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1.发明授权
公开(公告)号：US5475094A
公开(公告)日：1995-12-12
申请号：US288775
申请日：1994-08-11
IPC分类号： A61K31/70 , A61K31/7135 , A61P31/04 , C07H3/02 , C07H5/06 , C07H11/00 , C07H23/00 , C07K9/00 , C12N15/51 , C12P19/58 , C12P19/60 , C12R1/465 , C12P19/26 , A61K31/71 , C12N1/20
摘要： Salmycins, a process for their preparation and their use as a pharmaceutical Compounds of formula I, ##STR1## wherein R denotes .dbd.NOH (a), .dbd.O (b); --OH and --H (c), --NH.sub.2 and --H (d) or .dbd.N--O--R'(e);R' denotes phenyl or a branched or unbranched alkyl with 1 to 10 carbon atoms,R" denotes H, alkyl, hydroxy-alkyl and amino-alkyl, as well as the chemical equivalents and physiologically acceptable salts thereof. The salmycins and their derivatives are used as a pharmaceutical.
摘要翻译： 沙门氏菌素，其制备方法及其作为药物的用途式I，OH（a），= O（b）的化合物; -OH和-H（c），-NH 2和-H（d）或= N-O-R'（e）; R'表示苯基或具有1至10个碳原子的支链或非支链烷基，R“表示H，烷基，羟基 - 烷基和氨基 - 烷基，以及其化学等价物和生理上可接受的盐。 盐霉素及其衍生物用作药物。
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公开(公告)号：US4713371A
公开(公告)日：1987-12-15
申请号：US824939
申请日：1986-02-03
申请人： Werner Aretz , Hans G. Berscheid , Gerhard Huber , Hans-Wolfram Fehlhaber , Hans P. Kraemer , Hans-Harald Sedlacek , Bimal N. Ganguli , Ratan S. Sood , Julia Gandhi , Gauknapalli C. Reddy
发明人： Werner Aretz , Hans G. Berscheid , Gerhard Huber , Hans-Wolfram Fehlhaber , Hans P. Kraemer , Hans-Harald Sedlacek , Bimal N. Ganguli , Ratan S. Sood , Julia Gandhi , Gauknapalli C. Reddy
IPC分类号： A61K31/12 , A61K31/215 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P35/00 , C07C45/00 , C07C50/36 , C07C67/00 , C07H15/252 , C12P19/56 , C12R1/465 , A61K31/71 , C07H15/24
CPC分类号： C07H15/252 , C12P19/56
摘要： The present invention relates to the micro-organism Streptomyces purpurascens (DSM 2658), its mutants and variants, a process for the preparation of anthracycline derivatives by fermentation of these cultures and to the anthracycline derivatives themselves. The new compounds are distinguished by antibacterial activity and, in addition, they act against various types of tumors.
摘要翻译： 本发明涉及微生物链霉菌紫球菌（DSM 2658），其突变体和变体，通过这些培养物的发酵和蒽环类衍生物本身制备蒽环类衍生物的方法。 新化合物的特征在于抗菌活性，另外它们还可以抵抗各种类型的肿瘤。
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3.发明授权Chelating agents, their preparation from the antibiotics salmycin A,B,C, or D, and their use 失效螯合剂，它们由抗生素制备的salmycin A，B，C或D及其用途
公开(公告)号：US5519123A
公开(公告)日：1996-05-21
申请号：US286452
申请日：1994-08-05
IPC分类号： A61K31/70 , A61K31/7024 , A61P25/28 , C07C259/06 , C07F15/02 , C07G11/00 , C07H13/04 , C07H23/00 , C09K3/00 , C12P19/26
CPC分类号： C07H23/00 , C07C259/06 , C12P19/26
摘要： The novel substances nordanoxamine and desferrinordanoxamine, and desferrisalmycin A, B, C and D, as well as the known substances danoxamine and desferridanoxamine, are prepared from the antibiotics salmycin A, B, C and D, which are obtained by fermentation. These substances are used as chelating agents and pharmaceuticals.
