-
1.发明授权
公开(公告)号：US5091524A
公开(公告)日：1992-02-25
申请号：US426805
申请日：1989-10-26
IPC分类号： C12P17/06 , A01N43/16 , A61K31/00 , A61K31/35 , A61K31/351 , A61P3/00 , A61P3/08 , C07D309/14 , C12N9/99 , C12R1/47
CPC分类号： A01N43/16 , C07D309/14 , Y10S435/887 , Y10S514/866 , Y10S514/884 , Y10S514/909
摘要： Salbostatin, a compound of the formula I ##STR1## acts as a glycosidase inhibitor and is suitable for use in pharmacy and in plant protection.
摘要翻译： Salbostatin，式I化合物作为糖苷酶抑制剂，适用于制药和植物保护。
-
2.发明授权Amine containing pseudooligosaccharide, pharmaceutical composition and method of use 失效含有假低聚糖的胺，药物组合物和使用方法
公开(公告)号：US4618602A
公开(公告)日：1986-10-21
申请号：US771638
申请日：1985-09-03
IPC分类号： A61K49/00 , A61K8/00 , A61K8/73 , A61K31/715 , A61P1/02 , A61P3/00 , A61Q11/00 , C07H15/22 , C08B37/00 , C12P19/04 , C12P19/28 , C12R1/465 , A61K31/73
CPC分类号： C07H15/22 , C12P19/28 , Y10S514/835 , Y10S514/866
摘要： Pseudooligosaccharide of the formula I ##STR1## and physiologically acceptable salts thereof with acids, a process for the preparation, pharmaceutical products and the use are described. The compound has a .alpha.-glucosidase-inhibiting action.
摘要翻译： 描述了式I的伪低聚糖和其与酸的生理上可接受的盐，制备方法，药物产品和用途。 该化合物具有α-葡糖苷酶抑制作用。
-
3.发明授权Chelating agents, their preparation from the antibiotics salmycin A,B,C, or D, and their use 失效螯合剂，它们由抗生素制备的salmycin A，B，C或D及其用途
公开(公告)号：US5519123A
公开(公告)日：1996-05-21
申请号：US286452
申请日：1994-08-05
IPC分类号： A61K31/70 , A61K31/7024 , A61P25/28 , C07C259/06 , C07F15/02 , C07G11/00 , C07H13/04 , C07H23/00 , C09K3/00 , C12P19/26
CPC分类号： C07H23/00 , C07C259/06 , C12P19/26
摘要： The novel substances nordanoxamine and desferrinordanoxamine, and desferrisalmycin A, B, C and D, as well as the known substances danoxamine and desferridanoxamine, are prepared from the antibiotics salmycin A, B, C and D, which are obtained by fermentation. These substances are used as chelating agents and pharmaceuticals.
摘要翻译： 由发酵得到的抗生素萨尔霉素A，B，C和D制备了新型物质诺丁胺和去铁毒素，脱铁霉素A，B，C，D以及已知物质丹酰胺和去铁草胺。 这些物质用作螯合剂和药物。
-
公开(公告)号：US5763397A
公开(公告)日：1998-06-09
申请号：US907747
申请日：1992-06-29
IPC分类号： A61K31/33 , A61K31/00 , A61K38/00 , A61K38/12 , A61K38/14 , A61P31/00 , A61P31/04 , C07D519/00 , C07K1/02 , C07K1/113 , C07K1/20 , C07K7/06 , C07K7/52 , C07K9/00 , C07K14/195 , C07K14/41 , C12N1/20 , C12P21/00 , C12P21/02 , C12R1/04 , C12N1/22 , C12P19/60
CPC分类号： C07K7/06 , C07K9/008 , A61K38/00 , Y10S435/822
摘要： Desmethylbalhimycin, a compound of the formula C.sub.65 H.sub.71 Cl.sub.2 N.sub.9 O.sub.24, desmethylleucylbalhimycin, a compound of the formula C.sub.59 H.sub.60 Cl.sub.2 N.sub.8 O.sub.23, desglucobalhimycin, a compound of the formula C.sub.60 H.sub.63 Cl.sub.2 N.sub.9 O.sub.19, ureidobalhimycin, a compound of the formula C.sub.67 H.sub.74 Cl.sub.2 N.sub.10 O.sub.25, desmethyl-desglucobalhimycin, a compound of the formula C.sub.59 H.sub.61 Cl.sub.2 N.sub.9 O.sub.19 and balhimycin V, a compound of the formula C.sub.73 H.sub.84 Cl.sub.2 N.sub.10 I.sub.26, methylbalhimycin, a compound of the formula C.sub.67 H.sub.75 Cl.sub.2 N.sub.9 O.sub.24 and balhimycin R, a compound of the formula C.sub.72 H.sub.83 Cl.sub.2 N.sub.9 O.sub.28, have an antibiotic action.
