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41 条记录 (耗时 0.043 秒)

    Detection/measurement of malaria infection disease utilizing natural immunity by hemozoin induction, screening of preventative or therapeutic medicine for malaria infection disease, and regulation of natural immunity induction
    32.
    发明授权
    Detection/measurement of malaria infection disease utilizing natural immunity by hemozoin induction, screening of preventative or therapeutic medicine for malaria infection disease, and regulation of natural immunity induction 有权
    通过血红素诱导自然免疫的疟疾感染疾病的检测/测量，疟疾感染疾病的预防或治疗药物的筛选和天然免疫诱导的调节

    公开(公告)号：US09400279B2

    公开(公告)日：2016-07-26

    申请号：US13312260

    申请日：2011-12-06

    申请人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

    发明人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

    IPC分类号： A61K31/555 ,  A61K38/02 ,  C12N5/071 ,  G01N33/569

    CPC分类号： A61K39/015 ,  A01K2267/0387 ,  A61K2039/572 ,  G01N33/56905 ,  G01N2333/445 ,  G01N2333/70596 ,  G01N2500/10 ,  Y02A50/58

    摘要： The instant invention is to provide a method for detecting and measuring malaria infection utilizing the induction by hemozoin (HZ); a method for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection using the method for detecting and measuring; and a means for regulating the induction of innate immunity using the HZ, synthetic HZ, or derivatives thereof as an adjuvant or immunostimulant. Malaria infection is detected and measured of by detecting and measuring HZ-induced, TLR9-mediated, and MyD88-dependent innate immune activity. The detection and measurement of malaria infection can be used to diagnose malaria infection. The method for detecting and measuring is also used for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection. Further, HZ, synthetic HZ, or derivatives thereof are used as an adjuvant or immunostimulant to regulate HZ-induced innate immune induction.

    摘要翻译： 本发明是提供一种利用血红素（HZ）的诱导检测和测量疟疾感染的方法; 使用检测和测量方法筛选疟疾感染疫苗的方法和用于疟疾感染的预防或治疗剂; 以及使用HZ，合成HZ或其衍生物作为佐剂或免疫刺激剂来调节诱导天然免疫的方法。 通过检测和测量HZ诱导的TLR9介导的和MyD88依赖性先天免疫活性来检测和测量疟疾感染。 疟疾感染的检测和测量可用于诊断疟疾感染。 用于检测和测量的方法也用于筛选疟疾感染的疫苗和用于疟疾感染的预防或治疗剂。 此外，HZ，合成HZ或其衍生物用作佐剂或免疫刺激剂以调节HZ诱导的先天免疫诱导。

    Antibacterial medical equipment and method for producing the same
    33.
    发明授权
    Antibacterial medical equipment and method for producing the same 有权
    抗菌医疗设备及其制造方法

    公开(公告)号：US08877222B2

    公开(公告)日：2014-11-04

    申请号：US13321215

    申请日：2010-05-19

    申请人： Mamoru Aizawa ,  Tomoyuki Hoshikawa ,  Ken Ishii ,  Haruki Funao

    发明人： Mamoru Aizawa ,  Tomoyuki Hoshikawa ,  Ken Ishii ,  Haruki Funao

    IPC分类号： A61F2/00 ,  A61K33/42 ,  A61K33/38 ,  A61K33/06 ,  A61L31/16 ,  A61L27/54 ,  A61L31/02 ,  A61L29/02 ,  A61L29/16 ,  A61L27/12

    CPC分类号： A61L27/12 ,  A61L27/54 ,  A61L29/02 ,  A61L29/16 ,  A61L31/026 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/112 ,  A61L2300/404 ,  A61L2300/606

    摘要： An object of the present invention is to provide an antibacterial medical equipment which has sufficient antibacterial activity in vivo and is excellent in compatibility with living tissues, and also can maintain antibacterial activity over a long period and has high safety.An antibacterial medical equipment characterized in that inositol phosphate is bonded to a Ca compound of a medical equipment whose surface is at least coated with a layer of the Ca compound, or a medical equipment comprising the Ca compound. The antibacterial medical equipment as described above, wherein silver ions are bonded to the inositol phosphate. A method for producing an antibacterial medical equipment, which comprises bringing a medical equipment whose surface is at least coated with a layer of a Ca compound, or a medical equipment comprising a Ca compound into contact with an aqueous solution of inositol phosphate to obtain an antibacterial medical equipment in which inositol phosphate is bonded to the Ca compound. The method for producing an antibacterial medical equipment, wherein inositol phosphate is bonded to the Ca compound and then the Ca compound is brought into contact with an aqueous solution containing silver ions to obtain an antibacterial medical equipment in which silver ions are bonded to the inositol phosphate.

