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31.发明授权Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity 有权取代的环烷基胺衍生物作为趋化因子受体活性的调节剂公开(公告)号：US07378409B2
公开(公告)日：2008-05-27
申请号：US10923538
申请日：2004-08-19
申请人： Percy H. Carter , Robert J. Cherney , Douglas G. Batt , Gregory D. Brown , John V. Duncia , Daniel S. Gardner , Michael G. Yang
发明人： Percy H. Carter , Robert J. Cherney , Douglas G. Batt , Gregory D. Brown , John V. Duncia , Daniel S. Gardner , Michael G. Yang
IPC分类号： A61K31/166 , C07D265/30 , C07D487/04 , C07D239/74 , C07D239/26 , C07D213/76 , C07D231/12 , C07D207/333 , C07D205/04 , C07D307/46
CPC分类号： C07C237/22 , C07B2200/07 , C07C275/42 , C07C2601/14 , C07D205/04 , C07D207/34 , C07D213/38 , C07D213/64 , C07D213/65 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/40 , C07D231/56 , C07D233/56 , C07D235/30 , C07D239/28 , C07D239/42 , C07D239/94 , C07D257/04 , C07D261/20 , C07D271/06 , C07D277/28 , C07D295/205 , C07D295/215 , C07D307/66 , C07D307/68 , C07D401/04 , C07D413/12 , C07D487/04
摘要： The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.
摘要翻译： 本申请描述了可用于预防哮喘，多发性硬化，动脉粥样硬化和类风湿性关节炎的式（I）的MCP-1或其药学上可接受的盐形式的调节剂。
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公开(公告)号：US08642622B2
公开(公告)日：2014-02-04
申请号：US13160944
申请日：2011-06-15
IPC分类号： A61K31/445 , C07D211/00
CPC分类号： C07D211/52 , A61K31/451
摘要： The present application describes the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and arthrosclerosis using the compound of the invention are disclosed.
摘要翻译： 本申请描述了式（I）化合物或其立体异构体或其药学上可接受的盐。 此外，公开了使用本发明的化合物治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫病态如类风湿性关节炎和关节病的方法。
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33.发明授权公开(公告)号：US08501782B2
公开(公告)日：2013-08-06
申请号：US12670016
申请日：2008-07-23
申请人： Daniel S. Gardner , John V. Duncia , John Hynes , T.G. Murali Dhar , Percy H. Carter , Joseph B. Santella
发明人： Daniel S. Gardner , John V. Duncia , John Hynes , T.G. Murali Dhar , Percy H. Carter , Joseph B. Santella
IPC分类号： A61K31/4545 , A61K31/454 , A61K31/4525 , A61K31/451 , C07D405/12 , C07D401/12 , C07D401/04 , C07D211/52
CPC分类号： C07D401/12 , C07D211/52 , C07D405/12
摘要： The present application describes modulators of MIP-1α of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, Q, T, W, Z, R1, R3, R4, R5, R5a and R5b, are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using the modulators of formula (I) are disclosed.
摘要翻译： 本申请描述了式（I）的MIP-1α或其立体异构体或前药或其药学上可接受的盐的调节剂，其中m，Q，T，W，Z，R 1，R 3，R 4，R 5，R 5a和R 5b如上定义 这里。 此外，公开了使用式（I）的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和动脉粥样硬化的自身免疫病态的方法。
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公开(公告)号：US20090298833A1
公开(公告)日：2009-12-03
申请号：US12505724
申请日：2009-07-20
申请人： Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
发明人： Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
IPC分类号： A61K31/445 , C07D211/40 , C07D417/12 , C07D401/12 , C07D413/14 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P9/00 , A61P35/00 , A61P19/00 , A61P31/18
CPC分类号： C07D211/52 , C07D211/18 , C07D211/38 , C07D211/58 , C07D211/70 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107
摘要： The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.
摘要翻译： 本申请描述了MIP-1α或CCR-1的取代的哌啶基调节剂或其立体异构体或其药学上可接受的盐。 此外，公开了使用所述调节剂治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎和移植排斥的方法。
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35.发明授权Prodrugs of a piperidinyl derivative as modulators of chemokine receptor activity 有权哌啶衍生物的前药作为趋化因子受体活性的调节剂公开(公告)号：US08410139B2
公开(公告)日：2013-04-02
申请号：US12896955
申请日：2010-10-04
申请人： John Hynes , Percy H. Carter , Lyndon A. M. Cornelius , T.G. Murali Dhar , John V. Duncia , Satheesh Nair , Joseph B. Santella , Jayakumar S. Warrier , Hong Wu
发明人： John Hynes , Percy H. Carter , Lyndon A. M. Cornelius , T.G. Murali Dhar , John V. Duncia , Satheesh Nair , Joseph B. Santella , Jayakumar S. Warrier , Hong Wu
IPC分类号： A61K31/445 , C07D211/44
CPC分类号： C07D211/60 , C07D211/52 , C07F9/59
摘要： The present application describes prodrugs of the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis using the prodrug compounds of the invention are disclosed.