摘要翻译： 去甲基巴马霉素，式C65H71Cl2N9O24的化合物，脱甲基亮氨酰巴马霉素，式C59H60Cl2N8O23的化合物，去环巴豆霉素，式C 60 H 63 Cl 2 N 9 O 19的化合物，脲基巴拉霉素，式C67H74Cl2N10O25的化合物，脱甲基去环糊精霉素，式C59H61Cl2N9O19的化合物和巴利霉素V， 式C73H84Cl2N10I26的化合物，甲基巴马霉素，式C67H75Cl2N9O24的化合物和巴尔霉素R，式C72H83Cl2N9O28的化合物具有抗生素作用。
-
公开(公告)号：US5721208A
公开(公告)日：1998-02-24
申请号：US475642
申请日：1995-06-07
CPC分类号： C07K9/008 , A61K38/00 , Y10S435/822
摘要： Novel glycopeptides, a process for their preparation and their use Desmethylbalhimycin, a compound of the formula C.sub.65 H.sub.71 Cl.sub.2 N.sub.9 O.sub.24, desmethylleucylbalhimycin, a compound of the formula C.sub.59 H.sub.60 Cl.sub.2 N.sub.8 O.sub.23, desglucobalhimycin, a compound of the formula C.sub.60 H.sub.63 Cl.sub.2 N.sub.9 O.sub.19, ureidobalhimycin, a compound of the formula C.sub.67 H.sub.74 Cl.sub.2 N.sub.10 O.sub.25, desmethyl-desglucobalhimycin, a compound of the formula C.sub.59 H.sub.61 Cl.sub.2 N.sub.9 O.sub.19 and balhimycin V, a compound of the formula C.sub.73 H.sub.84 Cl.sub.2 N.sub.10 I.sub.26, methylbalhimycin, a compound of the formula C.sub.67 H.sub.75 Cl.sub.2 N.sub.9 O.sub.24 and balhimycin R, a compound of the formula C.sub.72 H.sub.83 Cl.sub.2 N.sub.9 O.sub.28, have an antibiotic action.
