公开(公告)号：US06733987B2

公开(公告)日：2004-05-11

申请号：US10045539

申请日：2001-10-26

申请人： Masashi Ogawa ,  Masatoshi Takahashi ,  Kazuko Hanai ,  Hiroshi Arakatsu

发明人： Masashi Ogawa ,  Masatoshi Takahashi ,  Kazuko Hanai ,  Hiroshi Arakatsu

IPC分类号： G01N144

CPC分类号： G01N1/2813 ,  G01N2001/284

摘要： An object of the present invention is to provide a method which comprises adhering a biological sample to a film, cutting out a target area of the sample, and then peeling off the film to collect the fragment which was cut out, wherein the operability is good and a cutting sharpness in cutting by a laser beam is good. The present invention provides a method for cutting a biological sample by light irradiation, which comprises locating the biological sample and a colored film having a thickness of 3 to 6 &mgr;m onto one side of a support, and irradiating the biological sample with a light beam, thereby cutting out a target area of the biological sample.

摘要翻译： 本发明的目的是提供一种方法，其包括将生物样品粘附到膜上，切割样品的目标区域，然后剥离膜以收集被切出的片段，其中可操作性良好 并且通过激光束切割的切割锐度是好的。 本发明提供一种通过光照射切割生物样品的方法，其包括将生物样品和厚度为3至6μm的着色膜定位在载体的一侧上，并用光束照射生物样品， 从而切除生物样品的目标区域。

公开(公告)号：US06589754B1

公开(公告)日：2003-07-08

申请号：US08946685

申请日：1997-10-08

申请人： Toshikage Hiraoka ,  Tetsuji Tanimoto ,  Yoshihiko Makino ,  Tadashi Ninomiya ,  Hiroshi Shinoki ,  Yoshihiro Ashihara ,  Naofumi Hora ,  Masashi Ogawa

发明人： Toshikage Hiraoka ,  Tetsuji Tanimoto ,  Yoshihiko Makino ,  Tadashi Ninomiya ,  Hiroshi Shinoki ,  Yoshihiro Ashihara ,  Naofumi Hora ,  Masashi Ogawa

IPC分类号： G01N3353

CPC分类号： G01N33/54386

摘要： An immunoassay element for quantitatively analyzing a macromolecular antigen by determining the change in enzymatic activity caused by a reaction between the macromolecular polymer antigen and an enzyme-labelled antibody. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. Also provided is a process for quantitatively analyzing a macromolecular antigen in a sample by the use of the immunoassay element.

摘要翻译： 一种用于通过测定由高分子聚合物抗原和酶标记的抗体之间的反应引起的酶活性的变化来定量分析大分子抗原的免疫测定元件。 免疫测定元件包括含有在酶存在下形成可扩散材料的不扩散基底的基底层和含有用于进一步将可扩散材料分解成较低分子量产物的碎裂酶的试剂层。 还提供了通过使用免疫测定元件定量分析样品中的大分子抗原的方法。

公开(公告)号：US06506567B2

公开(公告)日：2003-01-14

申请号：US09774895

申请日：2001-01-31

申请人： Yoshihiko Makino ,  Masashi Ogawa ,  Makoto Takagi ,  Shigeori Takenaka

发明人： Yoshihiko Makino ,  Masashi Ogawa ,  Makoto Takagi ,  Shigeori Takenaka

IPC分类号： C12Q168

CPC分类号： C07D471/06 ,  C12Q1/6816 ,  Y10T436/143333 ,  C12Q2563/173

摘要： A water-soluble fluorescent intercalator compound having the formula: F—La—X F is a fluorescent moiety, X is a divalent cyclic group, and La is a linking group, and at least one of X and La has a site imparting water solubility to the compound or a site that is convertible into a site imparting water solubility to the compound is favorably employable as a fluorescent intercalator in a method for fluorometrically detecting complementary DNA fragments.

