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47 条记录 (耗时 0.038 秒)

    Device and method for combining a treatment agent and a gel
    31.
    发明授权
    Device and method for combining a treatment agent and a gel 有权
    用于组合处理剂和凝胶的装置和方法

    公开(公告)号：US08500680B2

    公开(公告)日：2013-08-06

    申请号：US12013286

    申请日：2008-01-11

    申请人： Charles D. Claude ,  Paul J. Kawula ,  Syed Faiyaz Ahmed Hossainy ,  Kimchi Tran

    发明人： Charles D. Claude ,  Paul J. Kawula ,  Syed Faiyaz Ahmed Hossainy ,  Kimchi Tran

    IPC分类号： A61M37/00

    CPC分类号： A61K9/0024 ,  A61K9/06

    摘要： A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.

    摘要翻译： 一种方法，包括在哺乳动物宿主内的处理部位引入处理剂; 并在处理部位引入可生物浸渍的凝胶材料。 一种包括第一环形构件的装置，所述第一环形构件具有围绕所述第一环形构件的长度设置的第一腔和在所述第一环形构件的近端处的第一入口，以及联接到所述第一环形构件的第二环形构件，所述第二环形构件具有第二内腔 设置在所述第二环形构件的大约一定长度处和在所述第二环形构件的近端处的第二入口，其中所述第一环形构件和所述第二环形构件被定位成允许通过每个环形构件引入的处理剂在 治疗部位。

    DEVICE AND METHOD FOR COMBINING A TREATMENT AGENT AND A GEL
    32.
    发明申请
    DEVICE AND METHOD FOR COMBINING A TREATMENT AGENT AND A GEL 有权
    用于组合治疗剂和凝胶的装置和方法

    公开(公告)号：US20120296312A1

    公开(公告)日：2012-11-22

    申请号：US13559423

    申请日：2012-07-26

    申请人： Charles D. Claude ,  Paul J. Kawula ,  Syed Faiyaz Ahmed Hossainy ,  Kimchi Tran

    发明人： Charles D. Claude ,  Paul J. Kawula ,  Syed Faiyaz Ahmed Hossainy ,  Kimchi Tran

    IPC分类号： A61M5/00 ,  A61M25/00

    CPC分类号： A61K9/0024 ,  A61K9/06

    摘要： A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.

    摘要翻译： 一种方法，包括在哺乳动物宿主内的处理部位引入处理剂; 并在处理部位引入可生物浸渍的凝胶材料。 一种包括第一环形构件的装置，所述第一环形构件具有围绕所述第一环形构件的长度设置的第一腔和在所述第一环形构件的近端处的第一入口，以及联接到所述第一环形构件的第二环形构件，所述第二环形构件具有第二内腔 设置在所述第二环形构件的大约一定长度处和在所述第二环形构件的近端处的第二入口，其中所述第一环形构件和所述第二环形构件被定位成允许通过每个环形构件引入的处理剂在 治疗部位。

    Methods of delivering a drug using a medical device with a coating comprising a self-assembled molecular structure
    33.
    发明授权
    Methods of delivering a drug using a medical device with a coating comprising a self-assembled molecular structure 有权
    使用具有包含自组装分子结构的涂层的医疗装置递送药物的方法

    公开(公告)号：US07945319B2

    公开(公告)日：2011-05-17

    申请号：US12043884

    申请日：2008-03-06

    申请人： Connie S. Kwok ,  Charles D. Claude

    发明人： Connie S. Kwok ,  Charles D. Claude

    IPC分类号： A61N1/30

    CPC分类号： A61K9/0024 ,  A61N1/30

    摘要： A method for local delivery of a drug is provided. The method comprises acts of: (a) implanting a medical device including a drug-containing coating in a patient for the delivery of the drug, wherein the coating comprises a drug and a polymer; and (b) applying an electric current for an interval of time to the topcoat to cause the polymer to transform from a crystalline structure to an amorphous structure so as to increase the rate of release of the drug during the time interval, wherein after the electric current is terminated, the crystallinity of the polymer returns back to essentially the same degree of crystallinity or a more crystalline structure than that of when the polymer was exposed to the current.