    摘要翻译： 本发明的目的在于提供一种在体内具有足够的抗菌活性并且与活组织相容性优异的抗菌医疗设备，并且能够长时间保持抗菌活性且安全性高。 一种抗菌医疗设备，其特征在于磷酸肌醇与其表面至少涂覆有Ca化合物层的医疗设备的Ca化合物或包含Ca化合物的医疗设备结合。 如上所述的抗菌医疗设备，其中银离子与磷酸肌醇结合。 一种抗菌医疗设备的制造方法，其特征在于，将表面至少涂覆有Ca化合物的医疗器械，或包含Ca化合物的医疗器械与磷酸肌醇水溶液接触，得到抗菌剂 磷酸肌醇与Ca化合物结合的医疗设备。 生产抗菌医疗设备的方法，其中将磷酸肌醇与Ca化合物接合，然后使Ca化合物与含有银离子的水溶液接触，得到银离子与磷酸肌醇结合的抗菌医疗设备 。

    Olioodeoxynucleotide and its use to induce an immune response
    34.
    发明授权
    Olioodeoxynucleotide and its use to induce an immune response 有权
    氧化脱氧核苷酸及其诱导免疫应答的用途

    公开(公告)号：US08389495B2

    公开(公告)日：2013-03-05

    申请号：US13220497

    申请日：2011-08-29

    申请人： Dennis Klinman ,  Ken Ishii ,  Daniela Verthelyi ,  James J. Mond

    发明人： Dennis Klinman ,  Ken Ishii ,  Daniela Verthelyi ,  James J. Mond

    IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K45/00 ,  A61K47/00 ,  A61K31/70 ,  A61K9/127 ,  A01N43/04

    CPC分类号： C07H21/04 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/008 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55561 ,  C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  Y02A50/41 ,  Y02A50/423 ,  Y10T428/2989 ,  A61K2300/00

    摘要： A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula: 5′N1N2N3T-CpG-WN4N5N63′ wherein the CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are nucleotides, or the formula: 5′RY-CpG-RY3′ wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. In some embodiments, the oligodeoxynucleotide includes the nucleic acid sequences set forth as SEQ ID NO: 137.

    摘要翻译： 公开了至少10个核苷酸的基本上纯的或分离的寡脱氧核苷酸，其中所述寡脱氧核苷酸包含由下式表示的序列：5'N1N2N3T-CpG-WN4N5N63'，其中CpG基序是未甲基化的，W是A或T，N1，N2 ，N3，N4，N5和N6为核苷酸，或其中中心CpG基序未甲基化，R为A或G，Y为C或T的核苷酸或其结构式为：5'RY-CpG-RY3'以及寡脱氧核苷酸 递送复合物和包含本发明的寡脱氧核苷酸的药物组合物，以及通过将本发明的寡脱氧核苷酸施用于宿主来诱导免疫应答的方法。 在一些实施方案中，寡脱氧核苷酸包括如SEQ ID NO：137所示的核酸序列。

    SEMICONDUCTOR MANUFACTURING APPARATUS AND CLEANING METHOD THEREOF
    36.
    发明申请
    SEMICONDUCTOR MANUFACTURING APPARATUS AND CLEANING METHOD THEREOF 审中-公开
    半导体制造装置及其清洁方法

    公开(公告)号：US20120186604A1

    公开(公告)日：2012-07-26

    申请号：US13233190

    申请日：2011-09-15

    申请人： Kensuke Takano ,  Shinji Miyazaki ,  Ken Ishii ,  Takashi Nakao

    发明人： Kensuke Takano ,  Shinji Miyazaki ,  Ken Ishii ,  Takashi Nakao

    IPC分类号： B08B5/00 ,  H01L21/3065

    CPC分类号： C23C16/52 ,  C23C16/4405

    摘要： According to one embodiment, a cleaning gas is sealed in a chamber of a semiconductor manufacturing apparatus, and the cleaning gas and deposits adhered in the chamber are reacted with each other to generate a reactive gas. After a predetermined time, the gas is exhausted from the chamber. Then, the chamber is evacuated while the cleaning gas is introduced into the chamber, and the reactive gas concentration contained in an exhausted gas is measured. The reactive gas concentration is compared with a determination value obtained when the deposits are removed from the chamber to determine whether the cleaning is terminated.

    摘要翻译： 根据一个实施例，将清洁气体密封在半导体制造装置的室中，并且附着在室中的清洁气体和沉积物彼此反应以产生反应性气体。 在预定时间之后，气体从腔室排出。 然后，在将清洁气体引入室内的同时将室抽真空，并测量排出气体中所含的反应气体浓度。 将反应气体浓度与从室中移出沉积物时获得的确定值进行比较，以确定清洁是否终止。