公开(公告)号：US4977780A

公开(公告)日：1990-12-18

申请号：US500115

申请日：1990-03-27

申请人： Kaoru Machida ,  Yusichi Kikuchi ,  Masayuki Takano ,  Noriyoshi Kobayashi

发明人： Kaoru Machida ,  Yusichi Kikuchi ,  Masayuki Takano ,  Noriyoshi Kobayashi

IPC分类号： A61B8/00 ,  G10K11/02

CPC分类号： A61B8/4281 ,  G10K11/02

摘要： An ultrasonic probe device includes an ultrasonic probe for transmitting ultrasonic waves toward and receiving ultrasonic echoes from a target region in a body under examination, and an ultrasonic coupler for being interposed between the ultrasonic probe and the surface of the body. The ultrasonic probe device can accurately detect Doppler information on the central area of the target region.

摘要翻译： 一种超声波探头装置，包括：超声波探头，用于向被检体内的目标区域发送超声波并接收超声波回波;以及超声波联接器，其插入在超声波探头与身体的表面之间。 超声波探头装置可以准确地检测目标区域的中心区域的多普勒信息。

公开(公告)号：US4898177A

公开(公告)日：1990-02-06

申请号：US172546

申请日：1988-03-24

申请人： Masayuki Takano ,  Susumu Hiki ,  Yuusiti Kikuti

发明人： Masayuki Takano ,  Susumu Hiki ,  Yuusiti Kikuti

IPC分类号： A61B8/14 ,  A61B8/00 ,  G01N29/24

CPC分类号： A61B8/4281 ,  A61B8/42 ,  A61B8/4455

摘要： A pencil type ultrasonic probe to which a finger grip adapter is attached is fixed to a cable connected to an ultrasonic diagnosis apparatus. Operator's fingers are hooked on the adapter attached to the probe to allow the probe to be held by an operator's hand, thereby keeping the probe at a predetermined position of an organic body. The adapter comprises: a body having a through-hole in which the probe is inserted; and a finger grip portion extending from the body and allowing the operator's fingers to be hooked on. The body has a guide slit for allowing the cable to pass therethrough. Thus, the cable is guided into the through-hole through the guide slit, and the probe is inserted into the through-hole to be attached to the adapter. When the probe is pulled out from the through-hole of the body, the cable is located in the through-hole. Thereafter, the cable is taken out from the through-hole through the guide slit, so that the adapter can be quickly and easily detached from the cable.

摘要翻译： 将连接有手指夹适配器的铅笔型超声波探头固定在与超声波诊断装置连接的电缆上。 操作者的手指钩在连接到探头上的适配器上，以使探针能够被操作者的手握住，从而将探头保持在有机体的预定位置。 适配器包括：主体，其具有插入探针的通孔; 以及从身体延伸并允许操作者的手指被钩住的手指抓握部分。 主体具有用于允许电缆通过的引导狭缝。 因此，电缆通过引导狭缝被引导到通孔中，并且将探针插入到要连接到适配器的通孔中。 当探头从主体的通孔中拉出时，电缆位于通孔中。 此后，通过引导狭缝将电缆从通孔中取出，使得适配器可以快速方便地从电缆上拆下。

公开(公告)号：US4608609A

公开(公告)日：1986-08-26

申请号：US524558

申请日：1983-08-19

申请人： Masayuki Takano ,  Kenji Nakamura

发明人： Masayuki Takano ,  Kenji Nakamura

IPC分类号： H04N9/86 ,  H04N9/825 ,  H04N5/782

CPC分类号： H04N9/825

摘要： A color video signal recording apparatus recording a luminance signal and a chrominance signal on separate tracks in which a pair of chrominance component signals are time-compressed and serially recorded as the chrominance signals. In this case, there are provided a timebase compressor for time-compressing the pair of chrominance component signals and a clock generator for supplying a clock signal to the timebase compressor wherein the frequency of the clock signal is selected to be an integral multiple of the horizontal frequency.