摘要翻译： 本申请描述了式（I）化合物的前药或其立体异构体或其药学上可接受的盐。 此外，公开了使用本发明的前药化合物治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎的方法。
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公开(公告)号：US06984651B2
公开(公告)日：2006-01-10
申请号：US10635946
申请日：2003-08-07
IPC分类号： A61K31/44 , C07D401/12
CPC分类号： C07D401/06 , C07D207/06 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/52 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/10
摘要： The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
摘要翻译： 本申请描述了可用于预防哮喘和其它过敏性疾病的式（I）的CCR3或其药学上可接受的盐形式的调节剂。
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37.发明申请PRODRUGS OF A PIPERIDINYL DERIVATIVE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权哌啶衍生物作为化合物受体活性调节剂的产物公开(公告)号：US20110082113A1
公开(公告)日：2011-04-07
申请号：US12896955
申请日：2010-10-04
申请人： John Hynes , Percy H. Carter , Lyndon A.M. Cornelius , T.G. Murali Dhar , John V. Duncia , Joseph B. Santella , Hong Wu , Satheesh Nair , Jayakumar S. Warrier
发明人： John Hynes , Percy H. Carter , Lyndon A.M. Cornelius , T.G. Murali Dhar , John V. Duncia , Joseph B. Santella , Hong Wu , Satheesh Nair , Jayakumar S. Warrier
IPC分类号： A61K31/675 , C07D211/52 , A61K31/451 , A61P19/02 , A61P29/00 , A61P9/04 , A61P31/18 , A61P17/06 , A61P11/06 , A61P37/06 , A61P35/00 , C07D413/12 , A61K31/5377 , C07F9/113
CPC分类号： C07D211/60 , C07D211/52 , C07F9/59
摘要： The present application describes prodrugs of the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis using the prodrug compounds of the invention are disclosed.
摘要翻译： 本申请描述了式（I）化合物的前药或其立体异构体或其药学上可接受的盐。 此外，公开了使用本发明的前药化合物治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎的方法。
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公开(公告)号：US06638950B2
公开(公告)日：2003-10-28
申请号：US09885550
申请日：2001-06-20
IPC分类号： A61K31445
CPC分类号： C07D401/06 , C07D207/06 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/52 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/10
摘要： The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
摘要翻译： 本申请描述了可用于预防哮喘和其它过敏性疾病的式（I）的CCR3或其药学上可接受的盐形式的调节剂。
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公开(公告)号：US08877749B2
公开(公告)日：2014-11-04
申请号：US13500323
申请日：2010-10-06
申请人： T. G. Murali Dhar , John V. Duncia , Daniel S. Gardner , Weiwei Guo , John Hynes
发明人： T. G. Murali Dhar , John V. Duncia , Daniel S. Gardner , Weiwei Guo , John Hynes
IPC分类号： A61K31/535 , C07D413/12 , C07D471/04 , C07D405/12 , A61K31/4427 , C07D401/12
CPC分类号： C07D471/10 , A61K31/4427 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： The present application describes modulators of chemokine receptor activity of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
摘要翻译： 本申请描述了式（I）的趋化因子受体活性的调节剂或其立体异构体或其药学上可接受的盐。 此外，公开了使用式（I）的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和移植排斥反应的自身免疫病态的方法。
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公开(公告)号：US20120202802A1
公开(公告)日：2012-08-09
申请号：US13500323
申请日：2010-10-06
申请人： T.G. Murali Dhar , John V. Duncia , Daniel S. Gardner , Weiwei Guo , John Hynes
发明人： T.G. Murali Dhar , John V. Duncia , Daniel S. Gardner , Weiwei Guo , John Hynes
IPC分类号： A61K31/537 , C07D401/12 , A61K31/527 , A61K31/454 , C07D471/10 , A61K31/4545 , A61K31/4523 , A61P1/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P9/00 , A61P31/18 , A61P17/06 , A61P11/00 , A61P13/12 , A61P11/06 , A61P9/10 , A61P35/00 , C07D405/12 , C07D413/12
CPC分类号： C07D471/10 , A61K31/4427 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： The present application describes modulators of chemokine receptor activity of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
摘要翻译： 本申请描述了式（I）的趋化因子受体活性的调节剂或其立体异构体或其药学上可接受的盐。 此外，公开了使用式（I）的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和移植排斥反应的自身免疫病态的方法。
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