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    Insulin derivatives, process for their preparation, their use and a pharmaceutical preparation containing them
    32.
    发明授权
    Insulin derivatives, process for their preparation, their use and a pharmaceutical preparation containing them 失效
    胰岛素衍生物，其制备方法，其使用和含有它们的药物制剂

    公开(公告)号：US5149716A

    公开(公告)日：1992-09-22

    申请号：US603835

    申请日：1990-10-26

    申请人： Laszlo Vertesy ,  Karl Geisen ,  Richard Bicker

    发明人： Laszlo Vertesy ,  Karl Geisen ,  Richard Bicker

    IPC分类号： C12P21/06 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07K1/06 ,  C07K14/575 ,  C07K14/62 ,  C12P21/02

    CPC分类号： C07K14/62

    摘要： The invention relates to insulin derivatives of the formula III ##STR1## in which R.sup.30 and R.sup.31 together are OH, or R.sup.30 is a radical of a neutral, genetically encodable L-amino acid and R.sup.31 is OH or a physiologically acceptable organic group of basic character having up to 50 carbon atoms, whose synthesis involves 0 to 3 .alpha.-amino acids and whose optional terminal carboxyl function can be present free, as an ester function, as an amide function, as a lactone or reduced to CH.sub.2 OH, and R.sup.A-1 is a radical of a genetically encodable L-amino acid, and physiologically acceptable salts of said insulin derivative of the formula III.

    摘要翻译： 本发明涉及式III（III）的胰岛素衍生物，其中R30和R31一起是OH，或R30是中性的，可遗传编码的L-氨基酸的基团，R31是OH或生理上可接受的有机基团 具有多至50个碳原子的基本特征，其合成涉及0至3个α-氨基酸，并且其任选的末端羧基官能团可作为酯官能团作为酰胺官能团作为内酯，作为内酯或还原成CH2OH，以及 RA-1是基因编码的L-氨基酸的基团，以及所述式III的胰岛素衍生物的生理上可接受的盐。

    Process for obtaining cephalosporin C and the salts and derivatives thereof from culture filtrates or culture solutions
    36.
    发明授权
    Process for obtaining cephalosporin C and the salts and derivatives thereof from culture filtrates or culture solutions 失效
    从培养滤液或培养液中获得头孢菌素C及其盐和衍生物的方法

    公开(公告)号：US4204058A

    公开(公告)日：1980-05-20

    申请号：US954896

    申请日：1978-10-26

    申请人： Laszlo Vertesy ,  Gerhard Huber

    发明人： Laszlo Vertesy ,  Gerhard Huber

    IPC分类号： C12P35/06 ,  A61K20060101 ,  C07D501/12 ,  C07D501/28

    CPC分类号： C07D501/12

    摘要： A novel process for obtaining cephalosporin C and the salts and derivatives thereof from culture filtrates or culture solutions is provided which comprises drying the culture filtrate or culture solution, dissolving it in an optionally water-containing solvent different from water, and(a) forming a derivative of the amino group of cephalosporin C, and isolating it in the form of a free acid or a salt, or(b) precipitating the cephalosporin C or the scarcely soluble salt thereof directly.

    摘要翻译： 提供从培养滤液或培养液中获得头孢菌素C及其盐和衍生物的新方法，其包括干燥培养滤液或培养液，将其溶解在不同于水的任选含水溶剂中，和（a）形成 衍生的头孢菌素C的氨基，并以游离酸或盐的形式分离，或（b）直接沉淀头孢菌素C或其几乎不溶的盐。