摘要翻译： 一种彩色视频信号记录装置，其在一对色度分量信号被时间压缩并串行记录为色度信号的单独磁道上记录亮度信号和色度信号。 在这种情况下，提供了用于时间压缩一对色度分量信号的时基压缩器和用于向时基压缩器提供时钟信号的时钟发生器，其中时钟信号的频率被选择为水平的整数倍 频率。

公开(公告)号：US4366515A

公开(公告)日：1982-12-28

申请号：US130168

申请日：1980-03-13

申请人： Masayuki Takano ,  Sadao Hosoi ,  Yuichi Matsushita

发明人： Masayuki Takano ,  Sadao Hosoi ,  Yuichi Matsushita

IPC分类号： G11B5/588 ,  G11B21/10 ,  G11B5/56

CPC分类号： G11B5/588

摘要： In a video tape recorder which employs a rotary magnetic head secured on a deflectable device, such as a bi-morph leaf, to dynamically perform head tracking during reproduction of previously recorded tracks regardless of the tape transport speed; the height of the magnetic head is detected during recording to produce a feedback control signal which electrically adjusts the height of the magnetic head by deforming the bi-morph leaf to overcome hysteresis deflection of the bi-morph leaf so that the magnetic head is returned to and maintained at a normal height during recording.

摘要翻译： 在采用固定在诸如双变形叶片的可偏转装置上的旋转磁头的磁带录像机中，无论​​磁带传送速度如何，在先前记录的轨道的再现期间动态地执行磁头跟踪; 在记录期间检测磁头的高度，以产生反馈控制信号，该反馈控制信号通过使双变形叶变形来电调节磁头的高度，以克服双变形叶片的磁滞偏转，使得磁头返回到 并在记录期间维持在正常的高度。

公开(公告)号：US10273270B2

公开(公告)日：2019-04-30

申请号：US13636584

申请日：2011-03-24

申请人： Shinichi Yoshida ,  Dai Murata ,  Shunichi Taira ,  Masayuki Takano ,  Keita Iguchi ,  Yoshiyuki Nakano

发明人： Shinichi Yoshida ,  Dai Murata ,  Shunichi Taira ,  Masayuki Takano ,  Keita Iguchi ,  Yoshiyuki Nakano

IPC分类号： C07K14/195 ,  C07K1/22 ,  C07K14/31 ,  C07K16/06 ,  C07K16/32

摘要： An object of the present invention is to create a novel engineered Protein A ligand having better antibody dissociation properties in the acidic condition compared with known engineered Protein A ligands. The present invention provides a protein having an affinity for an immunoglobulin, including an amino acid sequence obtained by introducing, into an amino acid sequence derived from any of E, D, A, B and C domains of Protein A, at least one amino acid substitution at any one or more of amino acid residues corresponding to positions 31 to 37 of the A, B and C domains (positions 29 to 35 of the E domain, positions 34 to 40 of the D domain), which are conserved in all the domains, the protein having a lower affinity for an Fab region of an immunoglobulin than a protein having the amino acid sequence before introduction of the substitution.

公开(公告)号：US09403883B2

公开(公告)日：2016-08-02

申请号：US13258655

申请日：2010-03-24

申请人： Shinichi Yoshida ,  Dai Murata ,  Masayuki Takano ,  Junya Akagi ,  Keita Iguchi ,  Yoshiyuki Nakano

发明人： Shinichi Yoshida ,  Dai Murata ,  Masayuki Takano ,  Junya Akagi ,  Keita Iguchi ,  Yoshiyuki Nakano

IPC分类号： C07K14/31 ,  C07K14/47 ,  B01J20/286 ,  B01J20/32 ,  B01D15/38

CPC分类号： C07K14/47 ,  B01D15/3809 ,  B01J20/286 ,  B01J20/3244 ,  B01J20/3274 ,  C07K14/31

摘要： An object of the present invention is to create a novel engineered Protein A ligand having better antibody dissociation properties in the presence of an acid than conventional engineered Protein A ligands and a further object of the present invention is to create a novel engineered Protein A ligand having higher alkali resistance. The present invention is to provide a protein having an affinity for an immunoglobulin, including an amino acid sequence derived from any of E, D, A, B and C domains of Protein A, wherein at least one Gly residue in the amino acid sequence is replaced with an amino acid other than Ala, and the protein has a lower affinity for an Fab region of an immunoglobulin than a protein including an amino acid sequence in which the Gly residue is replaced with Ala. Also, the present invention is to provide the protein having an affinity for an immunoglobulin, which has improved chemical stability in an alkaline condition compared to the corresponding domain.

