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77 条记录 (耗时 0.102 秒)

    Polynucleotide encoding a human relaxin receptor, HGPRBMY5v1
    33.
    发明授权
    Polynucleotide encoding a human relaxin receptor, HGPRBMY5v1 有权
    编码人类松弛素受体的多核苷酸，HGPRBMY5v1

    公开(公告)号：US07189539B2

    公开(公告)日：2007-03-13

    申请号：US10994987

    申请日：2004-11-22

    申请人： Chandra S. Ramanathan ,  John N. Feder ,  Gabriel Mintier ,  Kelly L. Bennett

    发明人： Chandra S. Ramanathan ,  John N. Feder ,  Gabriel Mintier ,  Kelly L. Bennett

    IPC分类号： C12P21/02 ,  C12N5/16 ,  C12N1/21 ,  C12N15/63 ,  C07H21/04

    CPC分类号： C07K14/723

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码HGPRBMY5v1和HGPRBMY5v2多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY5v1和HGPRBMY5v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Hereditary Hemochromatosis Gene
    36.
    发明申请
    Hereditary Hemochromatosis Gene 有权
    遗传性色素沉着病基因

    公开(公告)号：US20100204051A1

    公开(公告)日：2010-08-12

    申请号：US12389324

    申请日：2009-02-19

    申请人： Winston J. Thomas ,  Dennis T. Drayna ,  John N. Feder ,  Andreas Gnirke ,  David Ruddy ,  Zenta Tsuchihashi ,  Roger K. Wolff

    发明人： Winston J. Thomas ,  Dennis T. Drayna ,  John N. Feder ,  Andreas Gnirke ,  David Ruddy ,  Zenta Tsuchihashi ,  Roger K. Wolff

    IPC分类号： C40B30/04 ,  C12Q1/68

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/70539 ,  C12Q1/6883

    摘要： The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.

    摘要翻译： 本发明一般涉及导致疾病遗传性血色素沉着症（HH）的基因及其突变。 更具体地，本发明涉及对应于正常和突变HH基因的DNA序列的鉴定，分离和克隆，以及它们的转录物和基因产物的表征。 本发明还涉及用于筛选HH纯合子的方法等，还涉及HH诊断，产前筛查和诊断以及HH疾病的治疗，包括基因治疗剂，基于蛋白质和基于抗体的治疗剂和小分子治疗剂。

    Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
    37.
    发明授权
    Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1 有权
    人类含有亮氨酸的重复含有蛋白质主要在骨髓HLRRBM1中表达

    公开(公告)号：US07304141B2

    公开(公告)日：2007-12-04

    申请号：US11107572

    申请日：2005-04-15

    申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol

    发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol

    IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N5/20 ,  C12P21/02

    CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K2039/53 ,  C07K14/47

    摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a human leucine-rich repeat domain containing protein, HLLRCR-1
    40.
    发明授权
    Polynucleotides encoding a human leucine-rich repeat domain containing protein, HLLRCR-1 有权
    编码富含人类富含亮氨酸的重复结构域的多核苷酸HLLRCR-1

    公开(公告)号：US07129085B2

    公开(公告)日：2006-10-31

    申请号：US10271078

    申请日：2002-10-11

    申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel Mintier

    发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel Mintier

    IPC分类号： C12N5/16 ,  C12N1/21 ,  C12N15/63 ,  C07H21/04

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码HLLRCR-1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLLRCR-1多肽应用于诊断，治疗和/或预防与这些多肽，特别是神经系统疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。