公开(公告)号：US20120191063A1

公开(公告)日：2012-07-26

申请号：US13436357

申请日：2012-03-30

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M5/168

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US07896809B2

公开(公告)日：2011-03-01

申请号：US12264160

申请日：2008-11-03

申请人： Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode ,  Apurv Ullas Kamath ,  James R. Petisce ,  Kum Ming Woo ,  Melissa A. Nicholas ,  Robert J. Boock ,  Monica A. Rixman ,  John Burd ,  Rathburn K. Rhodes ,  Mark A. Tapsak

发明人： Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode ,  Apurv Ullas Kamath ,  James R. Petisce ,  Kum Ming Woo ,  Melissa A. Nicholas ,  Robert J. Boock ,  Monica A. Rixman ,  John Burd ,  Rathburn K. Rhodes ,  Mark A. Tapsak

IPC分类号： A61B5/05

CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/14865 ,  B33Y70/00

摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.

摘要翻译： 本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干涉域。

公开(公告)号：US07693560B2

公开(公告)日：2010-04-06

申请号：US11692154

申请日：2007-03-27

申请人： Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode ,  Apurv U. Kamath ,  James R. Petisce ,  Kum Ming Woo ,  Melissa A. Nicholas ,  Robert J. Boock ,  Monica A. Rixman ,  John Burd ,  Rathburn K. Rhodes ,  Mark A. Tapsak

发明人： Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode ,  Apurv U. Kamath ,  James R. Petisce ,  Kum Ming Woo ,  Melissa A. Nicholas ,  Robert J. Boock ,  Monica A. Rixman ,  John Burd ,  Rathburn K. Rhodes ,  Mark A. Tapsak

IPC分类号： A61B5/00

摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.

公开(公告)号：US20090062633A1

公开(公告)日：2009-03-05

申请号：US12264835

申请日：2008-11-04

申请人： James H. Brauker ,  Mark A. Tapsak ,  Mark Shults ,  Victoria Carr-Brendel ,  Jack C. Fisher ,  William J. Seare, JR. ,  Paul V. Neale

发明人： James H. Brauker ,  Mark A. Tapsak ,  Mark Shults ,  Victoria Carr-Brendel ,  Jack C. Fisher ,  William J. Seare, JR. ,  Paul V. Neale

IPC分类号： A61B5/1473

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/6882

摘要： An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.

公开(公告)号：US07365134B2

公开(公告)日：2008-04-29

申请号：US11133627

申请日：2005-05-20

申请人： Michael Eric Benz ,  Christopher M. Hobot ,  David L. Miller ,  David A. Pearson ,  Mark A. Tapsak ,  Edward DiDomenico ,  Randall V. Sparer

发明人： Michael Eric Benz ,  Christopher M. Hobot ,  David L. Miller ,  David A. Pearson ,  Mark A. Tapsak ,  Edward DiDomenico ,  Randall V. Sparer

IPC分类号： C08L83/05

CPC分类号： C08G77/50 ,  A61L27/18 ,  C08G18/61 ,  C08L83/04 ,  C08L75/04

摘要： Compounds that include silicon-containing groups, and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.

摘要翻译： 包括含硅基团和任选的氨基甲酸酯基团，脲基团或其组合（即聚氨酯，聚脲或聚氨酯 - 脲）的化合物以及用于制备这些化合物的材料和方法。

公开(公告)号：US06879861B2

公开(公告)日：2005-04-12

申请号：US09745619

申请日：2000-12-21

申请人： Michael E. Benz ,  Mark A. Tapsak ,  Angela Pratt ,  Randall V. Sparer

发明人： Michael E. Benz ,  Mark A. Tapsak ,  Angela Pratt ,  Randall V. Sparer

IPC分类号： C08K5/54 ,  C08K5/5419 ,  H01B3/00 ,  H01B3/18 ,  H01B3/30 ,  H01B3/44 ,  H01B7/00 ,  A61N1/00

CPC分类号： H01B3/441 ,  C08K5/5419

摘要： A novel polymeric electrically insulating material that includes a linked voltage stabilizing agent. Also provided are methods of making the novel material and articles and devices that incorporate the novel material, particularly implantable medical devices.

摘要翻译： 一种新型聚合物电绝缘材料，其包括连接的电压稳定剂。 还提供了制造新颖材料和结合新材料的物品和装置的方法，特别是可植入的医疗装置。

公开(公告)号：US6080829A

公开(公告)日：2000-06-27

申请号：US103879

申请日：1998-06-24

申请人： Mark A. Tapsak ,  Edward Di Domenico

发明人： Mark A. Tapsak ,  Edward Di Domenico

IPC分类号： C08G77/48 ,  C08G77/50 ,  C08L83/07 ,  C08L83/14

CPC分类号： C08G77/50 ,  C08G77/485 ,  C08L83/14

摘要： Symmetric and asymmetric cyclic silalkylenesiloxane monomers and copolymers thereof are disclosed, as well as crosslinked and/or reinforced silalkylenesiloxane copolymers, medical devices containing such materials, and methods of preparation.

摘要翻译： 公开了对称和不对称的环状硅烷基二硅氧烷单体及其共聚物，以及交联和/或增强的硅烷基二硅氧烷共聚物，含有这些材料的医疗装置和制备方法。

公开(公告)号：US09155843B2

公开(公告)日：2015-10-13

申请号：US13559454

申请日：2012-07-26

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M31/00 ,  A61M1/00 ,  A61M5/315 ,  A61B5/00 ,  A61B5/145 ,  G06F19/00 ,  A61M5/172 ,  A61B5/1486

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US20120186581A1

公开(公告)日：2012-07-26

申请号：US13436257

申请日：2012-03-30

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M5/168 ,  A61M15/00 ,  A61M11/00 ,  A61M35/00

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US20110275919A1

公开(公告)日：2011-11-10

申请号：US13187277

申请日：2011-07-20

申请人： James Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel

发明人： James Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel

IPC分类号： A61B5/1468

CPC分类号： A61B5/1473 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/14735 ,  A61B5/14865

摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

摘要翻译： 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。