摘要:
Provided herein are compositions and methods for treating cancer by increasing the inhibitory effect of cetuximab on HIF1α expression by administering cetuximab in combination with anti-angiogenic thyroid hormone analogs such as tetrac or triac.
摘要:
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要:
Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof. Also disclosed are methods of increasing radiosensitivity of normal and/or radioresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof.
摘要:
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要:
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要:
The invention includes compositions comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or ischemia. The invention also includes methods for the treatment and prevention of cardiac injury comprising contacting a composition of the invention with a human patient.
摘要:
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要:
A call related information detector/receiver system which is capable of downloading call related information received at that device to another call related information detector/receiver system remote from the system which initially received the call related information, back over the telephone line. Thus, a remote user while away from the home or office can receive and synchronize call related information at a system other than the one which initially received the call related information. Thus, a remote user can update a local call related information system and review past callers to their home or business telephone at their leisure. Upon establishment of a telephone call between customer premises equipment respectively associated with the two relevant call related information detector/receiver systems, a remote call related information system will request download of call related information logged from another call related information system using the established telephone call. In the disclosed embodiment, the request signals are encoded with DTMF tones, which the receiving call related information system monitors for. Upon acceptance of a request to transmit logged call related information, previously logged call related information is retrieved from its log, formatted for transmission together with suitable header information such as the identity of the transmitting call related information system, and FSK modulated for transmission back over the telephone line. Preferably, the speaker or earpiece of off-hook customer premises equipment will be muted or suppressed during transmission of the data corresponding to the call related information. The particular call related information transmitted may be particularly or generally requested by the remote call related information system, either by pre-stored commands based on a power up configuration of the requesting call related information system, and/or in response to a direct command input by the remote user using DTMF tones.
摘要:
A multivalent antigen-binding protein comprises a first polypeptide comprising, in series, three or more variable domains of an antibody heavy chain and a second polypeptide comprising, in series, three of more variable domains of an antibody light chain, said first and second polypeptides being linked by association of the respective heavy chain and light chain variable domains, each associated variable domain pair forming an antigen binding site. Methods for their production and uses thereof, in particular for therapeutic and diagnostic applications, are disclosed.
摘要:
A completed green tire is automatically released from a tire assembly drum and transported by automated holders to a discharge station, where an unloading track is positioned beneath the green tire. The holders include grips at the ends of reciprocable arms, arranged so the grips engage the periphery of the green tire at diametrically opposite points, which are on a line rotated somewhat from vertical with the bottom of such line away from the unloading track. Thus as the grips release the green tire, it rolls by gravity on its circular periphery onto the track mechanism, and passes to a discharge conveying system which can take the complete green tires to a vulcanizing and molding operation.