摘要翻译： 由发酵得到的抗生素萨尔霉素A，B，C和D制备了新型物质诺丁胺和去铁毒素，脱铁霉素A，B，C，D以及已知物质丹酰胺和去铁草胺。 这些物质用作螯合剂和药物。
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4.发明授权2-alkenyloxy-3-(phosphono)oxypropanoic acids derived from the cleavage of phosphoglycolipid antibiotics 失效衍生自磷酸甘油脂抗生素切割的2-链烯氧基-3-（膦酰基）氧代丙酸
公开(公告)号：US5206405A
公开(公告)日：1993-04-27
申请号：US927886
申请日：1992-08-11
申请人： Werner Aretz , Dirk Bottger , Gerhard Seibert , Alois Tumulka , Peter Welzel , Kurt Hobert
发明人： Werner Aretz , Dirk Bottger , Gerhard Seibert , Alois Tumulka , Peter Welzel , Kurt Hobert
IPC分类号： C07C59/125 , C07C59/60 , C07F9/09 , C07F9/655 , C07H13/12 , C12N9/16 , C12P7/42 , C12P19/26 , C12P19/44
CPC分类号： C07H13/12 , C07C59/125 , C07C59/60 , C07F9/091 , C07F9/6552 , C12N9/16 , C12P19/26 , C12P19/44 , C12P7/42 , C12R1/07
摘要： A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylase inhibitors.
摘要翻译： 可以使用新的芽孢杆菌种类和由其获得的合适的酶来分解磷脂糖抗生素。 莫内霉素的分解产物显示抗生素活性，或可用作合成制备转糖基酶抑制剂的结构单元。
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公开(公告)号：US5710272A
公开(公告)日：1998-01-20
申请号：US480801
申请日：1995-06-07
IPC分类号： A61K31/52 , A61K31/522 , A61P9/00 , C07B37/10 , C07D473/04 , C07D473/06 , C07D473/08 , C07D473/10 , C12N1/16 , C12P17/18 , C12P41/00 , C12R1/645
CPC分类号： C12P41/002 , C07D473/06 , C07D473/08 , C07D473/10 , C12P17/18 , Y10S435/822 , Y10S435/911
摘要： A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be convened into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereoselectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.
摘要翻译： 已经发现红酵母菌株将己酮可可碱降至100％以得到S-醇。 此外，其它氧代烷基黄嘌呤衍生物也可以被引入到相应的S-醇中。 然后将微生物获得的S - （+） - 对映异构体立体选择性地转化成相应的R - （ - ） - 对映异构体。 通过配置对映选择性反转获得的相应的S-醇和R-醇导致脑血流量的增加。
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6.发明授权Process for the enantioselective preparation of (.beta.-1)-hydroxyalkylxanthines by reduction using Rhodotorula rubra 失效通过使用红酵母（Rhodotorula rubra）进行还原的对映选择性制备（β-1） - 羟基烷基黄嘌呤的方法
公开(公告)号：US5310666A
公开(公告)日：1994-05-10
申请号：US975996
申请日：1992-11-13
IPC分类号： A61K31/52 , A61K31/522 , A61P9/00 , C07B37/10 , C07D473/04 , C07D473/06 , C07D473/08 , C07D473/10 , C12N1/16 , C12P17/18 , C12P41/00 , C12R1/645
CPC分类号： C12P41/002 , C07D473/06 , C07D473/08 , C07D473/10 , C12P17/18 , Y10S435/822 , Y10S435/911
摘要： A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be converted into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereoselectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.
摘要翻译： 已经发现红酵母菌株将己酮可可碱降至100％以得到S-醇。 此外，其它氧代烷基黄嘌呤衍生物也可以转化为相应的S-醇。 然后将微生物获得的S - （+） - 对映异构体立体选择性地转化成相应的R - （ - ） - 对映异构体。 通过配置对映选择性反转获得的相应的S-醇和R-醇导致脑血流量的增加。
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公开(公告)号：US5506140A
公开(公告)日：1996-04-09
申请号：US403575
申请日：1995-03-14
申请人： Werner Aretz , Dirk Bottger , Gerhard Seibert , Alois Tumulka , Peter Welzel , Kurt Hobert
发明人： Werner Aretz , Dirk Bottger , Gerhard Seibert , Alois Tumulka , Peter Welzel , Kurt Hobert
IPC分类号： C07C59/125 , C07C59/60 , C07F9/09 , C07F9/655 , C07H13/12 , C12N9/16 , C12P7/42 , C12P19/26 , C12P19/44 , C12N1/20
CPC分类号： C07H13/12 , C07C59/125 , C07C59/60 , C07F9/091 , C07F9/6552 , C12N9/16 , C12P19/26 , C12P19/44 , C12P7/42 , C12R1/07 , Y10S435/832
摘要： A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylase inhibitors.
