-
31.发明授权
公开(公告)号：US5266692A
公开(公告)日：1993-11-30
申请号：US900463
申请日：1992-06-18
申请人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号： C07D498/18 , C07H19/01 , C12P17/18 , C12P19/44 , C07D498/16 , A61K31/395 , A61K31/695 , C07F7/04
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55
摘要： This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
-
公开(公告)号：US4977138A
公开(公告)日：1990-12-11
申请号：US375998
申请日：1989-07-06
申请人： Masakuni Okuhara , Toshio Goto , Yasuhiro Hori , Takashi Fujita , Hirotsugu Ueda , Nobuharu Shigematsu
发明人： Masakuni Okuhara , Toshio Goto , Yasuhiro Hori , Takashi Fujita , Hirotsugu Ueda , Nobuharu Shigematsu
IPC分类号： C12N1/20 , A61K38/00 , A61P31/04 , A61P35/00 , C07K5/10 , C07K5/103 , C07K14/195 , C07K14/41 , C12P21/02 , C12P21/04 , C12R1/01
CPC分类号： C07K5/101
摘要： The invention relates to a compound having antimicrobial and antitumor activity, the compound being designated FR901228 substance of the following formula: ##STR1##
-
公开(公告)号：US4939241A
公开(公告)日：1990-07-03
申请号：US173294
申请日：1988-03-25
申请人： Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
发明人： Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
IPC分类号： A61K31/22 , A61P35/00 , C07C67/00 , C07C241/00 , C07C245/18 , C12P13/00 , C12R1/465
CPC分类号： C12P13/04 , C07C245/18 , C12P13/00 , Y10S435/886
摘要： The invention relates to compounds of antitumor activity of the formula: ##STR1## ps in which R.sup.1 is hydrogen, lower allkyl, halo(lower)alkyl or aryl,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen,R.sup.4 is aminocarboxy(lower)alkyl, protected amino(lower)alkyl or protected aminocarboxy(lower)alkyl, andR.sup.5 is hydrogen or lower alkyl, or its pharmaceutical acceptable salt.
-
公开(公告)号：US4929611A
公开(公告)日：1990-05-29
申请号：US868749
申请日：1986-05-30
申请人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号： A01N43/38 , A61K31/00 , A61K31/33 , A61K31/40 , A61K31/407 , A61K31/435 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/453 , A61K31/4745 , A61P31/00 , A61P31/04 , A61P37/00 , A61P37/06 , C07D491/14 , C07D498/04 , C07D498/14 , C07D498/18 , C07D519/00 , C07H19/01 , C12N1/20 , C12P17/16 , C12P17/18 , C12P19/44 , C12R1/465 , C12R1/55
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要： This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
-
35.发明授权Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same 失效三环化合物，其生产方法和含有它们的药物组合物
公开(公告)号：US4894366A
公开(公告)日：1990-01-16
申请号：US799855
申请日：1985-11-20
申请人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号： A01N43/38 , A61K31/00 , A61K31/33 , A61K31/40 , A61K31/407 , A61K31/435 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/453 , A61K31/4745 , A61P31/00 , A61P31/04 , A61P37/00 , A61P37/06 , C07D491/14 , C07D498/04 , C07D498/14 , C07D498/18 , C07D519/00 , C07H19/01 , C12N1/20 , C12P17/16 , C12P17/18 , C12P19/44 , C12R1/465 , C12R1/55
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要： This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
摘要翻译： 本发明涉及可用于治疗和预防移植抵抗的三环类化合物，通过髓质移植移植物抗宿主病，自身免疫性疾病，感染性疾病等，其可以由下式表示：
（ I）涉及其制备方法，含有该方法的药物组合物及其用途。 -
公开(公告)号：US6028097A
公开(公告)日：2000-02-22
申请号：US84099
申请日：1998-05-26
申请人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号： A01N43/38 , A61K31/00 , A61K31/33 , A61K31/40 , A61K31/407 , A61K31/435 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/453 , A61K31/4745 , A61P31/00 , A61P31/04 , A61P37/00 , A61P37/06 , C07D491/14 , C07D498/04 , C07D498/14 , C07D498/18 , C07D519/00 , C07H19/01 , C12N1/20 , C12P17/16 , C12P17/18 , C12P19/44 , C12R1/465 , C12R1/55
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要： This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
摘要翻译： 本发明涉及可用于治疗和预防移植抵抗力的三环化合物，由髓质骨移植引起的移植物抗宿主病，自身免疫性疾病，感染性疾病等，其可以由下式表示： 它们的生产，涉及含有该组合物的药物组合物及其用途。
-
公开(公告)号：US5436140A
公开(公告)日：1995-07-25
申请号：US225915
申请日：1994-04-11
申请人： Tohru Kino , Motoaki Nishikawa , Masami Ezaki , Sumio Kiyoto , Masakuni Okuhara , Shigehiro Takase , Satoshi Okada , Nobuharu Shigematsu
发明人： Tohru Kino , Motoaki Nishikawa , Masami Ezaki , Sumio Kiyoto , Masakuni Okuhara , Shigehiro Takase , Satoshi Okada , Nobuharu Shigematsu
摘要： The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives thereof using Streptomyces violaceoniger No. 9326 in a biologically pure form is described herein.