摘要翻译： 新型糖肽，其制备方法及其应用去甲基巴马霉素，式C65H71Cl2N9O24的化合物，去甲基亮氨酰巴马霉素，式C59H60Cl2N8O23的化合物，去葡萄球菌霉素，式C60H63Cl2N9O19的化合物，脲基巴拉霉素，式C67H74Cl2N10O25的化合物，去甲基脱葡萄白蛋白霉素 ，式C59H61Cl2N9O19和巴利霉素V的化合物，式C73H84Cl2N10I26的化合物，甲基巴马霉素，式C67H75Cl2N9O24的化合物和巴霉素R，式C72H83Cl2N9O28的化合物具有抗生素作用。
-
6.发明授权Enkastins: new glycopeptides which act to inhibit enkephlinase, processes for their preparation, and their use as pharmaceutical products 失效恩卡斯汀：用于抑制肠胃蛋白酶的新糖肽，其制备方法及其作为药物的用途
公开(公告)号：US5302582A
公开(公告)日：1994-04-12
申请号：US727388
申请日：1991-07-05
申请人： Laszlo Vertesy , Peter Schindler , Herbert Kogler , Hans-Wolfram Fehlhaber , Francoise Delevallee
发明人： Laszlo Vertesy , Peter Schindler , Herbert Kogler , Hans-Wolfram Fehlhaber , Francoise Delevallee
IPC分类号： C12P21/02 , A61K31/70 , A61K31/7028 , A61K38/00 , A61K38/55 , A61P25/04 , C07H7/02 , C07H15/12 , C07K1/113 , C07K5/06 , C07K9/00 , C07K14/195 , C07K14/41 , C07K14/81 , C07K17/00 , C12N1/14 , C12N1/20 , C12N9/99 , C12P19/26 , C12P19/28 , C12R1/47
摘要： The invention relates to new biologically active glycopeptides of the general formulaSacch--A--B--Rin which Sacch represents a monosaccharide residue with, where appropriate, the OH groups being partially or completely substituted,A represents the residue of a neutral L- or D-amino acid or --if B is absent--represents the residue of a neutral D-amino acid,B is absent or represents the residue of a neutral L- or D-amino acid or of an optionally .omega.-substituted bi-functional acidic or basic L- or D-amino acid, and R represents hydroxyl, (C.sub.1 -C.sub.8)-alkoxy, an amino radical which is optionally substituted by one or two identical or different radicals from the series comprising (C.sub.1 -C.sub.8)-alkyl, (C.sub.5 -C.sub.8)-cycloalkyl, (C.sub.5 -C.sub.8)-heteroalkyl or (C.sub.5 -C.sub.8)-heteroaryl, or another acid derivative. These compounds have enkephalinase-inhibiting properties and can thus be used, for example, as analgesics in human and veterinary medicine. The isolation of these compounds from Streptomyces albus ATCC 21838, and further processes for their preparation, are also described.
摘要翻译： 本发明涉及通式为Sacch-ABR的新的生物活性糖肽，其中Sacch代表单糖残基，在适当的情况下OH基部分或完全被取代，A代表中性L-或D-氨基酸的残基 或 - 如果B不存在 - 表示中性D-氨基酸的残基，B不存在或表示中性L-或D-氨基酸或任选（ω） - 取代的双官能酸性或碱性的残基 L-或D-氨基酸，R代表羟基，（C1-C8） - 烷氧基，任选被一个或两个相同或不同的基团取代的氨基，所述基团包括（C 1 -C 8） - 烷基， -C 8） - 环烷基，（C 5 -C 8） - 杂烷基或（C 5 -C 8） - 杂芳基或其它酸衍生物。 这些化合物具有脑啡肽酶抑制性质，因此可用于例如人和兽医学中的镇痛药。 这些化合物从Streptomyces albus ATCC 21838的分离以及其制备方法也被描述。
-
7.发明授权
公开(公告)号：US4990500A
公开(公告)日：1991-02-05
申请号：US83807
申请日：1987-08-11
CPC分类号： C07H15/26 , C07H17/04 , Y10S435/886 , Y10S514/835 , Y10S514/866
摘要： Oxirane-pseudooligosaccharides of the formula I ##STR1## in which z is zero or 1, their physiologically acceptable salts with acids, a process for their preparation, pharmaceutical preparations, and their use are described. The compounds have an .alpha.-glucosidase-inhibiting action.
