公开(公告)号：US20060061691A1

公开(公告)日：2006-03-23

申请号：US10946070

申请日：2004-09-22

Applicant: Matthew Rabinowitz ,  Michael Sabin ,  Jimmy Omura

Inventor： Matthew Rabinowitz ,  Michael Sabin ,  Jimmy Omura

IPC: H04N7/16 ,  H04N7/18 ,  H04N7/173 ,  H04N5/21 ,  H04N9/64

CPC classification number: H04H60/51 ,  G01S5/0221 ,  G01S5/14 ,  G01S5/145 ,  G01S19/09 ,  G01S19/31 ,  G01S19/46 ,  H04N5/211 ,  H04N5/4401 ,  H04N5/4446 ,  H04N5/455 ,  H04N21/25841 ,  H04N21/41407 ,  H04N21/435 ,  H04N21/4382 ,  H04N21/6112 ,  H04N21/6181 ,  H04N21/654 ,  H04N21/658

Abstract: The present invention provides a method, system, and apparatus for rapidly acquiring and correlating synchronization codes for a mobile receiver used for position determination purposes. The receiver uses a processing unit to perform the correlation functions. The processing unit first computes, for each segment interval of the received signal, the phase offset of that interval. Each interval is appropriately adjusted to account for the computed phase offset. The processing unit then accumulates the phase-adjusted segment intervals, and may down-convert the accumulated signal to a baseband format from an intermediate frequency. The processing unit then correlates the accumulated signal with a reference signal to produce a correlation peak, from which the time delay of a synchronization code within the interval can be calculated. Ultimately, the receiver's position can be determined based on the calculated time delay.

Abstract translation: 本发明提供一种用于快速获取和关联用于位置确定目的的移动接收机的同步码的方法，系统和装置。 接收机使用处理单元执行相关功能。 对于接收信号的每个段间隔，处理单元首先计算该间隔的相位偏移。 适当调整每个间隔以计算相位偏移。 处理单元然后累积相位调整的段间隔，并且可以将累积信号从中频降频转换为基带格式。 然后，处理单元将累加的信号与参考信号相关联，以产生相关峰值，从而可以计算间隔内的同步码的时间延迟。 最终，接收机的位置可以基于计算的时间延迟来确定。

公开(公告)号：US06952182B2

公开(公告)日：2005-10-04

申请号：US10290984

申请日：2002-11-08

Applicant: James J. Spilker, Jr. ,  Matthew Rabinowitz

Inventor： James J. Spilker, Jr. ,  Matthew Rabinowitz

IPC: G01S1/00 ,  G01S5/00 ,  G01S5/02 ,  G01S5/12 ,  G01S5/14 ,  G01S19/46 ,  G01S3/02

CPC classification number: G01S5/145 ,  A63F2300/205 ,  G01C21/206 ,  G01S5/0036 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/02 ,  G01S5/0205 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/0221 ,  G01S5/0226 ,  G01S5/0236 ,  G01S5/12 ,  G01S19/46 ,  H04N21/25841 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/615 ,  H04N21/8126

Abstract: A method, apparatus, and computer-readable media for determining the position of a user terminal comprises receiving at the user terminal a digital television (DTV) broadcast signal from a DTV transmitter, wherein the DTV signal comprises an Integrated Services Digital Broadcasting-Terrestrial (ISDB-T) signal; determining a pseudo-range between the user terminal and the DTV transmitter based on a known component in the broadcast DTV signal; and determining a position of the user terminal based on the pseudo-range and a location of the DTV transmitter.

Abstract translation: 用于确定用户终端的位置的方法，装置和计算机可读介质包括在用户终端接收来自DTV发射机的数字电视（DTV）广播信号，其中所述DTV信号包括地面综合业务数字广播 ISDB-T）信号; 基于所述广播DTV信号中的已知组件，确定所述用户终端与所述DTV发射机之间的伪距离; 以及基于所述DTV发射机的伪距离和位置确定所述用户终端的位置。

公开(公告)号：US06879286B2

公开(公告)日：2005-04-12

申请号：US10353669

申请日：2003-01-28

Applicant: Matthew Rabinowitz ,  James J. Spilker, Jr.

Inventor： Matthew Rabinowitz ,  James J. Spilker, Jr.

IPC: G01S5/00 ,  G01S5/02 ,  G01S5/14 ,  G01S19/46 ,  H04N21/258 ,  H04N21/2662 ,  H04N21/2668 ,  H04N21/414 ,  H04N21/61 ,  H04N21/81 ,  G01S3/02

CPC classification number: G01S5/0221 ,  A63F2300/205 ,  G01C21/206 ,  G01S5/0036 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/14 ,  G01S5/145 ,  G01S19/46 ,  H04N21/25841 ,  H04N21/2662 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/615 ,  H04N21/8126

Abstract: A method, apparatus, and computer-readable media for determining the position of a user terminal comprises receiving, at the user terminal, a broadcast analog television signal comprising a chirp-type signal; and generating a pseudorange based on the chirp-type signal; and wherein the location of the user terminal is determined based on the pseudorange and a location of a transmitter of the broadcast analog television signal.

Abstract translation: 一种用于确定用户终端的位置的方法，装置和计算机可读介质包括在用户终端处接收包括啁啾型信号的广播模拟电视信号; 以及基于所述啁啾型信号产生伪距离; 并且其中基于广播模拟电视信号的伪距和发射机的位置来确定用户终端的位置。

公开(公告)号：US06559800B2

公开(公告)日：2003-05-06

申请号：US10054302

申请日：2002-01-22

Applicant: Matthew Rabinowitz ,  James J. Spilker, Jr.

Inventor： Matthew Rabinowitz ,  James J. Spilker, Jr.

