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公开(公告)号：US20080268502A1
公开(公告)日：2008-10-30
申请号：US12048599
申请日：2008-03-14
IPC分类号： C12P21/04 , C12N15/11 , C12N15/00 , C12P19/34 , C12P7/64 , C12N15/74 , C12P13/04 , C12N1/20 , C12P1/00
摘要： The present invention relates to multiple promoters and to expression units comprising them; to the use thereof for regulating transcription and expression of genes; to expression cassettes which comprise multiple promoters or expression units of this kind; to vectors which comprise such expression cassettes; to genetically modified microorganisms which comprise vectors and/or expression units of this kind; and to processes for preparing biosynthetic products by culturing said genetically modified microorganisms.
摘要翻译： 本发明涉及多种启动子和包含它们的表达单元; 用于调节基因的转录和表达; 包括多种启动子或这种表达单位的表达盒; 包含这种表达盒的载体; 涉及包含这种载体和/或表达单元的转基因微生物; 以及通过培养所述转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20080176295A1
公开(公告)日：2008-07-24
申请号：US12050146
申请日：2008-03-17
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US08044191B2
公开(公告)日：2011-10-25
申请号：US12038603
申请日：2008-02-27
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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34.发明申请Production Process for Methionine Using Microorganisms with Reduced Isocitrate Dehydrogenase Activity 审中-公开使用具有降低的异柠檬酸脱氢酶活性的微生物生产甲硫氨酸的方法公开(公告)号：US20110117614A1
公开(公告)日：2011-05-19
申请号：US12989772
申请日：2009-04-27
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of methionine.
摘要翻译： 本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物来生产甲硫氨酸的方法。
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公开(公告)号：US20090191610A1
公开(公告)日：2009-07-30
申请号：US11989369
申请日：2006-08-18
申请人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
发明人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
摘要： The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
摘要翻译： 本发明涉及用于生产具有增加甲硫氨酸合成效率的微生物的方法，提高甲硫氨酸合成效率的微生物以及确定生物相对于甲硫氨酸合成的最佳代谢通量的方法。
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公开(公告)号：US08071365B2
公开(公告)日：2011-12-06
申请号：US12030575
申请日：2008-02-13
CPC分类号： C12N15/77
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20080286841A1
公开(公告)日：2008-11-20
申请号：US12038642
申请日：2008-02-27
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20080118948A1
公开(公告)日：2008-05-22
申请号：US10582918
申请日：2004-12-15
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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39.发明授权Bacterial cells exhibiting formate dehydrogenase activity for the manufacture of succinic acid 有权表现出甲酸脱氢酶活性的细菌细胞用于制备琥珀酸公开(公告)号：US08883466B2
公开(公告)日：2014-11-11
申请号：US12643058
申请日：2009-12-21
IPC分类号： C12P7/46 , C12N1/20 , C12P21/06 , C12P19/34 , C07H21/04 , C07K1/00 , C12N9/02 , C12N9/04 , C12N9/10
CPC分类号： C12N9/0006 , C12N9/0008 , C12N9/1029 , C12P7/46 , C12Y101/02003 , C12Y102/01002 , C12Y203/01054
摘要： The present invention relates to a bacterial cell of the genus Pasteurella comprising a heterologous polypeptide having formate dehydrogenase activity. The present invention also relates to a method of manufacturing succinic acid and the use of the bacterial cell for the manufacture of succinic acid.
摘要翻译： 本发明涉及巴斯德氏菌属的细菌细胞，其包含具有甲酸脱氢酶活性的异源多肽。 本发明还涉及制备琥珀酸的方法以及细菌细胞在制备琥珀酸中的用途。
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40.发明授权Bacterial cells having a glyoxylate shunt for the manufacture of succinic acid 有权具有用于制备琥珀酸的乙醛酸分流的细菌细胞公开(公告)号：US08877466B2
公开(公告)日：2014-11-04
申请号：US12644059
申请日：2009-12-22
IPC分类号： C12P7/46 , C12N1/20 , C12P21/06 , C12P19/34 , C12N15/00 , C07H21/04 , C12N9/88 , C12N9/10 , C12N9/02
CPC分类号： C12N9/88 , C12N9/0008 , C12N9/1025 , C12P7/46
摘要： The present invention is concerned with bacteria for the production of succinic acid. Specifically, the invention relates to a bacterial cell of the genus Pasteurella comprising a heterologous polypeptide having isocitrate lyase activity and a heterologous polypeptide having malate synthase activity. Further, the present invention contemplates a polynucleotide comprising a nucleic acid encoding a polypeptide having isocitrate lyase activity and a nucleic acid encoding a polypeptide having malate synthase activity. Finally, the present invention relates to the use of a bacterial cell of the invention for the manufacture of succinic acid.
摘要翻译： 本发明涉及生产琥珀酸的细菌。 具体地，本发明涉及巴斯德氏菌属细菌细胞，其包含异柠檬酸裂解酶活性的异源多肽和具有苹果酸合酶活性的异源多肽。 此外，本发明涉及包含编码具有异柠檬酸裂解酶活性的多肽的核酸和编码具有苹果酸合酶活性的多肽的核酸的多核苷酸。 最后，本发明涉及本发明的细菌细胞用于制备琥珀酸的用途。
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