摘要翻译： 本发明的一个目的是在酸存在下产生具有比常规工程改造的蛋白A配体更好的抗体解离性能的新型工程改造的蛋白A配体，本发明的另一个目的是产生一种新的工程改造的蛋白A配体，其具有 耐碱性较高。 本发明提供一种对免疫球蛋白具有亲和性的蛋白质，其包括衍生自蛋白A​​的E，D，A，B和C结构域中的任一个的氨基酸序列，其中氨基酸序列中至少一个Gly残基为 被除Ala以外的氨基酸所取代，并且该蛋白质对包含氨基酸序列的蛋白质的免疫球蛋白Fab区域的亲和力低于其中Gly残基被Ala置换的蛋白质，本发明还提供 对于免疫球蛋白具有亲和力的蛋白质，与相应的结构域相比，其在碱性条件下具有改善的化学稳定性。

公开(公告)号：US20130096276A1

公开(公告)日：2013-04-18

申请号：US13636584

申请日：2011-03-24

申请人： Shinichi Yoshida ,  Dai Murata ,  Shunichi Taira ,  Masayuki Takano ,  Keita Iguchi ,  Yoshiyuki Nakano

发明人： Shinichi Yoshida ,  Dai Murata ,  Shunichi Taira ,  Masayuki Takano ,  Keita Iguchi ,  Yoshiyuki Nakano

IPC分类号： C07K14/195

CPC分类号： C07K14/195 ,  C07K1/22 ,  C07K14/31 ,  C07K16/065 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/92

摘要： An object of the present invention is to create a novel engineered Protein A ligand having better antibody dissociation properties in the acidic condition compared with known engineered Protein A ligands. The present invention provides a protein having an affinity for an immunoglobulin, including an amino acid sequence obtained by introducing, into an amino acid sequence derived from any of E, D, A, B and C domains of Protein A, at least one amino acid substitution at any one or more of amino acid residues corresponding to positions 31 to 37 of the A, B and C domains (positions 29 to 35 of the E domain, positions 34 to 40 of the D domain), which are conserved in all the domains, the protein having a lower affinity for an Fab region of an immunoglobulin than a protein having the amino acid sequence before introduction of the substitution.

摘要翻译： 本发明的目的是与已知的工程改造的蛋白A配体相比，在酸性条件下产生具有更好抗体解离性能的新型工程蛋白A配体。 本发明提供对免疫球蛋白具有亲和性的蛋白质，包括通过将衍生自蛋白A​​的E，D，A，B和C结构域的任何氨基酸序列导入的氨基酸序列，至少一个氨基酸 在对应于A，B和C结构域（E结构域的29至35位，D结构域的34至40位）的31至37位的氨基酸残基的任何一个或多个取代，其在所有 结构域，对于免疫球蛋白Fab区域的亲和力低于在引入取代之前具有氨基酸序列的蛋白质的蛋白质。

公开(公告)号：US20120216367A1

公开(公告)日：2012-08-30

申请号：US13372665

申请日：2012-02-14

申请人： Masayuki Takano ,  Takeshi Maeno

发明人： Masayuki Takano ,  Takeshi Maeno

IPC分类号： A47L5/12

CPC分类号： F04D25/084 ,  A01G20/43

摘要： A handheld blower has a body including a combustion engine and a blower section driven by the combustion engine, and a handle coupled to the body. The blower section has an air outlet directed forward with respect to an operator. The handle has a grip portion extending in a front-back direction with respect to the operator, a front arm extending from a front portion of the grip portion to the body, and a rear arm extending from a rear portion of the grip portion to the body. The front arm and the rear arm are more flexible in the front-back direction than in directions perpendicular to the front-back direction.

