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公开(公告)号：US5409701A
公开(公告)日：1995-04-25
申请号：US178245
申请日：1994-01-24
IPC分类号： A61K35/74 , A61P29/00 , A61P37/00 , A61P43/00 , C07G99/00 , C12N9/99 , C12P1/04 , C12R1/01 , C12P21/00
CPC分类号： C12P1/04 , A61K31/00 , C07G17/00 , Y10S435/822
摘要： A new FR901451 substance which is produced by culturing a FR901451 substance-producing strain of the genus Flexibacter in a nutrient medium, this new substance possessing a human leukocyte elastase-inhibiting activity.
摘要翻译： PCT No.PCT / JP92 / 00894 Sec。 371日期：1994年1月24日 102（e）日期1994年1月24日PCT提交1992年7月14日PCT公布。 公开号WO93 / 02203 日期：1993年2月4日。一种新的FR901451物质，其是通过培养在营养培养基中培养属于灵芝菌属的FR901451物质的FR901451物质，该物质具有人白细胞弹性蛋白酶抑制活性。
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2.发明授权WS7622A mono- or di- sulfate, process for preparation thereof and use thereof 失效WS7622A单硫酸盐或二硫酸盐，其制备方法和用途
公开(公告)号：US5292510A
公开(公告)日：1994-03-08
申请号：US713295
申请日：1991-06-11
申请人： Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara
发明人： Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara
IPC分类号： A61K38/00 , A61K38/55 , A61K39/12 , A61P9/10 , A61P11/00 , A61P29/00 , C07K1/113 , C07K4/04 , C07K14/00 , C07K14/195 , C07K14/36 , C07K14/81 , C12P1/06 , C12P21/00 , C12R1/465 , A61K35/74
摘要： WS7622A mono- or di-sulfate and pharmaceutically acceptable salts thereof. WS7622A exhibits human leukocyte elastase-inhibiting activity.
摘要翻译： WS7622A单硫酸盐或二硫酸盐及其药学上可接受的盐。 WS7622A具有人白细胞弹性蛋白酶抑制活性。
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3.发明授权Prophylactic/therapeutic composition for disseminated intravascular coagulation, chronic respiratory tract infectious disease or chronic bronchitis 失效弥散性血管内凝血，慢性呼吸道感染性疾病或慢性支气管炎的预防/治疗组合物
公开(公告)号：US5279826A
公开(公告)日：1994-01-18
申请号：US899915
申请日：1992-06-17
申请人： Noriaki Inamura , Yasuhiko Shinguh , Kunio Nakahara , Yoshitada Notsu , Masanori Okamoto , Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Nobuharu Shigematsu , Masakuni Okuhara
发明人： Noriaki Inamura , Yasuhiko Shinguh , Kunio Nakahara , Yoshitada Notsu , Masanori Okamoto , Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Nobuharu Shigematsu , Masakuni Okuhara
CPC分类号： C07K4/04 , C07K14/811 , A61K38/00 , A61K39/00
摘要： A method for therapy of disseminated intravascular coagulation, or chronic respiratory tract infectious disease characterized by administering to a patient in need thereof an effective dose suitable for therapeutic treatment of said condition of WS7622A mono- or di-sulfate ester or their pharmaceutically acceptable salt.
摘要翻译： 一种用于治疗弥漫性血管内凝血或慢性呼吸道感染性疾病的方法，其特征在于向有需要的患者施用适于治疗所述WS7622A单硫酸酯或二硫酸酯或其药学上可接受的盐的病症的有效剂量。
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4.发明授权WS7622A mono- or di-sulfate, process for preparation thereof and use thereof 失效WS7622A单硫酸或二硫酸盐，其制备方法和用途
公开(公告)号：US5364624A
公开(公告)日：1994-11-15
申请号：US87006
申请日：1993-07-07
申请人： Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara
发明人： Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara
IPC分类号： A61K38/00 , A61K38/55 , A61K39/12 , A61P9/10 , A61P11/00 , A61P29/00 , C07K1/113 , C07K4/04 , C07K14/00 , C07K14/195 , C07K14/36 , C07K14/81 , C12P1/06 , C12P21/00 , C12R1/465 , A61K35/74
摘要： A degenerative disease selected from the group consisting of cystic fibrosis, chronic bronchitis and bronchiectasia is treated by administering to a subject a therapeutically effective amount of WS7622A mono-or disulfate or pharmaceutically acceptable salt thereof.
