,  Jeroen Hans Nieuwenhuis ,  Peggy De Kievit ,  Kim Van Ommering

    IPC分类号： B03C1/02

    CPC分类号： B03C1/288 ,  B03C1/32

    摘要： The invention relates to an apparatus (300) and a method for the separation of magnetic particles (1, 2) according to their properties, particularly their magnetic susceptibility. The apparatus comprises a magnetic field generator (320) with which magnetic actuation forces (Fm) can be exerted on the magnetic particles (1, 2) that affect a prevailing movement of the particles (1, 2), said movement being caused by non-magnetic influences, e.g. thermal energy or viscous drag (Fh). The magnetic field generator may for example comprise: (i) a wire (321) that crosses the flow of a sample fluid with varying inclination (α); (ii) wires that generate a local minimum of a magnetic potential from which different particles escape by Brownian motion with different rates; or (iii) pairs of particle-attracting wires for which the attraction of one wire is temporarily interrupted to allow the fastest magnetic particles to escape.

    摘要翻译： 本发明涉及一种根据其特性，特别是它们的磁化率分离磁性颗粒（1,2）的装置（300）和方法。 该装置包括磁场发生器（320），通过该磁场发生器可以对影响颗粒（1,2）主要运动的磁性颗粒（1,2）施加磁力驱动力（Fm），所述运动由非磁性元件 磁影响，例如 热能或粘滞阻力（Fh）。 磁场发生器可以例如包括：（i）穿过具有不同倾斜度（α）的样品流体的流动的导线（321）; （ii）产生局部最小磁场的导线，不同的粒子由不同速率的布朗运动逃离; 或（iii）一对引线，其中一根导线的吸引力暂时中断，以允许最快的磁性颗粒逸出。