-
公开(公告)号：US4939241A
公开(公告)日：1990-07-03
申请号：US173294
申请日：1988-03-25
申请人： Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
发明人： Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
IPC分类号： A61K31/22 , A61P35/00 , C07C67/00 , C07C241/00 , C07C245/18 , C12P13/00 , C12R1/465
CPC分类号： C12P13/04 , C07C245/18 , C12P13/00 , Y10S435/886
摘要： The invention relates to compounds of antitumor activity of the formula: ##STR1## ps in which R.sup.1 is hydrogen, lower allkyl, halo(lower)alkyl or aryl,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen,R.sup.4 is aminocarboxy(lower)alkyl, protected amino(lower)alkyl or protected aminocarboxy(lower)alkyl, andR.sup.5 is hydrogen or lower alkyl, or its pharmaceutical acceptable salt.
-
公开(公告)号：US5545542A
公开(公告)日：1996-08-13
申请号：US415160
申请日：1995-03-31
申请人： Hidenori Nakajima , Yasuhiro Hori , Toshio Goto , Shigehiro Takase , Koen Verhaeghe , Hiroshi Terano , Masakuni Okuhara
发明人： Hidenori Nakajima , Yasuhiro Hori , Toshio Goto , Shigehiro Takase , Koen Verhaeghe , Hiroshi Terano , Masakuni Okuhara
CPC分类号： C12P1/04 , Y10S435/822 , Y10S435/874
摘要： WB2663 substance-producing bacteria belonging to the genus Pseudomonas are cultured to produce a physiologically active substance, from which are isolated neutral substances WB2663A, WB2663B and WB2663C having respective specific rotations[.alpha.].sub.D.sup.23 : -36.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -12.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -9.degree. (C=0.5, CH.sub.2 Cl.sub.2),These substances have an excellent antitumor effect.
摘要翻译： 培养属于假单胞菌属的WB2663物质产生细菌以产生生理活性物质，从其中分离具有各自的特定旋度αD23：-36°（C = 0.5，CH 2 Cl 2）的分离的中性物质WB2663A，WB2663B和WB2663C， αD23：-12°（C = 0.5，CH 2 Cl 2），αD 23：-9（C = 0.5，CH 2 Cl 2）。这些物质具有优异的抗肿瘤效果。
-
公开(公告)号：US07645614B2
公开(公告)日：2010-01-12
申请号：US10533237
申请日：2003-10-31
IPC分类号： G01N33/53
CPC分类号： G01N33/54353 , B01D15/3804 , B01J20/286 , B01J20/289 , G01N2500/00 , Y10S436/823 , Y10S436/824
摘要： The present invention provides a method of analyzing the specific interaction between a molecule to be analyzed and a molecule that specifically interacts with the former molecule on a solid phase using a molecule-immobilized solid phase support mixture prepared by binding the subject molecule to the solid phase support without specifying the binding position on the molecule side, particularly a method wherein the immobilization is conducted via a spacer introduced to the molecule without specifying the binding position on the molecule side, which method makes it possible to identify and select only a molecule that exhibits a specific interaction with a molecule to be analyzed, without an investigation of structure-activity correlation, which has conventionally been essential, and hence enables an analysis of the interaction between these molecules.
摘要翻译： 本发明提供了一种分析待分析分子与在固相上与前一分子特异性相互作用的分子之间的特异性相互作用的方法，其中所述分子固定的固相支持混合物是通过将受试分子与固相结合而制备的 特别是一种方法，其中通过分子引入的间隔物进行固定，而不指定分子侧的结合位置，该方法使得可以仅鉴定和选择表现出分子侧的结合位置的分子， 与待分析的分子的特异性相互作用，而不具有传统上必需的结构 - 活性相关性的研究，因此能够分析这些分子之间的相互作用。
-
4.发明授权公开(公告)号：US07371842B2
公开(公告)日：2008-05-13
申请号：US10511270
申请日：2003-04-28
CPC分类号： C12N9/88 , C07K14/4702 , G01N2500/00
摘要： It is intended to provide a protein participating in the regulation of sugar production, a polynucleotide encoding the same, a method of screening a compound participating in the regulation of sugar production and a drug for treating or preventing diabetes which contains the compound participating in the regulation of sugar production. A polynucleotide encoding a protein specifically binding to a substance WF00144 is found out from rat liver cells and thus a protein participating in the regulation of sugar production and a polynucleotide encoding the same are provided. Moreover, a method and a substance relating to a method of treating and preventing diabetes are found out and thus a method of treating diabetes relating to the regulation of sugar production relating to the method of treating and preventing diabetes is provided.