摘要翻译： 通过向受试者施用治疗有效量的WS7622A单或二硫酸盐或其药学上可接受的盐来治疗选自囊性纤维化，慢性支气管炎和支气管扩张症的退行性疾病。
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5.发明授权WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use thereof 失效WS7622A，B，C和D物质，其衍生物，其制备方法和用途
公开(公告)号：US5021240A
公开(公告)日：1991-06-04
申请号：US482822
申请日：1990-02-21
申请人： Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara , Shigehiro Takase
发明人： Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara , Shigehiro Takase
IPC分类号： C12P1/04 , A61K35/74 , A61P1/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P43/00 , C07G99/00 , C12P1/06 , C12R1/465
CPC分类号： C12P1/06 , Y10S435/886
摘要： The present invention relates to new WS7622A, B, C and/or D substances, derivatives thereof and pharmaceutical compositions containing the new substances as active ingredients.
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6.发明授权WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome 失效WS7622A，B，C和D物质，其衍生物，其制备方法和用于治疗肺气肿和成人呼吸窘迫综合征
公开(公告)号：US5167958A
公开(公告)日：1992-12-01
申请号：US645820
申请日：1991-01-25
申请人： Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara , Shigehiro Takase
发明人： Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara , Shigehiro Takase
IPC分类号： C12P1/04 , A61K35/74 , A61P1/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P43/00 , C07G99/00 , C12P1/06 , C12R1/465
CPC分类号： C12P1/06 , Y10S435/886
摘要： A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.
摘要翻译： 一种在有需要的受试者中治疗肺气肿或成人呼吸窘迫综合征的方法，其包括向受试者施用有效量的WS7622A，B，C和/或D，其衍生物或其药学上可接受的盐。
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7.发明授权
公开(公告)号：US6110933A
公开(公告)日：2000-08-29
申请号：US669395
申请日：1996-11-12
申请人： Shigehiro Takase , Nobuharu Shigematsu , Seiji Yoshimura , Satoshi Okada , Keiji Hemmi, deceased , Hirokazu Tanaka , Takanao Otsuka , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Naoki Fukami
发明人： Shigehiro Takase , Nobuharu Shigematsu , Seiji Yoshimura , Satoshi Okada , Keiji Hemmi, deceased , Hirokazu Tanaka , Takanao Otsuka , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Naoki Fukami
IPC分类号： C07D295/20 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/27 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/472 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P1/16 , A61P3/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07C227/02 , C07C227/08 , C07C229/22 , C07C235/08 , C07C235/12 , C07C237/04 , C07C237/22 , C07C271/22 , C07C271/54 , C07C275/14 , C07C275/16 , C07C311/19 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/75 , C07D213/78 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/54 , C07D233/64 , C07D241/14 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/22 , C07D295/28 , C07D317/58 , C07D471/04 , A61K31/325 , A61K31/16 , C07D215/02 , C07D217/00
CPC分类号： C07D213/40 , C07C235/08 , C07C235/12 , C07C271/22 , C07C271/54 , C07C275/16 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/64 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/32 , C07D317/58 , C07D471/04
摘要： The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R.sup.1 is acyl group, etc.;R.sup.2 is acyl(lower)alkyl;R.sup.3 is lower alkyl, etc.;R.sup.4 is hydrogen, etc.; andX is --O--, etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
摘要翻译： PCT No.PCT / JP95 / 00068 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT 1995年1月23日PCT PCT。 第WO95 / 19959号公报 日期：1995年7月27日本发明涉及下式的新型脂肪酸衍生物：其中R1为酰基等; R2是酰基（低级）烷基; R3是低级烷基等; R4是氢等; X为-O-等; 和其药学上可接受的盐，其可用作药物; 所述脂肪酸衍生物或其盐的制备方法; 包含所述脂肪酸衍生物或其药学上可接受的盐的药物组合物; 等等
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公开(公告)号：US4963585A
公开(公告)日：1990-10-16
申请号：US310323
申请日：1989-02-14
申请人： Masanori Okamoto , Eisaku Tsujii , Tsutomu Kaizu , Hiroshi Hatanaka , Masakuni Okuhara , Kozo Sawada , Hirokazu Tanaka
发明人： Masanori Okamoto , Eisaku Tsujii , Tsutomu Kaizu , Hiroshi Hatanaka , Masakuni Okuhara , Kozo Sawada , Hirokazu Tanaka
CPC分类号： C07J63/008 , C12P17/06
摘要： The invention relates to a compound of antimicrobial activity of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkanoyl,R.sup.2 is hydrogen or ##STR2## in which R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen or lower alkanoyl,R.sup.3 is carboxy or a protected carboxy, and pharmaceutically acceptable salt thereof.