摘要翻译： 具有式：F的水溶性荧光嵌入剂化合物是荧光部分，X是二价环状基团，La是连接基团，X和La中的至少一个具有赋予化合物水溶性的部位或 可以转化为赋予化合物水溶性的部位的部位在荧光测定互补DNA片段的方法中有利地用作荧光嵌入剂。

公开(公告)号：US06492119B1

公开(公告)日：2002-12-10

申请号：US09664408

申请日：2000-09-18

申请人： Masashi Ogawa

发明人： Masashi Ogawa

IPC分类号： G01N33531

CPC分类号： B01L3/508 ,  B01J2219/00274 ,  B01L3/5023 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/123 ,  Y10S435/969

摘要： A macro array comprises a film-shaped hard porous body and a plurality of spots, which contain test substances and are arrayed on the film-shaped hard porous body. The film-shaped hard porous body may be constituted of a surface layer region, which is provided with through-pores having a comparatively small mean pore diameter, and a base layer region, which is provided with through-pores having a comparatively large mean pore diameter. The surface of the film-shaped hard porous body, on which surface the spots are to be arrayed, may be coated with an auxiliary substance for promoting fixation of the test substances to the surface of the film-shaped hard porous body.

摘要翻译： 宏阵列包括膜状硬质多孔体和多个斑点，其含有测试物质并排列在膜状硬质多孔体上。 膜状硬质多孔体可以由设置有平均孔径较小的贯通孔的表层区域和基底区域构成，该基底区域设置有具有较大平均孔隙的通孔 直径。 可以在其上排列有斑点的表面上的膜状硬质多孔体的表面涂覆辅助物质，以促进测试物质固定在膜状硬质多孔体的表面上。

公开(公告)号：USD436618S1

公开(公告)日：2001-01-23

申请号：US29116668

申请日：2000-01-10

申请人： Yasuo Kotaki ,  Masashi Ogawa ,  Tsutomu Abe ,  Hitomi Ito

设计人： Yasuo Kotaki ,  Masashi Ogawa ,  Tsutomu Abe ,  Hitomi Ito

公开(公告)号：USD430602S

公开(公告)日：2000-09-05

申请号：US106435

申请日：1999-06-16

申请人： Yasuo Kotaki ,  Masashi Ogawa ,  Tsutomu Abe

设计人： Yasuo Kotaki ,  Masashi Ogawa ,  Tsutomu Abe

公开(公告)号：US5882935A

公开(公告)日：1999-03-16

申请号：US544133

申请日：1995-10-17

申请人： Kikuo Hirai ,  Hiroshi Shinoki ,  Masashi Ogawa ,  Yoshihiko Makino

发明人： Kikuo Hirai ,  Hiroshi Shinoki ,  Masashi Ogawa ,  Yoshihiko Makino

IPC分类号： G01N33/53 ,  G01N33/52 ,  G01N33/542 ,  G01N33/72 ,  H01L21/302 ,  H01L21/304 ,  H01L21/306 ,  H01L21/76

CPC分类号： G01N33/723 ,  G01N33/721

摘要： An analysis element for analyzing both amounts of glycated hemoglobin and total hemoglobin in an aqueous liquid sample to determine glycated hemoglobin content ratio in the sample. The element comprises a substrate layer for receiving a reaction mixture after the completion of an immunological reaction between the glycated hemoglobin in the sample and an enzyme-labelled antibody against the glycated hemoglobin, and a reagent layer. The substrate layer contains a non-diffusible substrate which forms a diffusible material in the presence of the enzyme of the enzyme-labelled antibody, the activity of the enzyme being effected relative to the steric hindrance due to the immunological reaction. The reagent layer contains a reagent composition for reacting with the diffusible material to form a dye detectable colorimetrically in a wavelength range which is not effected by an absorption spectrum of the hemoglobin. The total hemoglobin retained in the substrate layer and the dye formed in the reagent layer are colorimetrically analyzed separately, and the glycated hemoglobin content ratio is calculated from respective values. An analysis method using this analysis element is also provided.

