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31.发明申请公开(公告)号：US20070031399A1
公开(公告)日：2007-02-08
申请号：US10572811
申请日：2004-09-23
CPC分类号： C12P21/06 , A23J3/346 , A61K38/482
摘要： The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
摘要翻译： 本发明涉及肽或多肽的蛋白水解水解方法，所述肽或多肽包含4至40个，优选5至35个氨基酸残基，并且所述肽或多肽不能被枯草杆菌蛋白酶水解，因此所述肽或多肽 由pH6.5或更低，优选5.5或更低，更优选5.0或更低的脯氨酸特异性内切蛋白酶水解，以水解所述肽或多肽。
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32.发明申请Nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction 有权胰岛素敏化剂和肽级分的营养和治疗组合物公开(公告)号：US20050271744A1
公开(公告)日：2005-12-08
申请号：US10525959
申请日：2003-09-02
IPC分类号： A23J3/34 , A23L1/30 , A23L1/302 , A23L1/304 , A23L1/305 , A23L2/38 , A23L2/52 , A61K31/198 , A61K31/415 , A61K31/455 , A61K33/24 , A61K38/01 , A61K38/05 , A61K38/06 , A61K45/06 , A61P3/10 , A61K35/78 , A61K33/26
CPC分类号： A61K38/018 , A23L2/52 , A23L33/105 , A23L33/15 , A23L33/16 , A23L33/175 , A23L33/18 , A23V2002/00 , A61K31/198 , A61K31/415 , A61K31/455 , A61K33/24 , A61K38/011 , A61K38/05 , A61K38/06 , A61K2300/00 , A23V2250/5114 , A23V2250/61 , A23V2250/5486 , A23V2250/0628 , A23V2250/0638
摘要： The present invention discloses a composition comprising an insulin sensitizer and a peptide fraction, which promotes significant reduction in blood glucose levels and stabilizes blood glucose levels in individuals with type 2 diabetes.
摘要翻译： 本发明公开了一种包含胰岛素敏化剂和肽级分的组合物，其促进2型糖尿病患者血糖水平的显着降低和血糖水平的稳定。
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33.发明授权Structural genes encoding the various allelic and maturation forms of preprothaumatin, recombinant cloning vehicles comprising said structural genes and expression thereof in transformed microbial host cells 失效编码前油麻黄素的各种等位基因和成熟形式的结构基因，包含所述结构基因的重组克隆载体及其在转化的微生物宿主细胞中的表达
公开(公告)号：US4771000A
公开(公告)日：1988-09-13
申请号：US732818
申请日：1985-05-10
IPC分类号： C12N15/09 , C07K14/43 , C12N1/20 , C12N1/21 , C12P19/34 , C12P21/00 , C12P21/02 , C12R1/19 , C07H21/04 , C12N15/00 , C12P21/04
CPC分类号： C07K14/43
摘要： The invention relates to structural genes comprising encoding non-processed and partly processed thaumatin, to the various allelic forms of said non-processed thaumatin and to recombinant DNA's and plasmids comprising said structural genes coding for the various allelic forms of preprothaumatin, and naturally and/or artifically modified preprothaumatin in various stages of its natural processing, and to the use of said recombinant plasmids to transform microorganisms, particularly bacteria in which said genes are expressed.
摘要翻译： 本发明涉及包含编码未处理和部分处理的奇异果甜蛋白的结构基因，与所述未加工的马齿苋的各种等位基因型以及包含编码前油麻黄素的各种等位基因形式的所述结构基因的重组DNA和质粒，天然和/ 或在其天然加工的各个阶段的人工修饰的前油麻黄素，以及使用所述重组质粒转化微生物，特别是表达所述基因的细菌。
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34.发明授权Yeast of the genus kluyveromyces modified for the expression of preprothaumatin or its various allelic and modified forms or their maturation forms, and the proteins obtained by that expression 失效用于表达前油麻黄素或其各种等位基因和修饰形式或其成熟形式的克鲁维酵母属的酵母，以及通过该表达获得的蛋白质
公开(公告)号：US4657857A
公开(公告)日：1987-04-14
申请号：US570984
申请日：1984-01-18
IPC分类号： C12N15/00 , A61K35/74 , A61K38/00 , C07K14/43 , C12N1/16 , C12N1/19 , C12N9/34 , C12N9/64 , C12N15/09 , C12N15/68 , C12N15/81 , C12N15/90 , C12P21/00 , C12P21/02 , C12R1/645 , C12N1/00
CPC分类号： C12N9/2428 , C07K14/43 , C12N15/68 , C12N15/815 , C12N15/90 , C12N9/6481 , C07K2319/036
摘要： The invention relates to yeasts of the genus Kluyveromyces, in particular K. lactis, acting as hosts for the expression of preprothaumatin or its various allelic and modified forms or their maturation forms, which yeasts contain an rDNA plasmid comprising a structural gene encoding for a thaumatin-like protein, an autonomous replicating sequence derived from K. lactis (KARS), a yeast regulon derived from the GAPDH-genes of S. cerevisiae, and a selection marker, e.g. the trp-1 or the lac-4 gene from S. cerevisiae and K. lactis, respectively. Optionally the plasmid also contains a transcription terminator from a yeast. Further the preparation of such yeasts and the preparation of thaumatin-like proteins with such yeasts and the proteins so obtained are claimed. The yeast described give a better expression than obtained with E. coli as described in EP-PA (A2) 0 054 330 and 0 054 331, published on June 23, 1982.
