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公开(公告)号：US20050070466A1
公开(公告)日：2005-03-31
申请号：US10753729
申请日：2004-01-08
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Archer , Harry Wadsworth
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Archer , Harry Wadsworth
IPC分类号： A61K38/00 , A61K47/65 , A61K49/00 , A61K49/04 , A61K51/00 , A61K51/08 , A61P1/02 , A61P1/04 , A61P9/00 , A61P9/08 , A61P9/10 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K7/00 , C07K7/06 , C07K14/745 , A61K38/12 , C07K7/64
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译： 本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。
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公开(公告)号：US20050002865A1
公开(公告)日：2005-01-06
申请号：US10734730
申请日：2003-12-15
申请人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08 , A61K51/12
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译： 靶向诊断和/或治疗活性剂，例如 超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。
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33.发明授权Targeted diagnostic/therapeutic agents having more than one different vectors 失效具有多于一种不同载体的靶向诊断/治疗剂公开(公告)号：US06331289B1
公开(公告)日：2001-12-18
申请号：US08959206
申请日：1997-10-28
申请人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Lars Hoff , Klaus Bryn , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Lars Hoff , Klaus Bryn , Halldis Hellebust , Magne Solbakken
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译： 靶向诊断和/或治疗活性剂，例如 超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。
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34.发明授权Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors 失效具有偶联至一种或多种载体的微泡的诊断/治疗剂公开(公告)号：US06261537B1
公开(公告)日：2001-07-17
申请号：US08960054
申请日：1997-10-29
申请人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Anne Nævestad , Halldis Hellebust , Lars Hoff , Alan Cuthbertson , Dagfinn Løvhaug , Magne Solbakken
发明人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Anne Nævestad , Halldis Hellebust , Lars Hoff , Alan Cuthbertson , Dagfinn Løvhaug , Magne Solbakken
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/088 , A61K51/1227 , Y10S977/928
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.
摘要翻译： 靶向诊断和/或治疗活性剂，例如 超声造影剂，具有包含通过成膜表面活性剂的单层稳定的充气微泡的记者，所述报告基团与至少一个载体偶联或连接。
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公开(公告)号：US20110286922A1
公开(公告)日：2011-11-24
申请号：US13124703
申请日：2009-10-20
IPC分类号： A61K51/04 , C07C223/02 , C07C47/55 , C07C235/84 , C07C47/575 , C07C311/39 , C07D217/26 , C07D215/48 , C07D215/42 , C07D215/36 , C07F5/02 , C07D209/12 , C07D209/42 , A61P35/00 , A61K49/00
CPC分类号： A61K51/04 , A61K51/0446 , A61K51/0455 , A61K51/0478 , A61K51/0482
摘要： The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of tumours and treatment of cancer.
摘要翻译： 本发明涉及靶向酶醛脱氢酶（ALDH）并适用于体内成像肿瘤和治疗癌症的体内成像和放射治疗方法和试剂。
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公开(公告)号：US08563600B2
公开(公告)日：2013-10-22
申请号：US13010814
申请日：2011-01-21
IPC分类号： A61K51/08
CPC分类号： A61K51/088
摘要： The Invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
摘要翻译： 本发明涉及式（III）或（IIIa）的缀合物或其盐，它们作为放射性药物的用途，其制备方法以及在这些方法中使用的合成中间体。
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公开(公告)号：US20120020882A1
公开(公告)日：2012-01-26
申请号：US13204935
申请日：2011-08-08
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译： 本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。
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公开(公告)号：US07811551B2
公开(公告)日：2010-10-12
申请号：US12141123
申请日：2008-06-18
申请人： Alan Cuthbertson , Magne Solbakken
发明人： Alan Cuthbertson , Magne Solbakken
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425
摘要： The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma.
摘要翻译： 本发明涉及式（I）化合物及其作为靶向载体的用途，所述靶向载体与血管发生相关的受体结合。 因此，这样的化合物可用于诊断或治疗例如恶性疾病，心脏病，子宫内膜异位，炎症相关疾病，类风湿性关节炎和卡波西肉瘤。
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公开(公告)号：US20080267881A1
公开(公告)日：2008-10-30
申请号：US12141123
申请日：2008-06-18
申请人： Alan Cuthbertson , Magne Solbakken
发明人： Alan Cuthbertson , Magne Solbakken
IPC分类号： A61K49/04
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425
摘要： The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma.
摘要翻译： 本发明涉及式（I）化合物及其作为靶向载体的用途，所述靶向载体与血管发生相关的受体结合。 因此，这样的化合物可用于诊断或治疗例如恶性疾病，心脏病，子宫内膜异位，炎症相关疾病，类风湿性关节炎和卡波西肉瘤。
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公开(公告)号：US20070036722A1
公开(公告)日：2007-02-15
申请号：US11498651
申请日：2006-08-03
申请人： Pal Rongved , Dagfinn Loevhaug , Hege Fjerdingstad , Magne Solbakken , Aslak Godal , Alan Cuthbertson
发明人： Pal Rongved , Dagfinn Loevhaug , Hege Fjerdingstad , Magne Solbakken , Aslak Godal , Alan Cuthbertson
IPC分类号： A61K49/00 , C12Q1/70 , C12Q1/68 , G01N33/574 , A61K39/395 , A61K39/42 , A61M31/00
CPC分类号： G01N33/5306 , G01N33/5432
摘要： Separation of target material from a liquid sample is achieved by coupling the target to targetable encapsulated gas microbubbles, allowing the microbubbles and coupled target to float to the surface of the sample to form a floating microbubble/target layer, and separating this layer from the sample. In a positive separation process the microbubbles are then removed from the target, e.g. by bursting. In a negative separation process target-free sample material is recovered following separation of the floating layer. The method may also be used diagnostically to detect the presence of a disease marker in a sample. Novel separation apparatus is also described.
摘要翻译： 目标材料与液体样品的分离是通过将目标物与可靶向包封的气体微泡耦合来实现的，允许微泡和偶联的目标物漂浮到样品表面以形成浮动微泡/目标层，并将该层与样品分离 。 在正分离过程中，然后从目标物中除去微泡。 通过爆裂。 在负分离过程中，在浮选层分离后回收无目标样品材料。 该方法也可以在诊断上用于检测样品中疾病标志物的存在。 还描述了新颖的分离装置。
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