公开(公告)号：US5401466A

公开(公告)日：1995-03-28

申请号：US69420

申请日：1993-06-01

Applicant: Mary M. Foltz ,  Chen-Jung Hsu ,  Robert C. Payne ,  James A. Profitt

Inventor： Mary M. Foltz ,  Chen-Jung Hsu ,  Robert C. Payne ,  James A. Profitt

IPC: G01N33/48 ,  B01D15/08 ,  G01N33/52 ,  G01N33/92 ,  G01N31/02

CPC classification number: B01D15/362 ,  B01D15/00 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28083 ,  G01N33/526 ,  G01N33/92 ,  G01N2800/044 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: A dry phase device separates high density lipoprotein (HDL) from a blood (serum or plasma) sample. The device contains a fluid permeable material having dispersed therein finely divided, porous silica or silicate particles as selective absorbant for HDL. By combining the device with a second layer designed to remove very low density lipoproteins/chylomicrons from the blood, and a third layer containing means for quantitative cholesterol detection, there is provided a test device for the direct determination of low density lipoproteins cholesterol.

Abstract translation: 干相装置将高密度脂蛋白（HDL）与血液（血清或血浆）样品分离。 该装置包含流体可渗透的材料，其中分散有细碎的多孔二氧化硅或硅酸盐颗粒作为HDL的选择性吸收剂。 通过将该装置与设计用于从血液中除去非常低密度脂蛋白/乳糜微粒的第二层和含有用于定量胆固醇检测的装置的第三层组合，提供了用于直接测定低密度脂蛋白胆固醇的测试装置。

公开(公告)号：US5216178A

公开(公告)日：1993-06-01

申请号：US745623

申请日：1991-08-15

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D313/14

CPC classification number: C07D313/14

Abstract: Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.

Abstract translation: 公开了新的氨基烷基硫代二氧化硫蛋白，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽医制剂以及通过施用方法进行治疗。 这些化合物可用作镇痛药，抗抑郁药和抗惊厥药。 还公开了一种通过碱金属在低级烷醇中选择性还原烯烃的方法。

公开(公告)号：US5006664A

公开(公告)日：1991-04-09

申请号：US453872

申请日：1989-12-20

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D337/14

CPC classification number: C07D337/14

Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.

Abstract translation: 公开了新型氨基烷基硫代二苯并硫蛋白及其相关化合物，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽用制剂以及通过施用方法进行治疗。 这些化合物可用作抗抑郁药，止痛剂和抗惊厥剂。

公开(公告)号：US4775682A

公开(公告)日：1988-10-04

申请号：US14740

申请日：1987-02-13

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D337/14 ,  A61K31/38

CPC classification number: C07D337/14

Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.

Abstract translation: 公开了新型氨基烷基硫代二苯并硫蛋白及其相关化合物，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽用制剂以及通过施用方法进行治疗。 这些化合物可用作抗抑郁药，止痛剂和抗惊厥剂。

公开(公告)号：US4436748A

公开(公告)日：1984-03-13

申请号：US256470

申请日：1981-04-22

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07D333/52 ,  A61K31/38 ,  A61K31/381 ,  A61P7/10 ,  A61P9/12 ,  C07C45/63 ,  C07C49/80 ,  C07C333/02 ,  C07D333/54 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76

CPC classification number: C07D333/54 ,  C07C309/00 ,  C07C323/00 ,  C07C45/63 ,  C07C49/80 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76 ,  Y10S514/869

Abstract: Novel benzo[b]thiophenes, compositions containing same, process for the preparation thereof and methods of reducing blood pressure and producing diuresis by administration of the compounds and compositions are disclosed.

Abstract translation: 公开了新的苯并[b]噻吩，含有它们的组合物，其制备方法和通过施用化合物和组合物降低血压和产生利尿的方法。

公开(公告)号：US4409229A

公开(公告)日：1983-10-11

申请号：US313169

申请日：1981-10-20

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D211/52 ,  C07D211/54 ,  C07D495/10 ,  A61K31/445 ,  A61K31/40

CPC classification number: C07D495/10 ,  C07D211/52 ,  C07D211/54

Abstract: Novel substituted 1,3-dihydrospiro[benzo(c)thiophene]s and methods of preparing the same are described. These compounds are useful as antidepressants and tranquilizers and intermediates therefor.

Abstract translation: 描述了新型取代的1,3-二氢螺[苯并（c）噻吩]及其制备方法。 这些化合物可用作抗抑郁药和镇定剂及其中间体。

公开(公告)号：US4209625A

公开(公告)日：1980-06-24

申请号：US936185

申请日：1978-08-23

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07D211/64 ,  C07D471/10

CPC classification number: C07D471/10 ,  C07D211/64

Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.

Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。

公开(公告)号：US4198420A

公开(公告)日：1980-04-15

申请号：US2350

申请日：1979-01-10

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: A61K31/435 ,  A61K31/445 ,  A61P25/04 ,  A61P25/08 ,  A61P25/20 ,  C07D211/64 ,  C07D495/10 ,  A61K31/38 ,  A61K31/55 ,  C07D313/10

CPC classification number: C07D495/10 ,  C07C323/00 ,  C07D211/64

Abstract: Novel spiro[dibenz(b,f)thiepin-piperidine]s and methods of preparing same are described. These compounds are useful as analgetics, tranquilizers and anticonvulsants.

Abstract translation: 描述了新的螺[二苯并（b，f）硫蛋白 - 哌啶]和其制备方法。 这些化合物可用作止痛药，止痛药和抗惊厥药。

公开(公告)号：US20100093109A1

公开(公告)日：2010-04-15

申请号：US12598141

申请日：2008-03-14

Applicant: Michael J. Pugia ,  James A. Profitt

Inventor： Michael J. Pugia ,  James A. Profitt

IPC: G01N33/544

CPC classification number: B01L3/502738 ,  B01L3/0268 ,  B01L3/50273 ,  B01L2200/0621 ,  B01L2300/0636 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/086 ,  Y10T436/118339

Abstract: Assays in which samples of biological fluids are dispensed into the inlet port of a microfluidic device are improved in the accuracy and repeatability by dispensing the biological sample and/or associated liquids in small droplets and at timed intervals to control the operation of the microfluidic device.

Abstract translation: 通过以小液滴和定时的间隔分配生物样品和/或相关液体来控制微流体装置的操作，通过将生物流体的样品分配到微流体装置的入口端口的分析物的精度和重复性得到改善。

公开(公告)号：US07435381B2

公开(公告)日：2008-10-14

申请号：US10447969

申请日：2003-05-29

Applicant: Michael J. Pugia ,  James A. Profitt ,  Ronald G. Sommer ,  Sung-Kwon Jung

Inventor： Michael J. Pugia ,  James A. Profitt ,  Ronald G. Sommer ,  Sung-Kwon Jung

IPC: G01N33/48

CPC classification number: B01L3/502707 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/0672 ,  B01L2400/0406 ,  B01L2400/0677 ,  B01L2400/0683 ,  B29K2509/08

Abstract: A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.

Abstract translation: 包含具有延长的保存期限的液体试剂的微流体装置包含微储存器中的液体试剂，其在装置的保存期限内将水分逸出限制在小于10％。 微型储存器优选由聚丙烯制成并用金属化塑料膜覆盖。