摘要翻译： PCT No.PCT / EP83 / 00129 Sec。 371日期1984年1月18日 102（e）日期1984年1月18日PCT提交1983年5月19日PCT公布。 公开号WO83 / 04051 日本1983年11月24日。本发明涉及克鲁维酵母属的酵母，特别是乳酸克鲁维酵母作为前油麻黄素表达的宿主或其各种等位基因和修饰形式或其成熟形式，酵母含有rDNA质粒，其包含 编码类似丘脑蛋白的蛋白质的结构基因，来自乳酸克鲁维酵母（KARS）的自主复制序列，源自酿酒酵母的GAPDH基因的酵母调节物，以及选择标记，例如 分别来自酿酒酵母和乳酸克鲁维酵母的trp-1或lac-4基因。 任选地，质粒还含有来自酵母的转录终止子。 此外，要求保护这些酵母的制备以及用这些酵母制备象调蛋白样蛋白质和所得蛋白质。 与EP-PA（A2）0 054 330和0 054 331（1982年6月23日公布）中描述的所述酵母比用大肠杆菌获得的酵母更好。
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35.发明授权Process for the preparation of packaged heat-preserved aqueous drink comprising casein micelles and tryptophan-rich peptides, and product so obtained 有权用于制备包含酪蛋白胶束和富含色氨酸的肽的包装保温含水饮料的方法，以及如此获得的产品公开(公告)号：US08986773B2
公开(公告)日：2015-03-24
申请号：US12989876
申请日：2009-04-09
申请人： Rudolf Beckhoven Van , Arjen Bot , Alexander Duchateau , Luppo Edens , Joris Kloek , Andre L Ross De
发明人： Rudolf Beckhoven Van , Arjen Bot , Alexander Duchateau , Luppo Edens , Joris Kloek , Andre L Ross De
CPC分类号： A23L1/3056 , A23C9/1526 , A23C11/08 , A23L2/52 , A23L2/66 , A23L33/18 , A23L33/19 , A23V2002/00 , A23V2250/54246 , A23V2250/065
摘要： A process to prepare packaged pasteurized or sterilized aqueous drinkable products which comprise casein micelles (e.g. from dairy protein) and peptide-fractions, which peptide fractions are rich in tryptophan, and the products so-obtained. The process requires a heat preservation at a specific pH.
摘要翻译： 制备包含酪蛋白胶束（例如乳蛋白质）和肽级分的包装的巴氏灭菌或灭菌的含水可饮用产品的方法，该肽部分富含色氨酸，以及如此获得的产物。 该方法需要在特定pH下进行保温。
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公开(公告)号：US20120107847A1
公开(公告)日：2012-05-03
申请号：US13381865
申请日：2010-06-24
申请人： Maaike Johanna Bruins , Luppo Edens
发明人： Maaike Johanna Bruins , Luppo Edens
IPC分类号： G01N33/566 , G06Q90/00 , G06Q50/22 , C12N9/50
CPC分类号： G01N33/564 , G01N2800/06 , G06Q99/00
摘要： We describe a method to determine effectiveness of a compound or composition in treatment of celiac disease or gluten intolerance, the method comprising: administration of the compound or composition to one or more human patients who were on a gluten-free diet for 10 years or less, preferably 6 years or less; challenge with gluten of the one or more human patients who were administered the compound or composition; and determining whether there is a change in condition of celiac disease or gluten intolerance of the one or more patients that results from administration of the compound or composition and challenge with gluten; whereby no significant change in condition indicates that the compound or composition would be effective in treating celiac disease or gluten intolerance.