IPC: G01S302

CPC classification number: G01S5/0036 ,  A63F2300/205 ,  G01C21/206 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/02 ,  G01S5/0205 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/0221 ,  G01S5/0226 ,  G01S5/0236 ,  G01S5/14 ,  G01S5/145 ,  G01S19/46 ,  H04N21/25841 ,  H04N21/2662 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/615 ,  H04N21/8126

Abstract: A computer program product, apparatus, and method for determining the position of a user terminal. It includes receiving, at the user terminal, a broadcast analog television signal having a periodic component; and correlating the broadcast analog television signal with a predetermined reference signal based on the periodic component, thereby producing a pseudorange; and wherein the location of the user terminal is determined based on the pseudorange and a location of the transmitter of the broadcast analog television signal.

公开(公告)号：US10113196B2

公开(公告)日：2018-10-30

申请号：US13335043

申请日：2011-12-22

Applicant: Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

Inventor： Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

IPC: C12Q1/6869 ,  C12Q1/6876 ,  G06F19/14

Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.

公开(公告)号：US20130274116A1

公开(公告)日：2013-10-17

申请号：US13896293

申请日：2013-05-16

Applicant: Matthew Rabinowitz ,  Allison Rayan ,  George Gemelos ,  Milena Banjevic ,  Zachary Demko

Inventor： Matthew Rabinowitz ,  Allison Rayan ,  George Gemelos ,  Milena Banjevic ,  Zachary Demko

IPC: C12Q1/68

CPC classification number: G16B30/00 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06N7/005 ,  G16B20/00 ,  C12Q2537/16 ,  C12Q2537/165

Abstract: Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.

Abstract translation: 本文公开了用于在非侵入性产前诊断的上下文中确定胎儿中染色体的拷贝数的方法。 在一个实施方案中，分析来自含有胎儿DNA和母体DNA的遗传物质的样品的测量的遗传数据以及来自胎儿的生物亲本的遗传数据，并确定感兴趣的染色体的拷贝数。 在一个实施方案中，使用单核苷酸多态性（SNP）微阵列以及亲本基因组数据测量母体血清，并且使用染色体拷贝数的确定来进行与胎儿有关的临床决定。

公开(公告)号：US20130261004A1

公开(公告)日：2013-10-03

申请号：US13846160

申请日：2013-03-18

Applicant: Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

Inventor： Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6876 ,  C12Q2600/156 ,  G16B10/00

Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.

Abstract translation: 本文公开了非侵入性产前亲子鉴定的方法。 该方法使用从怀孕母亲获得的血浆进行的遗传测量，以及所称父亲的遗传测量以及母亲的遗传测量，以确定所称父亲是否是胎儿的生物之父。 这通过基于信息学的方法来实现，该方法可以将母体血浆中发现的胎儿DNA的遗传指纹与所称父亲的遗传指纹进行比较。

公开(公告)号：US20130178373A1

公开(公告)日：2013-07-11

申请号：US13791397

申请日：2013-03-08

Applicant: Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

Inventor： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/6862 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q2600/156 ,  G06F19/18 ,  G06F19/24 ,  C12Q2537/161 ,  C12Q2537/165

Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

公开(公告)号：US20120122701A1

公开(公告)日：2012-05-17

申请号：US13335043

申请日：2011-12-22

Applicant: Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

Inventor： Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

IPC: C12Q1/68 ,  G01N33/53 ,  G01N21/64 ,  C40B20/00

CPC classification number: C12Q1/6869 ,  C12Q1/6876 ,  C12Q2600/156 ,  G06F19/14

Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.

Abstract translation: 本文公开了非侵入性产前亲子鉴定的方法。 该方法使用从怀孕母亲获得的血浆进行的遗传测量，以及所称父亲的遗传测量以及母亲的遗传测量，以确定所称父亲是否是胎儿的生物之父。 这通过基于信息学的方法来实现，该方法可以将母体血浆中发现的胎儿DNA的遗传指纹与所称父亲的遗传指纹进行比较。

公开(公告)号：US08106828B1

公开(公告)日：2012-01-31

申请号：US12209971

申请日：2008-09-12

Applicant: Ju-Yong Do ,  Andy Lee ,  David Gotwisner ,  Dimitri Rubin ,  Matthew Rabinowitz

Inventor： Ju-Yong Do ,  Andy Lee ,  David Gotwisner ,  Dimitri Rubin ,  Matthew Rabinowitz

IPC: G01S3/02

CPC classification number: H04H60/51 ,  G01S5/0252 ,  H04B17/27 ,  H04N21/25841 ,  H04W64/00

Abstract: An apparatus for location identification using broadcast wireless signal signatures includes a receiver to receive first measurements of a plurality of wireless television signals. The first measurements are made by a remote device receiving the plurality of wireless television signals. In addition, the apparatus includes a processor to select one or more of a plurality of possible locations of the remote device based on the first measurements and a plurality of associations each associating one of the possible locations with expected values. Moreover, the receiver receives second measurements of the wireless television signals made by one or more monitor units, and the processor generates the expected values for the first measurements and the associations based on the second measurements and the locations of the one or more monitor units.

Abstract translation: 用于使用广播无线信号签名的位置识别的装置包括接收多个无线电视信号的第一测量的接收机。 第一测量由接收多个无线电视信号的远程设备进行。 另外，该设备包括处理器，用于基于第一测量值选择远程设备的多个可能位置中的一个或多个，以及多个关联，每个关联将每个可能位置之一与期望值相关联。 此外，接收机接收由一个或多个监视器单元产生的无线电视信号的第二测量，并且处理器基于第二测量和一个或多个监视器单元的位置，产生用于第一测量和关联的期望值。