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公开(公告)号：US5545542A
公开(公告)日：1996-08-13
申请号：US415160
申请日：1995-03-31
申请人： Hidenori Nakajima , Yasuhiro Hori , Toshio Goto , Shigehiro Takase , Koen Verhaeghe , Hiroshi Terano , Masakuni Okuhara
发明人： Hidenori Nakajima , Yasuhiro Hori , Toshio Goto , Shigehiro Takase , Koen Verhaeghe , Hiroshi Terano , Masakuni Okuhara
CPC分类号： C12P1/04 , Y10S435/822 , Y10S435/874
摘要： WB2663 substance-producing bacteria belonging to the genus Pseudomonas are cultured to produce a physiologically active substance, from which are isolated neutral substances WB2663A, WB2663B and WB2663C having respective specific rotations[.alpha.].sub.D.sup.23 : -36.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -12.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -9.degree. (C=0.5, CH.sub.2 Cl.sub.2),These substances have an excellent antitumor effect.
摘要翻译： 培养属于假单胞菌属的WB2663物质产生细菌以产生生理活性物质，从其中分离具有各自的特定旋度αD23：-36°（C = 0.5，CH 2 Cl 2）的分离的中性物质WB2663A，WB2663B和WB2663C， αD23：-12°（C = 0.5，CH 2 Cl 2），αD 23：-9（C = 0.5，CH 2 Cl 2）。这些物质具有优异的抗肿瘤效果。
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公开(公告)号：US5187195A
公开(公告)日：1993-02-16
申请号：US543437
申请日：1990-06-26
申请人： Nobutaka Oohata , Motoaki Nishikawa , Sumio Kiyoto , Shigehiro Takase , Keiji Hemmi , Hidetsugu Murai , Masakuni Okuhara
发明人： Nobutaka Oohata , Motoaki Nishikawa , Sumio Kiyoto , Shigehiro Takase , Keiji Hemmi , Hidetsugu Murai , Masakuni Okuhara
IPC分类号： C12P13/02 , A61K31/16 , A61K31/195 , A61K31/215 , A61K38/00 , A61P9/00 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , C07C323/25 , C07C323/41 , C07C323/59 , C07C323/60 , C07D209/20 , C07K5/06 , C07K5/083 , C12N1/20 , C12P13/00 , C12R1/38 , C12R1/465
CPC分类号： C12P13/001 , C07C323/59 , C07C323/60 , C07K5/0606 , C07K5/081 , A61K38/00 , C07C2103/42 , Y10S514/929
摘要： Anthraquinone compounds of the formula: ##STR1## wherein: R.sup.1 is hydrogen, hydroxy or acyloxy,R.sup.2 is hydrogen or acyl,R.sup.3 is acyl,R.sup.4 is hydrogen or acyl,R.sup.5 is hydrogen or acyl,R.sup.6 is hydrogen or acyl, andR.sup.7 is hydrogen or acylhave been found to possess endothelin antagonistic properties and are producible by various synthetic and fermentation processes.
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