摘要翻译： 目的在于提供参与糖生产调节的蛋白质，编码糖蛋白的多核苷酸，筛选参与糖生产调节的化合物的方法和用于治疗或预防糖尿病的药物，其含有参与调节的化合物 的糖生产。 从大鼠肝细胞中发现编码与物质WF00144特异性结合的蛋白质的多核苷酸，因此提供了参与糖产生调节的蛋白质和编码该多核苷酸的多核苷酸。 此外，发现了与治疗和预防糖尿病的方法有关的方法和物质，因此提供了治疗和预防糖尿病的方法中关于糖生产调节的糖尿病的治疗方法。
-
公开(公告)号：US20070062722A1
公开(公告)日：2007-03-22
申请号：US11252626
申请日：2005-10-19
申请人： Takashi Tanaka , Hidenori Nakajima , Yuichi Tokuda
发明人： Takashi Tanaka , Hidenori Nakajima , Yuichi Tokuda
IPC分类号： H05K1/00
CPC分类号： H05K1/028 , H05K1/144 , H05K3/4611 , H05K3/4635 , H05K3/4691 , H05K2201/09109
摘要： A hinge board having a hinge bending part and a rigid part includes: not less than two flexible wiring boards including a polyimide sheet layer, a conductor layer having a circuit formed on both sides or one side of the polyimide sheet layer, and a coverlay film layer covering the conductor layer; and a bonding material for bonding the flexible wiring boards. At least one of the flexible wiring boards is a flexible double-sided wiring board including the conductor layers on both sides of the polyimide sheet layer. Moreover, the flexible wiring boards are bonded to each other in the rigid part by use of the bonding material in such a manner that a space part is formed between the flexible wiring boards in the hinge bending part.
摘要翻译： 具有铰链弯曲部分和刚性部分的铰链板包括：不少于两个柔性布线板，包括聚酰亚胺片层，具有形成在聚酰亚胺片层的两侧或一侧上的电路的导体层和覆盖膜 覆盖导体层的层; 以及用于接合柔性布线板的接合材料。 柔性布线板中的至少一个是包含聚酰亚胺片层两侧的导体层的柔性双面布线板。 此外，柔性布线板通过使用接合材料在刚性部分中彼此结合，使得在铰链弯曲部分中的柔性布线板之间形成空间部分。
-
公开(公告)号：US20050214858A1
公开(公告)日：2005-09-29
申请号：US10511270
申请日：2003-04-28
CPC分类号： C12N9/88 , C07K14/4702 , G01N2500/00
摘要： It is intended to provide a protein participating in the regulation of sugar production, a polynucleotide encoding the same, a method of screening a compound participating in the regulation of sugar production and a drug for treating or preventing diabetes which contains the compound participating in the regulation of sugar production. A polynucleotide encoding a protein specifically binding to a substance WF00144 is found out from rat liver cells and thus a protein participating in the regulation of sugar production and a polynucleotide encoding the same are provided. Moreover, a method and a substance relating to a method of treating and preventing diabetes are found out and thus a method of treating diabetes relating to the regulation of sugar production relating to the method of treating and preventing diabetes is provided.