摘要翻译： 描述了其中z为零或1，其酸的生理学上可接受的盐，其制备方法，药物制剂及其用途的式I的视黄醛 - 假低聚糖。 该化合物具有α-葡糖苷酶抑制作用。
-
8.发明授权
公开(公告)号：US5475094A
公开(公告)日：1995-12-12
申请号：US288775
申请日：1994-08-11
IPC分类号： A61K31/70 , A61K31/7135 , A61P31/04 , C07H3/02 , C07H5/06 , C07H11/00 , C07H23/00 , C07K9/00 , C12N15/51 , C12P19/58 , C12P19/60 , C12R1/465 , C12P19/26 , A61K31/71 , C12N1/20
摘要： Salmycins, a process for their preparation and their use as a pharmaceutical Compounds of formula I, ##STR1## wherein R denotes .dbd.NOH (a), .dbd.O (b); --OH and --H (c), --NH.sub.2 and --H (d) or .dbd.N--O--R'(e);R' denotes phenyl or a branched or unbranched alkyl with 1 to 10 carbon atoms,R" denotes H, alkyl, hydroxy-alkyl and amino-alkyl, as well as the chemical equivalents and physiologically acceptable salts thereof. The salmycins and their derivatives are used as a pharmaceutical.
摘要翻译： 沙门氏菌素，其制备方法及其作为药物的用途式I，OH（a），= O（b）的化合物; -OH和-H（c），-NH 2和-H（d）或= N-O-R'（e）; R'表示苯基或具有1至10个碳原子的支链或非支链烷基，R“表示H，烷基，羟基 - 烷基和氨基 - 烷基，以及其化学等价物和生理上可接受的盐。 盐霉素及其衍生物用作药物。
-
9.发明授权Pseudooligosaccharides with an .alpha.-glucosidase-inhibiting action, their use and pharmaceutical products 失效具有α-葡糖苷酶抑制作用的伪低聚糖，其用途和药物产品
公开(公告)号：US4632917A
公开(公告)日：1986-12-30
申请号：US771610
申请日：1985-09-03
IPC分类号： G01N33/66 , A61K8/00 , A61K8/73 , A61K31/70 , A61K31/7028 , A61K31/715 , A61P1/02 , A61P3/00 , A61P3/06 , A61P43/00 , A61Q11/00 , C07H3/06 , C07H15/00 , C07H15/22 , C08B37/00 , C12P19/04 , C12P19/12 , C12P19/44 , C12R1/465 , A61K31/73
CPC分类号： C12R1/465 , C07H15/22 , C07H3/06 , C12P19/12 , C12P19/44 , Y10S514/835 , Y10S514/866
摘要： Pseudooligosaccharides of the formula I ##STR1## in which l, m and n have the meanings given, physiologically acceptable salts thereof with acids, a process for their preparation, pharmaceutical products and their use are described. The compounds have an .alpha.-glucosidase-inhibiting action.
摘要翻译： 其中l，m和n具有给定的含义，式Ⅰ的假寡糖，其酸的生理上可接受的盐，其制备方法，药物产品及其用途。 该化合物具有α-葡糖苷酶抑制作用。
-
公开(公告)号：US4988677A
公开(公告)日：1991-01-29
申请号：US89238
申请日：1987-08-25
申请人： Christopher M. M. Franco , Julia Gandhi , Sugata Chatterjee , Goukanapalli C. S. Reddy , Bimal N. Ganguli , Richard H. Rupp , Herbert Kogler , Hans-Wolfram Fehlhaber
发明人： Christopher M. M. Franco , Julia Gandhi , Sugata Chatterjee , Goukanapalli C. S. Reddy , Bimal N. Ganguli , Richard H. Rupp , Herbert Kogler , Hans-Wolfram Fehlhaber
摘要： The present invention relates to the macrolide antibiotic swalpamycin, to a microbiological process for its preparation, to a new microorganism strain Streptomyces species, and to the use of swalpamycin as a medicinal agent for the treatment of infections caused by bacteria, mycoplasmas and Actinomycetes.
摘要翻译： 本发明涉及大环内酯类抗生素swalpamycin，其制备微生物方法，新型微生物链霉菌属物种，以及使用吐温霉素作为治疗由细菌，支原体和放线菌引起的感染的药剂。
-
-
-
-
-
-
-
-
-
搜索结果
25 条记录 (耗时 0.017 秒)