摘要翻译： 我们描述了一种确定化合物或组合物治疗乳糜泻或麸质不耐症的有效性的方法，该方法包括：将化合物或组合物施用于一个或多个无麸质饮食10年以上的人类患者 ，优选6年以下; 对施用化合物或组合物的一个或多个人类患者的面筋进行挑战; 以及确定由所述化合物或组合物的施用引起的一种或多种患者的腹腔疾病或麸质不耐受状况是否发生变化，并用面筋进行攻击; 因此条件没有显着变化表明化合物或组合物将有效治疗乳糜泻或麸质不耐受。
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37.发明申请PROCESS FOR THE PREPARATION OF PACKAGED HEAT-PRESERVED AQUEOUS DRINK COMPRISING CASEIN MICELLES AND TRYPTOPHAN-RICH PEPTIDES, AND PRODUCT SO OBTAINED 有权制备包装加热保存的含有壳聚糖和三木糖的肽的水性饮料的方法和获得的产品公开(公告)号：US20110165287A1
公开(公告)日：2011-07-07
申请号：US12989876
申请日：2009-04-09
申请人： Rudolf Beckhoven Van , Arjen Bot , Alexander Duchateau , Luppo Edens , Joris Kloek , Andre L. Ross De
发明人： Rudolf Beckhoven Van , Arjen Bot , Alexander Duchateau , Luppo Edens , Joris Kloek , Andre L. Ross De
IPC分类号： A23L3/3571 , B65D85/80 , B65B55/00
CPC分类号： A23L1/3056 , A23C9/1526 , A23C11/08 , A23L2/52 , A23L2/66 , A23L33/18 , A23L33/19 , A23V2002/00 , A23V2250/54246 , A23V2250/065
摘要： A process to prepare packaged pasteurised or sterilised aqueous drinkable products which comprise casein micelles (e.g. from dairy protein) and peptide-fractions, which peptide fractions are rich in tryptophan, and the products so-obtained. The process requires a heat preservation at a specific pH.
摘要翻译： 制备包含酪蛋白胶束（例如乳蛋白质）和肽级分的包装的巴氏灭菌或灭菌的含水可饮用产品的方法，该肽部分富含色氨酸，以及如此获得的产物。 该方法需要在特定pH下进行保温。
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公开(公告)号：US20110086803A1
公开(公告)日：2011-04-14
申请号：US12447332
申请日：2007-10-30
申请人： Andre Leonardus De Roos , Luppo Edens , Rudolf Franciscus Van Beckhoven , Alexander Lucia Leonardus Duchateau , Joris Kloek
发明人： Andre Leonardus De Roos , Luppo Edens , Rudolf Franciscus Van Beckhoven , Alexander Lucia Leonardus Duchateau , Joris Kloek
摘要： The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
摘要翻译： 本发明涉及一种制备包含水溶性肽并且Trp / LNAA比大于0.15的组合物的方法，其包括水解溶菌酶，优选鸡蛋溶菌酶，以制备DH为5至45的水解产物 。
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公开(公告)号：US20100286034A1
公开(公告)日：2010-11-11
申请号：US12811051
申请日：2008-12-10
CPC分类号： A23J3/346 , A23K20/147 , A23L33/175 , A23L33/18 , A23V2002/00 , A23V2200/316 , A23V2250/548 , A23V2200/328
摘要： The present invention relates to a protein hydrolysate comprising free amino acids and peptides whereby the weight ratio of free amino acids to peptides is about 1:1 and wherein at least about 50 molar % of the peptides has a molecular weight of 400 Da or less. This composition may be rich in one or more branched-chain amino acid-(BCAA-) and or glutamine-containing di- or tripeptides. Also, the invention relates to the use of a water soluble protein-containing aqueous fraction obtained from a wet-milling process or the protein hydrolysate in: the manufacture of a medicament for the treatment or prevention of a condition associated with inappropriate blood sugar metabolism; aiding recovery and/or endurance during or after exercise; stimulating the generation of lean body mass; infant nutrition; or the preparation of a food or feed composition or a food or feed supplement.
摘要翻译： 本发明涉及包含游离氨基酸和肽的蛋白质水解物，其中游离氨基酸与肽的重量比为约1:1，其中至少约50摩尔％的肽具有400Da或更小的分子量。 该组合物可以富含一个或多个支链氨基酸 - （BCAA-）和/或含谷氨酰胺的二肽或三肽。 此外，本发明涉及在湿法研磨或蛋白质水解产物中得到的含水溶性蛋白质的水性组分的用途：制备用于治疗或预防与不适当的血糖代谢有关的病症的药物; 在运动期间或之后协助康复和/或耐力; 刺激瘦体重的产生; 婴幼儿营养; 或制备食物或饲料组合物或食品或饲料补充剂。
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公开(公告)号：US07648721B2
公开(公告)日：2010-01-19
申请号：US10483948
申请日：2002-07-18
摘要： The present invention provides a composition comprising hydrolysed milk casein and, preferably non-hydrolysed whey protein in a ratio from 9:1 to 1:1 (on dry weight), which is a clear liquid at pH 4 when dissolved or present in water in an amount of 40 g/liter at 10° C.
摘要翻译： 本发明提供了一种组合物，其包含水解乳酪蛋白和优选非水解乳清蛋白，其比例为9:1至1:1（干重），其在溶于或存在于水中时为pH4时的澄清液体 在10℃下的量为40g / l
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