摘要翻译： 目的在于提供参与糖生产调节的蛋白质，编码糖蛋白的多核苷酸，筛选参与糖生产调节的化合物的方法和用于治疗或预防糖尿病的药物，其含有参与调节的化合物 的糖生产。 从大鼠肝细胞中发现编码与物质WF00144特异性结合的蛋白质的多核苷酸，因此提供了参与糖产生调节的蛋白质和编码该多核苷酸的多核苷酸。 此外，发现了与治疗和预防糖尿病的方法有关的方法和物质，因此提供了治疗和预防糖尿病的方法中关于糖生产调节的糖尿病的治疗方法。
-
公开(公告)号：US07381901B2
公开(公告)日：2008-06-03
申请号：US11252626
申请日：2005-10-19
申请人： Takashi Tanaka , Hidenori Nakajima , Yuichi Tokuda
发明人： Takashi Tanaka , Hidenori Nakajima , Yuichi Tokuda
IPC分类号： H05K1/00
CPC分类号： H05K1/028 , H05K1/144 , H05K3/4611 , H05K3/4635 , H05K3/4691 , H05K2201/09109
摘要： A hinge board having a hinge bending part and a rigid part includes: not less than two flexible wiring boards including a polyimide sheet layer, a conductor layer having a circuit formed on both sides or one side of the polyimide sheet layer, and a coverlay film layer covering the conductor layer; and a bonding material for bonding the flexible wiring boards. At least one of the flexible wiring boards is a flexible double-sided wiring board including the conductor layers on both sides of the polyimide sheet layer. Moreover, the flexible wiring boards are bonded to each other in the rigid part by use of the bonding material in such a manner that a space part is formed between the flexible wiring boards in the hinge bending part.
摘要翻译： 具有铰链弯曲部分和刚性部分的铰链板包括：不少于两个柔性布线板，包括聚酰亚胺片层，具有形成在聚酰亚胺片层的两侧或一侧上的电路的导体层和覆盖膜 覆盖导体层的层; 以及用于接合柔性布线板的接合材料。 柔性布线板中的至少一个是包含聚酰亚胺片层两侧的导体层的柔性双面布线板。 此外，柔性布线板通过使用接合材料在刚性部分中彼此结合，使得在铰链弯曲部分中的柔性布线板之间形成空间部分。
-
公开(公告)号：US07056884B2
公开(公告)日：2006-06-06
申请号：US10333063
申请日：2001-07-09
摘要： The present invention relates to reduced FK228 of the formula (I) wherein R1 and R2 are the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and a histone deacetylase inhibitor containing this compound, an expression potentiator and a reactivation promoter of a transgene, and pharmaceutical agents containing them as active ingredients. The reduced FK228 or a salt thereof has a strong histone deacetylase inhibitory activity and this compound can be used for the prophylaxis or treatment of various diseases, in which histone deacetylation is involved, and for the gene therapy of such diseases.
摘要翻译： 本发明涉及式（I）的还原型FK228，其中R 1和R 2相同或不同，各自为氢原子或硫醇保护基 或其盐，以及含有该化合物的组蛋白脱乙酰酶抑制剂，转基因的表达增强子和再活化启动子以及含有它们作为有效成分的药剂。 还原的FK228或其盐具有强的组蛋白脱乙酰酶抑制活性，该化合物可用于预防或治疗涉及组蛋白脱乙酰化的各种疾病和用于这些疾病的基因治疗。
-
公开(公告)号：US20060024845A1
公开(公告)日：2006-02-02
申请号：US10533237
申请日：2003-10-31
IPC分类号： G01N33/543
CPC分类号： G01N33/54353 , B01D15/3804 , B01J20/286 , B01J20/289 , G01N2500/00 , Y10S436/823 , Y10S436/824
摘要： The present invention provides a method of analyzing the specific interaction between a molecule to be analyzed and a molecule that specifically interacts with the former molecule on a solid phase using a molecule-immobilized solid phase support mixture prepared by binding the subject molecule to the solid phase support without specifying the binding position on the molecule side, particularly a method wherein the immobilization is conducted via a spacer introduced to the molecule without specifying the binding position on the molecule side, which method makes it possible to identify and select only a molecule that exhibits a specific interaction with a molecule to be analyzed, without an investigation of structure-activity correlation, which has conventionally been essential, and hence enables an analysis of the interaction between these molecules.
摘要翻译： 本发明提供了一种分析待分析分子与在固相上与前一分子特异性相互作用的分子之间的特异性相互作用的方法，其中所述分子固定的固相支持混合物是通过将受试分子与固相结合而制备的 特别是一种方法，其中通过分子引入的间隔物进行固定，而不指定分子侧的结合位置，该方法使得可以仅鉴定和选择表现出分子侧的结合位置的分子， 与待分析的分子的特异性相互作用，而不具有传统上必需的结构 - 活性相关性的研究，因此能够分析这些分子之间的相互作用。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.028 秒)