摘要:
Disclosed are two PTH analog ligands, SP-PTH-AAK and Aib-SP-PTH-AAK, that have long-acting activity at the PTH receptor, as demonstrated both in vitro and in vivo. These polypeptides are thus particularly useful in the treatment of diseases, such as hypoparathyroidism, in which long-acting activity is desired. The method of making the analog polypeptides is also disclosed.
摘要:
In a mounting method for mounting a bump-equipped electronic component 5 with a plurality of metallic bumps 6 on a substrate 2 with a plurality of electrodes 3, during the process of connecting the metallic bumps 6 to the electrodes 3 by aligning the metallic bumps with the electrodes 3 with thermosetting resin 4 intervening between the electronic component 5 and substrate 2 and by pressing the electronic component 5 to the substrate 2 while exerting ultrasonic oscillation, heat and applied pressure on the electronic component 5, all of the metallic bumps 6 are brought into contact with the electrodes so that they are electrically connected to each other, and when some of the metallic bumps are metallic-bonded to the electrodes, ultrasonic oscillation is stopped. Thus, it is possible to prevent occurrence of damage owing to the excessive exertion of ultrasonic oscillation on the metallic bumps which have precedently started their metallic-bonding.
摘要:
A fast synchronization pull-in and an optimum error correction are achieved in a reproduction apparatus for reproducing data recorded on a recording medium even in the case where the quality of input data involving a seek or defect is low. A seek amount detection block 190 is provided, a seek change signal 201 is generated, and the width of a synchronization detection window pulse 161 and a correction algorithm in a correction block 230 are modified.
摘要:
An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.
摘要:
A temperature control apparatus comprises a light-emitting device, a light-emitting device controller, a Peltier device for controlling the temperature of the light-emitting device to a target temperature, a temperature detector for the light-emitting device, a first reference voltage holding unit for holding a voltage corresponding to the target temperature, a reference voltage controller for outputting a holding signal and a switching signal, a second reference voltage holding unit for holding the output voltage of the temperature detector on the basis of the holding signal, a reference voltage switching unit for selecting either the output of the first reference voltage holding unit or the output of the second reference voltage holding unit as a reference voltage, and a Peltier controller for controlling the Peltier device so as to minimize a difference between the output voltage of the temperature detector and the output voltage of the reference voltage switching unit.
摘要:
An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.
摘要:
Bone-associated proteins derived from bone of mammals, including mice and human beings, named OSF-6. The protein is the novel natural type mammal protein, which can play an important role in bone formation, and belongs to a group of transcription control factors.OSF-6 can be used as a therapeutic agent for bone metabolic diseases, and also as a diagnostic agent for bone metabolic diseases, since it may demonstrate a high organ specificity to bone.
摘要:
A transmitter includes a transmitting buffer (21) for temporarily storing the information received from a first bus (11) of N (N is a natural number) bits width and a transmitting input distributer (22) and a transmitting output distributer (23) respectively provided in the input side and output side of the transmitting system buffer (21). A receiver includes a receiving buffer (31) for temporarily storing the information received from the second bus (12) and for sending the information to the first bus (11) and a receiving input distributer (32) and a receiving distributer (33) respectively provided in the input side and output side of the receiving buffer. The transmitting buffer (21) has at least m (m is a natural number) buffers of N bits width. When the second bus (12) has N bits width, the transmitting input distributer (22) sequentially inputs the information sent from the first bus to m buffers and the transmitting output distributer (23) sequentially extracts the information input to the buffers to send to the second bus ( 12). When the second bus (12) has mN bits width, the transmitting input distributer (22) sequentially inputs the information sent from the first bus (11) to m buffers and the transmitting output distributer (23) simultaneously extracts the information into the m buffers to send to the second bus (12).
摘要:
An isolated speech word is extracted from an input speech signal. First, the speech signal is divided into a high frequency band signal and a low frequency band signal. Next, the power levels of each of the high and low frequency band signals are independently compared with respective threshold levels. Finally, the front and the end of the speech word are detected from these independent comparisons.
摘要:
The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides.