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公开(公告)号：US08058038B2
公开(公告)日：2011-11-15
申请号：US11960116
申请日：2007-12-19
摘要： 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxalacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.
摘要翻译： 可用作合成莫纳甜的中间体的4-（吲哚-3-基甲基）-4-羟基-2-氧戊二酸，可以由吲哚丙酮酸和丙酮酸（和/或草乙酸）通过使用 衍生自假单胞菌属，欧文氏菌属，黄杆菌属或黄单胞菌属的新型醛缩酶。
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公开(公告)号：US20080199921A1
公开(公告)日：2008-08-21
申请号：US12108889
申请日：2008-04-24
申请人： Masakazu Sugiyama , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
发明人： Masakazu Sugiyama , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
IPC分类号： C12P17/10
摘要： The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.
摘要翻译： 本发明涉及通过在式（2）的存在下将式（1）的取代的α-酮酸转化为式（2）的谷氨酸衍生物而有效地生产谷氨酸衍生物（包括其盐）的莫纳甜的方法 催化其转化。
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公开(公告)号：US20070072277A1
公开(公告)日：2007-03-29
申请号：US11561665
申请日：2006-11-20
申请人： Masakazu Sugiyama , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
发明人： Masakazu Sugiyama , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
摘要： The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.
摘要翻译： 本发明涉及通过在式（2）的存在下将式（1）的取代的α-酮酸转化为式（2）的谷氨酸衍生物而有效地生产谷氨酸衍生物（包括其盐）的莫纳甜的方法 催化其转化。
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公开(公告)号：US20060188976A1
公开(公告)日：2006-08-24
申请号：US11311467
申请日：2005-12-20
申请人： Rie Takeshita , Isao Abe , Masakazu Sugiyama , Kenzo Yokozeki , Seiichi Hara , Sonoko Suzuki , Shunichi Suzuki , Kunihiko Watanabe
发明人： Rie Takeshita , Isao Abe , Masakazu Sugiyama , Kenzo Yokozeki , Seiichi Hara , Sonoko Suzuki , Shunichi Suzuki , Kunihiko Watanabe
CPC分类号： C07K14/00 , C07K14/195 , C12N9/93
摘要： The present invention is to provide an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. A peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II): (I) The mutant protein having the amino acid sequence containing one or more mutations of the above mutations 1 to 38 in the amino acid sequence described in SEQ ID NO:2; and (II) The mutant protein having the amino acid sequence containing one or more mutations selected from the group consisting of substitution, deletion, insertion, addition and inversion at positions other than one or more mutation positions of the above mutation 1 to 38 in the mutant protein described in the above (I), and having a peptide-synthesizing activity.
摘要翻译： 本发明提供优异的肽合成蛋白质和有效生产肽的方法。 在下列（I）和（II）所示的至少一种蛋白质的存在下，使胺组分和羧基组分反应合成肽：（I）具有含有一个或多个突变的氨基酸序列的突变蛋白 在SEQ ID NO：2中描述的氨基酸序列中的上述突变1至38; 和（II）具有在上述变异株1〜38中的一个以上突变位置以外的位置上具有选自取代，缺失，插入，添加和倒位的一个或多个突变的氨基酸序列的突变蛋白质 上述（I）所述的突变型蛋白质，具有肽合成活性。
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35.发明申请公开(公告)号：US20120062213A1
公开(公告)日：2012-03-15
申请号：US13071555
申请日：2011-03-25
CPC分类号： G11B9/1418 , G01R1/06788 , G01R11/04 , G01R19/155 , Y10T29/49155
摘要： According to one embodiment, a microprobe includes a supporting base, an insulating layer, and an electrode layer arrayed in a first direction in this order. A principal surface of the microprobe is formed in a second direction different from the first direction. A step is formed on at least the electrode layer on the principal surface, and the electrode layer is partitioned into a first area and a second area by the step.
