-
公开(公告)号：US20140236267A1
公开(公告)日：2014-08-21
申请号：US14261693
申请日：2014-04-25
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker
CPC classification number: A61N5/0622 , A61K35/34 , C12N5/069
Abstract: Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.
Abstract translation: 描述了光敏心律调节结构和系统。 基因工程组织包括起搏细胞群，所述起搏细胞表达感光膜转运机制，其响应特定波长的光与光源，发电机和传感器中的一个或多个组合，提供起搏器和/ 或去纤颤器功能。 系统进一步提供用于电生理研究的体外模型系统。
-
公开(公告)号：US20250145956A1
公开(公告)日：2025-05-08
申请号：US18684234
申请日：2022-07-01
Applicant: President and Fellows of Harvard College
Inventor： John F. Zimmerman , Huibin Chang , Kevin Kit Parker
Abstract: Methods of evaluating functional activity of an engineered three-dimensional tissue, methods of identifying a compound that modulates tissue function, and methods for identifying a compounds that is useful for treating or preventing a disease affecting tissue function are provided herein. Some methods include providing or obtaining a three-dimensional tissue scaffold defining a lumen or a cavity, the tissue scaffold comprising one or more polymeric fibers each having a micron-scale or nanometer-scale diameter, at least some of the one or more polymeric fibers encircling the lumen or cavity at a helical angle with respect to a longitudinal axis of the lumen or cavity, at an azimuthal orientation with respect to the longitudinal axis of the lumen or cavity, or at both.
-
公开(公告)号：US20250034759A1
公开(公告)日：2025-01-30
申请号：US18910120
申请日：2024-10-09
Applicant: President and Fellows of Harvard College
Inventor： Qihan Liu , Kevin Kit Parker , Huibin Chang
Abstract: Systems and methods for focused direction deposition of a micron or nanometer dimension polymeric fiber and materials of such fibers are described herein. Systems and methods employ one or more gas flows to entrain and deflect fibers produced by a rotary jet spinning system forming a focused fiber stream. Some embodiments enable control of alignment and distribution of the fibers with a relatively high fiber throughput.
-
公开(公告)号：US12043922B2
公开(公告)日：2024-07-23
申请号：US17501005
申请日：2021-10-14
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Grant Michael Gonzalez , Holly M. Golecki , Kwanwoo Shin , Josue A. Goss
CPC classification number: D01D5/18 , C08J5/18 , D01D5/06 , D01F6/605 , D01F9/00 , C08J2377/10 , D10B2331/021 , Y10T428/249921
Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.
-
公开(公告)号：US11773359B2
公开(公告)日：2023-10-03
申请号：US17146264
申请日：2021-01-11
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Anthony Bahinski , Robert Cunningham , Josue A. Goss , Geraldine A. Hamilton , Christopher David Hinojosa , Daniel Levner , Kevin Kit Parker
IPC: C12M3/06 , C12M1/34 , G01N33/50 , B01L3/00 , B01L9/00 , C12M3/00 , C12M1/00 , C12M1/42 , A01N1/02
CPC classification number: C12M23/16 , A01N1/02 , B01L3/502715 , B01L9/52 , C12M21/08 , C12M23/42 , C12M29/10 , C12M35/04 , C12M35/08 , C12M41/00 , G01N33/5082 , G01N33/5088 , A01N1/021 , A01N1/0247 , A01N1/0273 , B01L3/5027 , B01L2200/0684 , B01L2200/0689 , B01L2200/146 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0663 , B01L2300/0867 , B01L2300/0877 , B01L2300/123 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M41/12 , C12M41/46 , G01N33/5005
Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
-
Patent Agency Ranking
公开(公告)号：US20230287318A1
公开(公告)日：2023-09-14
申请号：US18116863
申请日：2023-03-03
Applicant: President and Fellows of Harvard College
Inventor： Benjamin D. Pope , Kevin Kit Parker
CPC classification number: C12M21/08 , A61K35/28 , C12M23/20 , C12M25/00 , C12N5/0653 , C12N2533/30 , C12N2533/90 , C12N2535/00
Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.
-
公开(公告)号：US20220380943A1
公开(公告)日：2022-12-01
申请号：US17771530
申请日：2020-10-30
Applicant: President and Fellows of Harvard College
Inventor： Grant Michael Gonzalez , John F. Zimmerman , Kevin Kit Parker
Abstract: System, devices and methods for the fabrication of polymeric fibers, as well as resulting polymeric fibers, polymeric fiber materials and uses thereof are described. The polymeric fibers include poly(para-phenylene terephthalamide) (PPTA) fibers having an average fiber diameter in a range of 300 nm to 3 μm, and having an average Young's modulus in a range of 1 GPa to 100 GPa. Some materials including a plurality of the polymeric fibers have a thermal conductivity (k) in a range of 0.005 W/(m·K) to 10 W/(m·K) as measured perpendicular to a plane of the material.
-
公开(公告)号：US11511129B2
公开(公告)日：2022-11-29
申请号：US16689178
申请日：2019-11-20
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker
Abstract: Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.
-
公开(公告)号：US11384328B2
公开(公告)日：2022-07-12
申请号：US15777242
申请日：2016-11-18
Applicant: President and Fellows of Harvard College
Inventor： Alanna R. Gannon , Aaron L. Glieberman , Kevin Kit Parker , Benjamin D. Pope , Kevin L. Shores , Nina R. Sinatra
Abstract: Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological cells are described herein. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge. Microfluidic systems including a housing configured to receive a cartridge, the housing including channels for loading one or more biological cells within wells of the cartridge are described herein. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, and the use of such compositions, devices and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications are also described herein.
-
公开(公告)号：US11174571B2
公开(公告)日：2021-11-16
申请号：US16679578
申请日：2019-11-11
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Grant Michael Gonzalez , Holly M. Golecki , Kwanwoo Shin , Josue A. Goss
Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.
-
-
-
-
-
-
-
-
-
Search Results
71
records
(took 0.026 seconds)