摘要翻译： 可以使用新的芽孢杆菌种类和由其获得的合适的酶来分解磷脂糖抗生素。 莫内霉素的分解产物显示抗生素活性，或可用作合成制备转糖基酶抑制剂的结构单元。
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8.发明授权L-aminoacid oxidase from yeasts of the genus cryptococcus, their preparation and use 失效来自隐球菌属酵母的L-氨基酸氧化酶，其制备和用途
公开(公告)号：US4783404A
公开(公告)日：1988-11-08
申请号：US650638
申请日：1984-09-14
申请人： Werner Aretz , Klaus Sauber
发明人： Werner Aretz , Klaus Sauber
CPC分类号： C12N9/0022 , C12P41/006 , C12P7/40 , C12R1/645 , Y10S435/911
摘要： Yeasts of the genus cryptococcus, preferably of the species C. Laurentii, form, in the presence of aminoacids, an L-aminoacid oxidase which stereospecifically converts L-aminoacids and their derivatives into the corresponding .alpha.-ketoacids. The immobilized cells are advantageously used for this conversion, which can also be used to resolve racemates.
摘要翻译： 隐球菌属的酵母，优选品种C. Laurentii，在氨基酸存在下，形成L-氨基酸氧化酶，其立体选择性地将L-氨基酸及其衍生物转化成相应的α-酮酸。 固定的细胞有利地用于该转化，其也可用于溶解外消旋体。
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9.发明授权Calcium salts of lipopeptide antibiotics, method for producing same and their use 有权脂肽抗生素的钙盐，其制备方法及其用途公开(公告)号：US06624143B1
公开(公告)日：2003-09-23
申请号：US09623022
申请日：2000-08-25
申请人： Laszló Vértesy , Werner Aretz , Heinrich Decker , Eberhard Ehlers , Michael Kurz , Frank Rainer Schmidt
发明人： Laszló Vértesy , Werner Aretz , Heinrich Decker , Eberhard Ehlers , Michael Kurz , Frank Rainer Schmidt
IPC分类号： A61K3800
摘要： The invention relates to a calcium salt of the compound of formula (II), where R1 is a straight-chain or branched, saturated or unsaturated aliphatic acyl radical having 8 to 22 carbon atoms, which can optionally be interrupted by or linked to one or more phenyl or cycloalkyl groups and optionally interrupted by oxygen. The invention also relates to a method for producing said calcium salt and to its use as a medicine.
摘要翻译： 本发明涉及式（II）化合物的钙盐，其中R 1是具有8至22个碳原子的直链或支链，饱和或不饱和的脂族酰基，其可任选地被一个或多个 更多的苯基或环烷基并且任选被氧中断。 本发明还涉及一种生产所述钙盐和用作药物的方法。
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10.发明授权Process for using the yeast ADH II promoter system for the production of heterologous proteins in high yields 失效使用酵母ADH II启动子系统以高产量生产异源蛋白质的方法
公开(公告)号：US5866371A
公开(公告)日：1999-02-02
申请号：US757439
申请日：1996-11-27
申请人： Werner Badziong , Paul Habermann , Joerg Moeller , Werner Aretz
发明人： Werner Badziong , Paul Habermann , Joerg Moeller , Werner Aretz
IPC分类号： C12N15/09 , C07K14/575 , C07K14/62 , C07K14/815 , C07K19/00 , C12N15/81 , C12P21/00 , C12P21/02 , C12R1/645 , C12N1/19
CPC分类号： C12N15/81 , C07K14/5759 , C07K14/62 , C07K14/815 , C12P21/02 , C07K2319/00
摘要： The invention relates to a novel process for using the yeast ADH II promoter system for the production of heterologous proteins in high yields, for example for preparing hirudins, miniproinsulins, leptins or derivatives thereof.
摘要翻译： 本发明涉及一种使用酵母ADH II启动子系统以高产量产生异源蛋白质的新方法，例如用于制备水蛭素，小檗碱，瘦素或其衍生物。
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