摘要翻译： 根据一个实施例，微探针包括依次排列在第一方向上的支撑基底，绝缘层和电极层。 微探针的主表面形成在与第一方向不同的第二方向上。 至少在主表面上的电极层上形成台阶，电极层通过台阶分割成第一区域和第二区域。
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36.发明申请SEMICONDUCTOR DEVICE, PROCESS FOR PRODUCING SEMICONDUCTOR DEVICE, SEMICONDUCTOR SUBSTRATE, AND PROCESS FOR PRODUCING SEMICONDUCTOR SUBSTRATE 审中-公开半导体器件，用于制造半导体器件的工艺，半导体衬底和用于生产半导体衬底的工艺公开(公告)号：US20110233689A1
公开(公告)日：2011-09-29
申请号：US13133092
申请日：2009-11-27
申请人： Masahiko Hata , Noboru Fukuhara , Hisashi Yamada , Shinichi Takagi , Masakazu Sugiyama , Mitsuru Takenaka , Tetsuji Yasuda , Noriyuki Miyata , Taro Itatani , Hiroyuki Ishii , Akihiro Ohtake , Jun Nara
发明人： Masahiko Hata , Noboru Fukuhara , Hisashi Yamada , Shinichi Takagi , Masakazu Sugiyama , Mitsuru Takenaka , Tetsuji Yasuda , Noriyuki Miyata , Taro Itatani , Hiroyuki Ishii , Akihiro Ohtake , Jun Nara
IPC分类号： H01L29/78 , H01L29/04 , H01L21/336 , H01L29/20 , H01L21/20
CPC分类号： H01L29/045 , H01L29/20 , H01L29/7833 , H01L29/78681
摘要： There is provided a semiconductor device that includes a III-V Group compound semiconductor having a zinc-blende-type crystal structure, an insulating material being in contact with the (111) plane of the III-V Group compound semiconductor, a plane of the III-V Group compound semiconductor equivalent to the (111) plane, or a plane that has an off angle with respect to the (111) plane or the plane equivalent to the (111) plane, and an MIS-type electrode being in contact with the insulating material and including a metal conductive material.
摘要翻译： 提供了一种半导体器件，其包括具有锌闪光体型晶体结构的III-V族化合物半导体，与III-V族化合物半导体的（111）面接触的绝缘材料， 相当于（111）面的III-V族化合物半导体，或相对于（111）面或与（111）面相当的面的偏角的平面，和与MIS接触的MIS型电极 具有绝缘材料并且包括金属导电材料。
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公开(公告)号：USD563506S1
公开(公告)日：2008-03-04
申请号：US29272441
申请日：2007-02-07
申请人： Hisataka Kato , Masakazu Sugiyama
设计人： Hisataka Kato , Masakazu Sugiyama
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公开(公告)号：US06924131B2
公开(公告)日：2005-08-02
申请号：US10307385
申请日：2002-12-02
IPC分类号： C12N9/02 , C12N1/21 , C12N9/04 , C12N15/53 , C12P7/18 , C07H21/04 , C12N1/20 , C12N15/00 , C12Q1/68
CPC分类号： C12N9/0006 , C12P7/18
摘要： Xylitol is produced by allowing xylitol dehydrogenase or cells instoduced with a DNA coding for xylitol dehydrogenase, which is a protein of the following (A) or (B) to act on D-xylulose, and collecting produced xylitol: (A) a protein which has the amino acid sequence of SEQ ID NO: 4; (B) a protein which has the amino acid sequence of SEQ ID NO: 4 including substitution, deletion, insertion, addition, or inversion of one or several amino acids, and has xylitol dehydrogenase activity.
摘要翻译： 通过使木糖醇脱氢酶或用编码木糖醇脱氢酶的DNA（其是以下（A）或（B）的蛋白质）作用于D-木酮糖并收集产生的木糖醇的DNA产生木糖醇：（A） 具有SEQ ID NO：4的氨基酸序列; （B）具有SEQ ID NO：4的氨基酸序列的蛋白质，包括一个或几个氨基酸的取代，缺失，插入，添加或倒置，并具有木糖醇脱氢酶活性。
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公开(公告)号：US06340582B1
公开(公告)日：2002-01-22
申请号：US09509543
申请日：2000-04-11
IPC分类号： C12P718
CPC分类号： C12P7/18 , Y10S435/822 , Y10S435/823
摘要： A method for producing xylitol by allowing a microorganism belonging to the Gluconobacter oxydans or Acetobacter xylinum and having a D-arabitol dehydrogenase activity and a D-xylulose reductase (xylitol dehydrogenase) activity and an ability to convert D-arabitol to xylitol is acted on D-arabitol in a reaction mixture containing a carbon source to produce xylitol.
摘要翻译： 通过使属于氧化葡糖杆菌或木醋杆菌的具有D-阿拉伯糖脱氢酶活性和D-木酮糖还原酶（木糖醇脱氢酶）活性和将D-阿拉伯糖醇转化为木糖醇的能力的微生物生产木糖醇的方法作用于D - 阿糖醇在含有碳源的反应混合物中以产生木糖醇。
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公开(公告)号：USD287734S
公开(公告)日：1987-01-13
申请号：US654758
申请日：1984-09-25
申请人： Yoshihisa Ooie , Masakazu Sugiyama
设计人： Yoshihisa Ooie , Masakazu Sugiyama
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