摘要翻译： 分析元素，用于分析含水液体样品中糖化血红蛋白和总血红蛋白的量，以测定样品中糖化血红蛋白含量的比例。 该元件包括用于在样品中的糖化血红蛋白和糖化血红蛋白的酶标记抗体完成后的反应混合物和试剂层的基底层。 底物层含有在酶标记抗体的酶存在下形成可扩散材料的非扩散性底物，该酶的活性相对于由于免疫反应引起的空间位阻影响。 试剂层含有用于与可扩散材料反应的试剂组合物，以形成可在不受血红蛋白的吸收光谱影响的波长范围内比色测定的染料。 分别保留在基材层中的总血红蛋白和形成在试剂层中的染料，并根据各值计算糖化血红蛋白含量比。 还提供了使用该分析元素的分析方法。

公开(公告)号：US5819133A

公开(公告)日：1998-10-06

申请号：US768330

申请日：1996-12-17

申请人： Hisanobu Matsuzoe ,  Kouji Migita ,  Kazuo Hakukawa ,  Yasunori Sagara ,  Shinichi Kizu ,  Yusuke Shiibara ,  Masashi Ogawa ,  Yukinori Hara

发明人： Hisanobu Matsuzoe ,  Kouji Migita ,  Kazuo Hakukawa ,  Yasunori Sagara ,  Shinichi Kizu ,  Yusuke Shiibara ,  Masashi Ogawa ,  Yukinori Hara

IPC分类号： G03G15/01 ,  G03G15/16 ,  G03G15/14

CPC分类号： G03G15/167 ,  G03G2215/00974 ,  G03G2215/0187

摘要： In an image forming apparatus of transverse transfer type, toner images, carried by a toner-image carrying member extended by a plurality of rollers in a direction perpendicular to a direction of feed of printing paper, are transferred by a transfer opposed roller to the printing paper in a direction perpendicular to the direction of feed of the printing paper to be fixed. Among the rollers extending the toner image-carrying member, at least one of those rollers except for the transfer opposed roller, which comes closest to the transfer opposed roller at starting and terminal ends of a longest path of movement of the transfer opposed roller, respectively, is provided at a position spaced from a transfer surface of the printing paper, to which the toner images are transferred, by a distance larger than a diameter of the transfer opposed roller. With this construction, a non-transfer region, in which the transfer opposed roller can not move, is reduced, and therefore a body of the image forming apparatus can be made smaller in size.

摘要翻译： 在横向转印型的图像形成装置中，通过多个辊沿与打印纸的进给方向垂直的方向延伸的调色剂图像承载部件携带的调色剂图像通过转印相对的辊转印到印刷 纸垂直于要固定的打印纸的进给方向的方向。 在延伸调色剂图像承载构件的辊中，除了转印相对辊之外的那些辊中的至少一个分别在转印对置辊的最长运动路径的起始端和最终端处最靠近转印相对辊 设置在与转印相对辊的直径大的距离上与调色剂图像转印到的打印纸的转印面间隔开的位置处。 通过这种结构，转印对置辊不能移动的非转印区域被减少，因此可以使图像形成装置的主体尺寸更小。

公开(公告)号：US5787771A

公开(公告)日：1998-08-04

申请号：US752006

申请日：1996-11-15

申请人： Masashi Ogawa ,  Masayuki Tanio

发明人： Masashi Ogawa ,  Masayuki Tanio

IPC分类号： B23Q1/48 ,  B23Q1/70 ,  B23Q7/00 ,  B23B5/00

CPC分类号： B23Q7/006 ,  B23Q1/4852 ,  B23Q1/706 ,  Y10T82/10 ,  Y10T82/16983 ,  Y10T82/2516

摘要： In a lathe of a type employing a movable main spindle, the main spindle (2) is moved in a leftward and rightward direction (Y-axis direction) perpendicular to the longitudinal axis of the main spindle (2) after a workpiece (W) has been machined, and during the movement of the main spindle (2), the machined workpiece (W) is unloaded from the main spindle (2). At a position to which the main spindle (2) has further been moved, another workpiece (W) to be subsequently machined is loaded on the main spindle (2). The unloading of the machined workpiece (W) is carried out by a method in which the machined workpiece (W) is ejected by a workpiece eject means (7) built in a chuck (2a) in the main spindle (2).

