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31.发明申请SYSTEM AND METHOD FOR COMPENSATING FOR SHIFTING OF NEUROSTIMULATION LEADS IN A PATIENT 有权用于补偿患者神经细胞发生突变的系统和方法公开(公告)号：US20100331922A1
公开(公告)日：2010-12-30
申请号：US12495442
申请日：2009-06-30
申请人： Andrew DiGiore , Kristen Jaax , Courtney Lane
发明人： Andrew DiGiore , Kristen Jaax , Courtney Lane
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.
摘要翻译： 提供了一种用于确定神经刺激引线相对于患者的刺激目标组织的位置变化的方法。 该方法包括在患者的表面上植入第一接近传感器，在患者的表面上植入第二接近传感器，测量第一和第二接近传感器之间的距离的变化，并推断引线的位置变化 相对于刺激目标组织的距离测量的变化。 该方法还包括当第一和第二接近传感器之间的距离增加时，推断引线和刺激目标组织之间的距离的增加。 该方法还包括传送电刺激能量以治疗刺激刺激目标组织，以及响应于所测量的距离变化来调制刺激参数。
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32.发明申请ANCHORING UNITS FOR LEADS OF IMPLANTABLE ELECTRIC STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 有权可植入电刺激系统引导锚固单元及其制造和使用方法公开(公告)号：US20110295330A1
公开(公告)日：2011-12-01
申请号：US13207876
申请日：2011-08-11
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译： 神经刺激引线具有远端，近端和纵向长度。 神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。 神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。 所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。
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33.发明申请METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE SHIFTING 有权使用脉冲移位在多通道神经网络系统中避免频率锁定的方法公开(公告)号：US20110054567A1
公开(公告)日：2011-03-03
申请号：US12550213
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/08
CPC分类号： A61N1/36021 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B5/04004 , A61B5/0488 , A61B5/1118 , A61B5/112 , A61B5/4812 , A61B5/4836 , A61M5/1723 , A61N1/0529 , A61N1/08 , A61N1/306 , A61N1/36025 , A61N1/36031 , A61N1/36034 , A61N1/3605 , A61N1/3606 , A61N1/36062 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36171 , A61N1/36178
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the pulsed electrical waveforms that will potentially overlap temporally are predicted. Stimulation pulses in the respective pulsed electrical waveforms are temporally shifted in a manner that prevents overlap of the potentially overlapping pulse sets while preventing frequency locking between the timing channels.
摘要翻译： 提供了一种用于治疗患者的方法和神经刺激系统。 多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。 可以预测脉冲电波形内可能在时间上重叠的一组刺激脉冲。 相应脉冲电波形中的刺激脉冲以防止可能重叠的脉冲组重叠的方式在时间上移位，同时防止定时通道之间的频率锁定。
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34.发明申请ANCHORING UNITS FOR LEADS OF IMPLANTABLE ELECTRIC STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 有权可植入电刺激系统引导锚固单元及其制造和使用方法公开(公告)号：US20090248095A1
公开(公告)日：2009-10-01
申请号：US12413081
申请日：2009-03-27
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译： 神经刺激引线具有远端，近端和纵向长度。 神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。 神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。 所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。
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35.发明申请SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMODATION TO ELETRICAL STIMULATION 有权用于避免，反向和管理神经病学接受电子刺激的系统和方法公开(公告)号：US20100023090A1
公开(公告)日：2010-01-28
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/08
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译： 提供了一种用于编程神经刺激装置的方法和编程器。 该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形 根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置 刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。
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36.发明授权External charger for an implantable medical device having at least one moveable charging coil 有权用于具有至少一个可移动充电线圈的可植入医疗装置的外部充电器公开(公告)号：US08994325B2
公开(公告)日：2015-03-31
申请号：US13277522
申请日：2011-10-20
CPC分类号： H02J50/40 , A61N1/3787 , H01F38/14 , H02J7/0042 , H02J7/025 , H02J50/12 , H02J50/90
摘要： Improved external chargers for charging an implantable medical device, and particularly useful in charging a plurality of such devices, are disclosed. Each of the various embodiments include design elements for mechanically manipulating the position of one or more charging coils within the external charger to customize the magnetic charging field as appropriate for the charger/implantable device environment. For example, a single charging coil may be moved within a housing of the external charger to direct the charging field of the coil towards the currently “coldest” implant, i.e., the implant with the lowest coupling to the external charger. The one or more charging coils may be mechanically manipulated within the external charger housing in a number of ways, including by using linear actuators, by inflatable bladders, or even by hand.
