-
公开(公告)号：US06632836B1
公开(公告)日：2003-10-14
申请号：US09422143
申请日：1999-10-21
申请人： Robert K. Baker , Jianming Bao , Jennifer Chee , Maria L. Garcia , Gregory J. Kaczorowski , Frank Kayser , Andrew Kotliar , Chou Juitsai Liu , Shouwu Miao , William H. Parsons , Kathleen M. Rupprecht , William A. Schmalhofer , Christopher F. Claiborne , David A. Claremon , Nigel Liverton , Wayne J. Thompson
发明人： Robert K. Baker , Jianming Bao , Jennifer Chee , Maria L. Garcia , Gregory J. Kaczorowski , Frank Kayser , Andrew Kotliar , Chou Juitsai Liu , Shouwu Miao , William H. Parsons , Kathleen M. Rupprecht , William A. Schmalhofer , Christopher F. Claiborne , David A. Claremon , Nigel Liverton , Wayne J. Thompson
IPC分类号： A61K3116
CPC分类号： C07D207/08 , C07B2200/07 , C07C235/60 , C07C237/22 , C07C255/46 , C07C271/12 , C07C271/34 , C07C271/38 , C07C271/56 , C07C275/26 , C07C309/66 , C07C309/67 , C07C309/73 , C07C311/05 , C07C311/07 , C07C311/20 , C07C333/06 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D209/14 , C07D213/643 , C07D233/64 , C07D263/28 , C07D307/14 , C07D307/79
摘要： The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及可用作治疗自身免疫性疾病，心律失常等的钾通道抑制剂的一类式I的碳环化合物。
-
32.发明授权公开(公告)号：US06489354B1
公开(公告)日：2002-12-03
申请号：US09516771
申请日：2000-03-01
IPC分类号： A61K3140
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
摘要翻译： 本发明涉及可用作趋化因子受体活性调节剂的式I的吡咯烷化合物（其中R1，R2，R3，R4c，R4d和R4f如本文所定义）。 特别地，这些化合物可用作趋化因子受体CCR-3和/或CCR-5的调节剂。
-
公开(公告)号：US5998408A
公开(公告)日：1999-12-07
申请号：US946801
申请日：1997-10-08
申请人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
发明人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
IPC分类号： A61K31/34 , A61K31/365 , A61K31/445 , A61K31/47 , A61K31/52 , A61K38/13 , A61K45/06 , A61K31/35 , A61K31/54 , A61K31/535 , C07D313/02 , C07D307/77 , C07D409/02 , C07D493/22
CPC分类号： A61K31/52 , A61K31/34 , A61K31/365 , A61K31/445 , A61K31/47 , A61K38/13 , A61K45/06
摘要： The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
摘要翻译： 式I的化合物可用作免疫抑制剂。
-
公开(公告)号：US5952371A
公开(公告)日：1999-09-14
申请号：US943869
申请日：1997-10-08
申请人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
发明人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
IPC分类号： A61K31/335 , A61K31/365 , A61K31/445 , A61K31/47 , A61K31/52 , A61K38/13 , A61K45/06 , C07D493/04 , A61K31/34 , C07D307/77
CPC分类号： C07D493/04 , A61K31/335 , A61K31/365 , A61K31/445 , A61K31/47 , A61K31/52 , A61K38/13 , A61K45/06
摘要： The compounds of Formula I ##STR1## are useful as iumnunosuppressive agents.
摘要翻译： 式I的化合物可用作抑泡剂。
-
公开(公告)号：US5874594A
公开(公告)日：1999-02-23
申请号：US947307
申请日：1997-10-08
申请人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
发明人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
IPC分类号： C07D493/04 , C07D333/02 , A61K31/335 , A61K31/35 , A61K31/38
CPC分类号： C07D493/04
摘要： ##STR1## are useful as immunosuppressive agents.
摘要翻译：
我作为免疫抑制剂是有用的。 -
公开(公告)号：US5679705A
公开(公告)日：1997-10-21
申请号：US734247
申请日：1996-10-16
IPC分类号： A61K31/365 , C07D493/04 , A61K31/335 , C07D313/08
CPC分类号： C07D493/04 , A61K31/365
摘要： The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
-
公开(公告)号：US20240190892A1
公开(公告)日：2024-06-13
申请号：US18550332
申请日：2022-03-16
申请人： Natalija Cernaka , Anthony K. OGAWA , Alan C. CHENG , Jianming BAO , Phillip Patrick SHARP , Jovan Alexander LOPEZ , Dong XIAO , Haiqun TANG , Merck Sharp & Dohme LLC
发明人： Natalija Cernaka , Anthony K. Ogawa , Alan C. Cheng , Jianming Bao , Phillip Patrick Sharp , Jovan Alexander Lopez , Dong Xiao , Haiqun Tang
IPC分类号： C07D498/20 , A61K31/5386 , A61K45/06 , C07D519/00
CPC分类号： C07D498/20 , A61K31/5386 , A61K45/06 , C07D519/00
摘要： The present invention provides a compound of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age-related macular degeneration, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
-
公开(公告)号：US20230416227A1
公开(公告)日：2023-12-28
申请号：US18043357
申请日：2021-09-09
申请人： Merck Sharp & Dohme LLC , Anthony Ken OGAWA , Christopher J. SINZ , Jacqueline D. HICKS , Alan C. CHENG , Song YANG , Jianming BAO , Donna A. A. W. HAYES , Simon B. LANG , Maoqun TIAN , Salman JABRI , Galen Paul SHEARN-NANCE , Rongze KUANG , Zhiqiang ZHAO , Zhicai WU
发明人： Anthony Ken Ogawa , Christopher J. Sinz , Jacqueline D. Hicks , Alan C. Cheng , Song Yang , Jianming Bao , Donna A. A. W. Hayes , Simon B. Lang , Maoqun Tian , Salman Jabri , Galen Paul Shearn-Nance , Rongze Kuang , Zhiqiang Zhao , Zhicai Wu
IPC分类号： C07D401/14 , A61K45/06 , A61P9/10
CPC分类号： C07D401/14 , A61P9/10 , A61K45/06
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
-
![6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor](/abs-image/US/2019/06/25/US10329289B2/abs.jpg.150x150.jpg)
39.发明授权公开(公告)号：US10329289B2
公开(公告)日：2019-06-25
申请号：US15386009
申请日：2016-12-21
申请人： Jianming Bao , Xiaolei Gao , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Debra L. Ondeyka , Andrew W. Stamford , Fengqi Zhang
发明人： Jianming Bao , Xiaolei Gao , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Debra L. Ondeyka , Andrew W. Stamford , Fengqi Zhang
IPC分类号： C07D471/04 , C07F9/22 , C07D519/00 , C07D491/048 , C07D471/08 , C07D491/052 , A61K31/437 , A61P25/00
摘要： The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
-
公开(公告)号：US08563746B2
公开(公告)日：2013-10-22
申请号：US13125329
申请日：2009-10-19
申请人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
发明人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
IPC分类号： A61K31/4184 , A61K31/5377 , A61K31/497 , C07D235/26 , C07D235/28 , C07D401/10 , C07D401/06 , C07D409/04 , C07D403/10 , C07D413/10 , C07D413/14 , C07D417/04
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
-
-
-
-
-
-
-
-
-
搜索结果
45 条记录 (耗时 0.039 秒)