摘要翻译： 在采用可动主轴的车床中，主轴（2）在工件（W）之后沿与主轴（2）的纵轴垂直的左右方向（Y轴方向）移动， 在主轴（2）的移动过程中，机械加工的工件（W）从主轴（2）卸载。 在主轴（2）进一步移动的位置，随后加工的另一工件（W）被装载在主轴（2）上。 机械加工的工件（W）的卸载通过其中加工的工件（W）由主轴（2）中的卡盘（2a）中的工件排出装置（7）喷射的方法来执行。

公开(公告)号：US5716958A

公开(公告)日：1998-02-10

申请号：US513018

申请日：1995-08-09

申请人： Masashi Ogawa ,  Tadashi Morita ,  Kiyoshi Matsuda ,  Norihiro Iibuchi ,  Shinpei Kidokoro

发明人： Masashi Ogawa ,  Tadashi Morita ,  Kiyoshi Matsuda ,  Norihiro Iibuchi ,  Shinpei Kidokoro

IPC分类号： C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07F9/58 ,  C07F9/6558 ,  A61K31/495 ,  A61K31/445

CPC分类号： C07D401/12 ,  C07D209/42 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07F9/587 ,  C07F9/65583

摘要： A compound represented by the formula (1): ##STR1## wherein, m is an integer of 1 to 3; n is an integer 0 or 1; A represents CH or N atom, and forms together with the N atom bonded to the carbonyl group a piperidine ring or a piperazine ring; R.sub.1 independently represents a straight or branched chain alkyl group having 1 to 4 carbon atoms; a cycloalkyl group having 3 to 8 carbon atoms; a phenyl group, unsubstituted or substituted with a halogen atom or with an alkoxy group having 1 to 4 carbon atoms; or a pyridyl group; or two R.sub.1, together with the group >CH-- to which they bind, form a dibenzo cycloheptenyl group or a fluorenyl group; R.sub.2 represents a phenyl group substituted with a carboxyl or substituted carboxyl group; a pyridyl group substituted with a carboxyl or substituted carboxyl group, a pyrazyl group substituted with a carboxyl or substituted carboxyl group, an oxazolyl substituted with a carboxyl or substituted carboxyl group, a triazolyl substituted with one or two carboxyl or substituted carboxyl groups, or a phosphonopyridyl group; and R.sub.3 represents an indolyl group unsubstituted or substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, an alkoxy group having 1 to 4 carbon atoms and methoxycarbonyl ethyl group and the pharmaceutically acceptable salts thereof.

摘要翻译： 由式（1）表示的化合物：其中，m为1〜3的整数， n是整数0或1; A表示CH或N原子，并与与羰基键合的N原子一起形成哌啶环或哌嗪环; R1独立地表示具有1至4个碳原子的直链或支链烷基; 具有3-8个碳原子的环烷基; 未取代或被卤素原子或具有1至4个碳原子的烷氧基取代的苯基; 或吡啶基; 或两个R 1与它们所结合的基团> CH-一起形成二苯并环庚烯基或芴基; R2表示被羧基或取代羧基取代的苯基; 被羧基或取代羧基取代的吡啶基，被羧基或取代羧基取代的吡唑基，被羧基或取代羧基取代的恶唑基，被一个或两个羧基或取代羧基取代的三唑基，或 膦酰吡啶基; R3表示未取代或被选自卤素原子，羟基，具有1〜4个碳原子的烷氧基和甲氧基羰基乙基的取代基取代的吲哚基及其药学上可接受的盐。