    摘要翻译： 提供了一种局部递送药物的方法。 该方法包括以下动作：（a）将包括含药物涂层的医疗装置植入患者体内用于输送药物，其中所述包衣包含药物和聚合物; 和（b）将时间间隔的电流施加到面漆，使聚合物从晶体结构转变成非晶结构，从而在时间间隔期间增加药物的释放速率，其中在电 电流被终止，聚合物的结晶度返回到与聚合物暴露于电流时的结晶度基本相同的结晶度或更结晶的结构。

    COATINGS COMPRISING SELF-ASSEMBLED MOLECULAR STRUCTURES AND A METHOD OF DELIVERING A DRUG USING THE SAME
    37.
    发明申请
    COATINGS COMPRISING SELF-ASSEMBLED MOLECULAR STRUCTURES AND A METHOD OF DELIVERING A DRUG USING THE SAME 有权
    包含自组装分子结构的涂料和使用其组合的药物的方法

    公开(公告)号：US20080154231A1

    公开(公告)日：2008-06-26

    申请号：US12043884

    申请日：2008-03-06

    申请人： CONNIE S. KWOK ,  Charles D. Claude

    发明人： CONNIE S. KWOK ,  Charles D. Claude

    IPC分类号： A61N1/30

    CPC分类号： A61K9/0024 ,  A61N1/30

    摘要： A method for local delivery of a drug is provided. The method comprises acts of: (a) implanting a medical device including a drug-containing coating in a patient for the delivery of the drug, wherein the coating comprises a drug and a polymer; and (b) applying an electric current for an interval of time to the topcoat to cause the polymer to transform from a crystalline structure to an amorphous structure so as to increase the rate of release of the drug during the time interval, wherein after the electric current is terminated, the crystallinity of the polymer returns back to essentially the same degree of crystallinity or a more crystalline structure than that of when the polymer was exposed to the current.

    摘要翻译： 提供了一种局部递送药物的方法。 该方法包括以下动作：（a）将包括含药物涂层的医疗装置植入患者体内用于输送药物，其中所述包衣包含药物和聚合物; 和（b）将时间间隔的电流施加到面漆，使聚合物从晶体结构转变成非晶结构，从而在时间间隔期间增加药物的释放速率，其中在电 电流被终止，聚合物的结晶度返回到与聚合物暴露于电流时的结晶度基本相同的结晶度或更结晶的结构。

    Optical storage media and method for optical data storage via local changes in reflectivity of a format grating
    38.
    发明授权
    Optical storage media and method for optical data storage via local changes in reflectivity of a format grating 有权
    用于光学数据存储的光存储介质和方法，通过格式光栅的反射率的局部变化

    公开(公告)号：US06512606B1

    公开(公告)日：2003-01-28

    申请号：US09364324

    申请日：1999-07-29

    申请人： Matthew Lipson ,  Sergei Sochava ,  Lambertus Hesselink ,  Brian H. Cumpston ,  Robert R. MeLeod ,  Charles D. Claude

    发明人： Matthew Lipson ,  Sergei Sochava ,  Lambertus Hesselink ,  Brian H. Cumpston ,  Robert R. MeLeod ,  Charles D. Claude

    IPC分类号： G03H118

    CPC分类号： B82Y10/00 ,  C01P2004/64 ,  C09C1/56 ,  G03F7/001 ,  G03H2001/0264 ,  G03H2001/303 ,  G11B7/00455 ,  G11B7/0052 ,  G11B7/0065 ,  G11B7/24 ,  G11B7/26

    摘要： An optical data storage system and method comprising a photopolymer medium having generally a polymerizable monomer, an active binder, a first, hologram recording polymerization initiator, and a second, data writing polymerization initiator. The monomer is preferably a cationic ring-opening monomer. The hologram recording polymerization initiator preferably comprises a sensitizer and photoacid generator which initiate a first polymerization in the medium which defines a format hologram. The format hologram recording is carried out via interference of a signal and reference beam, with the sensitizer being specific for the wavelength(s) of the signal and reference beams. The hologram recording polymerization is only partial and does not consume all of the monomer present in the photopolymer medium. A second stage, a data writing polymerization initiator, specific to a data writing beam, locally advances polymerization at selected data storage locations to alter the previously recorded format hologram, resulting in optical data storage as localized alterations in the format hologram.

    摘要翻译： 一种光学数据存储系统和方法，其包括通常具有可聚合单体的光聚合物介质，活性粘合剂，第一全息记录聚合引发剂和第二数据书写聚合引发剂。 单体优选为阳离子开环单体。 全息记录聚合引发剂优选包括敏化剂和光致酸产生剂，其在介质中引发第一次聚合，其定义格式全息图。 格式全息图记录通过信号和参考光束的干涉进行，敏化剂特定于信号和参考光束的波长。 全息记录聚合仅仅是部分的，并且不消耗光聚合物介质中存在的所有单体。 第二阶段，特定于数据写入光束的数据写入聚合引发器在选定的数据存储位置局部地前进聚合以改变先前记录的格式全息图，导致光学数据存储为格式全息图中的局部改变。