摘要翻译： 手持式鼓风机具有主体，其包括内燃机和由内燃机驱动的鼓风机部分，以及与主体相连的手柄。 鼓风机部分具有相对于操作者向前指示的出气口。 手柄具有相对于操作者在前后方向上延伸的抓握部分，从把手部分的前部延伸到主体的前臂以及从把手部分的后部延伸到主体的后臂 身体。 前臂和后臂在前后方向上比在垂直于前后方向的方向上更柔性。

公开(公告)号：US20120208234A1

公开(公告)日：2012-08-16

申请号：US13258655

申请日：2010-03-24

申请人： Shinichi Yoshida ,  Dai Murata ,  Masayuki Takano ,  Junya Akagi ,  Keita Iguchi ,  Yoshiyuki Nakano

发明人： Shinichi Yoshida ,  Dai Murata ,  Masayuki Takano ,  Junya Akagi ,  Keita Iguchi ,  Yoshiyuki Nakano

IPC分类号： C12P21/02 ,  C07K19/00 ,  C12N15/31 ,  C12N15/62 ,  C12N1/21 ,  C07K16/12 ,  C07K1/14 ,  C07K14/31 ,  C12N15/74

CPC分类号： C07K14/47 ,  B01D15/3809 ,  B01J20/286 ,  B01J20/3244 ,  B01J20/3274 ,  C07K14/31

摘要： An object of the present invention is to create a novel engineered Protein A ligand having better antibody dissociation properties in the presence of an acid than conventional engineered Protein A ligands and a further object of the present invention is to create a novel engineered Protein A ligand having higher alkali resistance. The present invention is to provide a protein having an affinity for an immunoglobulin, including an amino acid sequence derived from any of E, D, A, B and C domains of Protein A, wherein at least one Gly residue in the amino acid sequence is replaced with an amino acid other than Ala, and the protein has a lower affinity for an Fab region of an immunoglobulin than a protein including an amino acid sequence in which the Gly residue is replaced with Ala. Also, the present invention is to provide the protein having an affinity for an immunoglobulin, which has improved chemical stability in an alkaline condition compared to the corresponding domain.

摘要翻译： 本发明的一个目的是在酸存在下产生具有比常规工程改造的蛋白A配体更好的抗体解离性能的新型工程改造的蛋白A配体，本发明的另一个目的是产生一种新的工程改造的蛋白A配体，其具有 耐碱性较高。 本发明提供一种对免疫球蛋白具有亲和性的蛋白质，其包括衍生自蛋白A​​的E，D，A，B和C结构域中的任一个的氨基酸序列，其中氨基酸序列中至少一个Gly残基为 被除Ala以外的氨基酸所取代，并且该蛋白质对包含氨基酸序列的蛋白质的免疫球蛋白Fab区域的亲和力低于其中Gly残基被Ala置换的蛋白质，本发明还提供 对于免疫球蛋白具有亲和力的蛋白质，与相应的结构域相比，其在碱性条件下具有改善的化学稳定性。

公开(公告)号：US07854291B2

公开(公告)日：2010-12-21

申请号：US12095027

申请日：2006-09-20

申请人： Eiji Akahane ,  Nobumi Toyoura ,  Shigeru Kojima ,  Masayuki Takano

发明人： Eiji Akahane ,  Nobumi Toyoura ,  Shigeru Kojima ,  Masayuki Takano

IPC分类号： G05G1/30

CPC分类号： E02F9/2004 ,  E02F9/2025 ,  Y10T74/20012 ,  Y10T74/20528 ,  Y10T74/2054

摘要： In a work machine equipped with a switchover means enabling selective operation of traveling devices and a work device by means of common operating levers, switchover can easily be performed and also easily recognized. In a work machine having traveling devices and a work device, operating levers that are capable of operating the traveling devices and the work device are respectively disposed at the sides of an operating seat. A foot switch connected to a controller is disposed in the proximity of and operable with a foot of an operator seated at the operating seat. While the foot switch is being operated with the foot, the traveling devices are operated by the operating levers through the controller. While the foot switch is not being operated, the work device is operated by means of the operating levers through the controller.

摘要翻译： 在配有切换装置的工作机械中，能够通过公共操作杆对行驶装置和作业装置进行选择性操作，能够容易地进行切换，也容易识别。 在具有行走装置和作业装置的作业机械中，能够操作行走装置和作业装置的操作杆分别设置在操作座椅的侧面。 连接到控制器的脚踏开关设置在坐在操作座上的操作者的脚部附近并可操作。 当脚踏开关用脚操作时，行驶装置由操作杆通过控制器操作。 当脚踏开关未被操作时，工作装置通过操作杆通过控制器操作。