摘要翻译： 公开了改进的用于对植入式医疗装置进行充电的外部充电器，并且对于多个这种装置的充电特别有用。 各种实施例中的每一个都包括用于机械地操纵外部充电器内的一个或多个充电线圈的位置的设计元件，以适应充电器/可植入装置环境来定制磁充电场。 例如，单个充电线圈可以在外部充电器的壳体内移动以将线圈的充电场引向当前“最冷”的植入物，即具有与外部充电器的最低耦合的植入物。 一个或多个充电线圈可以以多种方式在外部充电器壳体内机械地操作，包括通过使用线性致动器，可膨胀气囊，或甚至手动操作。
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37.发明授权Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse placement 有权使用脉冲放置避免频率锁定在多通道神经刺激系统中的方法公开(公告)号：US08543200B2
公开(公告)日：2013-09-24
申请号：US12550237
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/36071 , A61N1/36082
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.
摘要翻译： 提供了一种用于治疗患者的方法和神经刺激系统。 多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。 预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。 每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定 在定时通道之间。
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公开(公告)号：US20110276111A1
公开(公告)日：2011-11-10
申请号：US13099906
申请日：2011-05-03
IPC分类号： A61N1/36
CPC分类号： A61N1/37229 , A61N1/08 , A61N1/37205 , A61N1/37211 , A61N1/378 , A61N1/3787
摘要： Improved external chargers for charging an implantable medical device, and particularly useful in charging a plurality of such devices, are disclosed. Each of the various embodiments include a plurality of field customization coils for customizing the magnetic charging field generated by the external charger such that the magnetic charging field is not radially symmetric. For example, one embodiment includes a primary coil with a plurality of field customization coils distributed radially with respect to the coil. The generated magnetic charging field can be rendered radially asymmetric by selectively activating or disabling the field customization coils in response to data quantifying the coupling between the various implants and the field customization coils in the charger. If there is a relatively high coupling between a particular implant and a particular customization coil for example, that customization coil can be activated to counter the magnetic charging field at that location, while still maintaining a relatively high magnetic charging field at the location of other implants that may have lower couplings.
摘要翻译： 公开了改进的用于对植入式医疗装置进行充电的外部充电器，并且对于多个这种装置的充电特别有用。 各种实施例中的每一个包括用于定制由外部充电器产生的磁充电场的多个场定制线圈，使得磁充电场不是径向对称的。 例如，一个实施例包括具有相对于线圈径向分布的多个场定制线圈的初级线圈。 响应于量化各种种植体和充电器中的野外定制线圈之间的耦合的数据，通过选择性地激活或禁用场定制线圈，可以使产生的磁充电场呈径向不对称。 例如，如果特定植入物和特定定制线圈之间存在相对较高的耦合，则该定制线圈可以被激活以抵抗该位置处的磁充电场，同时在其它植入物的位置保持相对高的磁充电场 这可能会降低联轴器。
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39.发明申请METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE PLACEMENT 有权使用脉冲放置在多通道神经元系统中避免频率锁定的方法公开(公告)号：US20110054568A1
公开(公告)日：2011-03-03
申请号：US12550237
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
CPC分类号： A61N1/08 , A61N1/36071 , A61N1/36082
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.
摘要翻译： 提供了一种用于治疗患者的方法和神经刺激系统。 多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。 预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。 每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定 在定时通道之间。
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40.发明授权Anchoring units for leads of implantable electric stimulation systems and methods of making and using 有权可植入电刺激系统的引导锚定单元及其制作和使用方法公开(公告)号：US08224460B2
公开(公告)日：2012-07-17
申请号：US13207876
申请日：2011-08-11
IPC分类号： A61N1/00
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译： 神经刺激引线具有远端，近端和纵向长度。 神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。 神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。 所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。
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