摘要翻译： 新型肽WS-9326A，WS-9326B及其衍生物和药学上可接受的盐具有有用的药理活性，特别是用于治疗和/或预防哮喘和/或疼痛。 本文描述了以生物纯的形式生产肽WS-9326A和WS-9326B及其衍生物的方法。
-
公开(公告)号：US5409701A
公开(公告)日：1995-04-25
申请号：US178245
申请日：1994-01-24
IPC分类号： A61K35/74 , A61P29/00 , A61P37/00 , A61P43/00 , C07G99/00 , C12N9/99 , C12P1/04 , C12R1/01 , C12P21/00
CPC分类号： C12P1/04 , A61K31/00 , C07G17/00 , Y10S435/822
摘要： A new FR901451 substance which is produced by culturing a FR901451 substance-producing strain of the genus Flexibacter in a nutrient medium, this new substance possessing a human leukocyte elastase-inhibiting activity.
摘要翻译： PCT No.PCT / JP92 / 00894 Sec。 371日期：1994年1月24日 102（e）日期1994年1月24日PCT提交1992年7月14日PCT公布。 公开号WO93 / 02203 日期：1993年2月4日。一种新的FR901451物质，其是通过培养在营养培养基中培养属于灵芝菌属的FR901451物质的FR901451物质，该物质具有人白细胞弹性蛋白酶抑制活性。
-
39.发明授权Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same 失效三环化合物，其生产方法和含有它们的药物组合物
公开(公告)号：US5254562A
公开(公告)日：1993-10-19
申请号：US900487
申请日：1992-06-18
申请人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号： C07D498/18 , C07H19/01 , C12P17/18 , C12P19/44 , A61K31/395 , C07D498/16
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55
摘要： This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
摘要翻译： 本发明涉及可用于治疗和预防移植抵抗的三环类化合物，通过髓质移植移植物抗宿主病，自身免疫性疾病，感染性疾病等，其可以由下式表示：
（ I）涉及其制备方法，含有该方法的药物组合物及其用途。 -
40.发明授权WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome 失效WS7622A，B，C和D物质，其衍生物，其制备方法和用于治疗肺气肿和成人呼吸窘迫综合征
公开(公告)号：US5167958A
公开(公告)日：1992-12-01
申请号：US645820
申请日：1991-01-25
申请人： Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara , Shigehiro Takase
发明人： Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara , Shigehiro Takase
IPC分类号： C12P1/04 , A61K35/74 , A61P1/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P43/00 , C07G99/00 , C12P1/06 , C12R1/465
CPC分类号： C12P1/06 , Y10S435/886
摘要： A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.
摘要翻译： 一种在有需要的受试者中治疗肺气肿或成人呼吸窘迫综合征的方法，其包括向受试者施用有效量的WS7622A，B，C和/或D，其衍生物或其药学上可接受的盐。
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.031 秒)
