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65 条记录 (耗时 0.069 秒)

    Compositions and methods for the therapy and diagnosis of ovarian cancer
    33.
    发明授权
    Compositions and methods for the therapy and diagnosis of ovarian cancer 失效

    公开(公告)号：US06617109B1

    公开(公告)日：2003-09-09

    申请号：US09713550

    申请日：2000-11-14

    申请人： Jiangchun Xu ,  John A. Stolk

    发明人： Jiangchun Xu ,  John A. Stolk

    IPC分类号： C07H2100

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

    Compositions for treatment and diagnosis of breast cancer and methods for their use
    35.
    发明授权
    Compositions for treatment and diagnosis of breast cancer and methods for their use 失效
    用于乳腺癌的治疗和诊断的组合及其使用方法

    公开(公告)号：US06518237B1

    公开(公告)日：2003-02-11

    申请号：US09389681

    申请日：1999-09-02

    申请人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

    发明人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

    IPC分类号： C12Q168

    CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/118

    摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

    摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。