公开(公告)号：US11833327B2

公开(公告)日：2023-12-05

申请号：US16812142

申请日：2020-03-06

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Erik Montero ,  David C. Antonio ,  Eric Allan Larson ,  Meng Dai Yu ,  Samuel Finney ,  Hans K. Wenstad ,  David M. Aguirre ,  Andrew P. Lynch ,  Andrea Varsavsky ,  Ali Dianaty

IPC: A61M5/172

CPC classification number: A61M5/1723 ,  A61M2205/3303 ,  A61M2205/702

Abstract: A method of automatically initializing an analyte sensor for a user is disclosed here. A first analyte sensor is operated in a first measurement mode to generate first sensor signals indicative of an analyte level of the user. A second analyte sensor is deployed to measure the analyte level of the user, and is operated in an initialization mode, concurrently with operation of the first analyte sensor in the first measurement mode, to receive sensor configuration data generated by the first analyte sensor. During operation of the second analyte sensor in the initialization mode, the second analyte sensor is calibrated with at least some of the received sensor configuration data. After the calibrating, operation of the second analyte sensor is transitioned from the initialization mode to a second measurement mode during which the second analyte sensor generates second sensor signals indicative of the analyte level of the user.

公开(公告)号：US20230352186A1

公开(公告)日：2023-11-02

申请号：US18344471

申请日：2023-06-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Elaine Gee ,  Peter Ajemba ,  Bahman Engheta ,  Jeffrey Nishida ,  Andrea Varsavsky ,  Keith G. Nogueira

IPC: G16H40/67 ,  A61B5/00 ,  G16H20/17 ,  G16H50/70 ,  G06N3/045 ,  G16H50/50 ,  G16H10/60 ,  A61B5/145 ,  G06F18/214 ,  G06N3/0475 ,  G06N3/088 ,  G16H40/40 ,  G16H50/30 ,  G16H50/20 ,  G16H70/60

CPC classification number: G16H50/50 ,  A61B5/0022 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/7253 ,  A61B5/7267 ,  A61B5/7275 ,  G06F18/214 ,  G06N3/045 ,  G06N3/0475 ,  G06N3/088 ,  G16H10/60 ,  G16H20/17 ,  G16H40/40 ,  G16H40/67 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70 ,  G16H70/60 ,  A61M5/1723

Abstract: Techniques for sensor calibration involve determining a generative model using sensor measurements from different instances of a first glucose sensor together with corresponding reference glucose values. The generative model is configured to generate a simulated measurement representing a predicted output of the first glucose sensor under specific operating conditions. A set of simulated measurements is generated using operating conditions observed with respect to a second glucose sensor as inputs to the generative model. The second glucose sensor is a sensor of a different design. The operating conditions observed with respect to the second glucose sensor include reference glucose values obtained in connection with measurements made using the second glucose sensor. The simulated measurements are then used to determine an estimation model for the first glucose sensor. The estimation model is configured to estimate glucose level given one or more sensor measurements from the first glucose sensor.

公开(公告)号：US11766195B2

公开(公告)日：2023-09-26

申请号：US17175146

申请日：2021-02-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/1468 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/14503 ,  A61B5/14556 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20230260664A1

公开(公告)日：2023-08-17

申请号：US18305806

申请日：2023-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Elaine Gee ,  Peter Ajemba ,  Bahman Engheta ,  Jeffrey Nishida ,  Andrea Varsavsky ,  Keith G. Nogueira

IPC: G16H50/50 ,  G16H40/40 ,  G16H50/30 ,  G16H50/20 ,  G16H40/67 ,  G16H10/60 ,  A61B5/00 ,  A61B5/145 ,  G16H20/17 ,  G06F18/214 ,  G06N3/0475 ,  G16H50/70

CPC classification number: G16H50/50 ,  G16H40/40 ,  G16H50/30 ,  G16H50/20 ,  G16H40/67 ,  G16H10/60 ,  A61B5/7275 ,  A61B5/14532 ,  A61B5/0022 ,  G16H20/17 ,  A61B5/1451 ,  A61B5/7267 ,  A61B5/7253 ,  G06F18/214 ,  G06N3/0475 ,  G16H50/70 ,  A61M5/1723

Abstract: Disclosed are methods and corresponding systems and devices for providing an estimation model for use with one or more instances of a particular sensor. In some aspects, an estimation model usable for estimating a value of a physiological condition is determined based at least in part on simulated measurements. The simulated measurements are generated for a first sensor, through applying a translation model to convert historical measurements associated with a second sensor into measurements that would have been produced by the first sensor. The second sensor has a different design or configuration than the first sensor. The historical measurements represent changes in the physiological condition as observed by different instances of the second sensor. The estimation model can be made available to one or more electronic devices, including at least one device configured to apply the estimation model to a measurement from a corresponding instance of the first sensor.

公开(公告)号：US11103164B2

公开(公告)日：2021-08-31

申请号：US16266385

申请日：2019-02-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US10945630B2

公开(公告)日：2021-03-16

申请号：US14466160

申请日：2014-08-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Fei Yu ,  Ning Yang

IPC: A61B5/053 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/00 ,  A61M5/158 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/1486 ,  G01N27/02 ,  A61M5/172 ,  A61M5/142 ,  A61B5/0537 ,  A61B5/0538

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

公开(公告)号：US20200000381A1

公开(公告)日：2020-01-02

申请号：US16023943

申请日：2018-06-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Yunfeng Lu ,  Andrea Varsavsky

IPC: A61B5/1495 ,  A61B5/1486 ,  A61B5/145 ,  A61B90/00

Abstract: Vset-based systems and methods for performing sensor health diagnostics are disclosed. Methods and systems for in-body glucose sensor health diagnostics may use steady-state Isig characterization under full-range operating Vsets, transient Isig response characterization after Vset alternations, transient Vset characterization, and open circuit potential measurements for estimating sensor health and for monitoring sensor properties.

公开(公告)号：US20190274604A1

公开(公告)日：2019-09-12

申请号：US16426750

申请日：2019-05-30

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Yunfeng Lu ,  Jay Mung

IPC: A61B5/145 ,  A61B5/053 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/1486

Abstract: A single, optimal, fused sensor glucose value may be calculated based on respective sensor glucose values of a plurality of redundant working electrodes (WEs) of a glucose sensor. Respective electrochemical impedance spectroscopy (EIS) procedures may be performed for each of the WEs to obtain values of membrane resistance (Rmem) for each WE. A noise value and a calibration factor (CF) value may be calculated for each WE, and respective fusion weights may be calculated for Rmem, noise, and CF for each WE. An overall fusion weight may then be calculated based on the WE's Rmem fusion weight, noise fusion weight, and CF fusion weight, such that a single, optimal, fused sensor glucose value may be calculated based on the respective overall fusion weight and sensor glucose value of each of the plurality of redundant working electrodes.

公开(公告)号：US20190175079A1

公开(公告)日：2019-06-13

申请号：US15840515

申请日：2017-12-13

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jeffrey Nishida ,  Andrea Varsavsky ,  Taly G. Engel ,  Keith Nogueira ,  Andy Y. Tsai ,  Peter Ajemba

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00

Abstract: A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.

公开(公告)号：US20180184951A1

公开(公告)日：2018-07-05

申请号：US15903332

申请日：2018-02-23

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1495 ,  G01N33/66 ,  A61B5/145 ,  G01N27/416 ,  G01N21/00 ,  G01N33/49 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/172 ,  A61M5/142

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.