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公开(公告)号:US20220152178A1
公开(公告)日:2022-05-19
申请号:US17554182
申请日:2021-12-17
Applicant: ModernaTX, Inc.
Inventor: Giuseppe Ciaramella , Eric Yi-Chun Huang , Nicholas Valiante , Tal Zaks
Abstract: The invention relates to concatemeric peptide epitope RNAs, as well as methods and compositions thereof. mRNA vaccines are also provided according to the invention, including cancer vaccines.
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公开(公告)号:US11007260B2
公开(公告)日:2021-05-18
申请号:US15746286
申请日:2016-07-21
Applicant: ModernaTX, Inc.
Inventor: Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tai Zaks , Sunny Himansu
IPC: A61K39/12 , A61K9/00 , C07K16/28 , C07K14/005 , C07K16/10 , C07K14/18 , A61K48/00 , A61K9/14 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/28 , C12N7/00 , A61P31/12 , A61P31/14 , A61K9/51 , A61K39/00
Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号:US10709779B2
公开(公告)日:2020-07-14
申请号:US16048154
申请日:2018-07-27
Applicant: ModernaTX, Inc.
Inventor: Giuseppe Ciaramella , Axel Bouchon , Eric Yi-Chun Huang
IPC: A61K39/145 , A61K48/00 , A61K39/12 , A61K31/7105 , A61K39/39 , A61K9/00 , A61K39/155 , A61K9/127 , A61K9/51 , C12N7/00 , A61K39/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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公开(公告)号:US10449244B2
公开(公告)日:2019-10-22
申请号:US16009811
申请日:2018-06-15
Applicant: ModernaTX, Inc.
Inventor: Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu
IPC: A61K39/12 , A61P31/12 , A61P31/14 , A61K9/14 , A61K9/51 , C07K14/005 , C07K16/10 , C12N7/00 , A61K9/00 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/28 , C07K16/28 , A61K39/00
Abstract: Aspects of the disclosure describe compositions that comprise RNA polynucleotides having an open reading frame encoding one or more Zika virus antigens. Methods for preparing and using the compositions are also described.
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公开(公告)号:US20190060438A1
公开(公告)日:2019-02-28
申请号:US15746286
申请日:2016-07-21
Applicant: ModernaTX, Inc.
Inventor: Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu
IPC: A61K39/12
Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号:US20190008948A1
公开(公告)日:2019-01-10
申请号:US16036318
申请日:2018-07-16
Applicant: ModernaTX, Inc.
Inventor: Giuseppe Ciaramella , Axel Bouchon , Eric Yi-Chun Huang
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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公开(公告)号:US20180344839A1
公开(公告)日:2018-12-06
申请号:US16009880
申请日:2018-06-15
Applicant: ModernaTX, Inc.
Inventor: Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu , Sayda Mahgoub Elbashir
Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号:US20180344838A1
公开(公告)日:2018-12-06
申请号:US16009848
申请日:2018-06-15
Applicant: ModernaTX, Inc.
Inventor: Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu
CPC classification number: A61K39/12 , A61K9/0019 , A61K9/14 , A61K9/51 , A61K9/5123 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/28 , A61K2039/505 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/6056 , A61P31/14 , C07K14/005 , C07K16/1081 , C07K16/2851 , C07K2317/33 , C07K2317/76 , C12N7/00 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , Y02A50/383 , Y02A50/386 , Y02A50/39 , Y02A50/392 , Y02A50/51
Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号:US10022435B2
公开(公告)日:2018-07-17
申请号:US15089050
申请日:2016-04-01
Applicant: ModernaTX, Inc.
Inventor: Giuseppe Ciaramella , Axel Bouchon , Eric Yi-Chun Huang
IPC: A61K39/145 , A61K48/00 , A61K39/12 , A61K39/39 , C12N7/00 , A61K31/7105 , A61K9/00 , A61K39/155 , A61K9/127 , A61K9/51 , A61K39/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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公开(公告)号:US20180086816A1
公开(公告)日:2018-03-29
申请号:US15591820
申请日:2017-05-10
Applicant: ModernaTX, Inc.
Inventor: Stephen G. Hoge , Eric Yi-Chun Huang , Tirtha Chakraborty , Sayda M. Elbashir
IPC: C07K14/76 , C07K14/61 , C07K14/50 , C07K14/535 , C07K14/59 , C07K14/605 , C12N15/67 , C07K14/765 , C07K16/00
CPC classification number: C07K14/76 , A61K48/00 , C07K14/50 , C07K14/535 , C07K14/59 , C07K14/605 , C07K14/61 , C07K14/765 , C07K16/00 , C07K2319/00 , C12N15/67
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmRNA molecules.
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